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NIH Stroke Scale

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81. Stroke in Egyptian Clinical REgisTry

Registry. This includes cases with a principal/primary or secondary diagnosis of: Cerebral Infarction Intracerebral Hemorrhage (non-traumatic) Ischemic Stroke Subarachnoid Hemorrhage (non-traumatic) Transient Ischemic Attack (TIA) Cerebral Venous Sinus Thrombosis The investigators will use the available EMR and databases to search for these patients using relevant ICD-9/10 codes. or any other method used internally to archive stroke cases Criteria Inclusion Criteria: All patients with a diagnosis (...) Title: Stroke in Egyptian Clinical REgisTry Actual Study Start Date : May 20, 2018 Estimated Primary Completion Date : May 19, 2020 Estimated Study Completion Date : July 30, 2020 Groups and Cohorts Go to Group/Cohort Intervention/treatment Patients with stroke with structured management Patients with the Acute Brain injury, Transient Ischemic Attack, Acute and Chronic Ischemic and Hemorrhagic Stroke, Subarachnoid hemorrhage, and cerebral venous thrombosis from pre-hospitalization, hospitalization

2018 Clinical Trials

82. Exercise and Motor Learning After Stroke

information, Layout table for eligibility information Ages Eligible for Study: 18 Years to 85 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Age 18-85 Single, unilateral, chronic stroke (>6 months post-stroke), confirmed by MRI or CT scan Score >1 on question 1b and >0 on question 1c of the NIH Stroke Scale Able to walk at self-selected speed without assistance from another person Resting heart rate between 40-100 beats per minute (...) . FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Additional relevant MeSH terms: Layout table for MeSH terms Stroke Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Vascular Diseases Cardiovascular Diseases

2018 Clinical Trials

83. Zero Degree Head Positioning in Hyperacute Large Artery Ischemic Stroke

clinical assessors blinded to the intervention to determine neurologic deterioration on the NIH Stroke Scale Score following positioning to either zero degree or thirty degree heights. Primary Purpose: Treatment Official Title: Zero Degree Head Positioning in Hyperacute Large Artery Ischemic Stroke Actual Study Start Date : September 25, 2018 Estimated Primary Completion Date : June 30, 2022 Estimated Study Completion Date : June 30, 2023 Arms and Interventions Go to Arm Intervention/treatment (...) Infarction Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Vascular Diseases Cardiovascular Diseases Pathologic Processes Brain Infarction Brain Ischemia

2018 Clinical Trials

84. Non-invasive TRanscutaneous Cervical Vagus Nerve Stimulation as a Treatment for Acute Stroke; Safety and Feasibility Study

in NIH Stroke Scale Score) within 24 hours death within 24 hours Other Outcome Measures: Proportion of treatment eligible patients (feasibility measure 1) [ Time Frame: 6 hours ] Proportion of eligible patients in whom nVNS can be started within the first 6 hours. Proportion of patients completing all pre-specified treatment doses (feasibility measure 2) [ Time Frame: 12 hours ] Proportion of enrolled patients who receive all the pre-specified treatment doses per protocol. Stroke onset to treatment (...) ] Local irritation or skin reaction during treatment application Acute coronary syndrome (secondary safety measure 2) [ Time Frame: 24 hours ] Acute coronary syndrome Symptomatic intracerebral hemorrhage (secondary safety measure 3) [ Time Frame: 24 hours ] Symptomatic intracerebral hemorrhage: ≥ 4 points increase in NIH Stroke Scale Score (NIHSS) together with a PH2 (parenchymal hematoma-2) type intracerebral hemorrhage Death, clinical worsening, and acute coronary syndrome (secondary safety measure

