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Neonatal Teeth

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141. Oral Health Care During Pregnancy and Through the Lifespan

the maintenance of good oral health habits throughout their lives as well as the safety and importance of oral health care during pregnancy. Introduction The 2000 Surgeon General’s report Oral Health in America , stated that a “silent epidemic of oral diseases is affecting our most vulnerable citizens,” including the poor and many members of racial and ethnic minority groups ( ). Oral health, which includes health of the gums, teeth, and jawbone, is a “mirror for general health and well-being” (1). The World (...) Association recommends that prophylaxis for dental procedures is reasonable only for patients with heart conditions that place them at the highest risk of adverse outcomes from endocarditis ( ). For patients with these conditions, prophylaxis is reasonable for all dental procedures that involve manipulation of gingival tissue or the periapical region of teeth or perforation of the oral mucosa (12). It is important for patients to discuss screening for oral cancer with their dentists. Although the U.S

2013 American College of Obstetricians and Gynecologists

142. An evidence advent calendar!

about modest improvements in people’s diets, at least up to about a year. If you do indulge in some Christmas pudding, which we’ve been eating in some shape or form since the 15th century, better make sure you clean your teeth afterwards (though obviously that wasn’t a priority in the 1400’s, even for those who had teeth and weren’t just sucking on their meat-or-fish-with-fat-and-dried-fruit horror pudding). There’s some pretty decent this month that using a triclosan/copolymer fluoride toothpaste (...) that ibuprofen and paracetamol combined provide better pain relief than the same dose of either drug alone and with a smaller chance of needing more over about eight hours, or of experiencing side effects. These are the findings of a , which found three randomized trials exploring these painkillers in people after they had wisdom teeth surgically removed. This is often used to investigate the effectiveness of painkillers as the results are applicable to other forms of acute pain after trauma. Stay safe

2013 Evidently Cochrane

143. An evidence advent calendar!

about modest improvements in people’s diets, at least up to about a year. If you do indulge in some Christmas pudding, which we’ve been eating in some shape or form since the 15th century, better make sure you clean your teeth afterwards (though obviously that wasn’t a priority in the 1400’s, even for those who had teeth and weren’t just sucking on their meat-or-fish-with-fat-and-dried-fruit horror pudding). There’s some pretty decent this month that using a triclosan/copolymer fluoride toothpaste (...) that ibuprofen and paracetamol combined provide better pain relief than the same dose of either drug alone and with a smaller chance of needing more over about eight hours, or of experiencing side effects. These are the findings of a , which found three randomized trials exploring these painkillers in people after they had wisdom teeth surgically removed. This is often used to investigate the effectiveness of painkillers as the results are applicable to other forms of acute pain after trauma. Stay safe

2013 Evidently Cochrane

144. Gene Therapy for the “Butterfly Children”

teeth are digging into me. But we’ll have to do it all over tomorrow and the next day and every day for the rest of my life.” In another video, has red marks on his face and neck, with gauze wrapped around his arms and legs. “He has blisters all over. Every time you go to remove a bandage, you’re touching an open sore,” says his mom Heather as the boy screams in the background. “The worst disease you never heard of” is recessive dystrophic epidermolysis bullosa – RDEB. It’s inherited from carrier (...) parents. “At a birth, nurses and doctors know right away and call for a pediatric dermatology consult,” says John Maslowski, president and chief executive officer of , which is conducting a phase 1/2 clinical trial for a gene therapy for RDEB. But the disease is so rare that sometimes it isn’t obvious. According to an article in the , doctors repeatedly asked one mother if she had a herpes infection when they saw the missing skin on the bottoms of her newborn’s feet. When skin fell away when a nurse

2018 PLOS Blogs Network

145. Guidelines on Equipment to Manage a Difficult Airway During Anaesthesia Background Paper

of the glottis or supraglottis. 69 Reported incidence of airway obstruction with the ProSeal™ varies with the size of the mask (0.4 per cent 70 in adults, 6.6 per cent with the size 2.5 71 and 10 per cent with the size 1.5 64 ). In a randomised series of 46 consecutive neonates and infants, the size 1.0 ProSeal™ (which lacks a dorsal cuff and bite block) formed a more effective seal than the cLMA™, suggesting that the size 1.0 ProSeal™ might have a benefit in newborn infants requiring high airway pressures (...) Societies of Anesthesiologists 10, 46 and the Difficult Airway Society (UK) 7 . The cLMA™ is considered a useful device in neonatal resuscitation and is included in the 2005 European Resuscitation Council guidelines for neonatal resuscitation. 47 Case studies suggest that the cLMA™ can provide suitable ventilation when BMV and endotracheal intubation fails, but a Cochrane review found no eligible studies comparing LMA with BMV in neonatal resuscitation. 24 The cLMA™ has the advantage of being readily

