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Nephrogenic Diabetes Insipidus

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421. Defective aquaporin-2 trafficking in nephrogenic diabetes insipidus and correction by chemical chaperones. Full Text available with Trip Pro

Defective aquaporin-2 trafficking in nephrogenic diabetes insipidus and correction by chemical chaperones. Five single-point aquaporin-2 (AQP2) mutations that cause non-X-linked nephrogenic diabetes insipidus (NDI) were characterized to establish the cellular defect and to develop therapeutic strategies. In Xenopus oocytes expressing AQP2 cRNAs, single-channel water permeabilities of mutants L22V, T126M, and A147T were similar to that of wild-type AQP2, whereas R187C and C181W were

1998 Journal of Clinical Investigation

422. Unsuspected nephrogenic diabetes insipidus Full Text available with Trip Pro

Unsuspected nephrogenic diabetes insipidus 11451787 2001 08 16 2018 11 13 0959-8138 323 7304 2001 Jul 14 BMJ (Clinical research ed.) BMJ Unsuspected nephrogenic diabetes insipidus. 96-7 Waise A A Endocrine Clinic, Friarage Hospital, Northallerton, North Yorkshire DL6 1JG. awaise@nahs-tr.northy.nhs.uk Fisken R A RA eng Case Reports Journal Article England BMJ 8900488 0959-8138 0 Antimanic Agents 2BMD2GNA4V Lithium Carbonate AIM IM Aged Antimanic Agents adverse effects Diabetes Insipidus (...) , Nephrogenic chemically induced diagnosis Female Hospitalization Humans Lithium Carbonate adverse effects Male Middle Aged Water-Electrolyte Balance 2001 7 14 10 0 2001 8 17 10 1 2001 7 14 10 0 ppublish 11451787 PMC1120756 Scott Med J. 1997 Feb;42(1):16-7 9226773 Am J Med. 1975 Aug;59(2):153-7 168770 Psychol Med. 1989 Nov;19(4):825-31 2687916 Ann Intern Med. 1977 Apr;86(4):446-7 848808 Q J Med. 1984 Summer;53(211):369-79 6484119 Kidney Int. 1976 Jul;10(1):82-95 181631

2001 BMJ : British Medical Journal

423. Three Families with Autosomal Dominant Nephrogenic Diabetes Insipidus Caused by Aquaporin-2 Mutations in the C-Terminus Full Text available with Trip Pro

Three Families with Autosomal Dominant Nephrogenic Diabetes Insipidus Caused by Aquaporin-2 Mutations in the C-Terminus The vasopressin-regulated water channel aquaporin-2 (AQP2) is known to tetramerize in the apical membrane of the renal tubular cells and contributes to urine concentration. We identified three novel mutations, each in a single allele of exon 4 of the AQP2 gene, in three families showing autosomal dominant nephrogenic diabetes insipidus (NDI). These mutations were found

2001 American Journal of Human Genetics

424. An impaired routing of wild-type aquaporin-2 after tetramerization with an aquaporin-2 mutant explains dominant nephrogenic diabetes insipidus. Full Text available with Trip Pro

An impaired routing of wild-type aquaporin-2 after tetramerization with an aquaporin-2 mutant explains dominant nephrogenic diabetes insipidus. Autosomal recessive and dominant nephrogenic diabetes insipidus (NDI), a disease in which the kidney is unable to concentrate urine in response to vasopressin, are caused by mutations in the aquaporin-2 (AQP2) gene. Missense AQP2 proteins in recessive NDI have been shown to be retarded in the endoplasmic reticulum, whereas AQP2-E258K, an AQP2 mutant

1999 The EMBO journal

425. Pathogenesis of nephrogenic diabetes insipidus by aquaporin-2 C-terminus mutations. Full Text available with Trip Pro

Pathogenesis of nephrogenic diabetes insipidus by aquaporin-2 C-terminus mutations. We previously reported three aquaporin-2 (AQP2) gene mutations known to cause autosomal-dominant nephrogenic diabetes insipidus (NDI) (Am J Hum Genet 69:738, 2001). The mutations were found in the C-terminus of AQP2 (721delG, 763 to 772del, and 812 to 818del). The wild-type AQP2 is a 271 amino acid protein, whereas these mutant genes were predicted to encode 330 to 333 amino acid proteins due to the frameshift

2003 Kidney International

426. Tenofovir-related Fanconi syndrome with nephrogenic diabetes insipidus in a patient with acquired immunodeficiency syndrome: the role of lopinavir-ritonavir-didanosine. Full Text available with Trip Pro

Tenofovir-related Fanconi syndrome with nephrogenic diabetes insipidus in a patient with acquired immunodeficiency syndrome: the role of lopinavir-ritonavir-didanosine. Tenofovir-related tubular damage, like all other recently reported cases, occurred in patients receiving the protease inhibitor (PI) ritonavir, often with lopinavir. Increased plasma concentrations of didanosine were also observed after the addition of tenofovir. It was suspected that tenofovir with PIs interacted with renal

2003 Clinical Infectious Diseases

427. Tenofovir-related nephrotoxicity in human immunodeficiency virus-infected patients: three cases of renal failure, Fanconi syndrome, and nephrogenic diabetes insipidus. Full Text available with Trip Pro

Tenofovir-related nephrotoxicity in human immunodeficiency virus-infected patients: three cases of renal failure, Fanconi syndrome, and nephrogenic diabetes insipidus. We report 3 cases of renal toxicity associated with use of the antiviral agent tenofovir. Renal failure, proximal tubular dysfunction, and nephrogenic diabetes insipidus were observed, and, in 2 cases, renal biopsy revealed severe tubular necrosis with characteristic nuclear changes. Patients receiving tenofovir must be monitored

2003 Clinical Infectious Diseases

428. Cell-biologic and functional analyses of five new Aquaporin-2 missense mutations that cause recessive nephrogenic diabetes insipidus. (Abstract)

Cell-biologic and functional analyses of five new Aquaporin-2 missense mutations that cause recessive nephrogenic diabetes insipidus. Mutations in the Aquaporin-2 gene, which encodes a renal water channel, have been shown to cause autosomal nephrogenic diabetes insipidus (NDI), a disease in which the kidney is unable to concentrate urine in response to vasopressin. Most AQP2 missense mutants in recessive NDI are retained in the endoplasmic reticulum (ER), but AQP2-T125M and AQP2-G175R were

2002 Journal of the American Society of Nephrology

429. Aminoglycoside pretreatment partially restores the function of truncated V(2) vasopressin receptors found in patients with nephrogenic diabetes insipidus. Full Text available with Trip Pro

Aminoglycoside pretreatment partially restores the function of truncated V(2) vasopressin receptors found in patients with nephrogenic diabetes insipidus. By screening patients with X-linked nephrogenic diabetes insipidus (NDI) for mutations within the V(2) vasopressin receptor (AVPR2) gene, we have identified six novel and two recurrent mutations. Additionally, one patient revealed a genomic deletion of 3.2 kb encompassing most of the AVPR2 gene and the last exon/3'-region of C1 gene, which

2002 Journal of Clinical Endocrinology and Metabolism

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