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Myringosclerosis

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21. Pretreatment factors affecting traumatic tympanic membrane regeneration therapy using epidermal growth factor. (Abstract)

myringosclerosis were more likely to fail to close compared to those without preexisting myringosclerosis (P = 0.001). Multivariate logistic regression analyses showed that the duration of perforation (P = 0.011), size of perforation (P < 0.001), and involvement of the malleus in perforation (P = 0.005) were factors independently correlated with closure time.Daily application of EGF can be used to treat all traumatic TMPs. The size of the perforation and inverted edges did not affect the closure rate (...) , and the most beneficial dosage was sufficient to keep the eardrum moist. Multivariate logistic regression analyses revealed a significant correlation between preexisting myringosclerosis and failure to heal. Nevertheless, the size of perforation, starting time of application, and malleus injury were independent prognostic factors for prolonged healing time.Copyright © 2018 Elsevier Inc. All rights reserved.

2018 American Journal of Otolaryngology

22. Evaluation of Prognostic Factors in Tympanoplasty

descriptors. Black introduced the surgical, prosthetic, infection, tissues, and eustachian tube system (SPITE), and more recently Kartush developed middle ear risk index (MERI). Smoking is added as a middle ear risk. Furthermore, cholesteatoma and granulation tissue or effusion risk value has been increased in MERI 2001. Prognostic factors such as age, sex, presence of systemic diseases, location and size of perforation, duration of dry period, presence of myringosclerosis, presence of septal and conchal (...) of the surgical management whenever done. [ Time Frame: One year ] Prognostic factors such as age, sex, presence of systemic diseases, location and size of perforation, duration of dry period, presence of myringosclerosis, presence of septal and conchal pathology and status of the opposite ear and middle ear risk index will be investigated. Evaluation of middle ear risk index in tympanoplasty [ Time Frame: One year ] Each risk parameter will take a numerical value; Ear discharge: 0-3, Perforation: 0-2

2018 Clinical Trials

23. Tympanostomy Tubes in Children Full Text available with Trip Pro

blockage of the tympanostomy tube lumen in 7% of intubated ears, granulation tissue in 4%, premature extrusion of the tympanostomy tube in 4%, and tympanostomy tube displacement into the middle ear in 0.5%. Longer-term sequelae of tympanostomy tube placement include visible changes in the appearance of the tympanic membrane. Myringosclerosis consists of white patches in the ear drum from deposits of calcium and can be seen while the tube is in place or after extrusion. Myringosclerosis is more common

2013 American Academy of Otolaryngology - Head and Neck Surgery

24. Possible role of Dickkopf-1 protein in the pathogenesis of tympanosclerosis in a rat model. (Abstract)

the development of myringosclerosis. Haematoxylin and eosin staining was performed to observe the morphological changes. Western blot analysis and immunohistochemistry were performed to assess the expression of DKK1 protein.At day 15, sclerotic lesions were observed in 70 per cent of the tympanic membranes. Inflammatory infiltration and hyaline degeneration markedly appeared in the tympanic membranes and middle-ear mucosa. DKK1 protein was mainly distributed in the cytoplasm of epithelial cells, which were

2017 Journal of Laryngology & Otology

25. Endoscopic middle ear exploration in pediatric patients with conductive hearing loss. (Abstract)

on the stapes. 15% had adhesive myringosclerosis or severe granulation causing hearing loss. Prosthetic ossiculoplasty was done in 7/21 (33.3%) of the cases, with 1 TORP, 3 PORPs, and 3 IS joint replacements. Imaging was predictive of intra-operative findings in 13/20 cases (55%). Trainees assisted in 16/21(76%) of cases. The average improvement of PTA was 11.65 dB (range -10 to 36.25), and the average ABG improved 10.19 (range -11.25 to 28.75). There were no perioperative complications or adverse

2017 International Journal of Pediatric Otorhinolaryngology

26. The effect of caffeic acid phenethyl ester (CAPE) on tympanosclerosis. (Abstract)

. Intraperitoneal (i.p) CAPE were administrated to the CAPE group at 10 μmol/kg/day and 10% ethyl alcohol administrated to the alcohol group for 5 weeks. The control group were left untreated. Findings of myringosclerosis were recorded by otomicroscope at sixth week. Then, all rats were sacrificed and tympanic membrane thickness and severity of middle ear mucosal inflammation evaluated histopathalogically.Severity of myringosclerosis was significantly higher in the alcohol and control groups compared

