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Myringosclerosis

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41. Eustachian tube function and tympanic membrane findings after chronic secretory otitis media. (PubMed)

was found in 76% of the ears of SOM patients and in none (0%) of controls (P<0.001). The youngest patients had more atrophy than the older patients (P<0.05) and more myringosclerosis was observed in patients with shorter interval between SOM ending and examination. The patients were found to have significantly poorer active tubal function; i.e. higher inability to equilibrate negative or negative and positive middle ear pressure, compared with controls (P<0.001). The majority of the patients (74%) still

2004 International Journal of Pediatric Otorhinolaryngology

42. Calcium deposition and expression of bone modelling markers in the tympanic membrane following acute otitis media. (PubMed)

Calcium deposition and expression of bone modelling markers in the tympanic membrane following acute otitis media. In accordance with clinical findings, myringosclerosis develops after otitis media (OM) and paracentesis in an experimental setting. The pathogenesis of this phenomenon of calcification is poorly understood. As the calcification process and the sclerotic plaques of the drum mimics features of bone tissue, this study explores tympanic membrane calcium deposition in association (...) . These molecules may accordingly play a role in the pathogenesis of myringosclerosis, in which macrophages and fibrocytes appear as potential major players.

2006 International Journal of Pediatric Otorhinolaryngology

43. Determination of reactive oxygen species in myringotomized tympanic membranes: effect of vitamin e treatment. (PubMed)

Determination of reactive oxygen species in myringotomized tympanic membranes: effect of vitamin e treatment. Recent studies have established a strong relationship between the development of myringosclerosis and reactive oxygen species (ROS). The aims of the present study were to directly detect ROS in the tympanic membrane and middle ear mucosa of rats by measuring luminol amplified chemiluminescence, to evaluate the changes in the levels of ROS after treatment with vitamin E, and to examine (...) with groups 2 and 3. Histological studies confirmed sclerotic changes in the untreated myringotomized animals. The tympanic membranes of animals in groups 2 and 3 showed a white, chalk-like pattern of sclerotic changes, whereas animals in groups 4 and 5, with the exception of two animals in group 5, lacked these changes.Although the relationship between the development of myringosclerosis and ROS had been well documented previously, the present study is the first that has directly measured the levels

2004 Laryngoscope

44. Chronic otitis media with effusion sequelae in children treated with tubes. (PubMed)

loss, myringosclerosis, low static admittance (SA) and broad-peaked tympanogram, high SA and narrow-peaked tympanogram, and negative tympanometric peak pressure.Annual incidence of sequelae was typically greater during 3 to 5 years than 6 to 8 years of follow-up. Greatest increases in incidence during the 5-year follow-up were for atrophy (67%), high SA and narrow-peaked tympanogram (70%), and retraction pocket (47%). Prevalence of these sequelae also increased over time, whereas low SA and broad

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2003 Archives of Otolaryngology Head and Neck Surgery

45. Does passive smoking affect the outcome of grommet insertion in children? (PubMed)

myringosclerosis was 64 per cent if both parents smoked and less than 20 per cent if neither parents smoked. It is concluded that post-operative infection rate, attic retraction, post-extrusion myringosclerosis and permanent perforations of tympanic membrane were more common in children exposed to passive smoking. The study provides further support to professional and governmental advice that passive smoking is harmful.

2005 Journal of Laryngology & Otology

46. The effect of L-carnitine on the prevention of experimentally induced myringosclerosis in rats. (PubMed)

The effect of L-carnitine on the prevention of experimentally induced myringosclerosis in rats. The objective of this study was to investigate the possible effect of L-carnitine on the prevention of experimentally induced myringosclerosis. Twenty Sprague-Dawley rats were bilaterally myringotomized. The rats were divided into two groups randomly: group 1 which were intraperitoneally administered saline and group 2 which were intraperitoneally administered L-carnitine. Blood samples were (...) collected for biochemical evaluation and the tympanic membranes were harvested after 28 days. Histopathological and immunohistochemical evaluation were done under light microscopy. The mean malondialdehyde levels were 3.9+/-0.9 in group 2, and 7.9+/-1.1 in group 1 (P<0.001), nitric oxide levels were 25.6+/-6.4 in group 2 and 30.8+/-8.2 in group 1 (P=0.14) and acetylcholinesterase was 1035+/-60 in group 2 and 678+/-35 in group 1 (P=0.001). Myringosclerosis was more frequent and severe in group 1 than

