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Natural Family Planning

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15621. 3-D Laser Imaging to Analyze Neck Movement

of the measurement can be adjusted based on the nature of the object under investigation. This makes the technique suitable for a wide variety of applications. The benefits of these basic studies will include assisting physician and other allied health practitioners to more effectively detect and diagnose painful spinal disorders. This ultimately should enhance the treatment and management of spinal disorders. We plan to test the device on 134 people whom we will recruit from Northern Illinois University (...) Time Perspective: Longitudinal Time Perspective: Prospective Official Title: 3-D Laser Imaging for Cervical Spine Motion Analysis Study Start Date : January 2003 Study Completion Date : January 2006 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Outcome Measures Go to Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family

2001 Clinical Trials

15622. Dietary Phytoestrogens and Bone Metabolism

receptor modulators (SERMS) may help if they continue to show promise. Interest in natural sources of estrogenic substances to prevent postmenopausal bone loss is an expected outgrowth of the general interest in alternative medicinals for a wide variety of human disorders. Concerns about the potential for adverse consequences of the conventional use of estrogen replacement therapy, and limited knowledge about long term use of SERMS- add support to this quest. No systematic investigation of the role (...) clearly needs. The rationale for exploring the potential for phytoestrogens in the maintenance of skeletal health in postmenopausal women is clear and compelling. Women will be randomly assigned to one of three healthy eating plans and, over the course of the year-long study, will learn to choose and cook foods to help optimize health as they go through menopause and beyond. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Allocation: Randomized

2001 Clinical Trials

15623. Trastuzumab in Treating Patients With Advanced Salivary Gland Cancer

scans will be performed every 2 cycles Drug: Trastuzumab Other Name: Herceptin Outcome Measures Go to Primary Outcome Measures : Response Rate [ Time Frame: 2 years ] Secondary Outcome Measures : Time to Progression [ Time Frame: 2 years ] Toxicity [ Time Frame: 2 years ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study (...) be up to < 5 x institutional ULN Alkaline Phosphatase < 5 x institutional ULN * If from documented bone or liver involvement with cancer, no upper limit restriction. Baseline determination of normal left ventricular ejection fraction as evidenced MUGA or echocardiogram. Exclusion Criteria: Patients must not have received more than two regimens of cytotoxic chemotherapy for salivary gland cancer. Previous immunologic, hormonal, homeopathic, natural, or alternative medicine therapies are acceptable

1999 Clinical Trials

15624. Women's Interagency HIV Study (WIHS)

HIV subtypes or recombinant forms and their interaction with variably susceptible individuals; the change in the scope of HIV natural history studies in the era of combination antiretroviral therapy; and the contribution of such studies to the design of a wide spectrum of prevention modalities (e.g., prevention of HIV and prevention of opportunistic infections). In addition, studies of natural history of HIV-related malignancies and active surveillance of malignancies in HIV infected and high-risk (...) related topics: Groups and Cohorts Go to Outcome Measures Go to Biospecimen Retention: Samples With DNA Blood, bodily fluid, and hair collection Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below

1999 Clinical Trials

15625. Study of Proteus Syndrome and Related Congenital Disorders

biopsies from a normal area of skin and from a tumor. Condition or disease Proteus Syndrome PIK3CA Related Overgrowth Spectrum Detailed Description: The purpose of this project is to specifically delineate the phenotype and natural history and to better understand the genetic etiology of Proteus syndrome (PS) and other overgrowth disorders hypothesized to be in the AKT/PI3K pathway. As we have recently determined the molecular cause of PS and the related disorder of fibroadipose overgrowth, our main (...) objectives moving forward include genotype-phenotype correlations, identifying quantifiable phenotypic characteristics in patients and measuring changes in these characteristics over time, developing potential biomarkers for future therapeutic research, and using our new molecular insights to expand our understanding of both PS and related overgrowth disorders. The natural history and specific phenotypic characteristics of patients with PS and selected other overgrowth disorders will be determined

