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Myringosclerosis

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1. Clinical analysis of audiology in 277 patients with myringosclerosis. (PubMed)

Clinical analysis of audiology in 277 patients with myringosclerosis. 30784224 2019 03 12 1749-4486 2019 Feb 19 Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery Clin Otolaryngol Clinical analysis of audiology in two hundred seventy-seven patients with myringosclerosis. 10.1111/coa.13317 Zheng Yongbo Y http://orcid.org/0000-0003-1026-2058 Department of Otorhinolaryngology, Head and Neck Surgery, West

2019 Clinical Otolaryngology

2. Effect of Topical Dexamethasone for Preventing Experimentally Induced Myringosclerosis (PubMed)

Effect of Topical Dexamethasone for Preventing Experimentally Induced Myringosclerosis We aimed to examine the effect of topical dexamethasone by otomicroscopic and histologic examinations for preventing myringosclerosis induced by myringotomy in rat tympanic membranes.Twenty-one Sprague Dawley rats (42 ears) were randomly divided into the following three groups after otomicroscopic examinations: experimental surgical group (5 rats), control group (8 rats), and study group (8 rats). The rats (...) . The prevalence and process of myringosclerosis were evaluated by otomicroscopic examination, whereas inflammation, membrane thickness, and myringosclerosis intensity were evaluated by histologic examination.The growth of myringosclerosis with otomicroscopic examination was lesser in the study group in which topical dexamethasone was applied than the control and the experimental surgical groups. Moreover, it was observed that myringosclerosis effected fewer quadrants in the study group.Histologic examinations

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2017 Turkish Archives of Otorhinolaryngology

3. Predictive factors for the appearance of myringosclerosis after myringotomy with ventilation tube placement: randomized study. (PubMed)

Predictive factors for the appearance of myringosclerosis after myringotomy with ventilation tube placement: randomized study. Myringotomy with the insertion of ventilation tubes is the most frequent surgical procedure performed in children, and the appearance of myringosclerosis is one of its most frequent long-term complications. The objective of this study is to identify clinical factors and technique variations that may have a relation with the appearance of myringosclerosis, after tube (...) insertion. Patients submitted to myringotomy with transtympanic short-term tube insertion were studied in a longitudinal prospective and analytical cohort study with the prospective randomized open, blinded endpoint (PROBE) methodology, to study the influence of the location of myringotomy (anterior-inferior quadrant or posterior-inferior), directions of the incision (radial or non-radial) and aspiration or not of the middle ear. Our study included 156 patients (297 ears). Myringosclerosis was observed

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2016 European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

4. Myringosclerosis

Myringosclerosis Myringosclerosis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Myringosclerosis Myringosclerosis Aka (...) : Myringosclerosis , Tympanosclerosis From Related Chapters II. Definition Myringosclerosis (no effect on hearing) post-inflammatory scar Tympanosclerosis ( ) Spread of Myringosclerosis Involves TM, ossicles, middle ear III. Causes Recurrent s IV. Signs Irregular white patch of calcium deposit on TM Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Myringosclerosis." Click on the image (or right click) to open the source website in a new

2018 FP Notebook

5. Surgical Management of Myringosclerosis over an Entire Perforated Tympanic Membrane by Simple Underlay Myringoplasty (PubMed)

Surgical Management of Myringosclerosis over an Entire Perforated Tympanic Membrane by Simple Underlay Myringoplasty The aim of our study is to demonstrate the surgical management of myringosclerosis over a perforated whole tympanic membrane using simple underlay myringoplasty. Simple underlay myringoplasty with fibrin glue was performed in 11 ears with myringosclerosis over the entire tympanic membrane. The patients were one male and ten females and their mean age was 61.8 years (range, 40-73 (...)  yr). Surgical success was defined as an intact tympanic membrane 12 months after surgery. Closure of the perforation was successful in 10 (91%) of the 11 patients. Failure of the graft occurred in one patient who then underwent a revision procedure using her stored fascia in the outpatient clinic with a successful outcome. The overall success rate was 100%. Although this study included a small number of cases, removal of myringosclerosis at the edge of a perforation is a beneficial technique

