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Nasal Saline

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1. Hypertonic Saline Versus Isotonic Saline Nasal Irrigation: Systematic Review and Meta-analysis. (PubMed)

Hypertonic Saline Versus Isotonic Saline Nasal Irrigation: Systematic Review and Meta-analysis. Background Saline nasal lavage is one of the treatments of sinonasal diseases. Evidence from basic research favors hypertonic saline (HS) over isotonic saline (IS) for mucociliary clearance, but evidence from clinical studies is controversial. Conversely, HS may carry greater side effects. Objective To compare the effects of HS and IS nasal irrigation in treating sinonasal diseases. Methods (...) . Buffered saline and operative status did not have impact. HS brought greater minor adverse effects. No major adverse effects were reported. Conclusion HS improves symptoms over IS nasal irrigation in treating sinonasal diseases. There is no difference in disease-specific quality of life. However, HS brings greater minor side effects than IS.

2018 American journal of rhinology & allergy

2. Hemostatic effects of nasal saline irrigations during endoscopic sinus surgery: a systematic review and meta-analysis

Hemostatic effects of nasal saline irrigations during endoscopic sinus surgery: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated

2019 PROSPERO

3. Double-blind, randomised controlled trial on the efficacy of saline nasal irrigation with sodium hyaluronate after endoscopic sinus surgery. (PubMed)

Double-blind, randomised controlled trial on the efficacy of saline nasal irrigation with sodium hyaluronate after endoscopic sinus surgery. There is a growing interest in sodium hyaluronate for the clinical management of patients who undergo functional endoscopic sinus surgery for chronic rhinosinusitis, because of the mucosal regenerative properties of this macromolecule. However, its role in post-operative care is still debated. This study aimed to evaluate the effect of sodium hyaluronate (...) administered via nasal irrigation with saline, in the post-operative period, after functional endoscopic sinus surgery.A multicentric, prospective, randomised, double-blind, parallel group study was conducted on 56 consecutive patients who underwent functional endoscopic sinus surgery for chronic rhinosinusitis without polyps. Group 1 received the standard therapy of normal saline; group 2 received saline plus sodium hyaluronate.Both objective and subjective measurements, in terms of endoscopic appearance

2019 Journal of Laryngology & Otology

4. Nasal saline irrigation: a clinical update. (PubMed)

Nasal saline irrigation: a clinical update. Nasal saline irrigation (NSI) plays an important role in the treatment of chronic rhinosinusitis (CRS). It is a beneficial low-risk treatment that serves an adjunctive function in the medical and surgical management of CRS. NSI is hypothesized to function by thinning mucous, improving mucociliary clearance, decreasing edema, and reducing antigen load in the nasal and sinus cavities. Although its use in CRS is nearly universal, significant variety (...) overall efficacy, available delivery devices, solution composition, and hygiene.Current evidence and recommendations for nasal saline delivery methods, composition, and hygiene are presented.The most recent consensus statements and Cochrane Review recommend the use of NSI for CRS based on a preponderance of lower level evidence. A conclusion regarding the optimal method of delivery and solution composition cannot be drawn based on the current literature.© 2019 ARS-AAOA, LLC.

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2019 International forum of allergy & rhinology

5. Efficacy of Buffered Hypertonic Saline Nasal Irrigation for Nasal Symptoms in Children with Seasonal Allergic Rhinitis: A Randomized Controlled Trial. (PubMed)

Efficacy of Buffered Hypertonic Saline Nasal Irrigation for Nasal Symptoms in Children with Seasonal Allergic Rhinitis: A Randomized Controlled Trial. Saline nasal irrigation is labelled as an add-on treatment in patients with allergic rhinitis (AR). The primary aim of this study was to compare the efficacy of 21-day use of buffered hypertonic saline (BHS) versus normal saline solution (NSS) on reducing nasal symptoms in children with seasonal AR (SAR). Comparing their efficacy on nasal (...) cytology counts (NCC), quality of life, and sleep quality was the secondary aim.In this 21-day, open-label, randomized controlled study, 36 SAR children (aged 6-13 years) with a Total 5 Symptom Score (T5SS) ≥5 received twice-daily BHS or NSS delivered through a nasal douche. Efficacy measures were least square mean changes (LSmc) in T5SS, NCC, Paediatric Rhinoconjunctivitis Quality of Life Questionnaire (PRQLQ), and Pittsburgh Sleep Quality Index (PSQI) scores.BHS improved the T5SS total score

