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Neonatal Teeth

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501. Hyperparathyroidism

) Familial Hyperparathyroidism (10-20%): Younger patients ( ) ( ) Hyperparathyroidism-Jaw Tumor Syndrome Neonatal severe Primary Hyperparathyroidism Other related causes Therapy External neck radiation exposure Neck surgery with injury or resection Tertiary Hyperparathyroidism Accelerated response to chronic (in advanced ) over-produces PTH causing V. Causes: Secondary Hyperparathyroidism Decreased calcium intake stage 4 or stage 5 and Decreased 1,25 dihydroxyvitamin D Normocalcemic Hyperparathyroidism (...) before Repeat serum testing in 2 weeks if normal Miscellaneous 1,25 Dihydroxyvitamin D3 Indicated if low and Phosphate ( ) Hyperphosphaturia tests IX. Imaging Classic XRay Findings "Salt and pepper" skull Distal Clavicle resorption Hand XRay Second and third middle phalange bone resorption Dental XRay Bone resorption of Lamina dura around teeth Sestamibi Technetium Tc 99mParathyroid Scan for localizing adenoma: 95% Causes of non-localizing scan Ectopic PTH production Diagnostic error Four-gland

2015 FP Notebook

502. Oral Hygiene and Maternity Outcomes Multicenter Study (OHMOM)

Frame: 3 months ] Change from Baseline in Löe-Silness Gingivitis Index [ Time Frame: 2 months ] Change from Baseline in Löe-Silness Gingivitis Index [ Time Frame: 1 month ] Secondary Outcome Measures : Gestational Age (weeks) [ Time Frame: At delivery ] Other Outcome Measures: Neonate Birth Weight (grams) [ Time Frame: At delivery ] Preterm Birth (gestational age < 37 weeks) [ Time Frame: At delivery ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing (...) informed consent prior to participation and be given a signed copy of the informed consent form; be at least the age of legal consent; be between 8 and 24 weeks of pregnancy; have at least 20 natural teeth; have moderate-to-severe gingivitis during pregnancy, including at least 30 intraoral sites with evidence of marginal gingival bleeding. Exclusion Criteria: evidence of multiple gestations; history of HIV infection, AIDS, autoimmune disease, or diabetes other than gestational diabetes; indication

2012 Clinical Trials

503. Relationship of periodontal disease to pre-term low birth weight infants in a selected population--a prospective study. (Abstract)

Plaque index, Gingival index, Papillary Bleeding index, probing pocket depth and attachment loss were conducted.Pregnancy outcome data which included gestational age at delivery, birth weight of newborn and delivery complications were collected after delivery.Study sample of 73 mothers was approximately in 1:3 case:control ratio (21.9% & 78.1% respectively). Case was defined as those with preterm (PT) deliveries and low birth weight (LBW) infants whereas control was otherwise. 37 pregnant women were (...) diagnosed with periodontal disease (minimum 2 teeth with > or = 5 mm periodontal pockets and > or = 3 mm attachment loss) and 36 without periodontal disease (PD). Of those with PD, 4 (10.8%) had PT delivery and 3 (8.1%) had LBW infants. None of the PD variable means or PD status associated significantly with either of the two groups (P>0.05). Logistic regression analysis to test the possible predictor (demographic and clinical) for PT or LBW status indicated only Plaque Index mean as a significant

2012 Community dental health

504. CASES Full Text available with Trip Pro

CASES 14957873 2004 02 15 2018 12 01 0035-9157 45 7 1952 Jul Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Green teeth in baby due to rhesus incompatibility. 439 MacRAE D J DJ eng Journal Article England Proc R Soc Med 7505890 0035-9157 0 Rh-Hr Blood-Group System OM Anemia, Hemolytic Dental Enamel abnormalities Erythroblastosis, Fetal Fetus Humans Infant, Newborn Rh-Hr Blood-Group System 5222:44333:129:160:400 DENTAL ENAMEL/abnormalities ERYTHROBLASTOSIS, FETAL RH FACTOR 1952

