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1. COVID-19 deaths in England and Wales: resolving discrepancies in deaths outside of hospital

issues about data collected in England and Wales. Both of these suggest potential areas of concern in non-hospital settings. First, many more individuals, compared to a baseline of the weekly five-year average, appear to be dying at home. Second, a large discrepancy is apparent in COVID-19 deaths according to whether these are measured using a death certificate-based method or a positive test-based method. Explaining these issues has implications for public policy regarding COVID-19 mitigation (...) COVID-19 deaths in England and Wales: resolving discrepancies in deaths outside of hospital COVID-19 deaths in England and Wales: resolving discrepancies in deaths outside of hospital - CEBM CEBM The Centre for Evidence-Based Medicine develops, promotes and disseminates better evidence for healthcare. Navigate this website COVID-19 deaths in England and Wales: resolving discrepancies in deaths outside of hospital July 28, 2020 Daniel Howdon, Carl Heneghan We note two potentially important

2020 Oxford COVID-19 Evidence Service

2. Estimate of the economic costs and literature review of the benefits of dedicated research time for Hospital Consultants in the NHS

://www.rcplondon.ac.uk/guidelines-policy/delivering-research-all-expectations-and-aspirations- nhs-england Section 3 15 Downing et al (2016) tested the hypothesis that high, sustained hospital-level participation in interventional clinical trials improves outcomes for patients, using colorectal cancer as an example. Patients treated in Trusts with high research participation in their year of diagnosis had lower postoperative mortality (p<0.001) and improved survival (p<0.001) after adjustment for casemix (...) Estimate of the economic costs and literature review of the benefits of dedicated research time for Hospital Consultants in the NHS Providing consultancy and research in health economics for the NHS, pharmaceutical and health care industries since 1986 THE ACADEMY OF MEDICAL SCIENCES Estimate of the economic costs and literature review of the benefits of dedicated research time for Hospital Consultants in the NHS Final Report NICK HEX, Associate Director CAMERON COLLINS, Research Consultant

2020 Academy of Medical Sciences

3. Variations in mortality across the week following emergency admission to hospital: linked retrospective observational analyses of hospital episode data in England, 2004/5 to 2013/14 Full Text available with Trip Pro

Variations in mortality across the week following emergency admission to hospital: linked retrospective observational analyses of hospital episode data in England, 2004/5 to 2013/14 Variations in mortality across the week following emergency admission to hospital: linked retrospective observational analyses of hospital episode data in England, 2004/5 to 2013/14 Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry (...) - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} Mortality rates are higher during weekend and night-time admissions largely due to sicker patients selected for admission, and extending services for key specialties over critical periods is likely to be the most cost-effective approach. {{author

2017 NIHR HTA programme

4. From ward to washer: The survival of Clostridium difficile spores on hospital bed sheets through a commercial UK NHS healthcare laundry process. Full Text available with Trip Pro

From ward to washer: The survival of Clostridium difficile spores on hospital bed sheets through a commercial UK NHS healthcare laundry process. To quantify the survival of Clostridium difficile spores on hospital bed sheets through the United Kingdom National Health System (UK NHS) healthcare laundry process (Health Technical Memorandum (HTM) 01-04) in vitro and on bed sheets from patients with C. difficile through the commercial laundry.Clostridium difficile spores were inoculated onto cotton (...) sheets and laundered through a simulated washer extractor cycle using an industrial bleach detergent with sodium hypochlorite 15% and peracetic acid sour 14% (acetic acid and hydrogen peroxide; pH, 2-4). Spore survival on hospital sheets naturally contaminated with C. difficile was also assessed using a washer extractor plus drying and finishing cycles at a commercial laundry.PatientsNaturally contaminated C. difficile bed sheets were taken from beds of patients that had previously been diagnosed

2018 Infection control and hospital epidemiology

5. Interventions to reduce mortality from in-hospital cardiac arrest: a mixed-methods study Full Text available with Trip Pro

