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Nephrotic Syndrome

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1. Human albumin infusion for treating oedema in people with nephrotic syndrome. (Abstract)

Human albumin infusion for treating oedema in people with nephrotic syndrome. Oedema is a common clinical symptom in people with nephrotic syndrome and human albumin has been widely used in the treatment of oedema by increasing vascular volume and this inducing diuresis. It may be used with or without diuretics such as furosemide. However, the quantitative contribution of human albumin in treating oedema is not fully understood. If human albumin were found to be effective and safe (...) function and adverse effects in people with nephrotic syndrome. We excluded cross-over studies but data for the first period was to be included if available.Standard methods of the Cochrane Collaboration were used. Two authors independently assessed eligibility, risk of bias, study quality and extracted data. We calculated mean difference (MD) for continuous data with 95% confidence intervals (CI). We assessed the certainty of the evidence using GRADE.One study met our inclusion criteria (26 children

2019 Cochrane

2. Nephrotic syndrome

Nephrotic syndrome Evidence Maps - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 (...) of known issues . Also read , explaining issues with the system. NOTE : Chrome is the best browser to use! To get started, type a condition/disease into the search box above. Here are some examples to get you started: Building Evidence Map X Axis Alphabetically Risk of bias No. Articles Sample Size Risk of bias any low Minimum sample size Apply Follow us: © 2019 Trip Database Ltd. company number 04316414. Trip is proud to be made in the UK.

2018 Trip Evidence Maps

3. Assessment of nephrotic syndrome

. In contrast to these other 2 disorders, patients with oedema from nephrotic syndrome often can comfortably lie flat, allowing them to develop facial oedema. Generally, patients with CHF or severe liver disease cannot comfortably lie flat and tend not to develop facial oedema. The key feature differentiating renal disease from the other 2 diseases is the presence of severe proteinuria, which makes examination of the urine mandatory. Differentials Minimal change disease Focal segmental glomerulosclerosis (...) Assessment of nephrotic syndrome Assessment of nephrotic syndrome - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Assessment of nephrotic syndrome Last reviewed: February 2019 Last updated: June 2018 Summary Nephrotic syndrome is defined as the presence of proteinuria (>3.5 g/24 hours), hypoalbuminaemia (<30 g/L), and peripheral oedema. Hyperlipidaemia and thrombotic disease are also frequently seen. Despite heavy

2018 BMJ Best Practice

6. Sodium retention and edema in nephrotic syndrome: new models and therapeutic targets

system involved in the sodium retention in the nephrotic syndrome? Nephron. 1982;32(2):102-107. Steyl C, Van Zyl-Smit R. Mechanisms of oedema formation: the minor role of hypoalbuminaemia S Afr Med J . 2009 Jan;99(1):57-59. Russi E, Weigand K. Analbuminemia. Klin Wochenschr. 1983;61(11):541-545. Hoyer JR, Mauer SM, Michael AF. Unilateral renal disease in the rat. I. Clinical, morphologic, and glomerular mesangial functional features of the experimental model produced by renal perfusion (...) Sodium retention and edema in nephrotic syndrome: new models and therapeutic targets Sodium Retention and Edema in Nephrotic Syndrome: New Models and Therapeutic Targets – Clinical Correlations Search Sodium Retention and Edema in Nephrotic Syndrome: New Models and Therapeutic Targets July 23, 2019 4 min read By Maria Smith Peer Reviewed The mechanism of sodium retention and edema formation in patients with nephrotic syndrome has long been highly contested in the nephrology world

2019 Clinical Correlations

7. Prevalence of Asthma and Allergies and Risk of Relapse in Childhood Nephrotic Syndrome: Insight into Nephrotic Syndrome Cohort. (Abstract)

Prevalence of Asthma and Allergies and Risk of Relapse in Childhood Nephrotic Syndrome: Insight into Nephrotic Syndrome Cohort. To determine the lifetime prevalence of allergies in childhood nephrotic syndrome, the seasonality of presentation and relapses, and the impact of allergies on subsequent relapses.In a longitudinal cohort of children with nephrotic syndrome (ages 1-18 years), assessment for allergic diseases was conducted using the validated and modified version of the International (...) was not associated with frequently relapsing nephrotic syndrome (OR 1.20; 95% CI 0.60, 2.40), higher relapse rates (relative risk 0.95; 95% CI 0.71, 1.27), or risk of first relapse (hazard ratio 1.10; 95% CI 0.83, 1.47) compared with those with no history of allergic diseases. There was also no seasonal variation evident at initial presentation or frequency of relapses.Two-thirds of children with nephrotic syndrome at presentation have allergic symptoms and asthma; however, neither are associated

