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1. Neurologic Deficits in Patients With Newly Diagnosed Celiac Disease are Frequent and Linked With Autoimmunity to TG6. (PubMed)

Neurologic Deficits in Patients With Newly Diagnosed Celiac Disease are Frequent and Linked With Autoimmunity to TG6. Celiac disease is an autoimmune disorder induced by ingestion of gluten that affects 1% of the population and is characterized by gastrointestinal symptoms, weight loss, and anemia. We evaluated the presence of neurologic deficits and investigated whether the presence of antibodies to Transglutaminase 6 (TG6) increases the risk of neurologic defects in patients with a new (...) MR spectroscopy 1 year later.In a prospective cohort study of patients with a new diagnosis of celiac disease at a gastroenterology clinic, neurologic deficits were common and 40% had circulating antibodies against TG6. We observed a significant reduction in volume of specific brain regions in patients with TG6 autoantibodies, providing evidence for a link between autoimmunity to TG6 and brain atrophy in patients with celiac disease. There is a need for early diagnosis, increased awareness

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2019 Clinical Gastroenterology and Hepatology

2. Individual differences in social network size linked to nucleus accumbens and hippocampal volumes in functional neurological disorder: A pilot study. (PubMed)

Individual differences in social network size linked to nucleus accumbens and hippocampal volumes in functional neurological disorder: A pilot study. In the biopsychosocial formulation of functional neurological (conversion) disorder (FND), little is known about relationships between social behavior and brain anatomy. We hypothesized that social behavior would relate to brain areas implicated in affiliative behaviors and that social network size would correlate with symptom severity (...) -epileptic seizure diagnosis; social network size inversely related to lifetime trauma burden, post-traumatic stress disorder severity and age.Only patient-reported scales were used and social network size information was not collected for healthy subjects.This neuroimaging pilot adds to the literature linking affiliation network brain areas to pro-social behaviors and enhances the biopsychosocial conceptualization of FND.Copyright © 2019 Elsevier B.V. All rights reserved.

2019 Journal of Affective Disorders

3. Suspected neurological conditions: recognition and referral

Suspected neurological conditions: recognition and referral Suspected neurological conditions: Suspected neurological conditions: recognition and referr recognition and referral al NICE guideline Published: 1 May 2019 www.nice.org.uk/guidance/ng127 © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility The recommendations in this guideline represent the view of NICE, arrived (...) be interpreted in a way that would be inconsistent with complying with those duties. Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. Suspected neurological conditions: recognition and referral (NG127) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 2

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

4. The Spectrum of Neurological and White Matter Changes and Premutation Status Categories of Older Male Carriers of the FMR1 Alleles Are Linked to Genetic (CGG and FMR1 mRNA) and Cellular Stress (AMPK) Markers (PubMed)

The Spectrum of Neurological and White Matter Changes and Premutation Status Categories of Older Male Carriers of the FMR1 Alleles Are Linked to Genetic (CGG and FMR1 mRNA) and Cellular Stress (AMPK) Markers The fragile X premutation (PM) allele contains a CGG expansion of 55-200 repeats in the FMR1 gene's promoter. Male PM carriers have an elevated risk of developing neurological and psychiatric changes, including an approximately 50% risk of the fragile X-associated tremor/ataxia syndrome

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2018 Frontiers in genetics

5. Neurology data and analysis: a guide for health professionals

the number and type of adult neurological outpatient appointments offered in England and how close they are made to the patient’s home. This information can help commissioners and clinicians assess whether they comply with recommendations by the Royal College of Physicians for scheduled outpatient care. Further information . to our monthly bulletin which gives a snapshot of our latest resources and key messages that we wish to share. Published 3 May 2017 Last updated 6 March 2019 6 March 2019 Added link (...) to neurology data catalogue. 27 February 2018 Added 'deaths associated with neurological conditions'. 3 May 2017 First published. Explore the topic Is this page useful? Thank you for your feedback Help us improve GOV.UK Don’t include personal or financial information like your National Insurance number or credit card details. What were you doing? What went wrong? Send Help us improve GOV.UK To help us improve GOV.UK, we’d like to know more about your visit today. We’ll send you a link to a feedback form

2019 Public Health England

6. The Combined Use of Ultrasound and Fetal Magnetic Resonance Imaging for a Comprehensive Fetal Neurological Assessment in Fetal Congenital Cardiac Defects