Interventions to reduce mortality from in-hospital cardiac arrest: a mixed-methods study Interventions to reduce mortality from in-hospital cardiac arrest: a mixed-methods study Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue (...) }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} Standardisation and automation of the collection, interpretation and response to patient physiological observations may have the greatest potential to reduce avoidable mortality from in-hospital cardiac arrest. {{author}} {{($index , , , , , , & . Helen Hogan 1, * , Andrew Hutchings 1 , Jerome Wulff 2 , Catherine Carver 1 , Elizabeth Holdsworth 1 , John Welch 3 , David Harrison 2 , Nick Black 1 1 Department of Health Services Research

2019 NIHR HTA programme

6. Nurse staffing levels, missed vital signs and mortality in hospitals: retrospective longitudinal observational study Full Text available with Trip Pro

Nurse staffing levels, missed vital signs and mortality in hospitals: retrospective longitudinal observational study Nurse staffing levels, missed vital signs and mortality in hospitals: retrospective longitudinal observational study Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find (...) and Informatics, University of Portsmouth, Portsmouth, UK 6 Independent lay researcher c/o National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care, Southampton, UK 7 Clinical Outcomes Research Group, Portsmouth Hospitals NHS Trust, Queen Alexandra Hospital, Portsmouth, UK 8 Health and Social Sciences, Bournemouth University, Bournemouth, UK * Corresponding author Email: {{metadata.Journal}} Volume: {{metadata.Volume}}, Issue: {{metadata.Issue}}, Published

2018 NIHR HTA programme

7. The NHS at 70: How good is the NHS?

in a thousand people are admitted to hospital for diabetes in a given year, compared to over two in a thousand admitted in Austria or Germany. Key weaknesses include: The UK’s NHS performs worse than the average in the treatment of eight out of the 12 most common causes of death, including deaths within 30 days of having a heart attack and within five years of being diagnosed with breast cancer, rectal cancer, colon cancer, pancreatic cancer and lung cancer, despite narrowing the gap in recent years (...) . It is the third-poorest performer compared to the 18 developed countries on the overall rate at which people die when successful medical care could have saved their lives (known as ‘amenable mortality’). It has consistently higher rates of death for babies at birth or just after (perinatal mortality), and in the month after birth (neonatal mortality): seven in 1,000 babies died at birth or in the week afterwards in the UK in 2016, compared to an average of 5.5 across the comparator countries. Given limited

2018 The King's Fund

8. Evaluating the impact of cycle helmet use on severe traumatic brain injury and death in a national cohort of over 11000 pedal cyclists: a retrospective study from the NHS England Trauma Audit and Research Network dataset. Full Text available with Trip Pro

Evaluating the impact of cycle helmet use on severe traumatic brain injury and death in a national cohort of over 11000 pedal cyclists: a retrospective study from the NHS England Trauma Audit and Research Network dataset. In the last 10 years there has been a significant increase in cycle traffic in the UK, with an associated increase in the overall number of cycling injuries. Despite this, and the significant media, political and public health debate into this issue, there remains an absence (...) of studies from the UK assessing the impact of helmet use on rates of serious injury presenting to the National Health Service (NHS) in cyclists.The NHS England Trauma Audit and Research Network (TARN) Database was interrogated to identify all adult (≥16 years) patients presenting to hospital with cycling-related major injuries, during a period from 14 March 2012 to 30 September 2017 (the last date for which a validated dataset was available).11 patients met inclusion criteria. Data on the use of cycling

2019 BMJ open

9. Transforming health through innovation: Integrating the NHS and academia - supporting case studies

contributions to the advancement of patient care since the inception of the NHS. The list is not exhaustive, and additional examples can be found in the resources listed in Reference 1. 1 1940s Development of penicillin as a drug The antibiotic properties of the Penicillium mould were first discovered by Sir Alexander Fleming FRS FRSE in 1928 in his laboratory in St Mary’s Hospital in London. Ground-breaking work by Sir Ernst Chain FRS and Lord Florey OM FRS in the 1940s to purify and extract penicillin (...) to the NHS of £10,943, approximately 13% of total wound care costs. 58 Feedback to prescribers about prescribing errors Research at Imperial College Healthcare NHS Trust into the nature and causes of prescribing errors in hospital inpatients identified the lack of feedback on individual prescribers’ errors as a key issue. The group explored the acceptability of different approaches to receiving feedback, which led to the implementation of a new approach within the organisation, as well as in other NHS

