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Neonatal Teeth

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181. Silence isn’t golden when it comes to health

Silence isn’t golden when it comes to health Silence isn't golden when it comes to health Silence isn’t golden when it comes to health | | November 1, 2018 7 Shares When I was a preemie — all two-and-a-half pounds of me — my mom was understandably worried. She said her doctor wheeled her down the hall to the newborn nursery, and my mom could hear me screaming all the way down the hall. She said, “I’ve got to hand it to you. You let your voice be heard — you let your needs be known. I told her (...) for quite some time now, I know when something isn’t right, and I value when a doctor listens to me. If my gut tells me that a problem is with my tooth, and not with the gums or nerves surrounding it, someone needs to listen to me. It shouldn’t be like pulling teeth. After seeing seven dental professionals, someone finally listened to me. A picture, like an X-ray, is not always worth 1,000 words, as my X-rays proved. Not everything will show up on an X-ray. It was not my nerve — but my nerves that were

2018 KevinMD blog

183. Temporomandibular disorders (TMDs)

treatment or trauma). Chronic TMD pain is defined as lasting for more than 3 months. Complications of temporomandibular disorders (TMDs) include: Chronic pain. Psychosocial distress. Tooth wear, fracture or failure of teeth. Speech, chewing, and swallowing problems. A TMD should be suspected if a person presents with one or more of the following clinical features: Pain in and around the TMJ and/or muscles of mastication, which may radiate to other structures. Pain may be provoked by palpation of the TMJ (...) and associated muscles, or by jaw movement or function, or parafunction (such as teeth grinding or jaw clenching). Reproducible joint noise of the TMJ (clicking, popping, or crepitus) on any jaw movements, with or without restricted movement or locking of the TMJ. Headache limited to the temporal region. Otalgia and/or tinnitus in the absence of ear disease. Referral should be arranged to oral medicine or oral and maxillofacial surgery for specialist investigations and management, depending on clinical

2016 NICE Clinical Knowledge Summaries

184. Bruising

deficiencies of factors II, VII, IX, and X, and proteins C and S, and can cause bleeding in an infant in the first weeks of life, when it is known as Haemorrhagic Disease of the Newborn (HDN). HDN is more prevalent in exclusively breastfed babies, and those with an inadequate or omitted dose of prophylactic vitamin K after birth. Bleeding can vary from bruising or petechiae in the first few days of life through to severe and life-threatening intracranial haemorrhage and/or gastrointestinal bleeding (...) . Unexpected bleeding from the umbilical stump or delayed stump separation by up to 4 weeks, suggesting factor XIII deficiency. Haematoma after routine intramuscular vitamin K given at birth. Bleeding from the newborn heel prick test, suggesting factor XIII deficiency, or sometimes haemophilia. Assess the location and pattern of bruising, using pictorial or photographic records where possible and appropriate (for example in children): Distribution, number, site, shape, and measured size of bruises

2016 NICE Clinical Knowledge Summaries

185. What does the public really know about patient safety at US hospitals? Not much

a chilling tale in the Portland Tribune about a 52-year-old patient who died in 2015 after 12 teeth were pulled at Oregon Health & Science University’s dental surgery clinic. The man’s liver had trouble producing the clotting agents the body needs to stop bleeding. His infected teeth needed to be pulled in order for him to qualify for a liver transplant. However, instead of extracting a couple of teeth and hospitalizing him overnight to make sure his blood clotted properly, Oregon Health & Sciences (...) University pulled 12 teeth at once, observed the man for an hour, and sent him home, a three-and-a-half-hour drive from the hospital. “That series of decisions may have led” to the man’s death judging by interviews with several doctors experienced with liver patients and oral surgery, Budnick reported. One hematologist said, “the pre-surgery test results indicated red flags that were ‘clear.’” A case that raises larger questions Just as bad for the hospital was its attempt to pin the medical mistakes