2019 Journal of Pediatrics

8. Levamisole (Elmisol) - nephrotic syndrome

to treat nephrotic syndrome. Nephrotic syndrome is a kidney disease that is marked by presence of large amounts of protein in the urine and results in fluid build-up in the body, with swelling (oedema), high blood pressure and weight gain. Elmisol was to be used in patients in whom symptoms kept coming back after responding to initial treatment with corticosteroid medicines (steroid sensitive nephrotic syndrome). Elmisol was designated an ‘orphan medicine’ (a medicine to be used in rare diseases) on 28 (...) October 2005 for nephrotic syndrome. Further information on the orphan designation can be found here. How does Elmisol work? Levamisole has been used for many years to treat a variety of conditions, including worm infections and cancers. It is not completely understood how levamisole works in nephrotic syndrome, but it is known to affect the immune system (the body’s natural defences). In patients with nephrotic syndrome, the immune system is believed to attack the kidney in error, resulting

2017 European Medicines Agency - EPARs

9. Study protocol: mycophenolate mofetil as maintenance therapy after rituximab treatment for childhood-onset, complicated, frequently-relapsing nephrotic syndrome or steroid-dependent nephrotic syndrome: a multicenter double-blind, randomized, placebo-contr Full Text available with Trip Pro

Study protocol: mycophenolate mofetil as maintenance therapy after rituximab treatment for childhood-onset, complicated, frequently-relapsing nephrotic syndrome or steroid-dependent nephrotic syndrome: a multicenter double-blind, randomized, placebo-contr Idiopathic nephrotic syndrome (INS) is the most common chronic glomerular disease in children. Approximately 80-90% of patients with childhood INS have steroid-sensitive nephrotic syndrome (SSNS), and can obtain remission with steroid therapy (...) , while the remainder have steroid-resistant nephrotic syndrome (SRNS). Furthermore, approximately 50% of children with SSNS develop frequently-relapsing nephrotic syndrome (FRNS) or steroid-dependent nephrotic syndrome (SDNS). Children with FRNS/SDNS are usually treated with immunosuppressive agents such as cyclosporine, cyclophosphamide, or mizoribine in Japan. However, 10-20% of children receiving immunosuppressive agents still show frequent relapse and/or steroid dependence during or after

2018 BMC Nephrology Controlled trial quality: predicted high

10. [Comparative study of the conventional scheme and prolonged treatment with steroids on primary steroid-sensitive nephrotic syndrome in children]. Full Text available with Trip Pro

[Comparative study of the conventional scheme and prolonged treatment with steroids on primary steroid-sensitive nephrotic syndrome in children]. In the steroid-sensitive nephrotic syndrome (SSNS) the prolonged treatment with steroids could decrease the frequency of relapses. We conducted a comparative study of prolonged steroid scheme and the usual treatment of primary SSNS to assess: the number of patients with relapses, mean time to treatment initiation, to remission and to first relapse

2019 Boletin medico del Hospital Infantil de Mexico Controlled trial quality: uncertain

11. Long term tapering versus standard prednisolone treatment for first episode of childhood nephrotic syndrome: phase III randomised controlled trial and economic evaluation. Full Text available with Trip Pro

Long term tapering versus standard prednisolone treatment for first episode of childhood nephrotic syndrome: phase III randomised controlled trial and economic evaluation. To determine whether extending initial prednisolone treatment from eight to 16 weeks in children with idiopathic steroid sensitive nephrotic syndrome improves the pattern of disease relapse.Double blind, parallel group, phase III randomised placebo controlled trial, including a cost effectiveness analysis.125 UK National (...) in the study. A minimisation algorithm ensured balanced treatment allocation by ethnicity (South Asian, white, or other) and age (5 years or less, 6 years or more).The primary outcome measure was time to first relapse over a minimum follow-up of 24 months. Secondary outcome measures were relapse rate, incidence of frequently relapsing nephrotic syndrome and steroid dependent nephrotic syndrome, use of alternative immunosuppressive treatment, rates of adverse events, behavioural change using the Achenbach

2019 BMJ Controlled trial quality: predicted high

12. Omega-3 Fatty Acids for Proteinuria due to Nephrotic Syndrome: A Review of Clinical Effectiveness and Cost-Effectiveness