2020 Academy of Medical Sciences

10. The impact of a social norms approach on reducing levels of misperceptions around smokefree hospital entrances amongst patients, staff, and visitors of a NHS hospital: a repeated cross-sectional survey study. Full Text available with Trip Pro

The impact of a social norms approach on reducing levels of misperceptions around smokefree hospital entrances amongst patients, staff, and visitors of a NHS hospital: a repeated cross-sectional survey study. Smoking is a cause of avoidable morbidity and mortality. In the United Kingdom (UK) the national smoking ban inside hospital buildings is widely adhered to. There is a perception it has led to smokers congregating around hospital entrances (Selbie D. 2016, It's time for a truly smokefree (...) NHS. Public Health Matters Blog. Public Health England). Efforts to shift social norms and create positive smokefree environments might be strengthened by delivering social norms messages. This study explored the impact of a social norms approach campaign to reduce levels of misperceptions surrounding support for smokefree hospital entrances.Repeated cross sectional study design. Staff, patients, and hospital visitors at Pinderfields National Health Service (NHS) Hospital (Wakefield, United

2018 BMC Public Health

11. Epidemiology and health-economic burden of urinary catheter-associated infection in English NHS hospitals: a probabilistic modelling study. Full Text available with Trip Pro

Epidemiology and health-economic burden of urinary catheter-associated infection in English NHS hospitals: a probabilistic modelling study. Catheter-associated urinary tract infection (CAUTI) and bloodstream infection (CABSI) are leading causes of healthcare-associated infection in England's National Health Service (NHS), but health-economic evidence to inform investment in prevention is lacking.To quantify the health-economic burden and value of prevention of urinary catheter-associated (...) analyses were conducted.The model estimated 52,085 (95% uncertainty interval: 42,967-61,360) CAUTIs and 7,529 (6,857-8,622) CABSIs, of which 38,084 (30,236-46,541) and 2,524 (2,319-2,956) were hospital-onset infections, respectively. Catheter-associated infections incurred 45,717 (18,115-74,662) excess bed-days, 1,467 (1,337-1,707) deaths and 10,471 (4,783-13,499) lost QALYs. Total direct hospital costs were estimated at £54.4M (£37.3M-£77.8M), with an additional £209.4M (£95.7M-£270.0M) in economic

2019 Journal of Hospital Infection

12. Does regulation increase the rate at which doctors leave practice? Analysis of routine hospital data in the English NHS following the introduction of medical revalidation. Full Text available with Trip Pro

Does regulation increase the rate at which doctors leave practice? Analysis of routine hospital data in the English NHS following the introduction of medical revalidation. In 2012, the UK introduced medical revalidation, whereby to retain their licence all doctors are required to show periodically that they are up to date and fit to practise medicine. Early reports suggested that some doctors found the process overly onerous and chose to leave practice. This study investigates the effect (...) of medical revalidation on the rate at which consultants (senior hospital doctors) leave NHS practice, and assesses any differences between the performance of consultants who left or remained in practice before and after the introduction of revalidation.We used a retrospective cohort of administrative data from the Hospital Episode Statistics database on all consultants who were working in English NHS hospitals between April 2008 and March 2009 (n = 19,334), followed to March 2015. Proportional hazard

2019 BMC Medicine

13. Associations of 4AT with mobility, length of stay and mortality in hospital and discharge destination among patients admitted with hip fractures Full Text available with Trip Pro

