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Myxedema Coma

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1. Amiodarone induced myxedema coma: Two case reports and literature review. (Abstract)

Amiodarone induced myxedema coma: Two case reports and literature review. Amiodarone is a benzofuran derivative that contains 37% iodine by weight and is structurally similar to the thyroid hormones. Amiodarone has a complex effect on the thyroid gland, ranging from abnormalities of thyroid function tests to overt thyroid dysfunction, with either thyrotoxicosis or hypothyroidism. Myxedema coma secondary to amiodarone use has been rarely reported in the literature. Our two case reports (...) are an add on to the literature, and illustrate that amiodarone is an important cause of thyroid dysfunction including hypothyroidism and myxedema coma. Hence, healthcare providers should have a high index of suspicion for these conditions while treating patients who are taking amiodarone therapy as early recognition and management are essential to optimize outcomes.Copyright © 2018 Elsevier Inc. All rights reserved.

2018 Heart & Lung

2. Myxedema Coma Following the Administration of Gonadotropin-releasing Hormone Agonist Complicated by Acute Pancreatitis Full Text available with Trip Pro

Myxedema Coma Following the Administration of Gonadotropin-releasing Hormone Agonist Complicated by Acute Pancreatitis Gonadotropin-releasing hormone (GnRH) agonists have been used for the treatment of various diseases. Although autoimmune thyroid disease has been reported as a rare complication of these agents, the symptoms are almost always transient and non-life-threatening. We herein report a rare case of an 83-year-old man receiving GnRH agonist treatment for prostate cancer who developed (...) myxedema coma complicated by acute pancreatitis. This is the first report of myxedema coma potentially associated with a GnRH agonist. The follow-up of the thyroid function is necessary for patients undergoing treatment with GnRH agonists, especially those known to have or to be susceptible to autoimmune thyroid disease.

2018 Internal Medicine

3. Diagnosis of myxedema coma complicated by renal failure: a case report Full Text available with Trip Pro

Diagnosis of myxedema coma complicated by renal failure: a case report Myxedema coma, caused by severe lack of thyroid hormone, is characterized by deterioration of mental status, hypothermia, hypotension, hyponatremia, and hypoventilation. We describe an 84-year-old woman who presented with renal failure and new onset severe hypothyroidism leading to challenges in the recognition of myxedema coma.

2017 Clinical Case Reports

4. Sudden cardiac arrest as a rare presentation of myxedema coma: case report Full Text available with Trip Pro

Sudden cardiac arrest as a rare presentation of myxedema coma: case report Myxedema coma is a decompensated hypothyroidism which occurs due to long-standing, undiagnosed, or untreated hypothyroidism. Untreated hypothyroidism is known to affect almost all organs including the heart. It is associated with a decrease in cardiac output, stroke volume due to decreased myocardial contractility, and an increase in systemic vascular resistance. It can cause cardiac arrhythmias and the most commonly (...) seen conduction abnormalities are sinus bradycardia, heart block, ventricular tachycardia, and torsade de pointes. The authors report a case of an elderly man who presented with sudden cardiac arrest and myxedema coma and who was successfully revived.

2017 Journal of community hospital internal medicine perspectives

5. Split high‐dose oral levothyroxine treatment as a successful therapy option in myxedema coma Full Text available with Trip Pro

Split high‐dose oral levothyroxine treatment as a successful therapy option in myxedema coma High-dose intravenous thyroxine (T4) is the preferable treatment for myxedema coma. We describe the clinical course of a 69-year-old man who presented with myxedema coma and received oral levothyroxine (LT4) therapy (1 mg) in a split dose. This suggests split high-dose oral LT4 as a therapeutic option in myxedema coma.