Omega-3 Fatty Acids for Proteinuria due to Nephrotic Syndrome: A Review of Clinical Effectiveness and Cost-Effectiveness Omega-3 Fatty Acids for Proteinuria due to Nephrotic Syndrome: A Review of Clinical Effectiveness and Cost-Effectiveness | CADTH.ca Find the information you need Omega-3 Fatty Acids for Proteinuria due to Nephrotic Syndrome: A Review of Clinical Effectiveness and Cost-Effectiveness Omega-3 Fatty Acids for Proteinuria due to Nephrotic Syndrome: A Review of Clinical (...) Effectiveness and Cost-Effectiveness Published on: February 5, 2016 Project Number: RC0741-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of omega-3 fatty acid supplementation for reduction of proteinuria in patients with nephrotic syndrome? What is the cost-effectiveness of omega-3 fatty acid supplementation for reduction of proteinuria in patients with nephrotic syndrome? Key Message Four systematic reviews

2016 Canadian Agency for Drugs and Technologies in Health - Rapid Review

13. A randomized study on a 3-month versus a 7-month prednisolone regimen for the initial episode of childhood idiopathic nephrotic syndrome at a large Saudi center. Full Text available with Trip Pro

A randomized study on a 3-month versus a 7-month prednisolone regimen for the initial episode of childhood idiopathic nephrotic syndrome at a large Saudi center. The standard International Study of Kidney Disease in Children (ISKDC) regimen of prednisolone of 2 months duration for the treatment of the initial episode of Idiopathic Nephrotic Syndrome (INS) was associated with a high relapse rate. The long prednisolone protocols were introduced in order to reduce the relapse rate and steroid (...) with a confirmed diagnosis of Idiopathic Nephrotic Syndrome were included. The patients were randomized by simple randomization using sealed envelopes into two groups; group A comprised of 60 children using the daily regimen prednisolone 60 mg/m2 OD X 1 ½ months then 40mg/m2 on alternate day for 1 ½ months (total = 3 months) and group B also comprised of 60 children using the 7 months protocol, Prednisolone 60mg/m2 OD x 1 month then 40mg/m2 EOD x 2 months then 30mg/m2 EOD for 2 months then 20mg/m2 EOD for 2

2018 International journal of pediatrics & adolescent medicine Controlled trial quality: uncertain

14. NPHS2 V260E Is a Frequent Cause of Steroid-Resistant Nephrotic Syndrome in Black South African Children Full Text available with Trip Pro

NPHS2 V260E Is a Frequent Cause of Steroid-Resistant Nephrotic Syndrome in Black South African Children In South Africa (SA), steroid-resistant nephrotic syndrome (SRNS) is more frequent in black than in Indian children.Seeking a genetic basis for this disparity, we enrolled 33 Indian and 31 black children with steroid-sensitive nephrotic syndrome (SSNS) and SRNS from KwaZulu-Natal, SA; SRNS children underwent kidney biopsy. We sequenced NPHS2 and genotyped APOL1 in 15 SSNS and 64 SRNS

2018 Kidney international reports

15. Parental Whole-Exome Sequencing Enables Sialidosis Type II Diagnosis due to an NEU1 Missense Mutation as an Underlying Cause of Nephrotic Syndrome in the Child Full Text available with Trip Pro

Parental Whole-Exome Sequencing Enables Sialidosis Type II Diagnosis due to an NEU1 Missense Mutation as an Underlying Cause of Nephrotic Syndrome in the Child Monogenetic renal diseases, including recessively inherited nephrotic syndromes, represent a significant health burden despite being rare conditions. Precise diagnosis, including identification of the underlying molecular cause, is especially difficult in low-income countries and/or if affected individuals are unavailable for biochemical (...) corneal clouding and a cherry red spot on the macula was observed in only approximately 50% of cases. Fourteen of 16 previously reported cases were no longer alive at the time of reporting.Our findings demonstrate the power of parental WES to diagnose rare genetic diseases, such as childhood-onset nephrotic syndrome. We further provide a comprehensive overview of the clinical course of nephrosialidosis and raise awareness of this ultra-rare condition as an underlying cause of FSGS.