2018 Clinical Trials

85. Safety and Effectiveness Evaluation of the ISS System in Treatment of Acute Ischemic Stroke

infarct (pure motor hemiparesis, ataxic hemiparesis, sensorimotor stroke), unless brain imaging demonstrates a relevant lesion > 1.5 cm in size Not a stroke in the anterior circulation Minor stroke with non-disabling deficit or rapidly improving neurological symptoms with a high probably to Transient Ischemic Attack (TIA) Eligible to or treated with IV or IA t-PA or mechanical thrombolysis Baseline NIHSS >20 or < 7 Neurological deficit that has led to stupor or coma (NIHSS level of consciousness score (...) of Cerebral Blood Flow Trial-1. A Pilot Study Evaluating the Safety and Effectiveness of the Ischemic Stroke System for Treatment of Acute Ischemic Stroke Actual Study Start Date : July 6, 2006 Actual Primary Completion Date : January 2009 Actual Study Completion Date : January 2009 Arms and Interventions Go to Arm Intervention/treatment Experimental: Active Stimulation The Implant will be implanted using a minimal invasive approach. Following implantation, a CT localization imaging should be performed

2018 Clinical Trials

86. Enhancement of Stroke Rehabilitation With Levodopa

for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Acute ischemic stroke ≤ 7 days prior to randomization Clinically meaningful hemiparesis (i.e. ≥ 3 points on arm plus leg motor items of the NIH-stroke scale score) 24-hour latency period in case of thrombolysis or thrombectomy In-hospital rehabilitation required Capable to participate in standardized rehabilitation therapy (...) to complete the item using a 3-point ordinal scale (0=cannot perform; 1=performs partially and 2= performs fully). FMMA total scores range from 0 (no movements) to 100 (normal movements) with 66 points for movements of the upper limbs (FMMA-UE) and 34 for those of the lower limbs (FMMA-LE) Secondary Outcome Measures : Change in NIH-Stroke Scale score (NIHSS) [ Time Frame: Assessed at Day 0 (Randomization), 5 weeks after randomization, 3 months +/- 14 days after randomization, 6 months +/- 20 days after

2018 Clinical Trials

87. Dual antiplatelet therapy pretreatment in IV thrombolysis for acute ischemic stroke. (Abstract)

hemorrhage, favorable functional outcome (modified Rankin Scale score 0-1), and 3-month mortality.Among 790 IVT patients, 58 (7%) were on DAPP before stroke (mean age 68 ± 13 years; 57% men; median NIH Stroke Scale score 8). DAPP+ patients were older with more risk factors compared to DAPP- patients. The rates of sICH were similar between groups (3.4% vs 3.2%). In multivariable analyses adjusting for potential confounders, DAPP was associated with higher odds of asymptomatic intracranial hemorrhage (odds (...) Dual antiplatelet therapy pretreatment in IV thrombolysis for acute ischemic stroke. We sought to determine the safety and efficacy of IV thrombolysis (IVT) in acute ischemic stroke (AIS) patients with a history of dual antiplatelet therapy pretreatment (DAPP) in a prospective multicenter study.We compared the following outcomes between DAPP+ and DAPP- IVT-treated patients before and after propensity score matching (PSM): symptomatic intracranial hemorrhage (sICH), asymptomatic intracranial

2018 Neurology

88. Early Findings on Functional Connectivity Correlates of Behavioral Outcomes of Brain-Computer Interface Stroke Rehabilitation Using Machine Learning Full Text available with Trip Pro

found to be important correlates of across several behavioral outcomes and were stable upon inclusion of clinical variables as well. NIH Stroke Scale and motor impairment severity were the most influential clinical variables. Comparatively, linear SVR models aided in evaluation of contribution of individual correlates and seed regions while non-linear SVR models achieved higher performance in prediction of behavioral outcomes. (...) Test, Nine-Hole Peg Test, and Barthel Index as well as subjective measures including the Stroke Impact Scale. The present analysis focused on neuroplasticity and behavioral outcomes measured across pre-intervention, post-intervention and 1-month post-intervention to study immediate and carry-over effects. Rs-FC, changes in rs-FC within the motor network and the behavioral measures at preceding stages were used as input features and behavioral measures and associated changes at succeeding stages

2018 Frontiers in neuroscience

89. Prevalence and factors associated with memory disturbance and dementia after acute ischemic stroke Full Text available with Trip Pro

