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NIH Stroke Scale

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141. Tenecteplase in ischemic stroke offers improved recanalization: Analysis of 2 trials. (PubMed)

and at 24 hours post thrombolysis using the modified thrombolysis in cerebral infarction (TICI) scale. Twenty-four-hour poststroke NIH Stroke Scale (NIHSS) and 90-day modified Rankin Scale (mRS) scores were also compared between treatment groups using linear regression to generate odds ratios (ORs).From 146 pooled patients, 69 had a TICI 0/1 occlusion overall at baseline. Tenecteplase-treated patients with a complete vessel occlusion had greater complete recanalization rates at 24 hours (71 (...) Tenecteplase in ischemic stroke offers improved recanalization: Analysis of 2 trials. To test whether patients with complete vessel occlusion show greater recanalization at 24 hours and have improved clinical outcomes at 24 hours and 90 days when treated with tenecteplase compared to alteplase.Pooled clinical and imaging data from 2 phase 2 randomized trials comparing tenecteplase with alteplase allowed CT angiography (CTA) scans to be assessed centrally for occlusion status at baseline

2017 Neurology

142. Patient Outcomes with Stent-Retriever Thrombectomy for Anterior Circulation Stroke: A Meta-Analysis and Review of the Literature. (PubMed)

and 1634 patients from observational studies. Mean NIH Stroke Scale score on admission was 16.6, and mean time from onset to recanalization was 300 minutes. Successful recanalization was achieved in 82% (95%CI 77-86, 31 studies). The 90 day favorable outcome was achieved in 47% (95%CI 42-5.2, 34 studies) with an overall mortality rate of 17% (95%CI 13-20, 31 studies). Symptomatic intracerebral hemorrhage was identified in 6% (95%CI 4-8, 32 studies). In patients with AIS caused by a proximal (...) . Available literature published to date on observational studies and three randomized trials (MR CLEAN, ESCAPE, and EXTEND-IA) involving the stent-retriever device were reviewed. Successful recanalization and favorable clinical outcome were defined by a TICI ≥ 2b and modified Rankin Scale score of ≤ 2 at 90 days following AIS, respectively. A total of 2067 patients harboring an anterior circulation stroke were treated with a stent retriever: 433 patients from 3 randomized trials involving the device

2017 The Israel Medical Association journal : IMAJ

143. Endovascular therapy for ischemic stroke: Save a minute-save a week. (PubMed)

granted on average 4.2 days of extra healthy life, with a 95% prediction interval 2.3-5.4. Women gained slightly more than men due to their longer life expectancies. Patients younger than 55 years with severe strokes of NIH Stroke Scale score above 10 gained more than a week per each minute saved. In the whole cohort, every 20 minutes decrease in treatment delays led to a gain of average equivalent of 3 months of disability-free life.Small reductions in endovascular delays lead to marked health (...) Endovascular therapy for ischemic stroke: Save a minute-save a week. To quantify the patient lifetime benefits gained from reduced delays in endovascular therapy for acute ischemic stroke.We used observational prospective data of consecutive stroke patients treated with IV thrombolysis in Helsinki (1998-2014; n = 2,474) to describe distributions of age, sex, stroke severity, onset-to-treatment times, and 3-month modified Rankin Scale (mRS) in routine clinical practice. We used treatment effects

2017 Neurology

144. Integrity of normal-appearing white matter and functional outcomes after acute ischemic stroke. (Full text)

patients with DWIv and mRS score, mean age was 64.4 ± 15.9 years, and 183 participants (60%) were male. Median NIH Stroke Scale (NIHSS) score was 3 (interquartile range [IQR] 1-8), and median normalized WMHv was 6.19 cm3 (IQR 3.0-12.6 cm3). Admission stroke severity (β = 0.16, p < 0.0001) and small vessel stroke subtype (β = -1.53, p < 0.0001), but not diffusivity metrics, were independently associated with DWIv. However, median FA in contralesional NAWM was independently associated with mRS score (β (...) Integrity of normal-appearing white matter and functional outcomes after acute ischemic stroke. To characterize the effect of white matter microstructural integrity on cerebral tissue and long-term functional outcomes after acute ischemic stroke (AIS).Consecutive AIS patients with brain MRI acquired within 48 hours of symptom onset and 90-day modified Rankin Scale (mRS) score were included. Acute infarct volume on diffusion-weighted imaging (DWIv) and white matter hyperintensity volume (WMHv