2018 Kidney international reports

16. Direct-Acting Oral Anticoagulants as Prophylaxis Against Thromboembolism in the Nephrotic Syndrome Full Text available with Trip Pro

Direct-Acting Oral Anticoagulants as Prophylaxis Against Thromboembolism in the Nephrotic Syndrome We report 2 cases of apixaban use as prophylaxis against thromboembolism in the nephrotic syndrome (NS), and review the existing literature on direct-acting oral anticoagulant (DOAC) use in this scenario. Our cases appear to be the first reported use of apixaban as prophylaxis against thromboembolism in NS. We report our systematic review of the existing literature on direct-acting oral

2018 Kidney international reports

17. Effect of Combined Gluten-Free, Dairy-Free Diet in Children With Steroid-Resistant Nephrotic Syndrome: An Open Pilot Trial Full Text available with Trip Pro

Effect of Combined Gluten-Free, Dairy-Free Diet in Children With Steroid-Resistant Nephrotic Syndrome: An Open Pilot Trial Steroid-resistant nephrotic syndrome (SRNS) affects both children and adults and has a high rate of progression to end-stage renal disease. Although a subset of patients have well-characterized genetic mutation(s), in the majority of cases, the etiology is unknown. Over the past 50 years, a number of case reports have suggested the potential impact of dietary changes (...) in controlling primary nephrotic syndrome, especially gluten and dairy restrictions.We have designed a prospective, open-label, nonrandomized, pilot clinical trial, to study the effect of a gluten-free and dairy-free (GF/DF) diet in children with SRNS. The study will be organized as a 4-week summer camp to implement a GF/DF diet in a tightly controlled and monitored setting. Blood, urine, and stool samples will be collected at different time points during the study.The primary end point is a reduction

2018 Kidney international reports

18. Cost-Effectiveness of Administering Rituximab for Steroid-Dependent Nephrotic Syndrome and Frequently Relapsing Nephrotic Syndrome: A Preliminary Study in Japan Full Text available with Trip Pro

Cost-Effectiveness of Administering Rituximab for Steroid-Dependent Nephrotic Syndrome and Frequently Relapsing Nephrotic Syndrome: A Preliminary Study in Japan With regard to the use of rituximab for patients with steroid-dependent nephrotic syndrome and frequently relapsing nephrotic syndrome, not only has the regimen not been clinically verified but also there is a lack of health economics evidence. Therefore, we conducted a prospective clinical study on 30 patients before (with steroids

2017 Scientific reports

19. Learning to live with nephrotic syndrome: experiences of adult patients and parents of children with nephrotic syndrome Full Text available with Trip Pro

Learning to live with nephrotic syndrome: experiences of adult patients and parents of children with nephrotic syndrome People living with nephrotic syndrome (NS) need to develop an in-depth understanding of their condition in order to participate in treatment decisions, develop self-management skills and integrate illness into daily life. However, the learning needs of adult patients and parents of children with NS are unknown. We therefore explored patient and parent perspectives on learning (...) needs related to NS as part of a larger study to develop a shared learning tool for NS.Qualitative data were collected using semistructured focus groups and individual interviews with adult patients (n = 22) and parents of children with NS (n = 25).The complexity of NS and its treatment made decision making challenging, as patients/parents often had to assimilate information about a condition that is poorly understood. Specific informational needs related to understanding the diagnosis and treatment

2017 Nephrology Dialysis Transplantation

20. Efficacy of Rituximab vs Tacrolimus in Pediatric Corticosteroid-Dependent Nephrotic Syndrome: A Randomized Clinical Trial Full Text available with Trip Pro

Efficacy of Rituximab vs Tacrolimus in Pediatric Corticosteroid-Dependent Nephrotic Syndrome: A Randomized Clinical Trial Calcineurin inhibitors are an established first-line corticosteroid-sparing therapy for patients with corticosteroid-dependent nephrotic syndrome (CDNS), whereas B-lymphocyte-depleting therapy is mostly used as a rescue for calcineurin inhibitor-resistant cases. The positive efficacy and safety profile of rituximab raises the question of whether it could be used as a first (...) received either tacrolimus (along with tapering alternate-day prednisolone) for 12 months or a single course of rituximab (2 infusions of 375 mg/m2).Twelve-month relapse-free survival in the intention-to-treat population.Of the 176 children screened for eligibility, 120 were randomized and all but 3 patients completed 1 year of follow-up. The groups were comparable, with mean (SD) age of 7.2 (2.8) years, 32 boys (53.3%) in each group, mean (SD) disease duration of 2.5 (1.5) years and 2.3 (1.7

2018 EvidenceUpdates

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