2017 Clinical Case Reports

6. Thoracentesis-reverting cardiac tamponade physiology in a patient with myxedema coma and large pleural effusion Full Text available with Trip Pro

Thoracentesis-reverting cardiac tamponade physiology in a patient with myxedema coma and large pleural effusion A large pleural effusion causing cardiac tamponade physiology and severe hemodynamic compromise is an uncommon event. We report a case of a 53-year-old woman with severe hypothyroidism presenting with myxedema coma and refractory shock. Her hemodynamic status failed to respond to fluid resuscitation and vasopressors. A transthoracic echocardiogram and chest radiograph demonstrated

2017 Proceedings (Baylor University. Medical Center)

7. Clinical characteristics and outcomes of myxedema coma: Analysis of a national inpatient database in Japan Full Text available with Trip Pro

Clinical characteristics and outcomes of myxedema coma: Analysis of a national inpatient database in Japan Myxedema coma is a life-threatening and emergency presentation of hypothyroidism. However, the clinical features and outcomes of this condition have been poorly defined because of its rarity.We conducted a retrospective observational study of patients diagnosed with myxedema coma from July 2010 through March 2013 using a national inpatient database in Japan. We investigated characteristics (...) , comorbidities, treatments, and in-hospital mortality of patients with myxedema coma.We identified 149 patients diagnosed with myxedema coma out of approximately 19 million inpatients in the database. The mean (standard deviation) age was 77 (12) years, and two-thirds of the patients were female. The overall proportion of in-hospital mortality among cases was 29.5%. The number of patients was highest in the winter season. Patients treated with steroids, catecholamines, or mechanical ventilation showed higher

2017 Journal of Epidemiology

8. Myxedema coma: A case report of pediatric emergency care. Full Text available with Trip Pro

Myxedema coma: A case report of pediatric emergency care. Myxedema coma (MC) is extremely rare but lethal in pediatric patients with hypothyroidism leading to altered mental status and hypothermia. But there is no clinical guideline for such cases.A 6-year-old Chinese girl presented with coma and hypothermia preceded by pneumonia. Her lab results were: free thyroxin (T4) 4.18 pmol/L and thyroid-stimulating hormone (TSH) > 150 μIU/mL with extremely elevated anti-thyroid peroxidase (TPO-Ab

2017 Medicine

9. Myxedema Coma

Myxedema Coma Myxedema Coma Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Myxedema Coma Myxedema Coma Aka: Myxedema Coma From (...) to external sites (from Bing) These images are a random sampling from a Bing search on the term "Myxedema Coma." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Myxedema coma (C0238298) Concepts Disease or Syndrome ( T047 ) ICD10 SnomedCT 190292006 , 21263006 Italian Coma da mixedema French Coma de myxoedème , Coma myxoedèmateux Portuguese Coma de mixedema , Coma mixedematoso Spanish Coma por mixedema , coma

2018 FP Notebook

10. Morbidity and Mortality Risks of Premature Enteral Nutrition During the Recovery of Myxedema Coma (A Response to the Article Entitled “Pediatric Patient With Altered Mental Status and Hypoxemia”) Full Text available with Trip Pro

Morbidity and Mortality Risks of Premature Enteral Nutrition During the Recovery of Myxedema Coma (A Response to the Article Entitled “Pediatric Patient With Altered Mental Status and Hypoxemia”) 27583414 2017 04 24 2018 11 13 1535-1815 32 10 2016 10 Pediatric emergency care Pediatr Emerg Care Morbidity and Mortality Risks of Premature Enteral Nutrition During the Recovery of Myxedema Coma (A Response to the Article Entitled "Pediatric Patient With Altered Mental Status and Hypoxemia"). 738

2016 Pediatric Emergency Care

11. An Atypical Case of Myxedema Coma with Concomitant Nonconvulsive Seizure Full Text available with Trip Pro

An Atypical Case of Myxedema Coma with Concomitant Nonconvulsive Seizure Hypothyroidism is a prevalent condition in the general population that is treatable with appropriately dosed thyroid hormone replacement medication. Infrequently, patients will present with myxedema coma, characterized by hypothermia, hypotension, bradycardia, and altered mental status in the setting of severe hypothyroidism. Myxedema coma has also been known to manifest in a number of unusual and dangerous forms. Here, we (...) present the case of a woman we diagnosed with an uncharacteristic expression of myxedema coma and nonconvulsive seizure complicated by a right middle cerebral artery infarct.