2017 Neurology PubMed

145. An Analysis of EMS and ED Detection of Stroke. (PubMed)

alerts, and 131 were ED stroke alerts (70 called by physicians, 61 by nurses). The mean NIH Stroke Scale was higher in the EMS group (8.1 ± 7.6 vs. 3.0 ± 5.0, p < 0.0001). The positive predictive value of EMS stroke alerts was 0.60 (78/129), alerts by ED nurses was 0.25 (15/61), and alerts by ED physicians was 0.31 (22/70). The PPV for EMS was better than for nurses or physicians (both p < 0.001), and more patients in the EMS group had final diagnoses of stroke (62/129 vs. 24/131, p < 0.001 (...) ). The positive likelihood ratio was 1.53 for EMS personnel, 0.45 for physicians, and 0.77 for nurses. The mean time to order the CT (8.5 ± 7.1 min vs. 23.1 ± 18.2 min, p < 0.0001) and the mean ED length of stay (248 ± 116 min vs. 283 ± 128 min, p = 0.022) were shorter for the EMS stroke alert group. More EMS stroke alert patients received tPA (16/129 vs. 6/131, p = 0.027).EMS stroke alerts have better diagnostic test performance than stroke alerts by ED staff, likely due to higher NIH Stroke Scale scores

2017 Prehospital emergency care

146. Outcome Measure Scores Predict Discharge Destination in Patients With Acute and Subacute Stroke: A Systematic Review and Series of Meta-analyses.

; NIH Stroke Scale [NIHSS] score ≤5; etc) are 12 times (OR = 12.08; 95% CI, 3.550-41.07) more likely to discharge home. Patients who perform poorly (FIM ≤39; NIHSS score ≥14), experience discharge to institutionalized care 3.4 times (OR = 3.385; 95% CI, 2.591-4.422) more likely than home, with skilled nursing facility admission more likely than inpatient rehabilitation facility. Patients who perform average (FIM = 40-79; NIHSS score = 6-13) are 1.9 times (OR = 1.879; 95% CI, 1.227-2.877) more likely (...) Outcome Measure Scores Predict Discharge Destination in Patients With Acute and Subacute Stroke: A Systematic Review and Series of Meta-analyses. To identify the association between outcome measure score and discharge destination in adults following acute or subacute stroke in the United States.A systematic literature search was performed in 3 databases using the PRISMA guidelines. Cohort studies were selected that included patients with acute or subacute stroke, which explored the relationship

2017 Journal of neurologic physical therapy : JNPT

147. Stroke Motor Rehabilitation and Recovery Study

of zero or 1 on the NIH Stroke Scale Level of Consciousness Questions 1a and 1b and a score of zero on the NIH Stroke Scale Level of Consciousness Question 1c. Stable medical status as determined by primary care team Inpatient on the MGH stroke neurology service Exclusion Criteria Prior history of developmental, neurologic, or major psychiatric disorder resulting in functional disability Prior history of visual or auditory disorders limiting ability to participate in testing Evidence (...) Completion Date : June 30, 2022 Estimated Study Completion Date : June 30, 2023 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Outcome Measures Go to Primary Outcome Measures : Change in National Institute of Health Stroke Scale [ Time Frame: Time 1: Within 10 days of ischemic stroke date; Time 2: 42 days after stroke date (+/- 10 days); Time 3: 84 days after stroke date (+/- 10 days); Time 4: 168 days after stroke date (+/- 10 days); Time 5: 365 days

2017 Clinical Trials

148. Enhanced Reality for Hemiparetic Arm in the Stroke Patients

information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Arm motor Fugl-Mayer scale; wrist/hand subscales ≥ 2-20 9-hole pegboard ; ≥ 25% of contra-lateral hand Exclusion Criteria: Alexander apraxia scale ≤2 NIH stroke scale question Ia-c ≥1 Nottingham sensory scale; <75% of contra-lateral hand Ashworth scale ≥3 NIH stroke scale question IX ≥2 Beck (...) termination of treatment ] 9-hole pegboard Change of Stroke impact scale [ Time Frame: 1 day before the initiation of intervention, 10 day after the initiation of intervention, and 30 days after termination of treatment ] Stroke impact scale, hand function Change of Grasp force in Newtons [ Time Frame: 1 day before the initiation of intervention, 10 day after the initiation of intervention, and 30 days after termination of treatment ] Grasp force in Newtons Change of Active range of motion of wrist joint

2017 Clinical Trials

149. Quelling of Excitotoxicity in Acute Stroke With Ketamine

injection Injection Other Name: Versed Outcome Measures Go to Primary Outcome Measures : Change in weighted modified Rankin scale score between day 1 and 90 will be assessed. [ Time Frame: On day 1 and at 90 days ] An improvement of 2 in mRS score will be considered favorable outcome. Secondary Outcome Measures : Barthel's index [ Time Frame: On day 1, and at 90 days ] An improvement of 10 or more points in Barthel's index will be considered a favorable outcome. NIH stroke scale score [ Time Frame (...) ] Deterioration in neurologic status [ Time Frame: Up to day 4 or discharge whichever is earlier ] Increase of 4 or more points in the NIH stroke scale Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below