2012 Australian and New Zealand College of Anaesthetists

147. The effect of cultured autologous periodontal ligament cells on the healing of delayed autotransplanted dog's teeth. (Full text)

The effect of cultured autologous periodontal ligament cells on the healing of delayed autotransplanted dog's teeth. The regeneration of the periodontal structure for avulsed teeth extended dry times has been a goal of dentists. The aim of this study was to investigate a new strategy of delayed replantation for avulsed teeth that were not suitable for immediate replantation.Extracted dog's premolar teeth were maintained in a dry environment for a month after isolation and proliferation (...) of the periodontal ligament (PDL) cells. Then, tooth roots coated with 1 x 10(6) cultured autologous PDL cells were autotransplanted in artificial sockets created in the mandible. The dogs were sacrificed 60 days after transplantation. Histologic analyses showed that a root-PDL-bone complex was found in all cases of the PDL cell-loaded samples.The new PDL-like connective tissue was located between the alveolar bone and the transplanted roots, with fibers inserting into the newborn cementum on one end

2010 Journal of Endodontics PubMed abstract

148. Presurgical Nasoalveolar Molding of Bilateral Cleft Lip and Palate Infants: An Orthodontist’s Point of View (Full text)

Presurgical Nasoalveolar Molding of Bilateral Cleft Lip and Palate Infants: An Orthodontist’s Point of View Nonsyndromic complete cleft lip and palate deformity is primarily functional, then esthetic, and finally but not least importantly, a dental challenge. Feeding and facial appearance are important during the first years of a newborn. Nutrition is universally provided by passive feeding plates. If the Cleft Team prefers to use active plates, alveolar molding combined with nasal approaches (...) in infants is the best method to improve esthetics to date. Orthodontists are predominantly responsible for achieving both the goals. After those difficulties have been met in early days of the life, dentists are mainly responsible for the treatment thereafter. If the infants have a dentoalveolar unity without any fistulas and correctly aligned maxillary deciduous teeth, this is a real success. Therefore, this article is an overview of presurgical infant orthopedics and its contribution to subsequent

2017 Turkish Journal of Orthodontics PubMed abstract

149. Phenotypic Variation in Patients with Homozygous c.1678G>T Mutation in EVC Gene: Report of Two Mexican Families with Ellis-van Creveld Syndrome (Full text)

in the EVC or EVC2 (4p16) genes, with only a few cases caused by mutations in WDR35.  CASE REPORT Here, we report on two Mexican families with patients diagnosed with Ellis-van Creveld syndrome. Family 1 includes four patients: three females of 15, 18, and 23 years of age and a 7-year old male. Family 2 has only one affected newborn male. All patients exhibited multiple features including hypodontia, dysplastic teeth, extra frenula, mild short stature, distal limb shortening, postaxial polydactyly (...) Phenotypic Variation in Patients with Homozygous c.1678G>T Mutation in EVC Gene: Report of Two Mexican Families with Ellis-van Creveld Syndrome BACKGROUND Ellis-van Creveld syndrome is an autosomal recessive chondro-ectodermal dysplasia characterized by disproportionate short stature, limb shortening, narrow chest, postaxial polydactyly and dysplastic nails and teeth. In addition, 60% of cases present congenital heart defects. Ellis-van Creveld syndrome is predominantly caused by mutations

2017 The American journal of case reports PubMed abstract

150. Cardiopulmonary anomalies in incontinentia pigmenti patients. (Abstract)

Cardiopulmonary anomalies in incontinentia pigmenti patients. Incontinentia pigmenti (IP) is a rare inherited genodermatosis that usually involves the skin, and also teeth, oral cavity, central nervous system, eyes, blood with eosinophilia, and rarely skeletal system, breast, heart, and lungs. Skin lesions usually appear early, at birth or within the first 2 weeks of life, with four different phases tending to follow Blaschko lines that may overlap.We report a rare case of a neonate