1999 Clinical Trials

15626. Prevention of Neonatal Respiratory Distress Syndrome With Antenatal Steroid Administration

of disability and death in the newborn. In the United States, approximately 10 percent of all infants are premature, and each year about 50,000 cases of neonatal respiratory distress syndrome occur. Extensive studies in animal models on respiratory distress syndrome have demonstrated that antenatal administration of synthetic (dexamethasone) and natural (cortisol) corticosteroids accelerates lung maturation and significantly diminishes the occurrence of RDS. Although a variety of conditions in newborn (...) infants have been treated with steroids over the past 20 years without adverse effects, investigations have been needed on the short-term effects of corticosteroids administered antenatally on neonate and mother and on the long-term effects on the infant. The Planning Phase of this trial was completed in March 1977, with formulation of a common protocol and manual of operations. Patient screening and enrollment began in August 1977 and ended on March 1, 1980. Follow-up ended in August 1983 and data

1999 Clinical Trials

15627. Viral Load in Blood and Lymph Tissues of HIV-Infected Individuals

] In addition, we wish to delineate the precise nature of the immunoregulatory mechanisms and altered homing patterns that contribute to the perturbations in the phenotype and functions of various lymphocyte subsets in peripheral blood versus the ... [ Time Frame: Throughout ] The purpose of this project is to determine the relative burden of human immunodeficiency virus (HIV) and/or associated changes in hematopoiesis and immune activation as well as HIV-specific responses in the various subsets (...) of peripheral blood m... [ Time Frame: Throughout ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years

1999 Clinical Trials

15628. Study of Smith-Lemli-Opitz Syndrome

of SLOS patients. We propose to answer some of these questions by continuing our longitudinal natural history/prognosis study on patients with SLOS. We also plan on studying very closely related disorders such as lathosterolosis under this protocol. Lathosterolosis is caused by a deficiency in the enzyme sterol 3-beta-hydroxysteroid-delta-5-desaturase which is necessary for the conversion of lathosterol into 7-DHC. The clinical picture is very similar to SLOS with prominent features including (...) was developed to answer questions about the causes and complications of SLOS, as well as the effectiveness of cholesterol treatment. The study will enroll patients diagnosed with SLOS, and their mothers. The objectives of the study will be to address the following questions: What is the prognosis / natural history of the demyelination in the nervous system of patients with SLOS? Do patients with SLOS have other problems concerning the function of their endocrine systems? What

1999 Clinical Trials

15629. Magnetic Resonance Imaging of Blood Flow in the Liver and Abdomen

or disease Healthy Liver Disease Detailed Description: The involvement of the liver by certain disease processes is non-uniform and may be related to hepatic anatomy and the dynamics of portal blood flow. These differences may result from inhomogeneous delivery of hepatic toxins or trophic substances, tumor secretion products or tumor metastases to different portions of the liver. In addition to effects on the natural history of hepatic disease, these features may affect the performance (planning/methods (...) ) and interpretation of diagnostic studies, such as hepatic venous sampling for measurement of tumor secretion products. This study will combine non-invasive quantitative in vivo measurements of blood flow with in vitro modeling of the vascular system. The purpose of the study is to define the normal hemodynamics of hepatic blood flow, particularly portal flow, using Magnetic Resonance Angiography (MRA) and to draw inferences regarding the role of hemodynamics in the natural history of hepatic disease. Study

1999 Clinical Trials

15630. A Phase I Pharmacokinetic and Tolerance Study of 28-Day Regimens of Oral Ganciclovir

and Infectious Diseases (NIAID) Collaborator: Hoffmann-La Roche Information provided by (Responsible Party): National Institute of Allergy and Infectious Diseases (NIAID) Study Details Study Description Go to Brief Summary: To determine the pharmacokinetics (blood levels) of three dose treatment plans of oral ganciclovir during a 28-day dosing period. Other purposes of the study are to determine in a population of HIV seropositive persons with cytomegalovirus (CMV) viremia, the safety, tolerance, and patient (...) doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 13 Years to 60 Years (Child, Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria Concurrent Medication: Allowed: Topical acyclovir. There are two groups of patients. Group A must

1999 Clinical Trials

15631. The Tolerance of HIV-Infected Patients With Herpes Group Virus Infections to Oral Doses of FIAU

dose cohorts. There are a total of 4 dose cohorts of FIAU and each patient takes the required amount of FIAU syrup every 8 hours, 1 hour prior to or 3 hours after meals, for a total of 14 days. Entry of new patients at the next higher dose is based on results of tolerance and safety data for prior cohort when all 10 have received 14 days of therapy and at least 7 have met all of the tolerance criteria. Although not formally randomized due to the sequential nature of the study and serious medical (...) Purpose: Treatment Official Title: The Tolerance of HIV-Infected Patients With Herpes Group Virus Infections to Oral Doses of FIAU Actual Study Completion Date : February 1993 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Outcome Measures Go to Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends