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2016 International journal of otolaryngology

6. The effect of Nigella sativa oil on prevention of myringosclerosis in a Guinea pig model. (PubMed)

The effect of Nigella sativa oil on prevention of myringosclerosis in a Guinea pig model. In this study, our aim was to identify the possible effects of Nigella sativa L. (NS) [blackcumin] seed oil on the prevention of experimentally induced myringosclerosis (MS).Fourteen Guinea pigs were used and they were divided into three groups. Tympanic membranes (TM) of all animals were perforated and then group I was treated with saline soaked gel foams as a control group, group II was treated with 0.5 (...)  ml NS oil soaked gel foams at 0, 24 and 48 h and group III was treated with 5 ml NS oil orally at 0, 24, 48, 72 and 120 h. After 15 days, all animals were euthanized. Tympanic membranes were evaluated macroscopically and histopathologically.Groups I showed extensive myringosclerosis in contrast to those of Groups II and III which had significantly less changes (p < 0.05). The fibrosis and inflammation in the lamina propria of the tympanic membranes of Groups I was found to be significantly more

2016 International Journal of Pediatric Otorhinolaryngology

7. The effect of Hypericum perforatum L. (St. John's Wort) on prevention of myringosclerosis after myringotomy in a rat model. (PubMed)

The effect of Hypericum perforatum L. (St. John's Wort) on prevention of myringosclerosis after myringotomy in a rat model. The purpose of this study was to identify the possible effects of Hypericum Perforatum (HP) on the prevention of experimentally induced myringosclerosis (MS).Twenty eight Wistar Albino rats were used and they were divided into four groups. Tympanic membranes of all animals were perforated and then group I had no treatment as a control group, group II had treated with olive (...) oil only, group III had treated with HP orally and group IV had treated with HP topically.Groups I and II showed extensive myringosclerosis in contrast to those of Groups III and IV which had significantly less changes (p<0.05). The inflammation and fibrosis in the lamina propria of the tympanic membranes of Groups I and II were found to be significantly more pronounced (p<0.05). The tympanic membranes were found to be significantly thinner in Groups III and IV when compared with Groups I and II

2015 International Journal of Pediatric Otorhinolaryngology

8. Inhibitory effect of N-acetyl cysteine and ascorbic acid on the development of myringosclerosis: An experimental study. (PubMed)

Inhibitory effect of N-acetyl cysteine and ascorbic acid on the development of myringosclerosis: An experimental study. This study investigated the effects of ascorbic acid and N-acetyl cysteine (NAC) antioxidants on the development of myringosclerosis (MS) in an experimental model.Myringotomies were performed in the ears of 15 guinea pigs, and Spongostan pieces were placed on the perforated regions of the tympanic membrane. The subjects were divided randomly into three groups and treated

2014 International Journal of Pediatric Otorhinolaryngology

9. The effect of lycopene on experimental myringosclerosis. (PubMed)

The effect of lycopene on experimental myringosclerosis. The aim of this study was to investigate the effect of lycopene on myringosclerosis development using histopathological and immunohistochemical analyses.Fifty-six intact tympanic membranes of 28 guinea pigs were included in the study. Subjects were randomly divided into four groups (n=7/group). Group I (control group) did not receive any treatment after myringotomy. Group II (lycopene treatment after myringotomy) received oral lycopene (...) week before myringotomy using the same method and dose for seven days. Myringotomy was performed on day 8. Lycopene was not administered after myringotomy. Fourteen days after myringotomy, myringosclerosis was evaluated automicroscopically and scored. Following decapitation, bulla were removed and immersed in a 10% formaldehyde solution. Sections were cut for histopathological and immunohistochemical examination, and thickness, sclerosis, inflammation, and collagen-IV accumulation were scored semi