1952 Proceedings of the Royal Society of Medicine

505. Standing before them, I realize I made a terrible mistake

, as quickly as I read him. A strong jaw cuts the angle of his face into the space of the room around it. He does not need to smile for me to know his teeth will be perfect and symmetrical and white. Under each eye hangs a faint dark circle. He has not been sleeping well. I am guessing, of course, but it looks to be more than just work fatigue. Perhaps a struggle outside of work has started to spill over into what must be an all-consuming drive for achievement. Or perhaps it is nothing other than (...) body is turned partially away from me. She is resting her elbows on her knees, looking at the screen of her phone. She cradles it lovingly like a newborn. Marvelous red nails stand out against a white-and-gold iPhone. Her fingers are long and elegant like those of a famous pianist or a brain surgeon. She taps and slides the icons on the screen with elegance, as if they are servants being sent to do her bidding. Her forearms are bare and hairless, but it is her biceps that stand out. They are small

2015 KevinMD blog

506. The doctor-patient relationship is even more complex than you think

with a request to see my son’s latest pictures. She has gotten to see him grow from a newborn through lost teeth and starting kindergarten, while I have seen her deal with chemo, radiation, surgeries, miraculous recoveries, and not so miraculous recurrences with incredible grace. On this final visit, more really to say goodbye than to discuss her cancer one last time, I looked around for my nurse and PA, sure they would want to see her. I eventually found them already in the room with her, baby pictures out

2015 KevinMD blog

507. Anatomy of the Canine Skull in Low-grade Otocephaly Full Text available with Trip Pro

union of the cranial sutures and occasional membranous-like paietal bone replacement over the patent fontanelle. Partial agnathia was not obvious in the neonate, but became apparent during postnatal skeletal development. The major anatomical differences in the skulls of these dogs were compared with normal Beagles. Malocclusion of the lower mandible and teeth against the upper jaw during development may have resulted in changes in length and width of the upper jaw and certain cranial structures (...) Anatomy of the Canine Skull in Low-grade Otocephaly An inherited low-grade otocephaly in a strain of Beagles was studied. All cases were "mild" with partial agnathia a constant feature in the adult animal. One case of high-grade otocephaly with aprosopus was recorded in an outcrossed animal. Neonatal mortalities in the low-grade type were associated with gross patency of the parietal fontanelle and hydrocephaly. Enlarged lateral ventricles were found in adult dogs, associated with incomplete

1964 Canadian journal of comparative medicine and veterinary science

511. Cancer, fertility and pregnancy

Spontaneous abortion, major congenital anomalies Second and third trimester Intrauterine growth and maturation, continuing development of CNS, gonads, teeth–palate, eyes, ears Functional defects and minor anomalies of late-forming tissues, stillbirth, intrauterine growth retardation, premature delivery, myelosuppression Annals of Oncology clinical practice guidelines Volume 21 | Supplement 5 | May 2010 doi:10.1093/annonc/mdq198 | v267Complications are less frequently encountered after a diagnostic LLETZ (...) inadvertently been exposed to targeted agents. Trastuzumab caused oligohydramnios in four and abnormal implantation in one out of seven pregnant women, while no data exist on its effects on fetal cardiac development. This agent should be withheld until after delivery or pregnancy termination. Rituximab only caused transient neonatal lymphopenia in four reported cases. Imatinib was occasionally associated with low birth weight and premature delivery in 29 reported cases, though one case of hypospadias

2010 European Society for Medical Oncology

512. Overview of Lysosomal Storage Disorders

investigation have been reported at Temple University in Philadelphia. The university... 3D Model Cystic Fibrosis: Defective Chloride Transport Video How to do Neonatal Resuscitation SOCIAL MEDIA Add to Any Platform Loading Topic Resources Lysosomal enzymes break down macromolecules, either those from the cell itself (eg, when cellular structural components are being recycled) or those acquired outside the cell. Inherited defects or deficiencies of lysosomal enzymes (or other lysosomal components) can (...) )* ML IV See Sialolipidosis in — — *Gene has been identified, and molecular basis has been elucidated. OMIM = online mendelian inheritance in man (see the ). Table Other Lipidoses Disease (OMIM Number) Defective Proteins or Enzymes Defective Gene or Genes (Chromosomal Location) Comments (see also Niemann-Pick disease, types A and B in ) Onset: Highly variable (early or late infancy, adolescence, adulthood) Urine metabolites: None Clinical features: Vertical gaze palsy, hepatosplenomegaly, neonatal