2017 International Archives of Allergy and Immunology

6. Comparison between the use of saline and seawater for nasal obstruction in children under 2 years of age with acute upper respiratory infection. (PubMed)

Comparison between the use of saline and seawater for nasal obstruction in children under 2 years of age with acute upper respiratory infection. The effectiveness of isotonic and hypertonic saline solutions used to open the nasal passage and improve clinical symptoms was compared in children under 2 years of age admitted with the common cold.The study was performed as a randomized, prospective, and double-blind study. The study included 109 children. The children using saline (0.9 (...) %) and seawater (2.3%) as nasal drops (the patient group) and the control group (in which nasal drops were not administered) were compared. Seventy-four patients received nasal drops from package A (seawater) in single days and from package B (physiological saline) in double days.The mean age of the patients was 9.0 ± 3.9 months and the numbers of boys and girls were 65 (59.6%) and 44 (40.4%), respectively. There was no significant difference between Groups A and B in terms of nasal congestion (P > 0.05

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2018 Turkish Journal of Medical Sciences

7. [Effect of saline nasal irrigation with different temperature on the clinical symptoms and the level of inflammatory factors in patients with allergic rhinitis]. (PubMed)

[Effect of saline nasal irrigation with different temperature on the clinical symptoms and the level of inflammatory factors in patients with allergic rhinitis]. Objective:To study the effect of nasal spray on the clinical symptoms and the level of inflammatory factors in patients with allergic rhinitis by salines with different temperature normal salines.Method:One hundred and twenty patients were divided into control group (n = 60) and experimental group (n = 60) randomly and all the patients (...) were given specific immunotherapy. The patients in control group were treated with saline in 25 degrees for nasal douche, while the patients in the experimental group were treated with saline in 40 degrees. Clinical symptoms and inflammatory factors were compared between two groups.Result:In the experimental group, the total effective rate was 95.00%, while the control group was only 76.67%. The difference was statistically significant (P< 0.05). Before treatment, the symptoms scores of nasal

2018 Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery

8. [Budesonide saline nasal irrigation in treatment of children rhino-sinusitis]. (PubMed)

[Budesonide saline nasal irrigation in treatment of children rhino-sinusitis]. Objective:To study the effect of nasal irrigation in treatment of children rhinosinusitis.To compare the effect with different nasal irrigation methods and nasal spray with budesonide.Method:Seventy-five patients with rhinosinusitis were divided randomly into four groups.Nasal irrigation with saline(20 cases),treated with budesonide nasal spray(20 cases),nasal irrigation with saline and budesonide(20 cases),nasal (...) is budesonide nasal spray group >the 2.3% hypertonic saline group>the normal saline group.The differences between each group were significant.Conclusion:Nasal irrigation is a useful treatment in children rhinosinusitis.The efficiency of saline irrigation is less than budesonide aerosol spray.Add budesonide to the irrigation fluid combines the effect of the budesonide with irrigation and get more efficiency of treatment.Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head

2018 Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery

9. Postoperative Continuous Positive Airway Pressure Use and Nasal Saline Rinses After Endonasal Endoscopic Skull Base Surgery in Patients With Obstructive Sleep Apnea: A Practice Pattern Survey. (PubMed)