Trust, Surrey KT16 0PZ, UK. 7 Institute of Cardiovascular Research, Royal Holloway, University of London, Surrey TW20 0EX, UK. 8 Department of Clinical Neuroscience, Imperial College Healthcare NHS Trust, London W6 8RF, UK. 9 School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol BS8 1TD, UK. PMID: 31813951 DOI: Item in Clipboard Associations of 4AT With Mobility, Length of Stay and Mortality in Hospital and Discharge Destination Among Patients Admitted With Hip (...) , 95%CI = 1.2-8.2) but not with a 4AT score of 1-3. Change of residence on discharge was increased with a 4AT score ≥ 4 (OR = 3.1, 95%CI = 1.4-6.8). These associations persisted after excluding patients with dementia. 4AT score = 1-3 and ≥ 4 associated with increased LOS by 3 and 6 days, respectively. Conclusions: for older adults with hip fracture, the 4AT independently predicts immobility, prolonged LOS, death in hospital and change in residence on discharge. Keywords: NHS; cognitive function

2020 EvidenceUpdates

14. National Early Warning Score 2 (NEWS2) on admission predicts severe disease and in-hospital mortality from Covid-19 - a prospective cohort study Full Text available with Trip Pro

National Early Warning Score 2 (NEWS2) on admission predicts severe disease and in-hospital mortality from Covid-19 - a prospective cohort study National Early Warning Score 2 (NEWS2) on admission predicts severe disease and in-hospital mortality from Covid-19 - a prospective cohort study - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily (...) predicts severe disease and in-hospital mortality from Covid-19 - a prospective cohort study , , , , , , Affiliations Expand Affiliations 1 Department of Internal Medicine, Bærum Hospital Vestre Viken Hospital Trust, N-1346, Gjettum, Norway. marius.myrstad@vestreviken.no. 2 Department of Medical Research, Bærum Hospital Vestre Viken Hospital Trust, N-1346, Gjettum, Norway. marius.myrstad@vestreviken.no. 3 Department of Internal Medicine, Bærum Hospital Vestre Viken Hospital Trust, N-1346, Gjettum

2020 EvidenceUpdates

15. Implementing phase 3 of the NHS response to the COVID-19 pandemic

-pathways/advancing-mental-health-equality 7 https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/892376/COVID _stakeholder_engagement_synthesis_beyond_the_data.pdf Classification: Official 10 | Implementing Phase 3 of the NHS response to the COVID-19 pandemic retrospectively updating and completing the COVID-19 Hospital Episode Surveillance System (CHESS) is essential. Specific action is needed to improve the recording of ethnicity within general practice. We (...) – Regional Director, Public Health England Donna Hall CBE – Chair, New Local Government Network Classification: Official 12 | Implementing Phase 3 of the NHS response to the COVID-19 pandemic Jacob Lant – Head of Policy and Public Affairs, Healthwatch England Patricia Miller – CEO, Dorset County Hospital NHS Foundation Trust Patrick Nyarumbu – Regional Director of Nursing Leadership and Quality, NHS England and NHS Improvement Jagtar Singh – Chair of Coventry and Warwickshire Partnership NHS Trust Robin

2020 NHS England

16. Acute myocardial infarction hospital admissions and deaths in England: a national follow-back and follow-forward record-linkage study Full Text available with Trip Pro

in the knowledge about deaths and hospital admissions due to acute myocardial infarction.We used individually linked national hospital admission and mortality data for England from 2006 to 2010 to identify all primary and comorbid diagnoses of acute myocardial infarction during hospital stay and their associated fatality rates (during or within 28 days of being in hospital). Data were obtained from the UK Small Area Health Statistics Unit and supplied by the Health and Social Care Information Centre (now NHS (...) Acute myocardial infarction hospital admissions and deaths in England: a national follow-back and follow-forward record-linkage study Little information is available on how primary and comorbid acute myocardial infarction contribute to the mortality burden of acute myocardial infarction, the share of these deaths that occur during or after a hospital admission, and the reasons for hospital admission of those who died from acute myocardial infarction. Our aim was to fill in these gaps