2013 Merck Manual (19th Edition)

513. Overview of Drug Treatment in Children

effects on growth and development. Some common drugs with unique or higher risk of adverse effects in children are listed in Table . Table Drugs Manifesting Unusual Toxicity in Children Drug Clinical Syndrome Mechanism Comments Anesthetics, topical (eg, benzocaine , mixture of lidocaine and prilocaine) Cyanosis Formation of methemoglobin (ferrous iron oxidized to ferric iron) Incidence rare Ceftriaxone Bilirubin displaced from albumin Affects only neonates Codeine * Respiratory depression Death (...) not be used in children 50 kg (alternative should be used) Prochlorperazine Altered CNS function Extrapyramidal effects Opisthotonus Bulging fontanelles Actions via multiple CNS receptors Febrile and dehydrated infants especially at risk SSRIs Suicidal ideation Unknown Increased incidence of suicidal ideation in children and adolescents Tetracycline Discoloration and pitting of tooth enamel Chelation with calcium in growing teeth Not given to children 8 yr *See also the American Academy of Pediatrics

2013 Merck Manual (19th Edition)

514. Seizure Disorders

, possibly a paradoxical increase in seizure frequency Expanding intracranial lesions , , Hyperpyrexia Drug toxicity (eg, with or cocaine), , Metabolic disturbances Commonly, (eg, secondary to hypoparathyroidism), , Less commonly, aminoacidurias, , uremic encephalopathy, , , In neonates, Neurocutaneous disorders , Pressure-related Decompression illness, hyperbaric oxygen treatments Withdrawal syndromes , anesthetics, * Posttraumatic seizures occur in 25 to 75% of patients who have brain contusion, skull (...) fracture, intracranial hemorrhage, prolonged coma, or focal neurologic deficits. † Fifth day fits (benign neonatal seizures) are tonic-clonic seizures occurring between 4 and 6 days of age in otherwise healthy infants; one form is inherited. ‡ When given in toxic doses, various drugs can cause seizures. NMDA = N -methyl- d -aspartate. Classification In 2017, the International League Against Epilepsy (ILAE) developed a new classification system for seizures ( ). Initial classification is by type

2013 Merck Manual (19th Edition)

515. Infectious Disease in Pregnancy

cross the placenta and can displace bilirubin from binding sites. These drugs are often avoided after 34 weeks gestation because neonatal kernicterus is a risk. Tetracyclines cross the placenta and are concentrated and deposited in fetal bones and teeth, where they combine with calcium and impair development (see table ); they are not used from the middle to the end of pregnancy. Key Points Most common maternal infections (eg, UTIs, skin and respiratory tract infections) are usually not serious (...) Tests for these infections are done during routine prenatal evaluations or if symptoms develop. can be transmitted to the neonate during delivery. Risk is high enough that cesarean delivery is preferred in the following situations: When women have visible herpetic lesions When women who have a known history of infection develop prodromal symptoms before labor When herpes infection first occurs during the late 3rd trimester (when cervical viral shedding at delivery is likely) If visible lesions

2013 Merck Manual (19th Edition)

516. Drugs in Pregnancy

gestation, neonatal jaundice and, without treatment, In women or fetuses with G6PD deficiency, hemolysis — Slowed bone growth, enamel hypoplasia, permanent yellowing of the teeth, and increased susceptibility to cavities in offspring Occasionally, liver failure in pregnant women — Increased risk of neural tube defects due to folate antagonism — Anticoagulants Thrombocytopenia and maternal bleeding Compatible with pregnancy Unfractionated heparin Thrombocytopenia and maternal bleeding — (eg, rivaroxaban (...) and maternal hemorrhage Absolutely contraindicated during 1st trimester of pregnancy † Carbamazepine Hemorrhagic disease of the newborn Some risk of congenital malformations including neural tube defects — Lamotrigine No appreciable increased risk with dosage up to 600 mg/day Compatible with pregnancy Levetiracetam Minor skeletal malformations in animal studies, but no appreciable increased risk in humans Compatible with pregnancy Phenobarbital Hemorrhagic disease of the newborn Some risk of congenital