Postoperative Continuous Positive Airway Pressure Use and Nasal Saline Rinses After Endonasal Endoscopic Skull Base Surgery in Patients With Obstructive Sleep Apnea: A Practice Pattern Survey. Endoscopic skull base surgery continues to evolve in its indications, techniques, instrumentation, and postoperative care. As surgery of the skull base will often violate dura, intraoperative and postoperative cerebrospinal fluid (CSF) leak is not uncommon and represents a potential conduit for air (...) and bacterial contamination. Patients with obstructive sleep apnea (OSA) requiring continuous positive airway pressure (CPAP) therapy undergoing skull base surgery represent a challenging group. However, there appears to be a paucity of consensus regarding the postoperative management of this patient population. The objective of this study is to examine practice patterns and expert opinion on the use of postoperative CPAP and nasal saline in patients with OSA.A 14-item survey was generated by consensus

2018 American journal of rhinology & allergy

10. Nasal saline irrigation in pediatric rhinosinusitis: A systematic review. (PubMed)

Nasal saline irrigation in pediatric rhinosinusitis: A systematic review. To determine the efficacy of nasal saline irrigation (NSI) in reducing symptoms and improving quality of life in pediatric patients with acute (ARS) or chronic (CRS) rhinosinusitis.We searched the PubMed/MEDLINE and Embase electronic databases (indexed January, 1950 through April, 2017).Studies assessing the efficacy of NSI in pediatric patients with ARS or CRS were selected for analysis. Outcome measures, including

2018 International Journal of Pediatric Otorhinolaryngology

11. Does Heating up Saline for Nasal Irrigation Improve Mucociliary Function in Chronic Rhinosinusitis? (PubMed)

Does Heating up Saline for Nasal Irrigation Improve Mucociliary Function in Chronic Rhinosinusitis? Background Mucociliary function is affected by temperature. Exposure to cold air may impair ciliary beat frequency. While saline nasal irrigation improves in ciliary beat activity, there is no evidence supporting the use of heated saline irrigation in treating patients with chronic rhinosinusitis. Objective To compare the effects of heated saline to room-temperature saline nasal irrigation (...) on mucociliary clearance in chronic rhinosinusitis patients. Methods Adult patients with chronic rhinosinusitis were randomized into two groups receiving either heated saline or room-temperature saline nasal irrigation. Healthy subjects were included as control. Saccharin transit time was measured before and after nasal irrigation. Nasal patency was assessed by peak nasal inspiratory flow, anterior rhinomanometry, acoustic rhinometry, nasal obstruction score, and breathe-comfort score. Any adverse events

2018 American journal of rhinology & allergy

12. Disinfection of saline solutions and devices for nasal irrigation - why, when, and how? (PubMed)

Disinfection of saline solutions and devices for nasal irrigation - why, when, and how? 29451356 2018 12 21 2018 12 21 1749-4486 43 3 2018 06 Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery Clin Otolaryngol Disinfection of saline solutions and devices for nasal irrigation: Why, when and how? 970-971 10.1111/coa.13085 Ferreira M S MS Department of Otorhinolaryngology (ENT Center), Complexo (...) of Otorhinolaryngology (ENT Center), Complexo Hospitalar Edmundo Vasconcelos (CHEV), São Paulo, Brazil. eng Letter Comment 2018 03 07 England Clin Otolaryngol 101247023 1749-4478 0 Saline Solution IM Clin Otolaryngol. 2018 Feb;43(1):261-266 28815972 Disinfection Microwaves Nasal Lavage Paranasal Sinuses Saline Solution 2018 02 12 2018 2 17 6 0 2018 12 24 6 0 2018 2 17 6 0 ppublish 29451356 10.1111/coa.13085

2018 Clinical Otolaryngology

13. Saline nasal irrigations for chronic rhinosinusitis: From everyday practice to evidence-based medicine. An update (PubMed)