The Combined Use of Ultrasound and Fetal Magnetic Resonance Imaging for a Comprehensive Fetal Neurological Assessment in Fetal Congenital Cardiac Defects The Combined Use of Ultrasound and Fetal Magnetic Resonance Imaging for a Comprehensive Fetal Neurological Assessment in Fetal Congenital Cardiac Defects - Pasupathy - - BJOG: An International Journal of Obstetrics & Gynaecology - Wiley Online Library By continuing to browse this site, you agree to its use of cookies as described in our (...) . Search within Search term Search term RCOG Scientific Impact Paper Free Access The Combined Use of Ultrasound and Fetal Magnetic Resonance Imaging for a Comprehensive Fetal Neurological Assessment in Fetal Congenital Cardiac Defects Scientific Impact Paper No. 60 Corresponding Author E-mail address: Correspondence : Royal College of Obstetricians and Gynaecologists, 27 Sussex Place, Regent's Park, London NW1 4RG. Email: Corresponding Author E-mail address: Correspondence : Royal College

2019 Royal College of Obstetricians and Gynaecologists

7. Emerging Evidence for a Direct Link between EAAT-Associated Anion Channels and Neurological Disorders (PubMed)

Emerging Evidence for a Direct Link between EAAT-Associated Anion Channels and Neurological Disorders 28077704 2018 05 28 2018 12 02 1529-2401 37 2 2017 01 11 The Journal of neuroscience : the official journal of the Society for Neuroscience J. Neurosci. Emerging Evidence for a Direct Link between EAAT-Associated Anion Channels and Neurological Disorders. 241-243 10.1523/JNEUROSCI.2947-16.2017 Gonzalez-Suarez Aneysis D AD 0000-0003-3745-763X Yale University School of Medicine, Interdepartmental (...) ;9(11):1388-96 17041592 Prog Neurobiol. 2001 Sep;65(1):1-105 11369436 PLoS One. 2012;7(4):e35373 22506078 Cell. 2015 Jan 29;160(3):542-53 25635461 Curr Opin Neurobiol. 1999 Jun;9(3):293-8 10395570 J Biol Chem. 2015 Sep 18;290(38):22977-90 26203187 Glia. 2011 Feb;59(2):320-32 21125654 Curr Mol Pharmacol. 2013 Jul;6(2):66-73 23876150 Neurology. 2005 Aug 23;65(4):529-34 16116111 Neurochem Int. 2016 Sep;98:56-71 27013346 Brain. 2012 Nov;135(Pt 11):3416-25 23107647 J Neurosci. 2010 Oct 27;30(43):14446

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2017 The Journal of Neuroscience

8. Neurological Manifestations of X-Linked Ichthyosis: Case Report and Review of the Literature (PubMed)

Neurological Manifestations of X-Linked Ichthyosis: Case Report and Review of the Literature A 5-year-old boy presented with mild autism and attention-deficit hyperactivity disorder (ADHD). Chromosomal microarray demonstrated a 1.7 Mb deletion at Xp22.31, which was consistent with X-linked ichthyosis (XLI). Further exam revealed dry, scaly skin on his abdomen and pretibial areas. Patients with mutations involving solely the STS gene or the recurrent ~2 Mb deletion may present with ADHD, whereas (...) those with larger deletions including the NLGN4 gene can present with both ADHD and autism. However, our patient presented with mild autism in addition to ADHD despite having only the recurrent deletion without loss of NLGN4. Such neurological manifestations of XLI warrant attention as practical targets of clinical management.

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2017 Case Reports in Genetics

9. X-linked adult-onset adrenoleukodystrophy: Psychiatric and neurological manifestations (PubMed)

X-linked adult-onset adrenoleukodystrophy: Psychiatric and neurological manifestations Adult-onset adrenoleukodystrophy is a rare x-linked inborn error of metabolism occurring predominantly in males with onset in early 30s. Here, we report a 34-year-old male with first signs of disease in early 20s manifesting as a pure psychiatric disorder. Prior to onset of neurological symptoms, this patient demonstrated a schizophrenia and bipolar-like presentation. The disease progressed over the next 10 (...) -13 years and his memory and motor problems became evident around the age of 33 years. Subsequently, diagnostic testing showed the typical magnetic resonance imaging and lab findings for adult-onset adrenoleukodystrophy. This case highlights adult-onset adrenoleukodystrophy which may present as a pure psychiatric disturbance in early adulthood and briefly discusses the prolonged time between the onset of psychiatric symptoms and the onset of neurological disease.