2013 Merck Manual (19th Edition)

517. Palmoplantar Keratodermas

Diagnostic Tests for Skin Disorders Which of the following diagnostic tests is often done to evaluate pigmented lesions? Shaving Deep excision Patch test Scraping NEWS & VIDEOS Prenatal Fluconazole Exposure Increases Neonatal Risks WEDNESDAY, Feb. 20, 2019 (HealthDay News) -- Maternal exposure to fluconazole during pregnancy may increase the risk for spontaneous abortion, according to a study published online Feb. 19 in... SOCIAL MEDIA Add to Any Platform Loading Topic Resources Palmoplantar keratodermas (...) -Lefèvre syndrome: This form causes manifestations before age 6 mo. Severe can result in loss of teeth. Vohwinkel syndrome: In this autosomal dominant form, patients may also develop digital autoamputation and high-frequency hearing loss. Diffuse nonepidermolytic palmoplantar keratoderma: This autosomal dominant form develops in infancy and causes well-demarcated, symmetric keratoderma involving the entire palms and soles. Treatment Symptomatic treatment Symptomatic measures can include

2013 Merck Manual (19th Edition)

518. Vitamin Deficiency, Dependency, and Toxicity - Overview of Vitamins

health Carnitine, hormone, and amino acid formation Wound healing Deficiency: Scurvy (hemorrhages, loose teeth, gingivitis, bone defects) ( cholecalciferol , ergocalciferol ) Direct ultraviolet B irradiation of the skin (main source), fortified dairy products (main dietary source), fish liver oils, fatty fish, liver Calcium and phosphate absorption Mineralization and repair of bone Tubular reabsorption of calcium Insulin and thyroid function, improvement of immune function, reduced risk of autoimmune (...) in the GI tract after neonatal period Formation of prothrombin, other coagulation factors, and bone proteins Deficiency: Bleeding due to deficiency of prothrombin and other factors, osteopenia Table Potential Vitamin-Drug Interactions Nutrient Drug Antibiotics, anticonvulsants Alcohol, 5- fluorouracil , metformin , methotrexate , oral contraceptives, anticonvulsants (eg, phenobarbital , phenytoin , primidone ), sulfasalazine , triamterene , trimethoprim Alcohol, isoniazid Alcohol, barbiturates

2013 Merck Manual (19th Edition)

519. Physical Growth of Infants and Children

during infancy and childhood. Extremities grow faster than the trunk, leading to a gradual change in relative proportions; the crown-to-pubis/pubis-to-heel ratio is 1.7 at birth, 1.5 at 12 months, 1.2 at 5 years, and 1.0 after 7 years. Clinical Calculator: Clinical Calculator: Clinical Calculator: Weight Weight follows a similar pattern. Normal-term neonates generally lose 5 to 8% of birth weight in the days after delivery but regain their birth weight within 2 weeks. They then gain 14 to 28 g/day (...) %. The relatively larger amount of body water, its high turnover rate, and the comparatively high surface losses (due to a proportionately large surface area) make infants more susceptible to fluid deprivation than older children and adults. Tooth Eruption Tooth eruption is variable (see Table: ), primarily because of genetic factors. On average, normal infants should have 6 teeth by 12 months, 12 teeth by 18 months, 16 teeth by 2 years, and all teeth (20) by 2½ years; deciduous teeth are replaced by permanent

2013 Merck Manual (19th Edition)

520. Health Supervision of the Well Child

of a healthy lifestyle are Table Recommendations for Preventive Care During Infancy a Item Neonate Age 3–5 days By age 1 mo Age 2 mo Age 4 mo Age 6 mo Age 9 mo History (initial or interval) — X X X X X X X Measurements Length or height and weight X X X X X X X Head circumference X X X X X X X Weight for length X X X X X X X Blood pressure b RA RA RA RA RA RA RA Sensory screening Vision RA RA RA RA RA RA RA Hearing X RA RA RA RA RA RA Developmental and behavioral assessment Developmental surveillance c X X (...) X X X X Developmental screening d X Psychosocial and behavioral assessment X X X X X X X Physical examination — X X X X X X X Laboratory testing e Neonatal metabolic and hemoglobinopathy screening f ←––––––––––––––––––X–––––––––––––––––→ Critical congenital heart defect screening g X Hematocrit or hemoglobin RA Lead screening h RA RA Tuberculin test i RA RA Other Immunization j (see Table: and ) X X X X X X X Oral health k RA RA Fluoride varnish l X X Anticipatory guidance X X X X X X X

2013 Merck Manual (19th Edition)

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