2003 Hearing Research

47. The effect of caffeic acid phenethyl ester on the prevention of experimentally induced myringosclerosis. (PubMed)

The effect of caffeic acid phenethyl ester on the prevention of experimentally induced myringosclerosis. Myringosclerosis is a common sequela of ventilation tube insertion for the treatment of the otitis media with effusion. Several antioxidants have been identified to prevent myringosclerosis. The objective of this study was to investigate the effect of caffeic acid phenethyl ester (CAPE) on the prevention of experimentally induced myringosclerosis.Thirty-five Sprague-Dawley rats were (...) unilaterally myringotomized. The rats were divided into four groups randomly: group 1 received no treatment, group 2 received intraperitoneally administered saline and group 3 received intraperitoneally administered CAPE. The tympanic membranes were examined by otomicroscopy on the 15th day after treatment. The membranes were then harvested and evaluated histologically by light microscopy.The tympanic membranes from group 1 showed extensive myringosclerosis; those from group 2 showed a similar occurrence

2007 International Journal of Pediatric Otorhinolaryngology

48. Tympanometric changes in an experimental myringosclerosis model after myringotomy. (PubMed)

Tympanometric changes in an experimental myringosclerosis model after myringotomy. The goal of this experimental study was to investigate the specific effect of myringosclerosis on tympanograms in the tympanic membranes of myringotomized rats by using otomicroscopy, tympanometry, and histopathology.Myringosclerosis is a common sequela of ventilation tube treatment of otitis media with effusion. The condition involves the hyalinization and calcification of the collagen layer in certain areas (...) of the tympanic membrane. Previous animal experiments suggest an intimate relationship between the formation of myringosclerosis and an increased oxygen concentration in the environment of the wound after myringotomy. The result of a myringotomy therefore is an increased production of free oxygen radicals, initiating irreversible tissue damage involving fibrosis, hyalin degeneration, and finally apoptosis as observed in myringosclerosis. We propose an experimental model specific for creating sclerotic plaques

2006 Otology and Neurotology

49. The effect of Vitamin E treatment on the development of myringosclerosis after ventilation tube insertion. (PubMed)

The effect of Vitamin E treatment on the development of myringosclerosis after ventilation tube insertion. Recent studies have established the relationship between the reactive oxygen species and myringosclerosis. Furthermore several antioxidants have been known to prevent myringosclerosis. All the previous studies supporting this hypothesis have been performed on animals. The aim of our study is to investigate the possible effect of Vitamin E on the development of tympanosclerosis after VT (...) insertion on human subjects.72 children undergoing myringotomy and VT insertion were included in the study. Vitamin E was applied to the right ear and no treatment was applied to the left ear. Both ears were examined at the end of 9 months with otomicroscopy. Myringosclerosis formation at the end of the study period was noted for each ear.Myringosclerosis was found in 33 of the 144 ears. The overall incidence was 22.9%. While 22 (30.6%) of the 72 left ears showed myringosclerosis otomicroscopically

2006 International Journal of Pediatric Otorhinolaryngology

50. The anti-oxidant effect of alpha-tocopherol in the prevention of experimentally induced myringosclerosis. (PubMed)

The anti-oxidant effect of alpha-tocopherol in the prevention of experimentally induced myringosclerosis. The objective of this study was to investigate the possible effect of alpha-tocopherol on the prevention of experimentally induced myringosclerosis.Myringosclerosis is a common sequela of ventilation tube treatment of otitis media with effusion. The relationship between oxygen-derived free radicals and occurrence of myringosclerosis has been proven in experimental models, and it was also (...) shown that the formation of myringosclerosis after experimental myringotomy could be reduced by application of various free radical scavengers.Eighteen Wistar albino rats were myringotomized on the left side and randomly separated into two groups: group A consisted of rats which received intramuscular alpha-tocopherol injections 100 mg/kg daily and group B which were injected with physiological serum only. The occurrence of myringosclerotic plaques in the tympanic membranes of the two groups

2006 Otology and Neurotology

51. The effect of topical adrenaline on the development of myringosclerosis after tympanostomy tube insertion. (PubMed)

The effect of topical adrenaline on the development of myringosclerosis after tympanostomy tube insertion. To determine the effect of topical adrenaline application after myringotomy and before tympanostomy tube placement on the development of myringosclerosis.A prospective, randomized, double-blind study, with each patient acting as his or her own control. Ethical approval and full parental consent were obtained.Department of Otorhinolaryngology-Head and Neck Surgery in a university teaching (...) hospital.Fifty children satisfying inclusion and exclusion criteria for first-time tympanostomy tube insertion. THERAPEUTIC INTERVENTION: Myringotomy followed by adrenaline application to incision before tympanostomy tube insertion. Control contralateral ear received saline application after myringotomy. Follow-up examination was done 14 to 21 days after surgery and again after 1 year by a single blinded surgeon.Comparison of myringosclerosis between adrenaline-treated ears and matched control ears.No

2000 The American journal of otology Controlled trial quality: uncertain

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