2017 Clinical Trials

150. Allogenic Mesenchymal Stem Cell Derived Exosome in Patients With Acute Ischemic Stroke

. Patients must have a score on the NIH Stroke Scale 8-24, and mRS ≤ 1 Women of childbearing age should have a negative pregnancy test performed prior to inclusion Obtaining informed consent signed Exclusion Criteria: Comatose patients. brain tumour, cerebral oedema with compression of ventricles, cerebellar infarction or brainstem, or intraventricular, intracerebral or subarachnoid haemorrhage. alcohol use Active infectious disease, including HIV, hepatitis B, Hepatitis . patients with dementia. Specify (...) to Primary Outcome Measures : Incidence of Treatment-Emergent Adverse Events [ Time Frame: 12 months ] deteriorating stroke, stroke recurrences, brain oedema, seizures, hemorrhagic transformation Secondary Outcome Measures : measurement of Modified Ranking Scale [ Time Frame: 12 months ] measure the degree of disability in Stroke patients. score was recorded from 0-6. 0 No symptoms at all No significant disability despite symptoms; able to carry out all usual duties and activities Slight disability

2017 Clinical Trials

151. Blood-Brain Barrier Disruption in People With White Matter Hyperintensities Who Have Had a Stroke

and Medstar Washington Hospital Center) who had a stroke evaluation by the NIH stroke team will be eligible for enrollment. Enrolled subjects who meet the inclusion/exclusion criteria will be followed serially with MRI. The first research evaluation will be within 3-4 months of the qualifying event whenever possible, but could be up to 6 months. Research procedures will consist of an MRI, interval history and cognitive/clinical scaling. Research procedures will occur every 3 months for the first year (...) 2 or greater), obtain a MoCA score greater than 13, and have no other diagnosis to explain the finding (e.g. multiple sclerosis). The NIH stroke service currently evaluates 600 patients a year with MRI. Approximately 20% have confluent WMH on their FLAIR MRI and would meet the inclusion criteria for this study. Thus, the cohort for this study will be recruited from the population evaluated by the NIH stroke service. Design: Patients admitted to one of the two enrolling sites (Suburban Hospital

2017 Clinical Trials

152. Early arrival at the emergency department is associated with better collaterals, smaller established infarcts and better clinical outcomes with endovascular stroke therapy: SWIFT study. (Full text)

With the Intention For Thrombectomy (SWIFT) trial comparing two neurothrombectomy treatments was analyzed by time, Alberta Stroke Program Early CT Scores (ASPECTS), angiographic collaterals, and 90-day modified Rankin Scale outcomes. We determined the interaction of time with ASPECTS, collateral grade, reperfusion, and clinical outcomes, with established determinants of angiographic and clinical outcomes as covariates.137 patients (52% female) of mean age 67±12 years and median pretreatment NIH Stroke Scale (...) Early arrival at the emergency department is associated with better collaterals, smaller established infarcts and better clinical outcomes with endovascular stroke therapy: SWIFT study. Increasing time from symptom onset to emergency department arrival may incur greater ischemic injury and decreased likelihood of good outcomes after acute stroke therapy. The impact of time may be assessed bythe extent of acute CT changes, status of collateral vessels, and clinical outcomes.The SOLITAIRE FR

2017 Journal of neurointerventional surgery PubMed

153. Intracerebral Transplantation of Neural Stem Cells for the Treatment of Ischemic Stroke

cells to 8×107 cells, as tolerated. Outcome Measures Go to Primary Outcome Measures : Adverse Events [ Time Frame: 24 months ] Secondary Outcome Measures : Clinical improvement using NIH Stroke Scale [ Time Frame: 12 months ] Clinical improvement using Modified Rankin Scale [ Time Frame: 12 months ] Clinical improvement using Fugl-Meyer Motor Score [ Time Frame: 12 months ] Clinical Improvement using Mini-mental State Examination [ Time Frame: 12 months ] Other Outcome Measures: MRI analysis (...) Intracerebral Transplantation of Neural Stem Cells for the Treatment of Ischemic Stroke Intracerebral Transplantation of Neural Stem Cells for the Treatment of Ischemic Stroke - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2017 Clinical Trials

154. Comparison of Fatigue and Recovery After Stroke Depending on the Usual Management With or Without Physical Training

in circuit training (20 min), and balance and flexibility exercises. Outcome Measures Go to Primary Outcome Measures : Fatigue relief (assessed by the Fatigue Severity Scale) [ Time Frame: 4 months after the stroke ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may (...) contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Age > 18 years National health insurance cover 1st minor ischaemic stroke (initial NIH score ≤ 4) Satisfactory neurological recovery at discharge from hospital (modified Rankin score ≤2) Patient living close