. The demographics and clinical characteristics, previous illness and past medical history, and laboratory test results of the patients were collected from the medical records, while depression screening, NIH stroke scale (NIHSS) scoring and mini mental state examination (MMSE) were performed using particular medical record forms. The prevalence of memory disturbance and dementia was 56.6, 41.6 and 38.2% before discharge, three and six months after stroke, respectively. Based on logistic regression analysis, age (...) Prevalence and factors associated with memory disturbance and dementia after acute ischemic stroke Prevalence and risk factors associated with memory disturbance and dementia were determined in acute ischemic stroke (AIS) patients in hospitals before discharge, three and six months after stroke. A prospective cohort study was conducted during January-December 2017 with 401 AIS patients admitted to Srinagarind Hospital, Khon Kaen Hospital and Chum Phae Hospital, Khon Kaen, Thailand

2018 Neurology international

90. Commentary: Early Screening Parameters for Dysphagia in Acute Ischemic Stroke Full Text available with Trip Pro

Neuroscience, Sapienza University of Rome, Rome, Italy. eng Journal Article Comment 2018 03 20 Switzerland Front Neurol 101546899 1664-2295 Cerebrovasc Dis. 2017;44(5-6):285-290 28903096 Dysphagia NIH Stroke Scale Stroke 2018 02 05 2018 02 28 2018 4 5 6 0 2018 4 5 6 0 2018 4 5 6 1 epublish 29615955 10.3389/fneur.2018.00148 PMC5869246 Stroke. 1999 Apr;30(4):744-8 10187872 Eur Neurol. 2015;74(3-4):171-7 26492033 Cerebrovasc Dis. 2017;44(5-6):285-290 28903096 (...) Commentary: Early Screening Parameters for Dysphagia in Acute Ischemic Stroke 29615955 2018 11 14 1664-2295 9 2018 Frontiers in neurology Front Neurol Commentary: Early Screening Parameters for Dysphagia in Acute Ischemic Stroke. 148 10.3389/fneur.2018.00148 Toscano Massimiliano M Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy. Viganò Alessandro A Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy. Di Piero Vittorio V Department of Human

2018 Frontiers in neurology

91. Mean Platelet Volume, C-Reactive Protein, and Prognosis in Patients with Acute Ischemic Stroke Following Intravenous Thrombolytic Treatment Full Text available with Trip Pro

received IV thrombolytic treatment. Clinical data were retrieved from electronic medical records. MPV, CRP, and National Institutes of Health (NIH) Stroke Scale and the modified Rankin Scale (MRS) scores for physical disability were recorded. RESULTS Of the 129 patients, 65.9% were men, and more than half received IV thrombolytic treatment within between 3-4.5 hours. The NIH Stroke Scale scores at 24 hours and at three months after hospital admission were compared with the NIH Stroke Scale scores (...) on hospital admission. A significant correlation was found between the MPV values at 24 hours (r=0.221; p=0.012) and at three months after hospital admission (r=196; p=0.026). There was a significant correlation between CRP values at 24 hours (r=0.224; p=0.021), the difference in NIH Stroke Scale score between 24 hours and three months (r=0.249; p=0.005), and the MPV score at three months (r=0.186; p=0.035). CONCLUSIONS MPV and CRP values were significantly associated with improvement in the NIH Stroke

2018 Medical science monitor : international medical journal of experimental and clinical research

92. Racial disparities in refusal of stroke thrombolysis in Chicago. (Abstract)

(adjusted odds ratio [OR] 2.5, 95% confidence interval [CI] 1.3-4.6), self-pay status (adjusted OR 3.23, 95% CI 1.2-8.71), prior stroke (adjusted OR 2.11, 95% CI 1.14-3.90), age (adjusted OR 1.04, 95% CI 1.02-1.07), and NIH Stroke Scale score (adjusted OR 0.94, 95% CI 0.90-0.99).Among tPA-eligible patients with AIS in Chicago, over 7% refused tPA. Refusal was more common in black patients and accounted for the apparent lower rates of tPA use in black vs nonblack patients. Further research is needed (...) Racial disparities in refusal of stroke thrombolysis in Chicago. To evaluate race differences in tissue plasminogen activator (tPA) refusal among eligible patients with acute ischemic stroke (AIS) in Chicago.Using the Get With The Guidelines-Stroke registry data from 15 primary stroke centers between January 2013 and June 2015, we performed a retrospective analysis of patients with AIS presenting to the emergency department within 4.5 hours from symptom onset. Patient or proxy refusal