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2017 SAGE Open Medical Case Reports

10. Corticolimbic structural alterations linked to health status and trait anxiety in functional neurological disorder. (PubMed)

Corticolimbic structural alterations linked to health status and trait anxiety in functional neurological disorder. Affective symptoms influence health status (health-related quality of life) in functional neurological disorder (FND), and the salience network is implicated in the pathophysiology of FND and mood/anxiety disorders. We hypothesised that self-reported health status and affective symptoms would map onto salience network regions and that patients with FND would show decreased insular (...) limitations due to emotional problems, was independent of sensorimotor functional neurological symptom severity and motor FND subtype. In secondary within-group analyses, increased periaqueductal grey volume was associated with role limitations due to emotional problems. Impaired physical functioning correlated with decreased left anterior insular volumes.These findings support roles for several regions of the salience network in the pathophysiology of FND.© Article author(s) (or their employer(s) unless

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2017 Neurosurgery and Psychiatry

11. European Academy of Neurology guideline on trigeminal neuralgia

European Academy of Neurology guideline on trigeminal neuralgia European Academy of Neurology guideline on trigeminal neuralgia - Bendtsen - - European Journal of Neurology - Wiley Online Library By continuing to browse this site, you agree to its use of cookies as described in our . Search within Search term Search term The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Ean Guidelines Free Access European Academy of Neurology guideline on trigeminal (...) neuralgia Corresponding Author E-mail address: Department of Neurology, Faculty of Health and Medical Sciences, Danish Headache Center, Rigshospitalet‐Glostrup, University of Copenhagen, Glostrup, Denmark Correspondence: L. Bendtsen, Danish Headache Center, Department of Neurology, Rigshospitalet‐Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, 2600 Glostrup, Denmark (tel.: +45 38633065; fax: +45 38633839; e‐mail: ). Pain Management Centre, National Hospital for Neurology

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2019 European Academy of Neurology

12. Standards for Studies of Neurological Prognostication in Comatose Survivors of Cardiac Arrest: A Scientific Statement From the American Heart Association

Standards for Studies of Neurological Prognostication in Comatose Survivors of Cardiac Arrest: A Scientific Statement From the American Heart Association Standards for Studies of Neurological Prognostication in Comatose Survivors of Cardiac Arrest: A Scientific Statement From the American Heart Association | Circulation Search Hello Guest! Login to your account Email Password Keep me logged in Search December 2019 November 2019 October 2019 September 2019 August 2019 July 2019 June 2019 May (...) 2019 April 2019 March 2019 February 2019 January 2019 This site uses cookies. By continuing to browse this site you are agreeing to our use of cookies. Free Access article Share on Jump to Free Access article Standards for Studies of Neurological Prognostication in Comatose Survivors of Cardiac Arrest: A Scientific Statement From the American Heart Association , MD, Chair , MD, PhD, FAHA , MD, MS , MD , MD, MA, FAHA , MD, MAS , MD , MD , MD, MPP, MSCE, FAHA , PhD, RN, FAHA , MD, FAHA , MD, MSCE

2019 American Heart Association

13. Core Set of Outcome Measures for Patients with Neurologic Conditions

patients' perspectives, improve care delivery, increase transparency of outcomes, link clinicians' performance to patient outcomes and internal and external benchmarks, manage patient care, improve processes, strengthen public health, and generate knowledge. The core set of OMs recommended in this CPG provides a first and necessary step toward achieving the learning health system vision in neurologic physical therapy. Using OMs throughout a patient's episode of care is considered good clinical practice (...) Core Set of Outcome Measures for Patients with Neurologic Conditions A Core Set of Outcome Measures for Adults With Neurologic Co... : Journal of Neurologic Physical Therapy ')} You may be trying to access this site from a secured browser on the server. Please enable scripts and reload this page. Login No user account? Lippincott Journals Subscribers , use your username or email along with your password to log in. Remember me on this computer or Register for a free account Registered users can

2018 American Physical Therapy Association

14. Neurology Links

Neurology Links Neurology Links Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Neurology Links Neurology Links Aka: Neurology Links (...) II. Resources: Anatomy and Education The Whole Brain Atlas Neurosurgery Teaching Files Human Brain Map MRI Slicer III. Resources: Organizations National Institute of Neurological Disorders American Academy of Neurology Alzheimer's Association Foundation of America National Foundation National Society Neurosurgery On-Call Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Neurology Links." Click on the image (or right click