2017 International Journal of Pediatric Otorhinolaryngology

27. Does systemic clarithromycin therapy have an inhibitory effect on tympanosclerosis? An experimental animal study. (Abstract)

therapy was administered in the clarithromycin group. The other groups received no medical treatment.All eardrums in the clarithromycin and non-clarithromycin groups developed myringosclerosis, but there was only one eardrum, in the clarithromycin group, with very severe myringosclerosis. In the clarithromycin group, 11 ears showed no inflammation and there were no ears with severe inflammation. In the non-clarithromycin group, there were 11 ears with severe inflammation. The mean eardrum thickness

2015 Journal of Laryngology & Otology

28. Otoscopic and audiological findings in different populations of 5-14 year-old schoolchildren in Colombia. (Abstract)

(TP), (disruption of continuity in the tympanic membrane) and sequelea (scarring, myringosclerosis, retractions, secrections). Our results are described as frequencies in percentages. Audiometry was performed in every student. Readings were taken at 250, 500, 1000, 2000, 4000, and 8000 Hz for air-conduction and bone-conduction thresholds. Normal hearing is considered up to 20 dB, mild sensorineural hearing loss between 21 and 39 dB, moderate between 40 and 59 dB, severe between 60 and 89 dB

2015 International Journal of Pediatric Otorhinolaryngology

29. Pepsin deteriorates prognosis of children with otitis media with effusion who undergo myringotomy or tympanostomy tube insertion. (Abstract)

rate including otorrhea and myringosclerosis was much higher in patients with high pepsin concentrations than in those with low pepsin concentrations (P<0.05). Finally, in both subgroups, the recurrence rates of OME in pepsin(+) or patients with high pepsin concentrations (34.6% [9/26] and 28.6% [10/35]) were significantly higher than those in pepsin(-) or low pepsin concentrations (10.7% [3/28] and 5.0% [1/20]; χ(2)=4.456, P=0.035 and χ(2)=4.420, P=0.036). However, pepsinogen had no significant (...) effect on OME prognosis or recurrence.Pepsin but not pepsinogen could postpone tympanic membrane healing and pressure restoration in children with OME undergoing myringotomy and increase the incidence of recurrence and complications including otorrhea and myringosclerosis for those undergoing tympanostomy tube insertion. Therefore, pepsin could be considered a poor prognostic factor for OME, further emphasizing the important role of pepsin in OME pathogenesis.Copyright © 2014. Published by Elsevier

2014 International Journal of Pediatric Otorhinolaryngology

30. Levels of reactive oxygen species in rat tympanic membranes after incisional versus radiofrequency myringotomy. (Abstract)

Levels of reactive oxygen species in rat tympanic membranes after incisional versus radiofrequency myringotomy. A close relationship between reactive oxygen species (ROS) and myringosclerosis, which is a common complication of myringotomy, was recently reported. The objective of this study was to measure ROS levels directly in rat tympanic membranes using luminol-aided chemiluminescence (CL) in order to compare the levels of ROS after incisional and radiofrequency (RF) myringotomy.Fifteen (...) ). The difference in mean ROS level between Groups 2 and 3 was not significant (p>0.05). Otomicroscopy revealed increased vascularity and vessel dilation in all tympanic membranes that underwent myringotomy. Vascular dilation was observed in the annular region in the vessels that passed along the long arm of the malleus, in addition to the vessels feeding the anterior and posterior tympanomalleolar folds.Although the relationship between ROS and the development of myringosclerosis after myringotomy has been

