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NIH Stroke Scale

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161. Frequency, determinants, and effects of early seizures after thrombolysis for acute ischemic stroke: The ENCHANTED trial (PubMed)

days.Data were available for 3,139 acute ischemic stroke participants, of whom 42 (1.3%) had seizures at a median 22.7 hours after the onset of symptoms. Baseline variables associated with seizures were male sex (odds ratio [OR] 2.19, 95% confidence interval [CI] 1.07-4.50), severe neurologic impairment (NIH Stroke Scale score ≥10; OR 2.16, 95% CI 1.06-4.40), and fever (OR 4.55, 95% CI 2.37-8.71). Seizures independently predicted poor recovery: death or major disability (OR 2.88, 95% CI 1.28-6.47 (...) stroke were randomized to low-dose (0.6 mg/kg) or standard-dose (0.9 mg/kg) IV alteplase. The protocol prespecified prospective data collection on in-hospital seizures over 7 days postrandomization. Logistic regression models were used to determine variables associated with seizures and their significance on poor outcomes of death or disability (modified Rankin scale scores 3-6), symptomatic intracerebral hemorrhage (sICH), and European Quality of Life 5-Dimensions questionnaire [EQ-5D] over 90

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2017 Neurology: Clinical Practice

162. Thrombolytics for stroke: The evidence

of medicine. 2008; 359(13):1317-29. PMID: [ ] A multicenter, placebo controlled, double-blind, randomized trial Patients: 821 adult stroke patients (aged 18-80) who were able to received the drug with a 3-4 hours time frame after symptom onset (later extended to 3-4.5 hours). They excluded patients with a NIHSS >25 Intervention: t-Pa 0.9mg.kg Comparison: placebo Primary outcome: Disability at 90 days (looking at a modified Rankin scale 0-1) Results More people in the treatment group ended up (...) , the placebo group had a higher NIH stroke score than the tPa group when patients were enrolled. This isn’t anything nefarious. It is just something that happens by chance when you are dealing with small trials. Unfortunately, the single largest predictor of outcome in strokes is how severe the stroke is at baseline. These trials did not measure how much you improved, but instead asked how many patients were functionally independent at the end of the trial. Imagine we were testing two different pain

2017 First10EM

163. The Association between Diffusion MRI-Defined Infarct Volume and NIHSS Score in Patients with Minor Acute Stroke (PubMed)

The Association between Diffusion MRI-Defined Infarct Volume and NIHSS Score in Patients with Minor Acute Stroke Prior studies have shown a correlation between the National Institutes of Health Stroke Scale (NIHSS) and stroke volume on diffusion weighted imaging (DWI); data are more limited in patients with minor stroke. We sought to determine the association between DWI lesion(s) volume and the (1) total NIHSS score and (2) NIHSS component scores in patients with minor stroke.We included all (...) patients with minor stroke (NIHSS 0-5) enrolled in the Stroke Warning Information and Faster Treatment study. We calculated lesion(s) volume (cm3 ) on the DWI sequence using Medical Image Processing, Analysis, and Visualization (MIPAV, NIH, Version 7.1.1). We used nonparametric tests to study the association between the primary outcome, DWI lesion(s) volume, and the predictors (NIHSS score and its components).We identified 894 patients with a discharge diagnosis of minor stroke; 709 underwent magnetic

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2017 Journal of neuroimaging : official journal of the American Society of Neuroimaging

164. TREVO stent-retriever mechanical thrombectomy for acute ischemic stroke secondary to large vessel occlusion registry (PubMed)

device in everyday clinical practice.Twenty-three centers enrolled consecutive AIS patients treated from March 2013 through August 2015 with the Trevo device. The primary outcome was defined as achieving a Thrombolysis in Cerebral Infarction (TICI) score of ≥2b. Secondary outcomes included 90-day modified Rankin Scale (mRS), mortality, and symptomatic intracranial hemorrhage (sICH).A total of 634patients were included. Mean age was 66.1±14.8 years and mean baseline NIH Stroke Scale (NIHSS) score (...) TREVO stent-retriever mechanical thrombectomy for acute ischemic stroke secondary to large vessel occlusion registry Recent randomized clinical trials (RCTs) demonstrated the efficacy of mechanical thrombectomy using stent-retrievers in patients with acute ischemic stroke (AIS) with large vessel occlusions; however, it remains unclear if these results translate to a real-world setting. The TREVO Stent-Retriever Acute Stroke (TRACK) multicenter Registry aimed to evaluate the use of the Trevo

