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Necrobiosis Lipoidica

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1. Clinical Features and Comorbidities of Patients With Necrobiosis Lipoidica With or Without Diabetes. (PubMed)

Clinical Features and Comorbidities of Patients With Necrobiosis Lipoidica With or Without Diabetes. Necrobiosis lipoidica (NL) is a rare granulomatous condition. Current knowledge of its key features is based on a limited number of studies and case reports, leading to wide variability in the characterization of its defining features, with limited comparison of patients with or without diabetes.To evaluate the epidemiologic characteristics, clinical features, and disease associations of NL

2019 JAMA dermatology (Chicago, Ill.)

2. Papular Spreaded Necrobiosis Lipoidica: a rare clinical presentation of this pathology. (PubMed)

Papular Spreaded Necrobiosis Lipoidica: a rare clinical presentation of this pathology. 30739338 2019 02 28 1365-2230 2019 Feb 09 Clinical and experimental dermatology Clin. Exp. Dermatol. Papular spreading necrobiosis lipoidica: a rare clinical presentation of this pathology. 10.1111/ced.13947 Matas-Nadal C C Department of Dermatology, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLleida, Lleida, Catalunya, Spain. Fernández-Armenteros J M JM Department of Dermatology

2019 Clinical & Experimental Dermatology

3. Necrobiosis lipoidica: a rare complication of diabetes (PubMed)

Necrobiosis lipoidica: a rare complication of diabetes 30100968 2018 10 01 2018 10 01 1937-8688 29 2018 The Pan African medical journal Pan Afr Med J Necrobiosis lipoidica: a rare complication of diabetes. 214 10.11604/pamj.2018.29.214.15550 Elouarradi Nassiba N Service of Endocrinology, Diabetology and Metabolic Diseases, University Hospital of Marrakech, Marrakech, Morocco. Ansari Nawal El NE Service of Endocrinology, Diabetology and Metabolic Diseases, University Hospital of Marrakech (...) , Marrakech, Morocco. eng Case Reports Journal Article 2018 04 13 Uganda Pan Afr Med J 101517926 0 Hypoglycemic Agents 0 Insulin IM Diabetes Mellitus, Type 1 complications drug therapy Humans Hypoglycemic Agents therapeutic use Insulin therapeutic use Necrobiosis Lipoidica diagnosis etiology Young Adult Necrobiosis diabetes lipoidica 2018 03 24 2018 03 26 2018 8 14 6 0 2018 8 14 6 0 2018 10 3 6 0 epublish 30100968 10.11604/pamj.2018.29.214.15550 PAMJ-29-214 PMC6080969

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2018 The Pan African medical journal

4. La nécrobiose lipoïdique: à propos d’un cas: Necrobiosis lipoidica: about a case (PubMed)

La nécrobiose lipoïdique: à propos d’un cas: Necrobiosis lipoidica: about a case Necrobiosis lipoidica is a rare granulomatous dermatosis. It occurs in 0.3-1.2% of diabetic patients mainly at the level of the leg. The lesions appear as erythematous plaques with central depressions. We here report the case of a 21-year old female patient with a 6-year history of type 1 diabetes presenting with a 1-year history of well circumscribed, symmetrical and asymptomatic erythematous plaques (...) with atrophic yellowish center at the level of the anterior compartments of the legs (A, B). The diagnosis of necrobiosis lipoidica was suspected, a biopsy was performed which confirmed the diagnosis. The patient had a granulomatous inflammatory reaction with palisade-like border disposed around poorly delimited foci of altered connective tissue on the entire dermis layer. The inflammatory reaction was also characterized by multinucleate giant cells, dendrocytes and lipid deposits. Local corticosteroid

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2018 The Pan African medical journal

5. A Study to Evaluate the Safety and Tolerability of PCS499 for the Treatment of Necrobiosis Lipoidica

A Study to Evaluate the Safety and Tolerability of PCS499 for the Treatment of Necrobiosis Lipoidica A Study to Evaluate the Safety and Tolerability of PCS499 for the Treatment of Necrobiosis Lipoidica - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. A Study to Evaluate the Safety and Tolerability of PCS499 for the Treatment of Necrobiosis Lipoidica The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03698864 Recruitment