2017 International Journal of Dermatology

151. Tooth manganese as a biomarker of exposure and body burden in rats (Full text)

Tooth manganese as a biomarker of exposure and body burden in rats Neonates and children are particularly vulnerable to the toxic effects of excess manganese (Mn), but studies of Mn exposure during these developmental periods are hampered by a lack of validated biomarkers. Deciduous teeth may be used to assess Mn exposure during these developmental periods but require further validation to determine the relationship between tooth Mn, Mn in target tissues, and exposure.To determine (...) 0.76, p<0.001).Teeth are a sensitive biomarker of active and past Mn exposure and Mn burden in tissues. Unlike blood, teeth retain information on exposure history over the short and long-term.Copyright © 2017 Elsevier Inc. All rights reserved.

2017 Environmental Research PubMed abstract

152. Relative tooth size at birth in primates: Life history correlates (Full text)

and residuals from cranial length were calculated with least squares regressions to obtain relative dental volumes (RDVs).Relative dental volumes of deciduous or permanent teeth have an unclear relationship with relative neonatal mass in all primates. Relative palatal length (RPL), used as a proxy for midfacial size, is significantly, positively correlated with larger deciduous and permanent postcanine teeth. However, when strepsirrhines alone are examined, larger RPL is correlated with smaller RDV (...) postcanine teeth (only gestational length correlations are significant).Our results indicate a broad trend that primates with the shortest RGLs precociously develop deciduous teeth; in strepsirrhines, the opposite trend is seen for permanent molars. Anthropoids delay growth of permanent teeth, while strepsirrhines with short RGLs are growing replacement teeth concurrently. A comparison of neonatal volumes with existing information on extent of cusp mineralization indicates that growth of tooth germs

2017 American journal of physical anthropology PubMed abstract

153. Incontinentia Pigmenti: A Case Report of a Complex Systemic Disease (Full text)

Incontinentia Pigmenti: A Case Report of a Complex Systemic Disease Incontinentia Pigmenti is an uncommon X-linked genodermatosis, caused by mutations in the NEMO gene. It is a systemic disease that involves tissue of ectodermic and mesodermic origin, including cutaneous tissue, teeth, eyes and the central nervous system, amongst other organs. The Authors report a rare case of Incontinentia Pigmenti in a female newborn.

2017 Open access Macedonian journal of medical sciences PubMed abstract

154. Irx1 regulates dental outer enamel epithelial and lung alveolar type II epithelial differentiation (Full text)

, kidney, testis and developing teeth. Irx1 null mice are neonatal lethal and this lethality it due to pulmonary immaturity. Irx1-/- mice show delayed lung maturation characterized by defective surfactant protein secretion and Irx1 marks a population of SP-C expressing alveolar type II cells. Irx1 is specifically expressed in the outer enamel epithelium (OEE), stellate reticulum (SR) and stratum intermedium (SI) layers of the developing tooth. Irx1 mediates dental epithelial cell differentiation

2017 Developmental biology PubMed abstract

155. Strategies for Meaningful Engagement between Community-Based Health Researchers and First Nations Participants (Full text)

Strategies for Meaningful Engagement between Community-Based Health Researchers and First Nations Participants The Baby Teeth Talk Study (BTT) is a partnership-based research project looking at interventions to prevent early childhood caries (ECC) in First Nations populations in Canada. Community-based researchers (CBRs) conducted preventive and behavioral interventions that targeted expectant mothers and their newborns, over a 3-year period. The work of the CBRs requires a great deal

2017 Frontiers in public health PubMed abstract

156. Periodontitis and Adverse Pregnancy Outcomes in Metabolic Syndrome Patients- Interventional Study

of hopeless teeth followed by supragingival and subgingival scaling and root planing (SRP) of sites with PDs > 4 mm and polishing of all the teeth. Participants will be offered treatment under local anesthetic when necessary. No limits will be imposed on the number of dental visits needed to accomplish periodontal therapy. Other Name: Non Surgical Periodontal Therapy (NSPT) Active Comparator: Periodontitis Patients undergoing supragingival scaling The control group participants with periodontitis (...) will receive oral hygiene instruction and single visit supragingival scaling of all teeth at their baseline visit. Procedure: single visit supragingival scaling The control and Placebo group participants will receive oral hygiene instruction and supragingival cleaning of all teeth at their baseline visit. Active Comparator: Without Periodontitis undergoing supragingival scaling Placebo group participants without periodontitis will receive oral hygiene instruction and single visit supragingival scaling

