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Myringosclerosis

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41. Determination of reactive oxygen species in myringotomized tympanic membranes: effect of vitamin e treatment. (Abstract)

Determination of reactive oxygen species in myringotomized tympanic membranes: effect of vitamin e treatment. Recent studies have established a strong relationship between the development of myringosclerosis and reactive oxygen species (ROS). The aims of the present study were to directly detect ROS in the tympanic membrane and middle ear mucosa of rats by measuring luminol amplified chemiluminescence, to evaluate the changes in the levels of ROS after treatment with vitamin E, and to examine (...) with groups 2 and 3. Histological studies confirmed sclerotic changes in the untreated myringotomized animals. The tympanic membranes of animals in groups 2 and 3 showed a white, chalk-like pattern of sclerotic changes, whereas animals in groups 4 and 5, with the exception of two animals in group 5, lacked these changes.Although the relationship between the development of myringosclerosis and ROS had been well documented previously, the present study is the first that has directly measured the levels

2004 Laryngoscope

42. Tympanosclerosis

Tympanosclerosis Tympanosclerosis. Myringosclerosis Information | Patient TOPICS Try our Symptom Checker TREATMENT RESOURCES Try our Symptom Checker PROFESSIONAL Upgrade to Patient Pro / / Search Tympanosclerosis Authored by , Reviewed by | Last edited 17 Aug 2015 | Certified by This article is for Medical Professionals Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines. You may (...) find one of our more useful. In this article In This Article Tympanosclerosis In this article Tympanosclerosis is a condition in which there is calcification of tissue in the eardrum and middle ear, including the tympanic membrane. If extensive, it may affect hearing. Tympanosclerosis may be classified as: Myringosclerosis - involving only the tympanic membrane. Intratympanic tympanosclerosis - involving other middle ear sites: the ossicular chain or, rarely, the mastoid cavity. Aetiology

2008 Mentor

43. Cholesteatoma

. [ ] Differential diagnosis Myringosclerosis: thickening and calcification of the tympanic membrane secondary to inflammation. [ ] Myospherulosis (spherulocytosis): a very rare foreign body reaction to oil-based ointments used in packing after surgery. [ ] Investigations Following physical examination, these patients will undergo a spectrum of audiological tests: CT imaging is the investigation of choice if there is a need for assessment of the extent of the lesion and to assess subtle bony defects (...) with Laryngoscope. 2010 Mar120(3):625-30. ; Development of myringosclerosis during acute otitis media caused by Streptococcus Medicina (Kaunas). 200541(8):661-7. ; Chronic otorrhea caused by myospherulosis in the middle ear after tympanoplasty. Ann Otol Rhinol Laryngol. 2013 Jul122(7):461-3. ; The value of CT scanning in chronic suppurative otitis media. J Laryngol Otol. 1991 Dec105(12):990-4. ; Magnetic resonance imaging of cholesteatoma: an update. B-ENT. 20095(4):233-40. ; Postoperative Non-Echo-Planar

2008 Mentor

44. Chronic otitis media with effusion sequelae in children treated with tubes. Full Text available with Trip Pro

loss, myringosclerosis, low static admittance (SA) and broad-peaked tympanogram, high SA and narrow-peaked tympanogram, and negative tympanometric peak pressure.Annual incidence of sequelae was typically greater during 3 to 5 years than 6 to 8 years of follow-up. Greatest increases in incidence during the 5-year follow-up were for atrophy (67%), high SA and narrow-peaked tympanogram (70%), and retraction pocket (47%). Prevalence of these sequelae also increased over time, whereas low SA and broad

2003 Archives of Otolaryngology Head and Neck Surgery

45. Topical Application of Calcium Channel Blockers to Reduce the Progression of Experimentally Induced Myringosclerosis and Tympanosclerosis. (Abstract)

Topical Application of Calcium Channel Blockers to Reduce the Progression of Experimentally Induced Myringosclerosis and Tympanosclerosis. This study aimed to evaluate the ability of topically applied calcium channel blockers (diltiazem) to reduce the progression of experimentally induced myringosclerosis and tympanosclerosis.Animal model. Experimental prospective study.The study included 25 adult albino guinea pigs that were bilaterally myringotomized and inoculated with a suspension (...) of Streptococcus pneumonia type 3. The right ears were treated with topical application of diltiazem, and the untreated left ears served as the control group. Otomicroscopy and remyringotomy were conducted every week. One animal was sacrificed after 1 week and the remaining at the end of 6 weeks. Temporal bones were dissected, and tympanic bullae were analyzed with light microscopy.The untreated control ears showed evidence of extensive myringosclerosis on otomicroscopy, and the ears treated with calcium

2008 Laryngoscope

46. The effect of Vitamin E treatment on the development of myringosclerosis after ventilation tube insertion. (Abstract)

The effect of Vitamin E treatment on the development of myringosclerosis after ventilation tube insertion. Recent studies have established the relationship between the reactive oxygen species and myringosclerosis. Furthermore several antioxidants have been known to prevent myringosclerosis. All the previous studies supporting this hypothesis have been performed on animals. The aim of our study is to investigate the possible effect of Vitamin E on the development of tympanosclerosis after VT (...) insertion on human subjects.72 children undergoing myringotomy and VT insertion were included in the study. Vitamin E was applied to the right ear and no treatment was applied to the left ear. Both ears were examined at the end of 9 months with otomicroscopy. Myringosclerosis formation at the end of the study period was noted for each ear.Myringosclerosis was found in 33 of the 144 ears. The overall incidence was 22.9%. While 22 (30.6%) of the 72 left ears showed myringosclerosis otomicroscopically