2016 Case reports in critical care

12. A Rare Case of Myxedema Coma with Neuroleptic Malignant Syndrome (NMS) Full Text available with Trip Pro

A Rare Case of Myxedema Coma with Neuroleptic Malignant Syndrome (NMS) Myxedema coma or hypothyroid crisis is an endocrine emergency and needs ICU management. Neuroleptic malignant syndrome (NMS) is another medical emergency which needs high degree of clinical suspicion else mortality can be high. There is a paradox in co existence of myxedema coma and NMS. While one is hypometabolic state another is hypermetabolic state and both can be precipitated by antipsychotics use. Hypothermia (...) and flaccidity commonly expected in myxedema coma may mask fever and rigidity of classical NMS contributing to diagnostic problem and treatment delay. Scientific literature on coexistance of myxedema coma and NMS is sparse. We hereby report first case with coexisting myxedema coma and NMS in a patient of schizophrenia treated with antipsychotic, where classical symptoms of NMS were masked by myxedema coma. Prompt diagnosis and effective management by a team resulted in favourable outcome in our patient

2015 Journal of clinical and diagnostic research : JCDR

13. Treatment of Myxedema and Myxedema Coma Full Text available with Trip Pro

Treatment of Myxedema and Myxedema Coma 18747713 2010 06 30 2018 11 13 0093-0415 124 6 1976 Jun The Western journal of medicine West. J. Med. Treatment of myxedema and myxedema coma. 485 Abrass I B IB eng Journal Article United States West J Med 0410504 0093-0415 1976 6 1 0 0 1976 6 1 0 1 1976 6 1 0 0 ppublish 18747713 PMC1130108 N Engl J Med. 1974 Mar 7;290(10):529-33 4811096 Arch Intern Med. 1964 Jan;113:89-96 14067598 Am J Med Sci. 1971 Jan;261(1):46-50 4939220 Med Clin North Am. 1968 Mar;52

1976 Western Journal of Medicine

14. Myasthenic Crisis Complicated with Myxedema, Positive for Both Anti-acetylcholine Receptor and Anti-muscle-specific Tyrosine Kinase Antibodies Full Text available with Trip Pro

Myasthenic Crisis Complicated with Myxedema, Positive for Both Anti-acetylcholine Receptor and Anti-muscle-specific Tyrosine Kinase Antibodies We herein report the case of myasthenic crisis occurring in a 51-year-old man. He had experienced ptosis, increased body weight with edema, and fatigue with dyspnea. He presented at our emergency department with disturbed consciousness. He was originally diagnosed with myxedema coma, and he required artificial respiration. Because his weakness persisted (...) and he was positive for anti-acetylcholine receptor antibodies and anti-muscle-specific tyrosine kinase antibodies, we diagnosed myasthenic crisis after various examinations. His clinical response to treatment was good and he was discharged in an ambulatory status 3 months after admission. This case demonstrates that myasthenic crisis may occur in association with myxedema.

2017 Internal Medicine

15. Myxedema Coma or Crisis (Follow-up)

Myxedema Coma or Crisis (Follow-up) Myxedema Coma or Crisis Treatment & Management: Medical Care, Surgical Care, Consultations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTIzNTc3LXRyZWF0bWVudA== processing (...) > Myxedema Coma or Crisis Treatment & Management Updated: Oct 10, 2018 Author: Mohsen S Eledrisi, MD, FACP, FACE; Chief Editor: George T Griffing, MD Share Email Print Feedback Close Sections Sections Myxedema Coma or Crisis Treatment Medical Care Myxedema coma is a medical emergency that requires immediate attention. If the diagnosis is suspected, immediate management is necessary before confirming the diagnosis due to the high associated mortality rate. Patients with myxedema coma should be managed