Saline nasal irrigations for chronic rhinosinusitis: From everyday practice to evidence-based medicine. An update Saline nasal irrigations (SNIs) are often recommended as an additional non-pharmacological treatment for adults with chronic rhinosinusitis (CRS), for which it could even be considered a first-line treatment. However, there is a wide range of different SNI protocols. The aim of this article is to review the published literature regarding all of the potential therapeutic effects (...) of SNIs in adult CRS patients who had not undergone sinus surgery and clarify the role of the various saline nasal solutions and protocols (particularly the volume, frequency and duration of treatment), and describe the nasal devices used. A search was made of the PubMed, Google Scholar and Ovid databases using the key words 'saline nasal irrigation' and 'chronic rhinosinusitis', or medical subject headings. The search identified 11 studies involving 663 patients. There was no consensus about

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2018 International journal of immunopathology and pharmacology

14. Nasal Swab studyComparison of Effectiveness of Povidone-iodine Versus Saline Versus 3M Skin and Nasal Antiseptic 5% Povidone-Iodine USP Swabs for Decolonizing Intranasal MSSA/MRSA

Nasal Swab studyComparison of Effectiveness of Povidone-iodine Versus Saline Versus 3M Skin and Nasal Antiseptic 5% Povidone-Iodine USP Swabs for Decolonizing Intranasal MSSA/MRSA Nasal Swab studyComparison of Effectiveness of Povidone-iodine Versus Saline Versus 3M Skin and Nasal Antiseptic 5% Povidone-Iodine USP Swabs for Decolonizing Intranasal MSSA/MRSA - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results (...) information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Nasal Swab studyComparison of Effectiveness of Povidone-iodine Versus Saline Versus 3M Skin and Nasal Antiseptic 5% Povidone-Iodine USP Swabs for Decolonizing Intranasal MSSA/MRSA The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing

2016 Clinical Trials

15. Evaluation of patient nasal saline irrigation practices following endoscopic sinus surgery. (PubMed)

Evaluation of patient nasal saline irrigation practices following endoscopic sinus surgery. Functional endoscopic sinus surgery (FESS) is an effective treatment for chronic rhinosinusitis (CRS). Postoperative management strategies after FESS often vary from surgeon to surgeon. Recent data suggests that nasal saline irrigation following FESS is almost universally recommended; however, patient adherence has not been formally evaluated. The purpose of this study is to evaluate postoperative nasal (...) = 0.0095). Patients were more likely to irrigate with larger volumes if they were younger (p = 0.0284), had prior irrigation (p < 0.0001), or had revision surgery (p = 0.0056).Multiple factors are associated with patient compliance with nasal saline irrigation after FESS. Ethnic and cultural considerations, such as language barriers, should also be considered to improve outcomes. Identification of patients who may be noncompliant could potentially benefit from increased preoperative counseling

2017 International forum of allergy & rhinology

16. A randomized controlled trial comparing a xyloglucan-based nasal spray with saline in adults with symptoms of rhinosinusitis. (PubMed)

A randomized controlled trial comparing a xyloglucan-based nasal spray with saline in adults with symptoms of rhinosinusitis. This study assessed the efficacy, safety and tolerability of a xyloglucan-based nasal spray in the treatment of symptoms of rhinosinusitis.In this randomized, double-blind study, 40 patients with itching, nasal congestion or continuous sneezing and a Total Nasal Symptom Score (TNSS) of ≥8 were randomized to 2 weeks' treatment with a xyloglucan-based nasal spray (...) ("xyloglucan") or a physiological saline nasal spray ("saline"). Assessments included the TNSS, rhinosinusitis severity index, nocturnal awakenings, use of rescue medication, safety and tolerability.Baseline symptom scores were similar between groups. At treatment end, improvements from baseline were observed in both groups for TNSS (xyloglucan 58%; saline 35%, both p < .05) and number of nocturnal awakenings (p < .05). A significant improvement in the rhinosinusitis severity index was observed only

2017 Current medical research and opinion

17. Normal saline solution nasal-pharyngeal irrigation improves chronic cough associated with allergic rhinitis. (PubMed)

