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Nerve Conduction Velocity

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161. Saikosaponin a increases interleukin-10 expression and inhibits scar formation after sciatic nerve injury (PubMed)

level was considerably higher in the SNI + SSa group than in the SNI group. Masson staining and western blot assay demonstrated that at 8 weeks after injury, type I and III collagen content was lower and nerve scar formation was visibly less in the SNI + SSa group compared with the SNI group. Simultaneously, sciatic functional index and nerve conduction velocity were improved in the SNI + SSa group compared with the SNI group. These results confirm that SSa can increase the expression of the anti (...) Saikosaponin a increases interleukin-10 expression and inhibits scar formation after sciatic nerve injury Nerve scarring after peripheral nerve injury can severely hamper nerve regeneration and functional recovery. Further, the anti-inflammatory cytokine, interleukin-10, can inhibit nerve scar formation. Saikosaponin a (SSa) is a monomer molecule extracted from the Chinese medicine, Bupleurum. SSa can exert anti-inflammatory effects in spinal cord injury and traumatic brain injury. However

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2018 Neural Regeneration Research

162. Decompression nerve surgery for diabetic neuropathy: a structured review of published clinical trials (PubMed)

improvement in the sham leg comparable to the DNS leg and exceeding the improvement observed in the nonsurgical leg in the unblinded study. Sensory testing showed generally favorable results supporting DNS, and nerve conduction velocities increased post-DNS relative to deterioration in controls. Ultrasound revealed fusiform nerve swelling near compression sites. Morphological results of DNS were generally favorable but inconsistent, whereas hemodynamic measures showed a positive effect on arterial (...) parameters, as did transcutaneous oximetry (improved microcirculation). The incidence of initial and recurrent neuropathic diabetic foot ulcers appeared reduced post-DNS relative to the contralateral foot (borderline significant).The data remain insufficient to recommend DNS for painful DPN, given conflicting and unexpectedly positive results involving sham surgery relative to unblinded controls. The generally supportive sensory and nerve conduction results are compromised by methodological issues

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2018 Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

163. Negative Pressure Therapy in the Regeneration of the Sciatic Nerve Using Vacuum – Assisted Closure in a Rabbit Model (PubMed)

groups: Group A: 0 kPa; Group B: -20 kPa; Group C: -40 kPa. At 12 weeks following surgery, the following factors were studied: motor nerve conduction velocity (MNCV); the number of myelinated nerve fibers; the wet weight of the gastrocnemius muscle. Gastrocnemius muscle and sciatic nerve tissue samples were studied for the expression of S100, and brain-derived neurotrophic factor (BDNF) using Western blot. RESULTS At 12 weeks following VAC treatment, the MNCV, number of myelinated nerve fibers (...) Negative Pressure Therapy in the Regeneration of the Sciatic Nerve Using Vacuum – Assisted Closure in a Rabbit Model BACKGROUND The aim of this study was to investigate the effects of negative pressure therapy in the regeneration of the rabbit sciatic nerve using vacuum assisted closure (VAC). MATERIAL AND METHODS Thirty male New Zealand white rabbits underwent surgical injury of the sciatic nerve, followed by negative pressure therapy using vacuum assisted closure (VAC), in three treatment

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2018 Medical science monitor : international medical journal of experimental and clinical research

164. Attrition rupture of ulnar nerve in a patient with rheumatoid elbow arthritis: A case report. (PubMed)

numbness in the left ulnar nerve territory, dorsal interossei muscle atrophy, and resulting claw hand.Plain x-ray examination showed bone destruction of the left elbow joint and marked osteophyte formation in the medial joint space. In nerve conduction velocity (NCV) tests, the Motor NCV was immeasurable in the ulnar nerve territory. Based on these findings, a diagnosis of left cubital tunnel syndrome was made, and anterior transposition of the ulnar nerve was planned.When the ulnar nerve dissection (...) Attrition rupture of ulnar nerve in a patient with rheumatoid elbow arthritis: A case report. Cubital tunnel syndrome has been recognized as a common pathology in rheumatoid arthritis (RA) of the elbow. We encountered a patient with RA of the elbow showing attrition rupture of the ulnar nerve. This pathology is extremely rare, and we discussed preventive measures for similar cases in the future based on our case.A 53-year-old woman, received drug treatment for RA since 30 years earlier, had