2017 HealthNewsReview

186. Langerhans Cell Histiocytosis Treatment (PDQ®): Patient Version

that increases your risk of getting a disease is called a . Having a risk factor does not mean that you will get ; not having risk factors doesn't mean that you will not get cancer. Talk with your doctor if you think you may be at risk. Risk factors for LCH include the following: Having a parent who was exposed to certain . Having a parent who was exposed to metal, granite, or wood dust in the workplace. A of cancer, including LCH. Having a or family history of disease. Having infections as a newborn (...) . Fingernails that fall off or have discolored grooves that run across the nail. Mouth Signs or symptoms of LCH that affects the mouth may include: Swollen . Sores on the roof of the mouth, inside the cheeks, or on the tongue or lips. Teeth that become uneven or fall out. Bone Signs or symptoms of LCH that affects the bone may include: Swelling or a lump over a bone, such as the , jawbone, ribs, , , thigh bone, upper arm bone, elbow, eye socket, or bones around the ear. Pain where there is swelling

2015 PDQ - NCI's Comprehensive Cancer Database

187. Insomnia

in response to a stressful event but continues despite resolution of the event. Secondary insomnia may be caused by: Other sleep disorders including: Sleep apnoea. For more information, see the CKS topic on . Circadian rhythm disorders such as shift work, jet lag, advanced sleep phase syndrome and delayed sleep phase syndrome. For more information, see the CKS topic on . Parasomnias such as restless legs syndrome, periodic limb movement disorder, sleep talking, sleep walking, sleep terrors, teeth grinding (...) an increased incidence of cleft lip and palate in addition to cases of severe neonatal respiratory depression in late pregnancy. Adverse effects of Z-drugs include gastrointestinal effects such as nausea, vomiting and diarrhoea. Less commonly dizziness, drowsiness, dry mouth, headache amnesia, confusion, depression, hallucinations, nightmares, and paradoxical effects such as talkativeness, excitement, aggression and increased anxiety have been reported [ ; ]. Tolerance and dependence and withdrawal

2015 NICE Clinical Knowledge Summaries

188. Statement on pregnancy and travel

. Due to vertical trans- mission, neonatal hepatitis B may occur with high risk of carriage in the newborn (11) . Influenza vaccine (Fluviral, Fluzone) According to NACI, current evidence indicates that influenza vaccine is safe for pregnant women at all stages of pregnancy and for breastfeeding mothers (12) . All pregnant women who wish to avoid morbidity associated with influenza should be encouraged to be vaccinated (13) . Pregnant women are at increased risk for influenza- related complications (...) voyages. Par contre, de façon pratique, cela est rarement possible. 6 Toxoid vaccines Tetanus and Diphtheria Toxoids Adsorbed (Td) Based on extensive use in pregnant women there is no evidence that either tetanus or diptheria toxoid are teratogenic (6;7) . It is prudent to update tetanus immunization in pregnancy if it is a risk especially as maternal immunity is passed to the baby and can help protect against neonatal tetanus. Inactivated, killed, and recombinant DNA virus vaccines In general

2010 CPG Infobase

189. American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the Diagnosis and Treatment of Acromegaly

finding, and these changes can be disfiguring. The dental changes, including maxillary and mandibular widening with separa- tion of the teeth, mandibular overgrowth, jaw malocclu- sion, and overbite, may be disabling for patients (35 [EL 3]). Arthropathy develops early in the course of acromeg- aly and, with progression, resembles active osteoarthritis and often results in substantial disability (36 [EL 3], 37 [EL 4], 38 [EL 3]). Joint pains may be present in up to three-quarters of the patients (39

2011 American Association of Clinical Endocrinologists

190. Molar incisor hypomineralisation- review suggests link with childhood illnesses

incisors. Similar lesions presenting in second primary molars have been termed, hypomineralised second primary molars (HSPM). The prevalence of MIH is reported to be between 2.4-40.2% and HSPM to be 4.9-6.9%. Affected teeth are associated with a high burden of disease and the nature of the defect predisposes them to treatment failure. The aim of this review was to assess the strength of evidence linking aetiological factors for MIH and HSPM. Methods Searches were conducted in the Medline and Embase (...) studies reporting a crude association. Studies also evaluated associations between antibiotics, anti-asthma medication and breastfeeding. Only 3 studies looked at HSPM one study suggested that maternal antibiotic use during pregnancy is unlikely to be associated with HSPM but maternal alcohol intake may be. Another study reported possible associations with a large number of factors, with perinatal factors and neonatal illness being most common, followed by prenatal factors. Conclusions The authors