1999 Clinical Trials

15632. Study of Melatonin: Sleep Problems in Alzheimer's Disease

and exam, clinical laboratory results, and EKG. Actigraph evidence of a mean nocturnal sleep time of less than 7 hours per night (at least 5 nights of complete actigraph data must be collected over a single week. Stable home situation with no planned move during the 13-week investigational period. Residing with responsible spouse, family member, or professional caregiver who is present during the night and will agree to assume the role of the principal caregiver for the 13-week protocol, including (...) Description Go to Brief Summary: This protocol is a multicenter clinical trial of melatonin for sleep disturbances associated with Alzheimer's disease (AD). Frequent nocturnal awakening is a common behavioral symptom of AD. Nighttime wandering and agitated behavior may result in injuries and sleep disruption for caregivers. Alternatives are sorely needed to the currently available sleep medications that have marginal efficacy and serious side effects. Melatonin is a naturally occurring hormone secreted

1999 Clinical Trials

15633. A Study To Test An Anti-Rejection Therapy After Kidney Transplantation

transplant [ Time Frame: Throughout study ] Frequency and severity of rejection episodes [ Time Frame: Throughout study ] Time to first rejection [ Time Frame: Throughout study ] Length and frequency of hospitalization [ Time Frame: Throughout study ] Nature of acute cellular rejection at a molecular level [ Time Frame: Throughout study ] Nature of "heightened immune response" of younger children by studying gene expression in surveillance biopsies [ Time Frame: Throughout study ] Correlate intragraft (...) events during rejection with cytokine profile in the peripheral blood [ Time Frame: Throughout study ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table

1999 Clinical Trials

15634. A Study of HIV in Newly Infected Individuals

HIV behaves in these populations once they become infected can help with the planning of future HIV vaccine studies. Condition or disease HIV Infections Detailed Description: This study provides an opportunity to prospectively monitor markers of HIV infection and disease progression in cohorts suitable for HIV vaccine trials. The detection of changes in HIV phenotype and genotype, clinical progression rates, and antiretroviral resistance within study populations over time are important (...) for planning future HIV vaccine trials. This study consists of two parts. Part A includes HIV-infected patients who enrolled in HIVNET D01.1 (infected-participants cohort of HIVNET D01) and whose HIV disease has been closely monitored and characterized. This study continues to monitor these patients with follow-up evaluations every 3 months for the first 18 months and then every 6 months thereafter. Part B includes newly HIV-infected patients. These patients are monitored with clinical and laboratory

1999 Clinical Trials

15635. The National Strategy (PubMed)

, and funding agencies see this acknowledgement as a strength. The common core of the strategy is the administrative and coordinating structure of CAROS. CAROS plans to continue working with the research panels as they update their priorities, and these will be reviewed by interested stakeholders, especially consumers and families. CAROS also will maintain a database of ongoing research and will serve as a source of contact for researchers. Of special importance in implementing the National Strategy (...) The National Strategy The National Strategy for Research on Schizophrenia currently consists of research priorities and a proposed structure for collaboration. Research panels have already come up with priorities in six different fields of research. The National Strategy will assist researchers in submitting proposals that fit in with the priorities. It will also encourage cooperation between researchers, clinical centres, consumers (patients) and families. This will help to prevent duplication

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1994 Journal of Psychiatry and Neuroscience

15636. Cairo conference. (PubMed)

of overconsuming rich countries. By the end of the decade there will be over six billion people, of whom one half will live in cities. These demographic and environmental trends, if translated into climatic change, regional food shortages, and weakened ecosystems, would adversely affect human health. The World Health Organization is likely to concentrate only on accessible family planning and promotion of health for women and families. Continuing asymmetric child-saving aid, unaccompanied by substantial aid (...) to help mobilize the social and economic resources needed to reduce fertility, may delay the demographic transition in poor countries and potentiate future public health disasters. As a result of recent reductions in fertility, even in Sub-Saharan Africa, average family sizes have been halved. Yet the demographic momentum will double population by 2050. The biosphere is a complex of ecosystems and, if unsustained, it could not fulfill the productive, cleansing, and protective functions on which life

