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Nephrogenic Diabetes Insipidus

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101. Overview of diabetes

and/or target-tissue insulin resistance. Complications of diabetes mellitus include both macrovascular (cardiovascular) and microvascular (retinopathy, nephropathy, or neuropathy) sequelae. Diabetes insipidus (DI) is much less common and refers to disorders of vasopressin secretion (central DI) or action (nephrogenic DI), resulting in urinary concentrating abnormality. Related conditions Condition Description Common disorder characterised by insulin resistance and relative insulin deficiency. Most patients (...) syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2005 Sep;28(9):2289-304. http://care.diabetesjournals.org/content/28/9/2289.full http://www.ncbi.nlm.nih.gov/pubmed/16123508?tool=bestpractice.com Characterised by polydipsia, polyuria, increased thirst, and hypotonic urine. Central DI is due to defective synthesis or release of arginine vasopressin (AVP). Nephrogenic DI is due to renal

2018 BMJ Best Practice

102. Overview of diabetes

and/or target-tissue insulin resistance. Complications of diabetes mellitus include both macrovascular (cardiovascular) and microvascular (retinopathy, nephropathy, or neuropathy) sequelae. Diabetes insipidus (DI) is much less common and refers to disorders of vasopressin secretion (central DI) or action (nephrogenic DI), resulting in urinary concentrating abnormality. Related conditions Condition Description Common disorder characterised by insulin resistance and relative insulin deficiency. Most patients (...) syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2005 Sep;28(9):2289-304. http://care.diabetesjournals.org/content/28/9/2289.full http://www.ncbi.nlm.nih.gov/pubmed/16123508?tool=bestpractice.com Characterised by polydipsia, polyuria, increased thirst, and hypotonic urine. Central DI is due to defective synthesis or release of arginine vasopressin (AVP). Nephrogenic DI is due to renal

2018 BMJ Best Practice

103. Use of Copeptin in Diabetes Insipidus

: Prospective evaluation of the novel biomarker copeptin in the differential diagnosis of diabetes insipidus against the standard diagnostic test methods. Condition or disease Intervention/treatment Diabetes Insipidus Primary Polydipsia Other: Water deprivation test Other: Hypertonic saline infusion Detailed Description: Purpose of this study is to compare the overall diagnostic accuracy of the three following diagnostic test procedures in diabetes insipidus (central, nephrogenic) and primary polydipsia (...) : University Hospital, Basel, Switzerland ClinicalTrials.gov Identifier: Other Study ID Numbers: CODDI2013 First Posted: September 12, 2013 Last Update Posted: April 17, 2018 Last Verified: April 2018 Keywords provided by University Hospital, Basel, Switzerland: Copeptin differential diagnosis of polyuria polydipsia syndrome diabetes insipidus compulsive water drinking water deprivation test Diabetes insipidus (central and nephrogenic) Additional relevant MeSH terms: Layout table for MeSH terms Diabetes

2013 Clinical Trials

104. Aquaporin-2: new mutations responsible for autosomal-recessive nephrogenic diabetes insipidus—update and epidemiology (PubMed)

Aquaporin-2: new mutations responsible for autosomal-recessive nephrogenic diabetes insipidus—update and epidemiology It is clinically useful to distinguish between two types of hereditary nephrogenic diabetes insipidus (NDI): a 'pure' type characterized by loss of water only and a complex type characterized by loss of water and ions. Patients with congenital NDI bearing mutations in the vasopressin 2 receptor gene, AVPR2, or in the aquaporin-2 gene, AQP2, have a pure NDI phenotype with loss

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2012 Clinical kidney journal

105. Management of diabetes insipidus in children (PubMed)

Management of diabetes insipidus in children Diabetes Insipidus (DI) is a heterogeneous clinical syndrome of disturbance in water balance, characterized by polyuria (urine output > 4 ml/kg/hr), polydypsia (water intake > 2 L/m(2)/d) and failure to thrive. In children, Nephrogenic DI (NDI) is more common than Central DI (CDI), and is often acquired. The signs and symptoms vary with etiology, age at presentation and mode of onset. Neonates and infants with NDI are severely affected and difficult

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2011 Indian journal of endocrinology and metabolism