2018 FP Notebook

15. Burosumab (Crysvita) - X-linked hypophosphataemia/hypophosphatemia

Burosumab (Crysvita) - X-linked hypophosphataemia/hypophosphatemia 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5520 Send a question via our website www.ema.europa.eu/contact 14 December 2017 EMA/148319/2018 Committee for Medicinal Products for Human Use (CHMP) Assessment report Crysvita International non-proprietary name: burosumab Procedure No. EMEA/H/C/004275/0000 Note Assessment (...) Questionnaire CHO Chinese Hamster Ovary Cl chloride CKD Chronic kidney disease CL Clearance CL/F Clearance/bioavailability CLBA competitive ligand-binding assay CLss/F clearance at steady state/bioavailability Conc. concentration CPV Continued Process Verification CQA Critical Quality Attribute CrCL creatinine clearance CRT Controlled Room Temperature CT Computerized Tomography CTx carboxy-terminal cross-linked telopeptide of collagen type I CV Coefficient of Variation DHFR Dihydrofolate Reductase DLT dose

2018 European Medicines Agency - EPARs

16. Survival and Health Care Use After Feeding Tube Placement in Children With Neurologic Impairment

Survival and Health Care Use After Feeding Tube Placement in Children With Neurologic Impairment Children with neurologic impairment (NI) often undergo feeding tube placement for undernutrition or aspiration. We evaluated survival and acute health care use after tube placement in this population.This is a population-based exposure-crossover study for which we use linked administrative data from Ontario, Canada. We identified children aged 13 months to 17 years with a diagnosis of NI undergoing

2019 EvidenceUpdates

17. Screening Tools to Identify Adults with Cognitive Impairment Associated with a Neurological Impairment: Diagnostic Accuracy

Screening Tools to Identify Adults with Cognitive Impairment Associated with a Neurological Impairment: Diagnostic Accuracy TITLE: Screening Tools to Identify Adults with Cognitive Impairment Associated with a Neurological Impairment: Diagnostic Accuracy DATE: 7 November 2014 RESEARCH QUESTION What is the diagnostic accuracy of screening tools to identify adults with cognitive impairment associated with a neurological impairment? KEY FINDINGS Two systematic reviews, one randomized controlled (...) trial, and 25 non-randomized studies were identified regarding diagnostic accuracy of screening tools to identify adults with cognitive impairment associated with a neurological impairment. METHODS A limited literature search was conducted on key resources including PubMed, The Cochrane Library (2014, Issue 10), University of York Centre for Reviews and Dissemination (CRD), Pubmed, Medline (OVID), Canadian and major international health technology agencies, as well as a focused Internet search

2014 Canadian Agency for Drugs and Technologies in Health - Rapid Review

18. Continuous Electroencephalography versus Intermittent Electroencephalography in Patients with Neurological Disorders or Brain Trauma

Continuous Electroencephalography versus Intermittent Electroencephalography in Patients with Neurological Disorders or Brain Trauma Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable (...) . This report may be used for the purposes of research or private study only. It may not be copied, posted on a web site, redistributed by email or stored on an electronic system without the prior written permission of CADTH or applicable copyright owner. Links: This report may contain links to other information available on the websites of third parties on the Internet. CADTH does not have control over the content of such sites. Use of third party sites is governed by the owners’ own terms and conditions

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

19. Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new-onset epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and th

Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new-onset epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and th To update the 2004 American Academy of Neurology (AAN) guideline for treating new-onset focal or generalized epilepsy with second- and third-generation antiepileptic drugs (AEDs).The 2004 AAN criteria were used to systematically review (...) literature (January 2003-November 2015), classify pertinent studies according to the therapeutic rating scheme, and link recommendations to evidence strength.Several second-generation AEDs are effective for new-onset focal epilepsy. Data are lacking on efficacy in new-onset generalized tonic-clonic seizures, juvenile myoclonic epilepsy, or juvenile absence epilepsy, and on efficacy of third-generation AEDs in new-onset epilepsy.Lamotrigine (LTG) should (Level B) and levetiracetam (LEV) and zonisamide

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2018 EvidenceUpdates

20. Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs II: Treatment-resistant epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the

Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs II: Treatment-resistant epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the To update the 2004 American Academy of Neurology guideline for managing treatment-resistant (TR) epilepsy with second- and third-generation antiepileptic drugs (AEDs).2004 criteria were used to systemically review literature (January 2003 (...) to November 2015), classify pertinent studies according to the therapeutic rating scheme, and link recommendations to evidence strength.Forty-two articles were included.The following are established as effective to reduce seizure frequency (Level A): immediate-release pregabalin and perampanel for TR adult focal epilepsy (TRAFE); vigabatrin for TRAFE (not first-line treatment); rufinamide for Lennox-Gastaut syndrome (LGS) (add-on therapy). The following should be considered to decrease seizure frequency

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2018 EvidenceUpdates

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