2006 International Journal of Pediatric Otorhinolaryngology

47. The effect of caffeic acid phenethyl ester on the prevention of experimentally induced myringosclerosis. (Abstract)

The effect of caffeic acid phenethyl ester on the prevention of experimentally induced myringosclerosis. Myringosclerosis is a common sequela of ventilation tube insertion for the treatment of the otitis media with effusion. Several antioxidants have been identified to prevent myringosclerosis. The objective of this study was to investigate the effect of caffeic acid phenethyl ester (CAPE) on the prevention of experimentally induced myringosclerosis.Thirty-five Sprague-Dawley rats were (...) unilaterally myringotomized. The rats were divided into four groups randomly: group 1 received no treatment, group 2 received intraperitoneally administered saline and group 3 received intraperitoneally administered CAPE. The tympanic membranes were examined by otomicroscopy on the 15th day after treatment. The membranes were then harvested and evaluated histologically by light microscopy.The tympanic membranes from group 1 showed extensive myringosclerosis; those from group 2 showed a similar occurrence

2007 International Journal of Pediatric Otorhinolaryngology

48. Tympanometric changes in an experimental myringosclerosis model after myringotomy. (Abstract)

Tympanometric changes in an experimental myringosclerosis model after myringotomy. The goal of this experimental study was to investigate the specific effect of myringosclerosis on tympanograms in the tympanic membranes of myringotomized rats by using otomicroscopy, tympanometry, and histopathology.Myringosclerosis is a common sequela of ventilation tube treatment of otitis media with effusion. The condition involves the hyalinization and calcification of the collagen layer in certain areas (...) of the tympanic membrane. Previous animal experiments suggest an intimate relationship between the formation of myringosclerosis and an increased oxygen concentration in the environment of the wound after myringotomy. The result of a myringotomy therefore is an increased production of free oxygen radicals, initiating irreversible tissue damage involving fibrosis, hyalin degeneration, and finally apoptosis as observed in myringosclerosis. We propose an experimental model specific for creating sclerotic plaques

2006 Otology and Neurotology

49. The anti-oxidant effect of alpha-tocopherol in the prevention of experimentally induced myringosclerosis. (Abstract)

The anti-oxidant effect of alpha-tocopherol in the prevention of experimentally induced myringosclerosis. The objective of this study was to investigate the possible effect of alpha-tocopherol on the prevention of experimentally induced myringosclerosis.Myringosclerosis is a common sequela of ventilation tube treatment of otitis media with effusion. The relationship between oxygen-derived free radicals and occurrence of myringosclerosis has been proven in experimental models, and it was also (...) shown that the formation of myringosclerosis after experimental myringotomy could be reduced by application of various free radical scavengers.Eighteen Wistar albino rats were myringotomized on the left side and randomly separated into two groups: group A consisted of rats which received intramuscular alpha-tocopherol injections 100 mg/kg daily and group B which were injected with physiological serum only. The occurrence of myringosclerotic plaques in the tympanic membranes of the two groups

2006 Otology and Neurotology

50. The effect of topical adrenaline on the development of myringosclerosis after tympanostomy tube insertion. (Abstract)

The effect of topical adrenaline on the development of myringosclerosis after tympanostomy tube insertion. To determine the effect of topical adrenaline application after myringotomy and before tympanostomy tube placement on the development of myringosclerosis.A prospective, randomized, double-blind study, with each patient acting as his or her own control. Ethical approval and full parental consent were obtained.Department of Otorhinolaryngology-Head and Neck Surgery in a university teaching (...) hospital.Fifty children satisfying inclusion and exclusion criteria for first-time tympanostomy tube insertion. THERAPEUTIC INTERVENTION: Myringotomy followed by adrenaline application to incision before tympanostomy tube insertion. Control contralateral ear received saline application after myringotomy. Follow-up examination was done 14 to 21 days after surgery and again after 1 year by a single blinded surgeon.Comparison of myringosclerosis between adrenaline-treated ears and matched control ears.No

2000 The American journal of otology Controlled trial quality: uncertain

51. The effect of L-carnitine on the prevention of experimentally induced myringosclerosis in rats. (Abstract)

The effect of L-carnitine on the prevention of experimentally induced myringosclerosis in rats. The objective of this study was to investigate the possible effect of L-carnitine on the prevention of experimentally induced myringosclerosis. Twenty Sprague-Dawley rats were bilaterally myringotomized. The rats were divided into two groups randomly: group 1 which were intraperitoneally administered saline and group 2 which were intraperitoneally administered L-carnitine. Blood samples were (...) collected for biochemical evaluation and the tympanic membranes were harvested after 28 days. Histopathological and immunohistochemical evaluation were done under light microscopy. The mean malondialdehyde levels were 3.9+/-0.9 in group 2, and 7.9+/-1.1 in group 1 (P<0.001), nitric oxide levels were 25.6+/-6.4 in group 2 and 30.8+/-8.2 in group 1 (P=0.14) and acetylcholinesterase was 1035+/-60 in group 2 and 678+/-35 in group 1 (P=0.001). Myringosclerosis was more frequent and severe in group 1 than

2003 Hearing Research

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