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2018 Medicine

165. Non-invasive Vagus Nerve Stimulation (nVNS) in Pediatric Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

latency is the time it takes in milliseconds (ms) for an electrical signal to travel from the stimulating electrode to the distal muscle and back to the stimulating site. F waves are used to assess polyneuropathy and F wave latency can be extended or even absent in persons with CIDP. Change in nerve conduction study conduction velocity [ Time Frame: Baseline, Month 12, Month 24 ] Motor nerve conduction studies are used to examine conduction of electrical impulses along nerves. Electrodes are placed (...) on the skin in specific areas to evaluate peripheral nerves. An electrode will stimulate a nerve while the receiving site records how well electrical impulses are being conducted along the nerve. Conduction velocity measures the rate of impulse conduction (distance/time) and is often decreased in patients with CIDP as myelination is affected. Change in nerve conduction study conduction amplitude [ Time Frame: Baseline, Month 12, Month 24 ] Motor nerve conduction studies are used to examine conduction

2018 Clinical Trials

166. KV1 channels identified in rodent myelinated axons, linked to Cx29 in innermost myelin: support for electrically active myelin in mammalian saltatory conduction (PubMed)

renewed consideration of an electrically active role for myelin in increasing both saltatory conduction velocity and maximum propagation frequency in mammalian myelinated axons. Copyright © 2016 the American Physiological Society. (...) KV1 channels identified in rodent myelinated axons, linked to Cx29 in innermost myelin: support for electrically active myelin in mammalian saltatory conduction Saltatory conduction in mammalian myelinated axons was thought to be well understood before recent discoveries revealed unexpected subcellular distributions and molecular identities of the K(+)-conductance pathways that provide for rapid axonal repolarization. In this study, we visualize, identify, localize, quantify

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2016 Journal of neurophysiology

167. Preferential Conduction Block of Myelinated Axons by Nitric Oxide (PubMed)

Preferential Conduction Block of Myelinated Axons by Nitric Oxide Conduction block by nitric oxide (NO) was examined in myelinated and unmyelinated axons from both the central nervous system and peripheral nervous system. In rat vagus nerves, mouse optic nerves at P12-P23, adult and developing mouse sciatic nerves, and mouse spinal cords, myelinated fibers were preferentially blocked reversibly by concentrations of NO similar to those encountered in inflammatory lesions. The possibility (...) that these differences between myelinated and unmyelinated axons are due to the normal developmental substitution of Na+ channel subtype Nav 1.6 for Nav 1.2 at nodes of Ranvier was tested by repeating experiments on mice null for Nav 1.6. Results were unchanged in this mutant. In shiverer optic nerve, which has only scattered regions with nodes of Ranvier, only the fastest component of the compound action potential was reduced. NO was compared with three other methods of blocking conduction: low Na+ , high K

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2016 Journal of Neuroscience Research

168. Membrane properties and conduction velocity in sensory neurones following central or peripheral axotomy (PubMed)

Membrane properties and conduction velocity in sensory neurones following central or peripheral axotomy 1. The properties of dorsal root ganglion cells in the lumbosacral segments were examined with intracellular electrodes about 3 weeks after section of the central (dorsal roots) or peripheral processes in the cat.2. Chronic section of the peripheral nerve in the hind limb resulted in a reduction in conduction velocity of both the central and peripheral processes of sensory neurones.3. Sensory (...) neurones arising from the triceps surae and plantaris muscles were subject to ;disuse' conditions for about 3 weeks by section of the ventral roots combined with severance of the Achilles tendon. Under such conditions, the central and peripheral conduction velocities of these sensory neurones tended to decrease, but the decrease was significantly less than that following peripheral nerve section.4. Chronic section of the dorsal roots produced no significant changes in conduction velocity of the central