2017 Clinical Trials

155. Pilot Study of Acute Stroke Using the Brainpulseâ„¢

in the Stroke patient care workflow. Patients will be consecutively recruited and once patients have consented and met eligibility, they will be assigned to one of the four study Groups based on their confirmed clinical diagnosis. Each subject will complete one BrainPulse recording before neuro-intervention and within one hour of IV pharmacologic intervention. All subjects will also complete comprehensive neurological, cognitive and NIH Stroke Scale (NIHSS) assessments. Additionally, Ischemic Stroke (...) Pilot Study of Acute Stroke Using the Brainpulseâ„¢ Pilot Study of Acute Stroke Using the Brainpulse™ - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Pilot Study of Acute Stroke Using the Brainpulse™

2017 Clinical Trials

156. Use of Vibration to Improve Visual/Spatial Neglect in Patients Affected by Stroke

or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: 18 years old or older demonstrated visual/spatial neglect, as demonstrated by NIH Stroke Scale (NIHSS) and deficits in assessing tactile extinction and visuospatial neglect done on admission (...) Use of Vibration to Improve Visual/Spatial Neglect in Patients Affected by Stroke Use of Vibration to Improve Visual/Spatial Neglect in Patients Affected by Stroke - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2017 Clinical Trials

157. Neuroprotection in Acute Ischemic Stroke

(no symptoms) to 6 (dead). NIH Stroke Scale (NIHSS) [ Time Frame: 90 days ] 15-item neurologic examination scale for severity of stroke. Ratings for each item are scored with 3 to 5 grades. A total NIHSS of 0 is normal; 1-4 is considered a minor stroke; 5-15 moderate; 16-20 moderate to severe; and 21-42 severe. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends (...) will be administered i.v. or p.o. respectively, in place of minocycline. Outcome Measures Go to Primary Outcome Measures : simplified modified Rankin Scale (sMRSq) [ Time Frame: 90 days ] rating scale to assess level of functional independence for patients post-stroke. Scores range from 0 (no symptoms) to 6 (dead). Secondary Outcome Measures : simplified modified Rankin Scale (sMRSq) [ Time Frame: 45 days ] rating scale to assess level of functional independence for patients post-stroke. Scores range from 0

2017 Clinical Trials

158. Evaluation to Assess Safety and Tolerability of DM199 in Subjects With Acute Ischemic Stroke

baseline to Day 90 of NIH Stroke Scale. [ Time Frame: 90 Days ] Assessed by a reduction in points from baseline. Changes from baseline to Day 90 of Barthel Index. [ Time Frame: 90 Days ] Assessed by an increase in points from baseline. Changes from baseline to Day 90 of Modified Rankin Scale. [ Time Frame: 90 Days ] Assessed by a reduction in points from baseline. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal (...) ischemic stroke with onset ≤ 24 hours from enrollment. Subject has NIH stroke score (NIHSS) ≥ 6 and ≤ 25. Subject or legally authorized representative is willing and able to sign written informed consent. Exclusion Criteria: Subject is currently prescribed angiotensin-converting-enzyme inhibitors (ACEi) and is unable or unwilling to convert to another antihypertensive pharmacological treatment for the duration of the study. Subject has a history of significant allergic diathesis such as urticaria

2017 Clinical Trials

159. Wearable Device for Motivating Hand Use After Stroke

for eligibility information Ages Eligible for Study: 18 Years to 80 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: 18 to 80 years of age Experienced one or multiple strokes at least six months previously Upper Extremity Fugl-Meyer Score < 60 out of 66 Absence of moderate to severe upper limb pain (< 3 on the a 10 point visual-analog pain scale) Ability to understand the instructions to operate the device Exclusion Criteria: 80 years of age (...) Wearable Device for Motivating Hand Use After Stroke Wearable Device for Motivating Hand Use After Stroke - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Wearable Device for Motivating Hand Use After Stroke

2017 Clinical Trials

160. Cohort of Ischemic STROKE Patients

: October 2026 Groups and Cohorts Go to Outcome Measures Go to Primary Outcome Measures : Degree of disability (mRS Score) [ Time Frame: 5 years ] Degree of disability: modified Rankin Score Secondary Outcome Measures : infarct size [ Time Frame: day 6 ] cerebral infarct size on MRI Hemorrhagic transformation [ Time Frame: 24 hours ] Hemorrhagic transformation (ECASS scale) on imaging (CT or MRI) Neurological deficit [ Time Frame: up to 5 years ] Neurological deficit NIH stroke Scale Quality of life (...) Cohort of Ischemic STROKE Patients Cohort of Ischemic STROKE Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Cohort of Ischemic STROKE Patients (HIBISCUSSTROKE) The safety and scientific validity

2017 Clinical Trials

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