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2017 Journal of neurointerventional surgery

165. Society of Interventional Radiology Position Statement on Endovascular Acute Ischemic Stroke Interventions

and Recanalization of Stroke Clots Using Embolectomy, mRS = modi?ed Rankin scale, NIH = National Institutes of Health, NIHSS = National Institutes of Health Stroke Scale, TICI = Thrombolysis In Cerebral Infarction, tPA= tissue plasminogen activator, TREVO= Thrombectomy Revascularization of large Vessel Occlusions in Acute Ischemic Stroke In February 2013, the world of stroke interventions changed. Three trials were presented at the 2013 International Stroke Conference and then published in the New England (...) , buttheevidenceandassociatedconclusionsmustbereliable.Itisworth looking at each of these trials in detail. IMS III In the National Institutes of Health (NIH)–sponsored IMS III trial (1), patients were included if their ischemic stroke was severe enough to have an NIH Stroke Score (NIHSS) of at least 10, indicating a moderately severe stroke. Strokes of this severity have an approximately 80% likelihood of being caused by a large vessel occlusion in the internal carotid, vertebrobasilar, or proximal intracranial arterial circulation. Patients were

2013 Society of Interventional Radiology

166. Training Guidelines for Intra-arterial Catheter Directed Treatment of Acute Ischemic Stroke

, FSIR, and John F. Cardella, MD, FSIR J Vasc Interv Radiol 2009; 20:1507–1522 Abbreviations: ACC American College of Cardiology, ACGME Accreditation Council for Graduate Medical Education, ECASS European Cooperative Acute Stroke Study, IA intra-arterial, ICH intracranial hemorrhage, IV intravenous, MCA middle cerebral artery, MELT Middle cerebral artery Em- bolism Local fibrinolytic intervention Trial, MERCI Mechanical Embolus Removal in Cerebral Ischemia [trial], mRS modified Rankin Scale, NINDS (...) ,comparedwith25%inthecontrol group. MELT (42) affirmed the positive clinical benefit of IA lysis for MCA oc- clusion, demonstrating statistically sig- nificant improvement in excellent clini- caloutcome(mRS0–2at90days)inthe IA urokinase group compared with the controlgroup(42.1%vs22.8%;P.045; oddsratio,2.46;95%CI,1.09–5.54);35% ofpatientswhounderwentIAlysishad nearly complete neurologic recovery (National Institutes of Health Stroke Scale of 0–1 at 90 days), versus 14% in thecontrolgroup(P.017)(42).MELT (42

2013 Society of Interventional Radiology

167. Replication and extension of the simplified modified rankin scale in 150 Chinese stroke patients. (PubMed)

Replication and extension of the simplified modified rankin scale in 150 Chinese stroke patients. Recently, a simplified modified Rankin Scale (mRS) questionnaire (smRSq) showed good reliability but has not been tested for its validity by its original creators. Our study aimed to test its reliability and validity in Chinese stroke patients.Randomly chosen paired raters scored the smRSq, the conventional mRS, and the NIH Stroke Scale (NIHSS) face-to-face in 150 hospitalized stroke patients (...) ), and κw = 0.83 (95% CI 0.79-0.88). The correlation between the NIHSS and the smRSq (concurrent validity) was moderate (Spearman's correlation coefficient 0.70, p < 0.0001).Our results confirm the value of the smRSq in the assessment of stroke functional outcome in China. As this is a novel stroke tool, further validations are needed.Copyright © 2012 S. Karger AG, Basel.