Normal saline solution nasal-pharyngeal irrigation improves chronic cough associated with allergic rhinitis. Upper airway inflammation is one of the most commonly identified causes of chronic cough, although the underlying mechanism is not clear. This study compared normal saline solution nasal-pharyngeal irrigation (NSNPI) and fluticasone propionate nasal spray (FPNS) treatment for chronic cough associated with allergic rhinitis (AR).Patients with suspected AR to house-dust mite were enrolled (...) , and the symptom of cough was assessed by a cough symptom score and the Leicester Cough Questionnaire, and cough response to capsaicin was evaluated. AR was assessed by using the visual analog scale (VAS) and the Mini Juniper Rhinoconjunctivitis Quality of Life Questionnaire (MiniRQLQ). Mediators, including histamine, leukotriene C4, and prostaglandin D2, and the major basic protein from nasal lavage fluid (NLF) were examined. The patients were treated with NSNPI (the NSNPI group) or FPNS (the FPNS group

2017 American journal of rhinology & allergy

18. Can contaminated water be rendered safe for nasal saline irrigations? (PubMed)

Can contaminated water be rendered safe for nasal saline irrigations? To compare sterile water to three methods of sterilization (carbon filtration, boiling, and ultraviolet [UV] light) for preparation of nasal saline irrigants free of bacterial and amebic contaminants.Bench-top translational research and cost comparison.Sterile water was compared to common sterilization methods. Sterile water was contaminated with known concentrations of Staphylococcus aureus, Pseudomonas aeruginosa, Moraxella (...) in sterilization of all organisms. Negative (sham contaminated) samples produced no growth, whereas positive (untreated) samples grew numerous organisms as expected. A cost comparison between bottled water and UV water sterilization (with SteriPEN Ultra) became equal in less than 2 years of consistent use.Carbon filtration reduces contamination but does not sterilize water and is thus unsafe for preparation of nasal saline irrigant. Boiling and UV treatment resulted in sterilization and are equivalent

2017 Laryngoscope

19. Overnight delivery of hypertonic saline by nasal cannula aerosol for cystic fibrosis (PubMed)

Overnight delivery of hypertonic saline by nasal cannula aerosol for cystic fibrosis Inhaled hypertonic saline increases mucociliary clearance, improves pulmonary function, and decreases exacerbations in cystic fibrosis (CF) but contributes to the already significant treatment burden of CF. Overnight delivery of inhaled medications via a specially designed nasal cannula-aerosol device (Trans-nasal Pulmonary Aerosol Delivery [tPAD]) is an alternative approach. Here, we test whether overnight (...) inhalation of hypertonic saline via tPAD improves mucociliary clearance and assess the tolerability of the device.In this study, 12 CF subjects inhaled 7% hypertonic saline (HS) for 8 h overnight using the tPAD system. Safety and tolerability were assessed and measurements of mucociliary and absorptive clearance (MCC/ABS) were performed after the treatment. Comparisons were made versus sham treatment where the same subjects wore the nasal cannula overnight but did not receive aerosol.Both the HS and sham

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2017 Pediatric pulmonology

20. Saline irrigation for allergic rhinitis. (PubMed)

Saline irrigation for allergic rhinitis. Allergic rhinitis is a common condition affecting both adults and children. Patients experience symptoms of nasal obstruction, rhinorrhoea, sneezing and nasal itching, which may affect their quality of life.Nasal irrigation with saline (salty water), also known as nasal douching, washing or lavage, is a procedure that rinses the nasal cavity with isotonic or hypertonic saline solutions. It can be performed with low positive pressure from a spray, pump (...) or squirt bottle, with a nebuliser or with gravity-based pressure in which the person instils saline into one nostril and allows it to drain out of the other. Saline solutions are available over the counter and can be used alone or as an adjunct to other therapies.To evaluate the effects of nasal saline irrigation in people with allergic rhinitis.The Cochrane ENT Information Specialist searched the ENT Trials Register; CENTRAL; Ovid MEDLINE; Ovid Embase; CINAHL; Web of Science; ClinicalTrials.gov; ICTRP

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2018 Cochrane

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