2018 Clinical Trials

6. An atypical case of papular necrobiosis lipoidica masquerading as sarcoidosis (PubMed)

An atypical case of papular necrobiosis lipoidica masquerading as sarcoidosis 30246132 2019 02 26 2352-5126 4 8 2018 Sep JAAD case reports JAAD Case Rep An atypical case of papular necrobiosis lipoidica masquerading as sarcoidosis. 802-804 10.1016/j.jdcr.2018.07.011 Hashemi David A DA Department of Dermatology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. Nelson Caroline A CA Department of Dermatology, The University of Pennsylvania School of Medicine (...) , Philadelphia, Pennsylvania. Elenitsas Rosalie R Department of Dermatology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. Rosenbach Misha M Department of Dermatology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. eng Case Reports 2018 09 14 United States JAAD Case Rep 101665210 2352-5126 NL, necrobiosis lipoidica cutaneous sarcoidosis granulomatous skin disease necrobiosis lipoidica 2018 9 25 6 0 2018 9 25 6 0 2018 9 25 6 1 epublish 30246132

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2018 JAAD Case Reports

7. A systematic review of the relationship between glycemic control and necrobiosis lipoidica diabeticorum in patients with diabetes mellitus. (PubMed)

A systematic review of the relationship between glycemic control and necrobiosis lipoidica diabeticorum in patients with diabetes mellitus. The association of specific skin disorders with diabetes mellitus (DM) has been well established. Current literature suggests that approximately 30-91% of patients with diabetes will experience at least one cutaneous manifestation of this systemic disease in their lifetime. To date, there are limited articles summarizing the link between necrobiosis (...) after implementing various methods of glycemic control (diabetic diet consisting of 1600 kcal/day [1 patient], insulin regimen [3 patients], and pancreatic transplantation [9 patients]). Glycemic control may have a role in influencing the prognosis of necrobiosis lipoidica in patients with diabetes; however, there is currently insufficient evidence to support or refute this claim.© 2017 The International Society of Dermatology.

2017 International Journal of Dermatology

8. A granulomatous conundrum: Concurrent necrobiosis lipoidica, cutaneous sarcoidosis and erythema nodosum in a nondiabetic patient. (PubMed)

A granulomatous conundrum: Concurrent necrobiosis lipoidica, cutaneous sarcoidosis and erythema nodosum in a nondiabetic patient. Necrobiosis lipoidica (NL) and cutaneous sarcoidosis are granulomatous disorders with a largely unknown aetiopathogenesis. Evidence of co-existing NL and sarcoidosis in the same patient may suggest a degree of overlap between these entities through shared granulomatous inflammatory pathways. Occasionally, one condition can mimic the other, making their distinction

2017 Australasian Journal of Dermatology

9. Granulomatous skin disease with a histological pattern of palisading granuloma – an atypical facial necrobiosis lipoidica or more? (PubMed)

Granulomatous skin disease with a histological pattern of palisading granuloma – an atypical facial necrobiosis lipoidica or more? 29422829 2018 11 13 1642-395X 34 6 2017 Dec Postepy dermatologii i alergologii Postepy Dermatol Alergol Granulomatous skin disease with a histological pattern of palisading granuloma - an atypical facial necrobiosis lipoidica or more? 618-621 10.5114/ada.2017.72468 Rosińska-Więckowicz Anna A Department of Dermatology, Poznan University of Medical Sciences, Poznan

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2017 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

10. Ulcerative necrobiosis lipoidica in the setting of anti–tumor necrosis factor-α and hydroxychloroquine treatment for rheumatoid arthritis (PubMed)

Ulcerative necrobiosis lipoidica in the setting of anti–tumor necrosis factor-α and hydroxychloroquine treatment for rheumatoid arthritis 28331899 2019 02 26 2352-5126 3 2 2017 Mar JAAD case reports JAAD Case Rep Ulcerative necrobiosis lipoidica in the setting of anti-tumor necrosis factor-α and hydroxychloroquine treatment for rheumatoid arthritis. 127-130 10.1016/j.jdcr.2017.01.006 Fehlman Jennifer Albus JA Department of Dermatology, Saint Louis University, Saint Louis, Missouri. Burkemper (...) Nicole M NM Department of Dermatology, Saint Louis University, Saint Louis, Missouri. Missall Tricia A TA Department of Dermatology, Saint Louis University, Saint Louis, Missouri. eng Case Reports 2017 03 12 United States JAAD Case Rep 101665210 2352-5126 NL, necrobiosis lipoidica RA, rheumatoid arthritis anti–tumor necrosis factor-α inhibitors etanercept hydroxychloroquine necrobiosis lipoidica 2017 3 24 6 0 2017 3 24 6 0 2017 3 24 6 1 epublish 28331899 10.1016/j.jdcr.2017.01.006 S2352-5126(17)30009