2017 The Lancet. Public health

17. Portable Normothermic Cardiac Perfusion System in Donation After Cardiocirculatory Death

Technology Assessment Series; Vol. 20: No. 3, pp. 1–90, March 2020 10 Neurological determination of death (NDD) donors who are without known risk factors that can impact transplant outcomes are referred to as standard criteria donors (e.g., donors aged 50% before WLST Primary: 90-day survival Secondary: Cardiac performance Need for support (inotropic, mechanical, or ventilator) Rejection episodes Length of stay: ICU and hospital García-Sáez et al, 2016 40 United Kingdom (Harefield Hospital) Case series 2 (...) a DCD hearts procured via NRP + OCS Maastricht category III DCD Age: 16–50 years Consent: provided by next of kin or is on organ donation register Description of clinical course Dhital et al, 2015 39 Australia (St. Vincent’s Hospital) Case series 3 DCD hearts procured via DPP + OCS Maastricht category III DCD Age: .05 for both; Table 3). 36 The causes of the two deaths in the NRP subgroup at POD 31 and POD 88 are described in Table 2. No information was provided on the survival of these subgroups

2020 Health Quality Ontario

18. Reconciling COVID-19 death rate in the UK

at 2 pm every day; Deaths outside NHS services are not included. Reporting The Public Health England dashboard ( ) extracts data at 5 pm each day and reports the following day, so numbers visible on the 8 th April are current for the 7 th of April. NHS England releases data at 2 pm each day and reports daily count up to the previous day as well as a total figure. The ONS mortality statistics are compiled from information supplied when deaths are certified and registered as part of civil (...) registration and so released much later. This is because deaths can be registered five days after the death date (longer, if it is referred to a coroner for investigation). As of the 31 st March, the ONS issues a report every Tuesday, and their data includes cases from outside hospital and cases where COVID-19 is suspected, but no formal diagnostic test has taken place. ONS reports include data a week before the publish date and daily death numbers for the end of the previous week. Hence the report

2020 Oxford COVID-19 Evidence Service

19. COVID-19 Death Data in England

COVID-19 Death Data in England COVID-19 death data in England - Update 9th April - CEBM CEBM The Centre for Evidence-Based Medicine develops, promotes and disseminates better evidence for healthcare. Navigate this website COVID-19 death data in England – Update 9th April April 9, 2020 Jason Oke, Carl Heneghan NHS England releases data at 2 pm each day and reports daily counts up to the previous day as well as a total figure. We wrote about the problems with reconciling the different data (...) : Today’s figure is 765 deaths in hospitals in England These deaths are distributed across the following days: Figure 2 shows the updated counts by date of death in England Summary Daily reports generally add more to the previous two days (up to a maximum 300 deaths), and can add back to the previous week’s counts (the grey shaded area in figure 2). We consider the data is now flatlining consistent with hitting the peak.* *Inaccuracies in the data can give rise to considerable uncertainties. See also

2020 Oxford COVID-19 Evidence Service

20. Five Don'ts to Prevent Novel Coronavirus Infection (COVID-19) and Death - part 2

, bleeding with melena. In addition, intestinal bacteria can enter the blood stream through injured mucosal membranes and be translocated throughout the body, causing severe systemic infections (bacteremia and sepsis). During the last influenza season (2018/19), 4.27 million patients with influenza were prescribed with Xofluza. Total 37 death cases were reported by doctors who suspected these deaths may be related to the drug. Mortality rate is at least 1 in 120,000. For those over 60 years of age (...) , mortality rate was 1 in 80,000. There were no reports of deaths among 3 million inhaler users, such as Relenza and Inavir. .Page 22 · MED CHECK April 2020/ Vol.6 No.17 The novel coronavirus is transmitted not only from the respiratory tract such as the lungs, but also from the mouth and enters the gastrointestinal tract. If the intestine is injured with Xofluza, intestinal mucosa is easily infected with novel coronaviruses. As described in detail in the next section, the enzyme called ACE2, which acts

2020 Med Check - The Informed Prescriber

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