2018 Neurology

93. Usefulness of ADAMTS13 to predict response to recanalization therapies in acute ischemic stroke. Full Text available with Trip Pro

, NIH Stroke Scale score, and time from stroke onset.Patients who achieved tPA-induced recanalization had higher baseline ADAMTS13 activity (78.1% [68%-88%] vs 70.1% [61%-79%], p = 0.021). In logistic regression analysis, ADAMTS13 activity >75% was an independent predictor of recanalization (odds ratio = 6.76 [1.52-30.02], p = 0.012), together with absence of early ischemic signs and Oxfordshire Community Stroke Project classification. Regarding endovascular therapies, a reduced ADAMTS13 (...) Usefulness of ADAMTS13 to predict response to recanalization therapies in acute ischemic stroke. We aimed to analyze ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) in relation to arterial recanalization in patients treated with IV tissue plasminogen activator (tPA) and in relation to futile recanalization in patients treated with mechanical thrombectomy.Acute ischemic stroke patients (n = 108) with documented arterial occlusions treated with IV-tPA

2018 Neurology

94. Challenge of intravascular volume assessment in acute ischemic stroke. (Abstract)

in the emergency department. Patients with NIH stroke scale ≥4 within 12 h of symptom onset were included. A trained ultrasonographer performed bi-dimensional imaging of the IVC with passive respiration to determine the percent inspiratory collapse and maximum diameter. We defined low intravascular volume as >50% IVC collapse and a maximal diameter < 2.1 cm. Analysis was limited to patients with confirmed ischemic stroke.There were 42 patients, of whom 31 had confirmed acute ischemic stroke. The mean age (...) was 65 ± 15 years, 52% were female, and 71% were hypertensive. The median NIH stroke scale score was 7 (IQR 5-15). Based on IVC ultrasound, low intravascular volume was present in 63% (95% CI 44-80%) of patients. A higher proportion of hypertensive patients had low intrasvascular volume (72% vs. 33%). There was poor correlation between IVC assessment of intrasvascular volume and blinded clinician assessment or laboratory markers of dehydration.The majority of ED acute ischemic stroke patients

2018 American Journal of Emergency Medicine

95. Antiplatelet vs R-tPA for Acute Mild Ischemic Stroke

-2) [ Time Frame: 90±7 days ] change in NIH Stroke Scale score compared with baseline [ Time Frame: 24 hours ] incidence of early neurological improvement [ Time Frame: 24 hours ] more than 2 NIH Stroke Scale score decrease compared with baseline Incidence of early neurological deterioration [ Time Frame: 7 days ] more than 2 NIH Stroke Scale score increase (not result of cerebral hemorrhage) compared with baseline occurrence of stroke or other vascular events [ Time Frame: 90±7 days ] proportion (...) Verified: October 2018 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: No Layout table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Additional relevant MeSH terms: Layout table for MeSH terms Stroke Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Vascular Diseases Cardiovascular Diseases Aspirin Tissue Plasminogen Activator Clopidogrel Anti-Inflammatory

2018 Clinical Trials

96. Left Atrial Appendage Occlusion Versus Novel Oral Anticoagulation for Stroke Prevention in Atrial Fibrillation

documented non-valvular atrial fibrillation (paroxysmal, persistent or permanent) Eligible for long-term Novel Oral Anticoagulation (NOAC) therapy Ischemic stroke within the recent 6 months verified by neuroimaging, or Transient ischemic attack within 6 months with proven cerebral ischemia based on cerebral magnetic resonance imaging (MRI) Exclusion Criteria: Modified rankin scale > 3 at time of enrollment Glomerular filtration rate (GFR) below 15 ml/min/1.73 m2 Contraindication towards long-term aspirin (...) with novel oral anticoagulants (NOAC) have not been carried out. This study aims to assess the effect of left atrial appendage occlusion (LAAO) to reduce the incidence of stroke, systemic embolism, major bleeding and all-cause mortality in patients with atrial fibrillation (AF) and a prior ischemic stroke or transient ischemic attack (TIA). Condition or disease Intervention/treatment Phase Atrial Fibrillation Stroke Device: Left atrial appendage occlusion Drug: NOAC Not Applicable Detailed Description