2013 International Journal of Pediatric Otorhinolaryngology

31. Fat Myringoplasty Outcome Analysis With Otoendoscopy: Who is the Suitable Patient? (Abstract)

Fat Myringoplasty Outcome Analysis With Otoendoscopy: Who is the Suitable Patient? This study evaluates the success of fat graft myringoplasty under local anesthesia in relation to the size and location of the perforation and the presence of myringosclerosis using otoendoscopy findings.Prospective cohort study.Tertiary referral center.Eighty-two patients without history of previous ear surgery underwent a fat graft myringoplasty under local anesthesia and followed up for 6 months. The fat graft (...) harvested from the ear lobe in all cases. Otoendoscopy was used to record preoperative perforation and postoperative course. Measurements on endoscopic findings performed with Adobe acrobat software. Factors assessed were perforation size, location and myringosclerosis preoperatively, and residual perforation and graft neoangiogenesis postoperatively. Pure tone audiogram preoperatively and postoperatively was performed.Successful closure of the perforation was observed in 70 (85.36%) of 82 ears

2012 Otology and Neurotology

32. Hearing 25 years after surgical treatment of otitis media with effusion in early childhood. (Abstract)

normal hearing. Treatment modality (myringotomy or ventilation tube) has no impact on the long-term hearing level. The regression analyses showed that the presence of myringosclerosis is associated with an overall hearing loss in myringotomised ears (4-5 dB), but not in tubed ears, for which only high frequencies were affected. Conversely, tensa atrophy is associated with an overall hearing loss in tubed ears (3-4 dB), but not in myringotomised ears, for which only high frequencies were (...) affected.Hearing 25 years after surgical treatment of chronic OME is not different from age and gender matched normal hearing. In addition, treatment modality (myringotomy or ventilation tube) has no impact on the long-term hearing level. However, atrophy is associated with a hearing loss in tubed ears, whereas myringosclerosis is associated with a hearing loss in myringotomised ears. The hearing loss associated with pathology is of limited magnitude (up to about 5 dB PTA). Even though pathology does occur

2012 International Journal of Pediatric Otorhinolaryngology

33. Expressions of TGF-β1 and MMP-9 in a guinea pig model of tympanosclerosis: Possible role in the pathogenesis of this disorder. Full Text available with Trip Pro

as controls, and the other 60 were used in the tympanosclerosis group by inoculation of type-3 Streptococcus pneumoniae microorganisms. The experimental animals were further divided into six subgroups on the basis of six time points. Otomicroscopy was employed to observe the development of myringosclerosis. Hematoxylin-eosin and von Kossa staining were performed to determine the morphological changes and calcium depositions. The expressions of TGF-β1 and MMP-9 were assessed by Western blot (...) and immunohistochemistry.Slight sclerotic changes in tympanic membrane were found at week 2, and extensive myringosclerosis was observed at week 6. Hyalinization and calcification in the tympanic membrane and middle ear mucous membrane were clearly visible at week 6. Expression of TGF-β1 was significantly increased with the development of tympanosclerosis. Expression of MMP-9 was increased from week 1 to week 4, and then declined at week 6. These two cytokines were both distributed in the cytoplasm of fibroblast cells

2012 Laryngoscope

34. Influence of coexisting myringosclerosis on myringoplasty outcomes in children. (Abstract)

Influence of coexisting myringosclerosis on myringoplasty outcomes in children. To obtain information on the success rate of tympanoplasty with concomitant myringosclerosis.The medical records of 40 children with myringosclerosis (23 girls, 17 boys; age range six to 16 years, mean age 9.85 years) who had undergone primary tympanoplasty were retrospectively studied. Surgical success was defined as the perforation remaining closed 12 months post-operatively.Sclerotic plaques occupied whole (...) remnant eardrums in 17 patients, and were located in various parts of the eardrum in 23. Tympanosclerosis associated with myringosclerosis was present in six patients. The success rate of primary tympanoplasty was 92.5 per cent. All three surgical failures were observed in girls with marginal perforations. These children underwent successful revision procedures for their residual perforations, variously at four, eight and 10 months after the initial surgery.Appropriate freshening of the perforation

2009 Journal of Laryngology & Otology

35. Study of Different Kinds of Ear Tubes

of the ventilation tube from the tympanic membrane [ Time Frame: 45 months ] Secondary Outcome Measures : Persistent tympanic membrane perforation [ Time Frame: 45 months ] Need for tube extraction (pain or infection) [ Time Frame: 45 months ] Pain leading to health care contact [ Time Frame: 45 months ] Tube related ear infection [ Time Frame: 45 months ] Obstruction of the tube [ Time Frame: 45 months ] Presence of myringosclerosis [ Time Frame: 45 months ] Eligibility Criteria Go to Information from