106. A Study of Minirin Melt in Japanese Patients With Central Diabetes Insipidus (CDI).

specific gravity, and serum sodium (mEq/L) maintained at a normal level by desmopressin nasal administration Outpatient The participant is, in the investigator's opinion, otherwise healthy Be willing and able to comply with the protocol requirements including restriction of water intake Exclusion Criteria: Presence or a history of nephrogenic diabetes insipidus or diabetes mellitus Presence of uncorrected hypothyroidism, hypoadrenalism or hypogonadism Abnormalities or disease of the oral cavity (...) A Study of Minirin Melt in Japanese Patients With Central Diabetes Insipidus (CDI). A Study of Minirin Melt in Japanese Patients With Central Diabetes Insipidus (CDI). - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2011 Clinical Trials

107. On the Mechanism of Lithium-Induced Diabetes Insipidus in Man and the Rat (PubMed)

. The normal corticopapillary gradient for sodium was not reduced by lithium treatment. The polyuria was not interrupted by brief intravenous doses of vasopressin (5-10 mU/kg) or dibutyryl cyclic AMP (10-15 mg/kg) capable of reversing water diuresis in normal and hypothalamic diabetes insipidus rats (Brattleboro strain). The present studies suggest that nephrogenic diabetes insipidus is a common finding after lithium treatment and results in part from interference with the mediation of vasopressin (...) On the Mechanism of Lithium-Induced Diabetes Insipidus in Man and the Rat The mechanism of lithium-induced diabetes insipidus was investigated in 96 patients and in a rat model. Polydipsia was reported by 40% and polyuria (more than 3 liter/day) by 12% of patients receiving lithium. Maximum concentrating ability after dehydration and vasopressin was markedly impaired in 10 polyuric patients and was reduced in 7 of 10 nonpolyuric patients studied before and during lithium therapy. Severe

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1974 Journal of Clinical Investigation

108. The Clinical Physiology of Water Metabolism: Part II: Renal Mechanisms for Urinary Concentration; Diabetes Insipidus (PubMed)

or the pituitary stalk. Possible causes include idiopathic, familial, trauma, tumor, infection or vascular lesions. Patients present with polyuria, usually beginning over a period of a few days. The diagnosis is made by showing that urinary concentration is impaired after water restriction but that there is a good response to exogenous vasopressin therapy. Nephrogenic diabetes insipidus can be identified by a patient's lack of response to AVP. Nephrogenic diabetes insipidus is caused by a familial defect (...) , although milder forms can be acquired as a result of various forms of renal disease. Central diabetes insipidus is eminently responsive to replacement therapy, particularly with dDAVP, a long lasting analogue of AVP. Nephrogenic diabetes insipidus is best treated with a combination of thiazide diuretics as well as a diet low in sodium and protein.

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1979 Western Journal of Medicine

109. Lack of MRI neurohypophyseal bright signal in a child with congenital nephrogenic diabetes insipidus (PubMed)

Lack of MRI neurohypophyseal bright signal in a child with congenital nephrogenic diabetes insipidus 25984077 2015 05 18 2018 11 13 1753-0784 3 5 2010 Oct NDT plus NDT Plus Lack of MRI neurohypophyseal bright signal in a child with congenital nephrogenic diabetes insipidus. 511-2 10.1093/ndtplus/sfq120 Chehade Hassib H Children's Hospital of Geneva . Pediatric Nephrology, 6 Rue Willy-Donzé, 1211 Geneva 14 , Switzerland. Parvex Paloma P Children's Hospital of Geneva . Pediatric Nephrology, 6 Rue

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2010 NDT Plus

110. A de novo novel missense mutation in AVPR2 with severe nephrogenic diabetes insipidus (PubMed)

A de novo novel missense mutation in AVPR2 with severe nephrogenic diabetes insipidus We describe a paediatric case of nephrogenic diabetes insipidus (NDI) with a novel mutation in the arginine vasopressin receptor 2 gene (AVPR2) in the absence of a family history of congenital polyuria. The patient, a 5-month-old Caucasian boy, had failure to thrive and hypernatraemia. On admission to hospital, he had a plasma sodium of 171 mEq/L with a concomittant urine osmolality of 131 mOsm/kg. Molecular

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2010 NDT Plus

111. {alpha}ENaC-Mediated Lithium Absorption Promotes Nephrogenic Diabetes Insipidus. (PubMed)