2017 Clinical Trials

157. Developmental Impact of NICU Exposures (DINE)

States, over 300,000 preterm infants are admitted to neonatal intensive care units (NICUs) where they are exposed to a chemical-intensive hospital environment during a developmentally vulnerable period. Many life-saving and supportive respiratory, nutritional, hematologic and pharmaceutical therapies in the NICU expose preterm infants to potentially harmful chemicals during a life stage analogous to the third trimester of gestation. The NIH-funded DINE study capitalizes on the infrastructure (...) Enrollment : 854 participants Observational Model: Cohort Time Perspective: Prospective Target Follow-Up Duration: 7 Years Official Title: Developmental Impact of Neonatal Intensive Care Unit (NICU) Exposures: Environmental Influences on Child Health Outcomes (ECHO) Actual Study Start Date : April 1, 2017 Estimated Primary Completion Date : August 31, 2023 Estimated Study Completion Date : August 31, 2023 Groups and Cohorts Go to Group/Cohort Prematurity and Respiratory Outcomes Program (PROP) extant

2017 Clinical Trials

158. MRI Spectroscopy and Neuropsychological Functioning in Phenylketonuria

to tolerate MRI procedures without sedation Has metal implants or braces on teeth not compatible with MRI Has any known contraindication for MRI PKU Group: Pre-treatment/off-diet blood Phe concentration below 600 umol/L) PKU Group: Not identified through newborn screening or treatment was initiated after 30 days of life Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact (...) by (Responsible Party): Susan Waisbren, Boston Children’s Hospital Study Details Study Description Go to Brief Summary: This is a study about the relationship of brain biomarkers with neuropsychological functioning in PKU. All participants will undergo MRI spectroscopy, will provide a blood specimen and will receive neuropsychological testing. Condition or disease Phenylketonuria Detailed Description: Despite newborn screening and early initiation of treatment, many adolescents and adults with PKU experience

2017 Clinical Trials

159. A Comparison of Video Laryngoscopes and the Direct Laryngoscope in Simulated Normal and Difficult Infant Airway.

Date : September 27, 2017 Arms and Interventions Go to Arm Intervention/treatment Experimental: normal airway Time (normal airway) using the novel King Vision™ Pediatric aBlade (KV) video laryngoscope, C-MAC™ D-blade Ped (DP), C-MAC™ Miller Blade (MB), shortened as VL, compared with conventional direct laryngoscopy (DL) Device: normal airway The Time interval between the laryngoscope blade passing the teeth/gums to the announcing of the first ventilation was recorded as the time to ventilation (...) with the Video laryngoscopy (VL) or conventional direct laryngoscopy (DL) Device: difficult airway The Time interval between the laryngoscope blade passing the teeth/gums to the announcing of the first ventilation was recorded as the time to ventilation with the Video laryngoscopy (VL) or conventional direct laryngoscopy (DL) Experimental: difficult airway Time (difficult airway) using the novel King Vision™ Pediatric aBlade (KV) video laryngoscope, C-MAC™ D-blade Ped (DP), C-MAC™ Miller Blade (MB

2017 Clinical Trials

160. Hypophosphatasia: An overview For 2017. (Abstract)

richly expressed in the skeleton, liver, kidney, and developing teeth. In HPP, TNSALP substrates accumulate extracellularly. Among them is inorganic pyrophosphate (PPi), a potent inhibitor of mineralization. Superabundance of extracellular PPi explains the hard tissue complications of HPP that feature premature loss of deciduous teeth and often rickets or osteomalacia as well as calcific arthropathies in some affected adults. In infants with severe HPP, blocked entry of minerals into the skeleton can (...) is essential for recurrence risk assessment for HPP in future pregnancies and for prenatal diagnosis. HPP was the final rickets/osteomalacia to have a medical treatment. Now, significant successes using asfotase alfa, a mineral-targeted recombinant TNSALP, are published concerning severely affected newborns, infants, and children. Asfotase alfa was approved by regulatory agencies multinationally in 2015 typically for pediatric-onset HPP.Copyright © 2017 Elsevier Inc. All rights reserved.

2017 Bone

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