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2017 JAAD Case Reports

11. Risk factors for necrobiosis lipoidica in Type 1 diabetes mellitus. (PubMed)

Risk factors for necrobiosis lipoidica in Type 1 diabetes mellitus. To compare the clinical and metabolic characteristics of patients with Type 1 diabetes and necrobiosis lipoidica with those of patients with Type 1 diabetes who do not have necrobiosis lipoidica. A multicentre analysis was performed.Clinical and laboratory data were obtained from 64 133 patients (aged 0-25 years) with Type 1 diabetes with and without necrobiosis lipoidica who were registered in the German/Austrian Diabetes (...) Prospective Documentation Initiative registry. Data were analysed using multivariable regression modelling. Age, diabetes duration, treatment year and sex were considered as confounding factors.Results adjusted for demographic variables are presented. In patients with necrobiosis lipoidica, metabolic control was worse (HbA1c 72 vs. 67 mmol/mol, 8.7% vs. 8.3%; P = 0.0065) and the duration of diabetes was longer [6.24 (3.28-9.97) vs. 5.11 (2.08-8.83) years; P = 0.014; not adjusted]. Patients

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2016 Diabetic Medicine

12. Cofactors and comorbidities of necrobiosis lipoidica: analysis of the German DRG data from 2012.

Cofactors and comorbidities of necrobiosis lipoidica: analysis of the German DRG data from 2012. Necrobiosis lipoidica (NL) is a rare granulomatous inflammatory skin disease of unknown pathophysiology. Its potential association with diabetes mellitus is well known. Other relevant cofactors and comorbidities are subject to controversial debate.DRG (diagnosis-related groups) data of all inpatients with a coded primary or secondary diagnosis of NL treated at German hospitals in 2012 were

2016 Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

13. Scald-Induced Necrobiosis Lipoidica in a Patient with Diabetes Mellitus and Psoriasis (PubMed)

Scald-Induced Necrobiosis Lipoidica in a Patient with Diabetes Mellitus and Psoriasis The Koebner phenomenon (KP) was first introduced by Heinrich Koebner in the 1870s to describe the appearance of psoriatic lesions following trauma in psoriasis patients. KP has since been defined in numerous diseases, including necrobiosis lipoidica diabeticorum (NLD). Since most Koebnerized dermatological lesions can localise to a site of previous trauma, Weiss et al. (Eur Acad Dermatol Venereol 2002;16:241 (...) -248) classified them into four categories (I-IV) according to the Boyd-Nelder classification (Int J Dermatol 1990;29:401-410) system. In this system, necrobiosis lipoidica is classified as category III, which includes diseases that occasionally localise at the site of trauma. We report a case of NLD that developed after scald in a psoriasis patient. NLD after trauma has often been reported, but this is the first case of NLD that coincidentally occurred at a scald site in a psoriasis patient.

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2016 Case reports in dermatology

14. Necrobiosis Lipoidica

Necrobiosis Lipoidica Necrobiosis Lipoidica Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Necrobiosis Lipoidica Necrobiosis (...) Lipoidica Aka: Necrobiosis Lipoidica , Necrobiosis Lipoidica diabeticorum II. Epidemiology Age of onset : 22 (mean age of onset) : 30 to 50 years Most common in women by 3 fold III. Pathophysiology Unknown etiology Appears related to microvascular changes IV. Associated Conditions: Diabetes Mellitus Necrobiosis patients with comorbid diabetes: 11-65% of necrobiosis in Diabetes: 0.3 to 1.6% Necrobiosis predicts of future diabetes development V. Symptoms Lesions are painless in most cases VI. Signs Slowly