{alpha}ENaC-Mediated Lithium Absorption Promotes Nephrogenic Diabetes Insipidus. Lithium-induced nephrogenic diabetes insipidus (NDI) is accompanied by polyuria, downregulation of aquaporin 2 (AQP2), and cellular remodeling of the collecting duct (CD). The amiloride-sensitive epithelial sodium channel (ENaC) is a likely candidate for lithium entry. Here, we subjected transgenic mice lacking αENaC specifically in the CD (knockout [KO] mice) and littermate controls to chronic lithium treatment

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2010 Journal of the American Society of Nephrology

112. Nephrogenic Syndrome of Inappropriate Antidiuresis (PubMed)

Nephrogenic Syndrome of Inappropriate Antidiuresis Mutations in the vasopressin V2 receptor gene are responsible for two human tubular disorders: X-linked congenital nephrogenic diabetes insipidus, due to a loss of function of the mutant V2 receptor, and the nephrogenic syndrome of inappropriate antidiuresis, due to a constitutive activation of the mutant V2 receptor. This latter recently described disease may be diagnosed from infancy to adulthood, as some carriers remain asymptomatic for many

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2012 International journal of pediatrics

113. Central Diabetes Insipidus

Endocrine System Video Overview of Buffering and the Henderson-Hasselbalch Equation SOCIAL MEDIA Add to Any Platform Loading , MBBS, PhD, University of Adelaide, Royal Adelaide Hospital Click here for Patient Education NOTE: This is the Professional Version. CONSUMERS: Topic Resources Diabetes insipidus (DI) results from a deficiency of vasopressin (ADH) due to a hypothalamic-pituitary disorder (central DI [CDI]) or from resistance of the kidneys to vasopressin (nephrogenic DI [NDI]). Polyuria (...) Water deprivation test Sometimes vasopressin levels Central diabetes insipidus must be differentiated from other causes of polyuria, particularly psychogenic polydipsia (see Table: ) and nephrogenic diabetes insipidus. All tests for CDI (and for NDI) are based on the principle that increasing the plasma osmolality in normal people will lead to decreased excretion of urine with increased urine osmolality. Table Common Causes of Polyuria Mechanism Example Vasopressin -sensitive polyuria Decreased

2013 Merck Manual (19th Edition)

114. George Thomas: Diabetes mellitus—the need for better terminology

is “dysglycemic metabolism” syndrome and not dysglycemic “metabolic syndrome,” although the latter comes under the domain of the definition. Similarly, the term dysglycemia is automatically included in the ambit of the new terminology. Type 1 diabetes mellitus and should be called “hypoinsulinism.” This term will be similar to hypothyroidism or hypopituitarism. Similarly, diabetes insipidus should be termed “hypovasopressinism.” Nephrogenic diabetes insipidus should be plain “nephrogenic polyuria (...) George Thomas: Diabetes mellitus—the need for better terminology George Thomas: Diabetes mellitus—the need for better terminology - The BMJ ---> Diabetes is . However, the term “diabetes” connotes archaic concepts and needs to be reviewed. The ancient Greek physician Aretaeus of Cappadocia is often recorded as the first person to use the term “diabetes” (meaning “excessive discharge of urine”) in the first century CE. Later, the word “mellitus” (sweet) after he noted the sweetness of patients

2015 The BMJ Blog

115. Diabetes insipidus

Diabetes insipidus Diabetes insipidus - Wikipedia Diabetes insipidus From Wikipedia, the free encyclopedia Not to be confused with . Diabetes insipidus Pronunciation "Diabetes: or Symptoms Large amounts of dilute urine, increased thirst , Usual onset Any age Types Central, nephrogenic, dipsogenic, gestational Causes Depends on the type , , Treatment Drinking sufficient fluids Medication , , Prognosis Good with treatment Frequency 3 per 100,000 per year Diabetes insipidus ( DI (...) DI occurs only during . Diagnosis is often based on , , and the . is a separate condition with an unrelated mechanism, though both can result in the production of large amounts of urine. Treatment involves drinking sufficient fluids to prevent dehydration. Other treatments depend on the type. In central and gestational DI treatment is with . Nephrogenic DI may be treated by addressing the underlying cause or the use of a , , or . The number of new cases of diabetes insipidus each year is 3