2012 European neurology

168. Heart Disease and Stroke Statistics?2012 Update

None None None None Susan M. Hailpern Independent Consultant None None None None None None None John A. Heit Mayo Clinic None None None None None None None Virginia J. Howard University of Alabama at Birmingham School of Public Health NIH/NINDS None None None None None None Brett M. Kissela University of Cincinnati Nexstim None Allergan Expert witness for defense in 1 stroke-related case in 2010 None Allergan None Steven J. Kittner University of Maryland School of Medicine None None None None None (...) Heart Disease and Stroke Statistics?2012 Update Heart Disease and Stroke Statistics—2012 Update | Circulation Search Hello Guest! Login to your account Email Password Keep me logged in Search March 2019 March 2019 March 2019 March 2019 March 2019 February 2019 February 2019 February 2019 February 2019 January 2019 January 2019 January 2019 January 2019 January 2019 Free Access article Share on Jump to Free Access article Heart Disease and Stroke Statistics—2012 Update A Report From the American

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2012 American Heart Association

169. Oral antithrombotic agents for the prevention of stroke in nonvalvular atrial fibrillation

person- years versus 1.52 (95% CI, 1.19–10.94) for CHADS 2 score=1, 2.50 (95% CI, 1.98–3.15) for CHADS 2 score=2, 5.27 (95% CI, 4.15–6.70) for CHADS 2 score=3, 6.02 (95% CI, 3.90–9.29) for CHADS 2 score=4, and 6.88 (95% CI, 3.42–13.84) CHADS 2 score=5 or 6. A limitation of the CHADS 2 scheme that applies to secondary prevention involves patients with prior stroke or TIA and no other risk factors. 2 These patients score 2 on the CHADS 2 scale (point estimate of thromboembolic risk 2.50 per 100 person (...) Oral antithrombotic agents for the prevention of stroke in nonvalvular atrial fibrillation 3442 T he rate of stroke among adults with atrial fibrilla- tion (AF) varies widely, ranging between 1% and 20% annually (mean 4.5% per year) depending on comorbidi- ties and a patient’s history of prior cerebrovascular events. 1 Stratification of stroke risk is important, because the major risk of antithrombotic medications used to lower the incidence of AF- related stroke is bleeding. For warfarin

2012 American Academy of Neurology

170. Inclusion of stroke in cardiovascular risk prediction instruments

Inclusion of stroke in cardiovascular risk prediction instruments AHA/ASA Scientific Statement Inclusion of Stroke in Cardiovascular Risk Prediction Instruments A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Daniel T. Lackland, DrPH, FAHA, Co-Chair; Mitchell S.V. Elkind, MD, MS, FAAN, FAHA, Co-Chair; Ralph D’Agostino, Sr, MD (...) , FAHA; Mandip S. Dhamoon, MD, MPH; David C. Goff, Jr, MD, PhD, FAHA; Randall T. Higashida, MD, FAHA; Leslie A. McClure, PhD; Pamela H. Mitchell, PhD, RN, FAAN, FAHA; Ralph L. Sacco, MD, MS, FAAN, FAHA; Cathy A. Sila, MD, FAAN, FAHA; Sidney C. Smith, Jr, MD, FAHA; David Tanne, MD, FAHA; David L. Tirschwell, MD, MSc, FAAN, FAHA; Emmanuel Touze ´, MD, PhD; Lawrence R. Wechsler, MD, FAHA; on behalf of the American Heart Association Stroke Council, Council on Epidemiology and Prevention, Council

2012 American Academy of Neurology

171. Reorganization of large-scale physiology in hand motor cortex following hemispheric stroke (PubMed)

Reorganization of large-scale physiology in hand motor cortex following hemispheric stroke 21383330 2011 05 06 2018 11 13 1526-632X 76 10 2011 Mar 08 Neurology Neurology Reorganization of large-scale physiology in hand motor cortex following hemispheric stroke. 927-9 10.1212/WNL.0b013e31820f8583 Miller Kai J KJ Department of Neurological Surgery, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA. kjmiller@uw.edu Abel Taylor J TJ Hebb Adam O AO Ojemann Jeffrey G JG eng (...) NS065186 NS NINDS NIH HHS United States NS07144 NS NINDS NIH HHS United States Case Reports Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. United States Neurology 0401060 0028-3878 AIM IM Electroencephalography methods Functional Laterality physiology Hand physiopathology Humans Male Motor Cortex physiopathology Stroke pathology physiopathology Young Adult 2011 3 9 6 0 2011 3 9 6 0 2011 5 7 6 0 ppublish 21383330 76/10/927 10.1212/WNL.0b013e31820f8583