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1977 The Journal of physiology

169. Acute conduction velocity changes in guinea-pigs after administration of diphenylhydantoin (PubMed)

Acute conduction velocity changes in guinea-pigs after administration of diphenylhydantoin Motor nerve conduction velocity was measured after dosing guinea-pigs with 200-400 μmol/kg diphenylhydantoin (DPH) daily for three to four days. Conduction velocity fell by a mean value of 13% in animals that achieved plasma DPH levels over 200 μmol/l. There was no change in velocity with DPH levels below this value.

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1976 Journal of neurology, neurosurgery, and psychiatry

170. Conduction velocity and spike configuration in myelinated fibres: computed dependence on internode distance. (PubMed)

Conduction velocity and spike configuration in myelinated fibres: computed dependence on internode distance. It has been argued theoretically and confirmed experimentally that conduction velocity (theta) should be proportional to nerve fibre diameter for myelinated fibre tracts, such as normal peripheral nerve, exhibiting 'structural' similarity'. In some axons, however, the nodes of Ranvier are more closely spaced than in normal peripheral nerve. Analytic arguments have suggested that when (...) internodal distance (L) alone is changed, the plot of theta versus L should have a relatively flat maximum. This was confirmed by several previous computer simulations of myelinated axons, but internode lengths of less than half the normal case were not examined. In order to gain insight into impulse propagation in myelinated and remyelinated fibres with short internodal lengths, the present study examines the conduction velocity and spike configuration for a wide range of internodal lengths. As L

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1977 Journal of neurology, neurosurgery, and psychiatry

171. Electrophysiological aspects of sensory conduction velocity in healthy adults. 2. Ratio between the amplitude of sensory evoked potentials at the wrist on stimulating different fingers in both hands. (PubMed)

Electrophysiological aspects of sensory conduction velocity in healthy adults. 2. Ratio between the amplitude of sensory evoked potentials at the wrist on stimulating different fingers in both hands. The normal ratio between the amplitude of the sensory evoked potential (SEP) at the wrist on stimulating digits 1, 2, 3, and 5 was determined in 44 healthy adult subjects. The first digit had the larger amplitude, and the fifth digit the smallest SEP. The amplitude expresses the density of sensory (...) innervation in each finger. The ratio between the amplitude of different fingers varied according to the age of the subject. The amplitude of the SEP from a digit innervated by the median nerve decreased in the elderly more than the SEP amplitude of the digit innervated by the ulnar nerve, probably because of a chronic compression in the carpal tunnel. The changes in the normal amplitude ratio can be applied to the topographic diagnosis of radicular and brachial plexus lesions if a fixed segmental sensory

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1978 Journal of neurology, neurosurgery, and psychiatry

172. Axonal conduction velocity and voluntary discharge properties of individual short toe extensor motor units in man. (PubMed)

Axonal conduction velocity and voluntary discharge properties of individual short toe extensor motor units in man. 1. The axonal conduction velocity and the voluntary discharge properties of 120 short toe extensor motor units were studied in man. 2. Electromyographic techniques were used which permitted the identification of individual motor unit potentials after proximal and distal electrical nerve stimulation and during maximum voluntary effort. 3. The necessary selectivity of the e.m.g (...) . recordings was achieved in two circumstances. In some subjects, previous motor nerve lesions distal to the point of stimulation had led to collateral sprouting with larger motor unit potentials. In other subjects an accessory deep peroneal nerve was present, so that lidocaine block of the main motor nerve left a small number of innervated motor units. 4. The axonal conduction velocities of the individual motor units ranged from 30 to 54 m/sec with most motor units between 35 and 45 m/sec. 5. Motor units