2018 FP Notebook

15. Atypical Localization of Necrobiosis Lipoidica: Involvement of the Face and Scalp (PubMed)

Atypical Localization of Necrobiosis Lipoidica: Involvement of the Face and Scalp 28560219 2018 11 13 2296-9195 3 2 2017 May Skin appendage disorders Skin Appendage Disord Atypical Localization of Necrobiosis Lipoidica: Involvement of the Face and Scalp. 92-94 10.1159/000462980 Yaşar Şirin Ş Department of Dermatology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey. Kaynak Emre E Department of Dermatology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey

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2017 Skin appendage disorders

16. Treatment Modalities of Necrobiosis Lipoidica: A Concise Systematic Review. (PubMed)

Treatment Modalities of Necrobiosis Lipoidica: A Concise Systematic Review. Necrobiosis lipoidica (NL) is a rare inflammatory granulomatous skin disorder closely associated with diabetes mellitus. The aim of this paper is to review and discuss all the treatment modalities proposed and tested for this disease. A systematic review of the existing literature was conducted to investigate all the available data and summarize all the clinical trials, case reports and original articles on NL. Two

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2015 Dermatology Reports

17. Pentoxifylline: An effective therapy for necrobiosis lipoidica. (PubMed)

Pentoxifylline: An effective therapy for necrobiosis lipoidica. Necrobiosis lipoidica (NL) is a rare chronic inflammatory granulomatous skin disorder that remains challenging to treat. Here we report three patients at different stages of disease successfully treated with pentoxifylline, a haemorrheological and anti-inflammatory agent. We demonstrate for the first time that early stage NL may be completely reversible with this treatment. Our findings are also consistent with previous isolated

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2015 Australasian Journal of Dermatology

18. Detection of factor XIII-A is a valuable tool for distinguishing dendritic cells and tissue macrophages in granuloma annulare and necrobiosis lipoidica. (PubMed)

Detection of factor XIII-A is a valuable tool for distinguishing dendritic cells and tissue macrophages in granuloma annulare and necrobiosis lipoidica. Factor XIII subunit A (FXIII-A) is used as a diagnostic marker in a wide range of dermatological diseases ranging from inflammatory lesions to malignancies, although neither the cell types responsible for its expression nor the mechanism(s) resulting in its local accumulation in pathological conditions have been characterized.In this study, we (...) aimed to gain information on the cells showing an immunohistochemical reaction for FXIII-A and answer the question whether macrophages and/or dendritic cells are labelled for FXIII-A.We carried out our studies on samples of granuloma annulare (GA) and necrobiosis lipoidica (NL), the prime examples for granulomatous skin lesions with a non-infectious background in which extracellular matrix remodelling is a key feature without any sign of malignant transformation. We used markers for macrophages

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2014 Journal of the European Academy of Dermatology and Venereology

19. Effectiveness of platelet-rich plasma in healing necrobiosis lipoidica diabeticorum ulcers. (PubMed)

Effectiveness of platelet-rich plasma in healing necrobiosis lipoidica diabeticorum ulcers. Necrobiosis lipoidica diabeticorum (NLD) is a chronic condition, which is characterized by single or multiple lesions on the legs, and occurs in 0.3% of patients with diabetes. Recently, platelet-rich plasma (PRP) has been used in several clinical settings to promote sustained healing and better outcome. We propose the use of PRP for the treatment of NLD-associated recalcitrant wounds. In this study, 15

2014 Clinical & Experimental Dermatology

20. Necrobiosis Lipoidica (Overview)

Necrobiosis Lipoidica (Overview) Necrobiosis Lipoidica: Background, Etiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTEwMzQ2Ny1vdmVydmlldw== processing > Necrobiosis Lipoidica Updated: Feb 12 (...) , 2018 Author: Cheryl J Barnes, MD; Chief Editor: George T Griffing, MD Share Email Print Feedback Close Sections Sections Necrobiosis Lipoidica Overview Background Necrobiosis lipoidica is a disorder of collagen degeneration with a granulomatous response, thickening of blood vessel walls, and fat deposition. The main complication of the disease is ulceration, usually occurring after trauma. Infections can occur but are uncommon. There have been rare reported cases of squamous cell carcinomas

2014 eMedicine.com

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