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2011 Neurology

172. Association of dementia with death after ischemic stroke: A two-year prospective study (PubMed)

with death, independent of age, atrial fibrillation, previous stroke and NIH stroke scale. In conclusion, the mortality rate is increased in stroke patients with dementia. Dementia is an important risk factor for death after stroke, independent of age, atrial fibrillation, previous stroke, and the severity of the stroke. (...) Association of dementia with death after ischemic stroke: A two-year prospective study The association between dementia and the risk of death after ischemic stroke was investigated. Neurological, neuropsychological and functional assessments were evaluated in 619 patients with acute ischemic stroke. Dementia was diagnosed at admission and at three months after stroke onset. The patients were scheduled for a two-year follow-up after the index stroke. The Kaplan-Meier survival and Cox

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2016 Experimental and therapeutic medicine

173. Changes in the cellular immune system and circulating inflammatory markers of stroke patients (PubMed)

) cells in stroke patients on days 1, 3, and 7. Serum levels of TNF-α, C-reactive protein (CRP), IL-4, IL-6, IL-10, IL-17, IL-23, and TGF-β increased, whereas serum level of IFN-γ decreased at all time points after stroke. Stroke patients with infection exhibited a similar tendency toward changes in some lymphocyte subpopulations and inflammatory markers as stroke patients without infection. After controlling for NIH Stroke Scale (NIHSS), we observed no differences in lymphocyte subpopulations between (...) Changes in the cellular immune system and circulating inflammatory markers of stroke patients This study was designed to investigate dynamic changes in the cellular immune system and circulating inflammatory markers after ischemic stroke. Blood was collected from 96 patients and 99 age-matched control subjects for detection of lymphocyte subpopulations and inflammatory markers. We observed decreases in B cells, Th cells, cytotoxic T cells, and NK cells and an increase in regulatory T (Treg

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2016 Oncotarget

174. Efficacy Study of the LARA Wheelchair System for Subacute Stroke Patients

at the time of enrollment Severe tone in the affected upper extremities (Score ≥ 4 on the Modified Ashworth Spasticity Scale) Severe language problem that would prevent participants from properly understanding instructions Severe reduced level of consciousness Severe aphasia (score of 3 on the NIH stroke scale (question 9)) Severe loss of sensation in stroke-affected upper extremities (Score < 1 on the Nottingham sensory assessment) Currently pregnant Difficulty in understanding or complying (...) using a Likert scale Modified Ashworth Spasticity Scale [ Time Frame: from baseline visit to the 3-month visit after the end of intervention ] To evaluate and measure of spasticity of the upper extremity after stroke Timed 10-meter walk [ Time Frame: from baseline visit to the 3-month visit after the end of intervention ] To measure gait velocity for a distance of 10 meters Box and Block Test [ Time Frame: from baseline visit to 3-month visit after the end of intervention ] To measure unilateral

2016 Clinical Trials

175. Promoting Recovery Optimization With WALKing Exercise After Stroke

, stent placement or myocardial infarction within past 3 months Musculoskeletal pain that limits activity Inability to communicate with investigators score >1 on question 1b and >0 on question 1c on the NIH Stroke Scale. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (...) Promoting Recovery Optimization With WALKing Exercise After Stroke Promoting Recovery Optimization With WALKing Exercise After Stroke - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Promoting Recovery

2016 Clinical Trials

176. Mechanisms of Walking Recovery After Stroke

, severe claustrophobia) inability to perform mental imagery (time dependent motor imagery screening test [TDMI]) evidence of significant arrhythmia or myocardial ischemia on treadmill ECG stress test, or significant baseline ECG abnormalities that would make an exercise ECG uninterpretable recent (<3 months) cardiopulmonary hospitalization unable to communicate with investigators or correctly answer consent comprehension questions significant ataxia or neglect (score of 2 on NIH stroke scale item 7 (...) Test [ Time Frame: baseline, 4 weeks, 8 weeks ] Stroke and Aphasia Quality of Life Scale [ Time Frame: baseline, 4 weeks, 8 weeks ] Brain Locomotor Network Activation [ Time Frame: baseline, 4 weeks, 8 weeks ] Brain Locomotor Network Connectivity [ Time Frame: baseline, 4 weeks, 8 weeks ] Walking Capacity [ Time Frame: baseline, 4 weeks, 8 weeks ] 6-minute walk test Daily Walking Activity [ Time Frame: baseline, 4 weeks, 8 weeks ] activity monitor Walking Speed [ Time Frame: baseline, 4 weeks, 8