2008 Clinical Trials

36. The Effect of Topical Doxycycline in the Prevention of Experimental Tympanosclerosis. (Abstract)

The Effect of Topical Doxycycline in the Prevention of Experimental Tympanosclerosis. The aim of this study is to determine the effectiveness of topical doxycycline used in the process of experimental myringosclerosis and tympanosclerosis.A prospective experimental animal study.Experimental tympanosclerosis was accomplished in 25 healthy adult guinea pigs by inoculation with 2.5 x 10(7) colony-forming units of type-3 Streptococcus pneumoniae microorganisms followed by bilateral myringotomy (...) . While the animals' right ears received a topical doxycycline treatment daily, their left ears were left untreated and used as controls. Otomicroscopic examination was carried out weekly and healing tympanic membranes were remyringotomized. After a 6-week follow-up, the temporal bones of 24 of 25 animals were removed and light-microscopy examination was done regarding tympanic membrane myringosclerosis and middle ear mucosal sclerosis.Myringosclerosis was noticed to a lesser extent in the doxycycline

2008 Laryngoscope

37. Myringotomy Versus Ventilation Tubes in Secretory Otitis Media: Eardrum Pathology, Hearing, and Eustachian Tube Function 25 Years After Treatment. (Abstract)

media were treated by bilateral myringotomy and insertion of a ventilation tube on the right side only. The children were reexamined by otomicroscopy, tympanometry, and pure tone audiometry after 3, 7, and 25 years. At the last evaluation, the eustachian tube function was evaluated by the 9-step test.1) Myringosclerosis and late atrophy were more prevalent in tube ears. 2) Prevalence of eardrum retraction decreased over time, whereas that of sclerosis remained unchanged in tube ears and increased (...) in myringotomy ears. 3) Prevalence of atrophy increased over time in tube ears. 4) Extension of myringosclerosis increased, whereas that of atrophy and tensa retraction decreased over time, regardless of treatment. 5) Hearing was better in the tube ear during, but not after treatment. 6) Tympanometric findings were not related to treatment. 7) Eustachian tube function at 25 years was not related to treatment.The insertion of a ventilation tube after myringotomy leads not only to better hearing until

2008 Otology and Neurotology

38. Eustachian tube function and tympanic membrane findings after chronic secretory otitis media. (Abstract)

was found in 76% of the ears of SOM patients and in none (0%) of controls (P<0.001). The youngest patients had more atrophy than the older patients (P<0.05) and more myringosclerosis was observed in patients with shorter interval between SOM ending and examination. The patients were found to have significantly poorer active tubal function; i.e. higher inability to equilibrate negative or negative and positive middle ear pressure, compared with controls (P<0.001). The majority of the patients (74%) still

2004 International Journal of Pediatric Otorhinolaryngology

39. Calcium deposition and expression of bone modelling markers in the tympanic membrane following acute otitis media. (Abstract)

Calcium deposition and expression of bone modelling markers in the tympanic membrane following acute otitis media. In accordance with clinical findings, myringosclerosis develops after otitis media (OM) and paracentesis in an experimental setting. The pathogenesis of this phenomenon of calcification is poorly understood. As the calcification process and the sclerotic plaques of the drum mimics features of bone tissue, this study explores tympanic membrane calcium deposition in association (...) . These molecules may accordingly play a role in the pathogenesis of myringosclerosis, in which macrophages and fibrocytes appear as potential major players.

2006 International Journal of Pediatric Otorhinolaryngology

40. Does passive smoking affect the outcome of grommet insertion in children? (Abstract)

myringosclerosis was 64 per cent if both parents smoked and less than 20 per cent if neither parents smoked. It is concluded that post-operative infection rate, attic retraction, post-extrusion myringosclerosis and permanent perforations of tympanic membrane were more common in children exposed to passive smoking. The study provides further support to professional and governmental advice that passive smoking is harmful.

2005 Journal of Laryngology & Otology

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