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1994 BMJ : British Medical Journal

15637. Conscientious refusal to assist with abortion. (PubMed)

and Reproduction Abortion, Induced Anti-abortion Groups Attitude Behavior Critique Delivery Of Health Care Ethics Family Planning Fertility Control, Postconception Health Health Personnel Interest Groups Nurses Philosophical Overview Physicians Political Factors Psychological Factors Staff Attitude KIE BoB Subject Heading: abortion Editorial Full author name: Dooley, Dolores TJ: BMJ : BRITISH MEDICAL ASSOCIATION. 1994 9 10 1994 9 10 0 1 1994 9 10 0 0 ppublish 8086982 PMC2541479 J Med Ethics. 1986 Sep;12(3):123 (...) when examining whether physicians and nurses have rights to refuse to assist in abortion on conscientious grounds. People with fundamentally different moral outlooks already determine what is morally right or wrong, good or evil. Health professionals who refuse to assist in abortion base their decision on beliefs about moral duties, injunctions of natural law, and the essentially nonnegotiable rights of people to be protected from intentional harm. They know and regret the adverse effects

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1994 BMJ : British Medical Journal

15638. Psychiatric illness and psychosocial concerns of patients with newly diagnosed lung cancer. (PubMed)

Psychiatric illness and psychosocial concerns of patients with newly diagnosed lung cancer. To determine the nature and incidence of psychiatric illness, symptoms of potential psychiatric significance, substance abuse and psychosocial concerns among patients with newly diagnosed lung cancer.Case series.Kingston Regional Cancer Centre, a tertiary care facility for ambulatory cancer patients.Seventy-one consecutive English-speaking patients with recently diagnosed lung cancer undergoing (...) radiotherapy or chemotherapy were asked to participate; 52 of the 57 patients who agreed were available for evaluation.Current and previous psychiatric diagnoses of affective, anxiety and adjustment disorders, and alcohol and tobacco abuse; symptoms of sadness, fear, shock, anger, denial, acceptance, guilt, suicidal ideation, thoughts of death, insomnia, loss of libido, impaired concentration and reduced level of work or interest; psychosocial concerns about family, work and finances; and an impression

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1995 CMAJ: Canadian Medical Association Journal

15639. Embryonic abnormalities at medical termination of pregnancy with mifepristone and misoprostol during first trimester: observational study (PubMed)

loss rate in early pregnancy. Abortifacient Agents Abortion, Drug Induced Abortion, Induced Abortion, Spontaneous Biology Clinical Research Congenital Abnormalities Developed Countries Diseases Endocrine System England Europe Family Planning Fertility Control, Postconception Hormone Antagonists Hormones Incidence Measurement Misoprostol Neonatal Diseases And Abnormalities Northern Europe Physiology Pregnancy Complications Prostaglandins Prostaglandins, Synthetic Research Methodology Research Report (...) Mifepristone Misoprostol Pregnancy Pregnancy Trimester, First 137245 00281535 The availability of new medical techniques for induced abortion in the first trimester enables observation of the incidence and nature of embryonic and fetal abnormalities in early pregnancy. 506 women, presenting to the Liverpool (England) Women's Hospital in 1994-96 for induced abortion before 9 weeks of gestation, were given oral mifepristone followed by oral misoprostol. Fetal tissue was collected from 206 (44

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1998 BMJ : British Medical Journal

15640. Physical activity promotion through primary health care in England. (PubMed)

Physical activity promotion through primary health care in England. There is increasing research supporting the argument for a beneficial link between physical activity and health maintenance and, in the past five years, this has led to a growth in physical activity promotion schemes involving primary health care.To document and critically examine the extent and nature of physical activity promotion in general practice in England.A postal survey to all family health services authorities (...) and primary care facilitators was conducted to identify existing and planned activity promotion schemes involving primary health care. Telephone interviews with leaders from 50 selected schemes and further detailed case studies of 11 schemes provided descriptive information of the nature of physical activity promotion.The initial phase revealed 157 existing schemes and a further 35 planned schemes. Two basic models of physical activity promotion were identified that were distinguishable by the primary

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1997 The British Journal of General Practice

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