2016 Clinical Trials

177. Effects of Cerebrolysin Combined With Rehabilitation on Motor Recovery in Stroke

-existing and active major neurological disease Pre-existing and active (e.g., on chronic medication) major psychiatric disease, such as major depression, schizophrenia, bipolar disease, or dementia A history of significant alcohol or drug abuse in the prior 3 years Advanced liver, kidney, cardiac, or pulmonary disease A terminal medical diagnosis consistent with survival < 1 year Substantial decrease in alertness at the time of randomization, defined as score of 2 on NIH Stroke Scale Pregnancy (...) on global function (Korean version Modified Barthel Index, K-MBI), severity of stroke (National Institute of Health Stroke Scale, NIHSS), cognitive function (Korean Version of Mini-Mental State Exam, K-MMSE; Korean version Montreal Cognitive Assessment, K-MoCA), upper limb function (Action Research Arm Test, ARAT; Box and block test, B&B) and neuroplasticity measure (resting-state functional MRI(rsfMRI), diffusion tensor image(DTI), and motor evoked potential(MEP)) at 3 months after stroke. Condition

2016 Clinical Trials

178. Ventilatory Muscle Training in Stroke

, including: age, gender, race, marital status, education, employment, smoking history, ischemic stroke etiology, stroke severity with NIH Stroke Scale, and stroke location. This information may also be obtained from the RIC electronic medical record. Each subject will undergo a thorough neurologic assessment. Study participants will be randomly assigned to one of two groups: the experimental group with high resistance EMT and the control group with low resistance EMT. The participants will be randomized (...) Ventilatory Muscle Training in Stroke Ventilatory Muscle Training in Stroke - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Ventilatory Muscle Training in Stroke The safety and scientific validity

2016 Clinical Trials

179. Prevention of Ischemic Conditions in Non-disabling Stroke/Transient Ischemic Attack With Remote Ischemic Conditioning

[ Time Frame: within 3 months ] the proportion of patients fulfill the treatment Incidence rate of vascular events [ Time Frame: within 3 months ] hemorrhage stroke, myocardial infarction and vascular death Improvements in NIH Stroke Scale [ Time Frame: within1, 3 months ] improvements in NIH Stroke Scale in patients without recurrence or vascular events Improvements in modified Rankin Scale [ Time Frame: within 1, 3 months ] improvements in modified Rankin Scale Scale in patients without recurrence (...) or vascular events Improvements in Barthel Scale [ Time Frame: within 1,3 months ] improvements in Barthel Scale in patients without recurrence or vascular events Other Outcome Measures: Recurrent rate of ischemic stroke/transient ischemic stroke within 1 months [ Time Frame: within 1 months ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding

2016 Clinical Trials

180. Get With the Guidelines-Stroke Registry

Study Completion Date : January 2020 Groups and Cohorts Go to Intervention Details: Other: GWTG Stroke program Evidence based recommended therapies and counseling prior to hospital discharge. Outcome Measures Go to Primary Outcome Measures : NIHSS reported [ Time Frame: 30 days post discharge from hospital ] Percent of ischemic stroke and stroke not otherwise specified patients with a score reported for NIH Stroke Scale In-hospital mortality [ Time Frame: 6 days - mean for length of hospitalization (...) for Stroke patients ] Modified Rankin Scale at Discharge [ Time Frame: 6 days - mean for length of hospitalization for Stroke patients ] Patients grouped by Modified Rankin Scale at discharge Risk-Adjusted Mortality Ratio (for Ischemic-Only and Ischemic and Hemorrhagic models) [ Time Frame: 30 days post discharge from hospital ] A ratio comparing the actual in-hospital mortality rate to the risk-adjusted expected mortality rate. Eligibility Criteria Go to Information from the National Library of Medicine

2016 Clinical Trials

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