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1978 The Journal of physiology

173. Electrophysiological study of the peripheral nervous system in children. Changes in proximal and distal conduction velocities from birth to age 5 years. (PubMed)

Electrophysiological study of the peripheral nervous system in children. Changes in proximal and distal conduction velocities from birth to age 5 years. Hoffman's reflex was evoked in the soleus muscle of 105 normal children from birth to age 5 years. This technique made it possible to determine conduction time and to estimate conduction velocity over the reflex arc. For 59 children, proprioceptive and motor distal nerve conduction velocities were calculated for the tibial nerve trunk (...) . These measurements enabled the common changes for these three velocities to be described in terms of an exponential curve. Proximal conduction velocity has similar values to those of proprioceptive distal nerve fibres: it is always higher than motor nerve conduction velocity, but the difference gradually diminishes, remaining constant after the eighteenth month. Conduction time diminishes between birth and one year of age, whereas height increases. Then conduction time increases slowly, reaching at about age 5

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1979 Journal of neurology, neurosurgery, and psychiatry

174. Conduction velocity in proximal and distal portions of forelimb axons in the baboon (PubMed)

Conduction velocity in proximal and distal portions of forelimb axons in the baboon 1. Peripheral nerves of the baboon's forelimb were stimulated at different sites, and the latencies of antidromic action potentials were measured in intracellular records from forelimb motoneurones.2. The conduction velocity of single motor axons was slower in the brachial plexus than in the nerves of the arm and forearm. This proximal slowing of conduction velocity was more marked for rapidly conducting axons (...) than for the more slowly conducting ones.3. Gross recordings from dorsal and ventral roots showed that the conduction velocity was slower in the brachial plexus than in the arm for fast afferent as well as efferent nerve fibres.4. The proximal slowing of conduction velocity was shown to be due neither to errors of measurement nor to proximo-distal differences of temperature.

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1968 The Journal of physiology

175. Recovery of conduction velocity distal to a compressive lesion (PubMed)

Recovery of conduction velocity distal to a compressive lesion Nerve conduction studies have been carried out pre- and postoperatively on 26 hands of patients with a carpal tunnel syndrome. When examined six to eight weeks postoperatively, there had been no significant change in conduction velocity or action potential amplitude in the fingers distal to the compression. Velocity had increased over the carpal tunnel segment. When the patients were seen between 12 and 18 weeks postoperatively (...) , velocity and amplitude had increased in the fingers. The group with marked electrical abnormalities had improved more than the group in which digital amplitude was originally within the control range. The improvement occurred too early to be due to regeneration after relief of compression. It is suggested that either maturation of regenerating fibres was delayed by the compression or a reversible change had occurred in surviving fibres.

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1974 Journal of neurology, neurosurgery, and psychiatry

176. Nerve conduction, tactile sensibility, and the electromyogram after suture or compression of peripheral nerve: a longitudinal study in man. (PubMed)

Nerve conduction, tactile sensibility, and the electromyogram after suture or compression of peripheral nerve: a longitudinal study in man. In three patients sequential studies were performed of sensory and motor conduction after complete section and suture of the median nerve at the wrist and in one patient after partial section of the nerve. The sensory potential evoked by stimuli to digits III and I and recorded proximal to the suture line at the wrist appeared after a delay of three to four (...) years was three times faster than in adults. In the adults and in the children the maximum sensory conduction velocity was 10-25% of normal. It then increased at 3% per month during the first two years, and thereafter 10 times slower. Forty months after suture in the adults and 13-19 months after suture in the children the conduction velocity had reached 65-75% of normal. The pattern of discrete electrical activity during voluntary effort and the prolonged duration of motor unit potentials indicate

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1979 Journal of neurology, neurosurgery, and psychiatry