2016 The Dental Elf

191. Emergency Airway Management Part 3: Intubation - the procedure

a huge bend in the endotracheal tube. Light travels in a straight line, so if you can see the cords, the tube primarily has to travel straight. (Obviously, this is not true with video devices.) The slight bend in the tube is so that you can keep it below your line of site and enter the cords from below. Use the right side of the mouth so avoid interference from the teeth, and have an assistant pull the cheek to provide more room if necessary. Confirm placement: Use end-tidal capnography (...) medicine junkie. “One special advantage of the skeptical attitude of mind is that a man is never vexed to find that after all he has been in the wrong.” - William Osler You may also like Published A summary of the resuscitation of the newborn infant, updates with the 2015 ILCOR guidelines Share this: Like this: Like Loading... Published An approach to the initial management of the severely hypotensive atrial fibrillation patients Share this: Like this: Like Loading... Published A critique

2017 First10EM

193. Carglumic acid (Carbaglu)

(neonatal-onset) presentation correlates with the presence of either 2 NAGS null alleles or 2 missense mutations, which lead to complete absence of NAGS activity. Symptoms result primarily from hyperammonemia. Newborns who have hyperammonemia may present with respiratory alkalosis, hypotonia, lethargy, and vomiting. Symptoms may progress to include cerebral edema, seizures, and death. If newborns survive the acute hyperammonemic episode, they usually tend to exhibit significant development delays (...) diagnostic methods became available in 2003. 3 Meijer A, et al. Control of Ureagenesis. Eur J. Biochem 1985: 148: 189-196 Clinical Review Virginia Elgin, M.D. and Helen Sile, M.D NDA 22-562/S-000 Carbaglu (carglumic acid) 20 The autosomal recessive disorder expresses phenotypes that range from acute neonatal onset to late-onset disease in adults. The neonatal-onset phenotype has a devastating clinical course, and usually reflects complete absence of NAGS activity. It is thought that the early-onset

2010 FDA - Drug Approval Package

194. The Path towards Endangered Species: Prehistoric Fisheries in Southeastern Brazil Full Text available with Trip Pro

The Path towards Endangered Species: Prehistoric Fisheries in Southeastern Brazil Brazilian shellmounds are archaeological sites with a high concentration of marine faunal remains. There are more than 2000 sites along the coast of Brazil that range in age from 8,720 to 985 cal BP. Here, we studied the ichthyoarchaeological remains (i.e., cranial/postcranial bones, otoliths, and teeth, among others) at 13 shellmounds on the southern coast of the state of Rio de Janeiro, which are located (...) (i.e., 265 spp.) that have been documented along the coast of Rio de Janeiro state. This high fish diversity recovered from the shellmounds is clear evidence of well-developed prehistoric fishery activity that targeted sharks, rays and finfishes in a productive area influenced by coastal marine upwelling. The presence of adult and neonate shark, especially oceanic species, is here interpreted as evidence of prehistoric fisheries capacity for exploitation and possibly overexploitation in nursery

2016 PloS one

195. ClC-7 Deficiency Impairs Tooth Development and Eruption Full Text available with Trip Pro

development and tooth eruption. Firstly, chitosan-Clcn7-siRNA nanoparticles were injected around the first maxillary molar germ of newborn mice and caused the delay of tooth eruption and deformed tooth with root dysplasia. Secondly, E13.5 molar germs infected with Clcn7 shRNA lentivirus were transplanted under the kidney capsule and presented the abnormal changes in dentin structure, periodontal tissue and cementum. All these teeth changes have been reported in the patients with CLCN7 mutation. In vitro (...) ClC-7 Deficiency Impairs Tooth Development and Eruption CLCN7 gene encodes the voltage gated chloride channel 7 (ClC-7) in humans. The mutations in CLCN7 have been associated with osteopetrosis in connection to the abnormal osteoclasts functions. Previously, we found that some osteopetrosis patients with CLCN7 mutations suffered from impacted teeth and root dysplasia. Here we set up two in vivo models under a normal or an osteoclast-poor environment to investigate how ClC-7 affects tooth