2018 Clinical Trials

97. Repeated Muscle Vibration in Acute Stroke

are recorded. All patients undergo a clinical examination, performed at all time-points by an experienced investigator, blinded to group assignment and different from the recruiting one. Clinical evaluation consists of stroke severity evaluation, by means of NIH Stroke Scale; motor and functional limbs abilities are evaluated by using both the Fugl-Meyer scale and the Motricity Index; post-stroke spasticity is assessed with Ashworth scale, modified by Bohannon and Smith. All participants undergo a daily (...) corresponds to normal traction (66 points for the upper limb, 34 for the lower one) and a minimum score of 0 (no traction) Stroke Recovery [ Time Frame: 4 ± 1 days ] Stroke recovery is expressed as the differences over time (from T-0 to T-1) between the two groups concerning NIH Stroke Scale scores. This scale assesses the stroke severity; it consists of 11 items and the total score goes from a minimum of 0 = normal neurological examination at a maximum of 42, severe severe neurological deficit

2018 Clinical Trials

98. Who should undergo a comprehensive cognitive assessment after a stroke? A cognitive risk score. Full Text available with Trip Pro

Disorders and Stroke-Canadian Stroke Network battery 6 months after stroke, we used multivariable logistic regression and bootstrap analyses to determine factors associated with NCDs. Independent, internally validated factors were included in a cognitive risk score.Cognitive impairment was present in 170 of the 320 patients with a Rankin Scale score ≥1. The backward logistic regression selected 4 factors (≥73% of the permutations): NIH Stroke Scale score on admission ≥7 (odds ratio [OR] 2.73, 95 (...) Who should undergo a comprehensive cognitive assessment after a stroke? A cognitive risk score. To validate the ability of a specifically developed cognitive risk score to identify patients at risk of poststroke neurocognitive disorders (NCDs) who are eligible for a comprehensive cognitive assessment.After assessing 404 patients (infarct 91.3%) in the Groupe de Réflexion pour l'Evaluation Cognitive VASCulaire (GRECogVASC) cross-sectional study with the National Institute of Neurological

2018 Neurology

99. TEC4Home Stroke

Systolic Hypertension Transient Ischemic Attack Cerebrovascular Accident Detailed Description: The investigators propose a two-year pilot study (TEC4Home Stroke) to assess the feasibility of using home telemonitoring technology in managing hypertension among patients with minor stroke/TIA (NIH Stroke Scale Score <5) at the VGH Stroke Prevention Clinic (SPC). The Vancouver Stroke Program SPC receives 1200 referrals per year for assessment of patients with strokes or TIAs. Of the total number of patients (...) Drug Product: No Studies a U.S. FDA-regulated Device Product: No Keywords provided by Karina Villaluna Murray, Vancouver Coastal Health Research Institute: Hypertension management Stroke Secondary Prevention Modifiable stroke risk factor Home blood pressure monitoring system Telehealth Telus Health Telemonitoring Systolic hypertension Cerebrovascular Accident TIA Additional relevant MeSH terms: Layout table for MeSH terms Hypertension Stroke Ischemic Attack, Transient Vascular Diseases

2018 Clinical Trials

100. China Antihypertensive Trial in Acute Ischemic Stroke II

terms Stroke Ischemia Cerebral Infarction Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Vascular Diseases Cardiovascular Diseases Pathologic Processes Brain Infarction Brain Ischemia Antihypertensive Agents (...) antihypertensive treatment with a BP goal of <140/90 mmHg. The primary study endpoint is a composite outcome of death and major disability at three months. The major secondary endpoint will be the first recurrent stroke (hemorrhagic or ischemic) over three-month follow-up after randomization. Other secondary endpoints include ordered 7-level categorical score of the modified Rankin Scale, all-cause mortality, major vascular events, cognitive impairment, and health-related quality of life at three months

2018 Clinical Trials

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