177. Low Level Laser Therapy Effects in Peripheral Nerves Patient With Leprosy.

can become an important alternative treatment to improve conduction velocity, tactile sensitivity, temperatures of hands and feet, muscle strength and pain, which will prevent nerve damage and disabilities Condition or disease Intervention/treatment Phase Leprosy Neuropathy Device: LLLT Device: Sham LLLT Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 92 participants Allocation: Randomized Intervention Model (...) . Below is a description of the technique employed in each of these nerves: Ulnar Motor Nerve: Normal values: Amplitude≥ 3.80mv, conduction velocity ≥ 50m/s, distal latency ≤ 3.1 m/s. Delta conduction velocity (difference between the distal segment and the elbow segment)≥10m/s; (b)Common Peroneal Motor Study: Normal values: Amplitude ≥ 2.80 mv, conduction velocity ≥ 40m/s, distal latency(handle)≤ 5.0 msec. Delta conduction velocity (difference between the distal segment and the peroneal head segment

2017 Clinical Trials

178. ُEfficacy of Insulin Versus Hyalase Hydro-dissection of Median Nerve in Rheumatoid Arthritis Patients

normal saline ultrasonic guided Drug: Insulin hydro-dissection injection of median nerve inside carpal tunnel using 10 IU insulin and 10 cc saline Other Name: crystalline insulin Outcome Measures Go to Primary Outcome Measures : pain intensity [ Time Frame: 6 months ] Visual analog scale 0-100 Secondary Outcome Measures : nerve conduction [ Time Frame: 6 months ] sensory velocity ultrasound [ Time Frame: 6 months ] cross sectional area Eligibility Criteria Go to Information from the National Library (...) Status : Recruiting First Posted : January 9, 2018 Last Update Posted : July 13, 2018 See Sponsor: Assiut University Information provided by (Responsible Party): Manal Hassanien, Assiut University Study Details Study Description Go to Brief Summary: Carpal tunnel syndrome (CTS) is a common peripheral entrapment neuropathy in Rheumatoid arthritis patients proved by nerve conduction studies and ultrasound parameters, this study aims to evaluate the effect of hydro-dissection using insulin versus

2017 Clinical Trials

179. The Effect of Nerve Hydrodissection for Carpal Tunnel Syndrome

-sectional area (CSA) of the median nerve, sensory nerve conduction velocity of the median nerve, and global assessment of treatment. The evaluations were performed pretreatment as well as on the 2nd week, 1st, 3rd and 6th month after injecton. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 60 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (Participant, Investigator) Primary Purpose (...) and multiple time frame after treatment. Change from baseline of conduction velocity, amplitude of median nerve on 2nd week, 1st, 3rd and 6th month after injection [ Time Frame: Pre-treatment, 2nd week, 1st, 3rd and 6th month after injection ] Antidromic sensory nerve conduction velocity of the median nerve before treatment and multiple time frame after treatment. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal

2017 Clinical Trials

180. Cavernous Nerve Injury by Radiation Therapy May Potentiate Erectile Dysfunction in Rats. (PubMed)

-induced neurogenic injury in RiED has not been fully established. The cavernous nerves (CN) are postganglionic parasympathetic nerves located beside the prostate gland that assist in penile erection. This study was designed to investigate the role of CN injury, tissue damage, and altered signaling pathways in an RiED rat model.Male rats were exposed to a single dose of 25 Gy prostate-confined RT. Erectile function was evaluated by intracavernous pressure (ICP) measurements conducted both 9 and 14 (...) analysis showed significant impairment of the CN conduction velocity after RT. RT also significantly increased RhoA/Rho-associated protein kinase 1 (ROCK1) mRNA and protein expression. In addition, penile tissue showed increased apoptosis and fibrosis 14 weeks after RT.RT-induced CN injury may contribute to RiED; this is therefore a rationale for developing novel therapeutic strategies to mitigate CN and tissue damage. Moreover, further investigation of the RhoA/ROCK pathway's role in mitigating RiED

2017 Biology and Physics

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