2016 Scientific reports

196. Early-life metal exposure and schizophrenia: A proof-of-concept study using novel tooth-matrix biomarkers Full Text available with Trip Pro

Early-life metal exposure and schizophrenia: A proof-of-concept study using novel tooth-matrix biomarkers Despite evidence for the effects of metals on neurodevelopment, the long-term effects on mental health remain unclear due to methodological limitations. Our objective was to determine the feasibility of studying metal exposure during critical neurodevelopmental periods and to explore the association between early-life metal exposure and adult schizophrenia.We analyzed childhood-shed teeth (...) with schizophrenia than controls. The differences in log Mn(2+) and log Cu(2+) changed relatively linearly over time to postnatal negative values. There was a positive correlation between early-life Pb(2+) levels and psychotic experiences in adulthood. Moreover, we found a negative correlation between Pb(2+) levels and adult IQ.In our proof-of-concept study, using tooth-matrix biomarker that provides direct measurement of exposure in the fetus and newborn, we provide support for the role of metal exposure during

2016 European psychiatry : the journal of the Association of European Psychiatrists

197. Use of an Occlusal Support Device During the Second Stage of Labor

Apgar scores in newborns Condition or disease Intervention/treatment Phase Pregnancy Device: Occlusal Support Device Other: Control Not Applicable Detailed Description: Prolonged labor, especially during the second stage of active expulsive effort (the pushing phase), is associated with increased risk of maternal complications (e.g. tissue trauma, postpartum hemorrhage, intra-amniotic infection). Developing an effective method to assist and maximize maternal expulsion effort should be of great value (...) [ Time Frame: Baseline ] Determine if the use of an OSD can improve Apgar scores in newborns. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility

2016 Clinical Trials

198. Calcium-vitamin D & Periodontal Therapy for Improving Metabolic and Inflammatory Profile Among Pregnant Women

Study Completion Date : March 1, 2019 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Early PT plus Fortified Milk early periodontal therapy (during pregnancy) plus fortified milk Other: Early PT Women will receive conventional non-surgical periodontal therapy (PT), consisting of prophylactic dental polishing to remove the sticky bacterial film that forms on the teeth over time, scaling and root planing (...) semi-skimmed milk powder (provided by the study) and one sachet with 500 IU of vitamin D3 and 1,2 g of a calcium supplement from milk extract (300 mg of calcium) twice a day. Experimental: Early PT plus Plain Milk early periodontal therapy (during pregnancy) plus plain milk Other: Early PT Women will receive conventional non-surgical periodontal therapy (PT), consisting of prophylactic dental polishing to remove the sticky bacterial film that forms on the teeth over time, scaling and root planing

2016 Clinical Trials

199. SLC13A5 is the second gene associated with Kohlschütter-Tönz syndrome. (Abstract)

and absence of ROGDI mutations as well as one patient with unexplained epileptic encephalopathy were investigated by clinical and dental evaluation, parametric linkage analysis (one family), and exome and/or Sanger sequencing. Dental histological investigations were performed on teeth from individuals with SLC13A5-associated and ROGDI-associated KTZS.Biallelic mutations in SLC13A5 were identified in 10 affected individuals. Epileptic encephalopathy usually presents in the neonatal and (less frequently (...) associated with the clinical diagnosis of KTZS, characterised by neonatal epileptic encephalopathy and hypoplastic AI. Careful clinical and dental delineation provides clues whether ROGDI or SLC13A5 is the causative gene. Hypersensitivity of teeth as well as high caries risk requires individual dental prophylaxis and attentive dental management.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to

2016 Journal of Medical Genetics

200. Grown-Up Congenital Heart Disease

surgery or percuta- neous technique. The recommendation is limited to dental procedures requiring manipulation of the gingival or periapical region of the teeth or perforation of the oral mucosa. Antibiotics are not recommended for respiratory tract, gastrointestinal, genitourinary, dermatological, or musculoskeletal procedures unless there is an established infection. The updated recommendations dramatically change long- established practice for primary care physicians, cardiologists, den- tists

2010 European Society of Cardiology

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