2014 eMedicine.com

16. Hypothyroidism and Myxedema Coma (Diagnosis)

Hypothyroidism and Myxedema Coma (Diagnosis) Hypothyroidism and Myxedema Coma: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNzY4MDUzLW92ZXJ2aWV3 processing (...) > Hypothyroidism and Myxedema Coma Updated: Feb 26, 2018 Author: Erik D Schraga, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP Share Email Print Feedback Close Sections Sections Hypothyroidism and Myxedema Coma Overview Background is a clinical syndrome in which the deficiency or absence of thyroid hormone slows bodily metabolic processes. Symptoms can manifest in all organ systems and range in severity based on the degree of hormone deficiency. The disease typically progresses over months to years but can

2014 eMedicine Emergency Medicine

17. Hypothyroidism and Myxedema Coma (Follow-up)

Hypothyroidism and Myxedema Coma (Follow-up) Hypothyroidism and Myxedema Coma Follow-up: Further Inpatient Care, Complications, Prognosis Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNzY4MDUzLWZvbGxvd3Vw (...) processing > Hypothyroidism and Myxedema Coma Follow-up Updated: Feb 26, 2018 Author: Erik D Schraga, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP Share Email Print Feedback Close Sections Sections Hypothyroidism and Myxedema Coma Follow-up Further Inpatient Care Further inpatient care is as follows: Admit patients with myxedema coma to ICU. Provide supportive ventilatory and hemodynamic management. Treat precipitating events (eg, infection). Continue rewarming as required. Confirm diagnosis

2014 eMedicine Emergency Medicine

18. Myxedema Coma or Crisis (Overview)

Myxedema Coma or Crisis (Overview) Myxedema Coma or Crisis: Practice Essentials, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTIzNTc3LW92ZXJ2aWV3 processing > Myxedema Coma (...) or Crisis Updated: Oct 10, 2018 Author: Mohsen S Eledrisi, MD, FACP, FACE; Chief Editor: George T Griffing, MD Share Email Print Feedback Close Sections Sections Myxedema Coma or Crisis Overview Practice Essentials Myxedema is a term generally used to denote severe . Myxedema is also used to describe the dermatologic changes that occur in hypothyroidism and occasionally . In this setting, myxedema refers to deposition of mucopolysaccharides in the dermis, which results in swelling of the affected area

2014 eMedicine.com

19. Myxedema Coma or Crisis (Treatment)

Myxedema Coma or Crisis (Treatment) Myxedema Coma or Crisis Treatment & Management: Medical Care, Surgical Care, Consultations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTIzNTc3LXRyZWF0bWVudA== processing (...) > Myxedema Coma or Crisis Treatment & Management Updated: Oct 10, 2018 Author: Mohsen S Eledrisi, MD, FACP, FACE; Chief Editor: George T Griffing, MD Share Email Print Feedback Close Sections Sections Myxedema Coma or Crisis Treatment Medical Care Myxedema coma is a medical emergency that requires immediate attention. If the diagnosis is suspected, immediate management is necessary before confirming the diagnosis due to the high associated mortality rate. Patients with myxedema coma should be managed

2014 eMedicine.com

20. Myxedema Coma or Crisis (Diagnosis)

Myxedema Coma or Crisis (Diagnosis) Myxedema Coma or Crisis: Practice Essentials, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTIzNTc3LW92ZXJ2aWV3 processing > Myxedema Coma (...) or Crisis Updated: Oct 10, 2018 Author: Mohsen S Eledrisi, MD, FACP, FACE; Chief Editor: George T Griffing, MD Share Email Print Feedback Close Sections Sections Myxedema Coma or Crisis Overview Practice Essentials Myxedema is a term generally used to denote severe . Myxedema is also used to describe the dermatologic changes that occur in hypothyroidism and occasionally . In this setting, myxedema refers to deposition of mucopolysaccharides in the dermis, which results in swelling of the affected area

2014 eMedicine.com

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