2012 Wikipedia

116. Severe hydramnios and preterm delivery in association with transient maternal diabetes insipidus. (PubMed)

Severe hydramnios and preterm delivery in association with transient maternal diabetes insipidus. Diabetes insipidus is rare in pregnancy. It is characterized by hypoosmolar polyuria and may be central, nephrogenic, or transient in etiology; the latter is presumably related to excess placental vasopresinase production. In theory, fetal effects of this endocrine condition may include hydramnios secondary to fetal polyuria.A pregnant patient developed rapid-onset second-trimester hydramnios (...) that prompted a thorough fetal and maternal evaluation. She ultimately was diagnosed with transient diabetes insipidus of pregnancy because of an abrupt change in her voiding pattern at 20 weeks of gestation, significant polydipsia, and laboratory studies that revealed a hypoosmolar polyuria with normal serum and urine electrolytes. Transient neonatal polyuria also was confirmed in association with this unique maternal endocrine syndrome.The most likely cause of hydramnios in this case is transient maternal

2010 Obstetrics and Gynecology

117. Hereditary nephrogenic diabetes insipidus: a major conundrum during labour and delivery (PubMed)

Hereditary nephrogenic diabetes insipidus: a major conundrum during labour and delivery 25949385 2015 05 07 2018 11 13 1753-0784 2 6 2009 Dec NDT plus NDT Plus Hereditary nephrogenic diabetes insipidus: a major conundrum during labour and delivery. 482-4 10.1093/ndtplus/sfp098 Castillo Eliana E Department of Medicine. Magee Laura A LA Bichet Daniel D Halperin Mitchell M Division of Nephrology, Department of Medicine, St Michaels Hospital , University of Toronto , Toronto, ON , Canada. eng (...) Journal Article 2009 08 04 England NDT Plus 101472665 1753-0784 balance diabetes insipidus hyponatremia water 2009 07 06 2009 07 07 2015 5 8 6 0 2009 12 1 0 0 2009 12 1 0 1 ppublish 25949385 10.1093/ndtplus/sfp098 sfp098 PMC4421319 Am J Physiol Renal Physiol. 2004 Dec;287(6):F1093-101 15522987 Intensive Care Med. 2001 May;27(5):921-4 11430551 J Clin Invest. 1960 Jul;39:1062-9 13849679 Crit Care Med. 2007 Jan;35(1):33-40 17133186 J Physiol. 1941 Mar 25;99(3):265-82 16995250 Am J Kidney Dis. 1993 Feb;21

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2009 NDT Plus

118. Diverse Vasopressin V2 Receptor Functionality Underlying Partial Congenital Nephrogenic Diabetes Insipidus. (PubMed)

Diverse Vasopressin V2 Receptor Functionality Underlying Partial Congenital Nephrogenic Diabetes Insipidus. X-linked congenital nephrogenic diabetes insipidus (CNDI) is characterized by a defective renal response to the antidiuretic hormone (AVP) due to variations in the arginine vasopressin receptor 2 (AVPR2) gene. In a unique group of patients, the renal insensitivity to the effects of AVP is incomplete resulting in a partial phenotype. To investigate the molecular defects, two previously

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2009 American Journal of Physiology. Renal physiology

119. Metabolic profiling of kidney and urine in rats with lithium-induced nephrogenic diabetes insipidus by 1H-NMR-based metabonomics. (PubMed)

Metabolic profiling of kidney and urine in rats with lithium-induced nephrogenic diabetes insipidus by 1H-NMR-based metabonomics. Lithium (Li) treatment for bipolar affective disorders is associated with a variety of renal side effects. The metabolic response of the kidney to chronic Li treatment has rarely been studied. We applied a novel method of (1)H-nuclear magnetic resonance (NMR)-based metabonomics to integrate metabolic profiling and to identify the changes in the levels of metabolites

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2009 American Journal of Physiology. Renal physiology

120. CHARACTERIZATION OF D150E AND G196D AQUAPORIN-2 MUTATIONS RESPONSIBLE OF NEPHROGENIC DIABETES INSIPIDUS; IMPORTANCE OF A MILD PHENOTYPE. (PubMed)

CHARACTERIZATION OF D150E AND G196D AQUAPORIN-2 MUTATIONS RESPONSIBLE OF NEPHROGENIC DIABETES INSIPIDUS; IMPORTANCE OF A MILD PHENOTYPE. Aquaporin-2 (AQP2) is a water channel responsible for the final water reabsorption in renal collecting ducts. Alterations in AQP2 function induce nephrogenic diabetes insipidus (NDI), a condition characterized by severe polyuria and polydipsia. Three patients affected with severe NDI, who were compound heterozygous for the AQP2 mutations D150E and G196D

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2009 American Journal of Physiology. Renal physiology

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