2014 International Journal of Pediatric Otorhinolaryngology

10. Effect of local use of l-carnitine after myringotomy on myringosclerosis development in rats. (PubMed)

Effect of local use of l-carnitine after myringotomy on myringosclerosis development in rats. This study aimed to investigate the effect of local and intraperitoneal administration of L-carnitine on the prevention of experimentally induced myringosclerosis, and to compare treatment efficiency.Twenty-four Albino-Wistar rats (48 ears) were bilaterally myringotomised and divided randomly into four groups: group one received no treatment, group two received intraperitoneal L-carnitine, group three (...) received local L-carnitine, and group four received both intraperitoneal and local L-carnitine. On the 15th day after treatment, tympanic membranes were harvested and evaluated histopathologically for myringosclerotic plaque formation, fibroblastic proliferation, tympanic membrane thickness and new vessel formation.The group one tympanic membranes showed extensive thickness, and the incidence of myringosclerosis and fibroblast proliferation were greater than in groups two and four. There were

2013 Journal of Laryngology & Otology

11. Immunohistochemical Investigation of Inducible Nitric Oxide Synthase, Osteopontin, and Calcium-Sensing Receptor in a Myringosclerosis/Tympanosclerosis Model. (PubMed)

Immunohistochemical Investigation of Inducible Nitric Oxide Synthase, Osteopontin, and Calcium-Sensing Receptor in a Myringosclerosis/Tympanosclerosis Model. To investigate roles of types of inflammation, inducible nitric oxide synthase (iNOS), osteopontin (OPN), and calcium sensing receptor (CaSR) in the tympanic membrane and middle ear in etiopathogenesis of myringosclerosis/tympanosclerosis (MT).Etiopathogenesis of myringosclerosis/tympanosclerosis is still unclear. Clinical and experimental

2013 Otology and Neurotology

12. Myringosclerosis

Myringosclerosis Myringosclerosis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Myringosclerosis Myringosclerosis Aka (...) : Myringosclerosis , Tympanosclerosis From Related Chapters II. Definition Myringosclerosis (no effect on hearing) post-inflammatory scar Tympanosclerosis ( ) Spread of Myringosclerosis Involves TM, ossicles, middle ear III. Causes Recurrent s IV. Signs Irregular white patch of calcium deposit on TM Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Myringosclerosis." Click on the image (or right click) to open the source website in a new

2015 FP Notebook

13. Myringosclerosis: An Indication of A Blocked Aditus (PubMed)

Myringosclerosis: An Indication of A Blocked Aditus Tympanoplasty has been the mainstay of treatment in chronic otitis media. In a non cholesteatomatous chronic otitis media, there has been much debate whether a cortical mastoidectomy is required or not. Creating an aerating mastoidectomy in cases of blocked aditus ad antrum helps in reducing the recurrence. However, the status of aditus is not always known unless a mastoidectomy is performed. In this study we try to find out if there is any (...) clinical clue regarding a blocked aditus ad antrum by looking at the tympanic membrane. Fourty-three cases of cortical mastoidectomies were retrospectively studied in this series. Patency of aditus ad antrum was analyzed with respect to presence of myringosclerosis and the status of middle ear mucosa. In this study myringosclerosis was found to be significantly associated with a blocked aditus while no such association was found with the status of middle ear mucosa. The presence of myringosclerosis may

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2011 Indian Journal of Otolaryngology and Head & Neck Surgery

14. The preventive effect of N-nitro l-arginine methyl ester in experimentally induced myringosclerosis. (PubMed)

The preventive effect of N-nitro l-arginine methyl ester in experimentally induced myringosclerosis. The purpose of this study was to investigate the antiinflammatory and antifibrotic effects of N-nitro L-arginine methyl ester (L-name) in experimentally induced myringosclerosis.Twenty Wistar albino rats were bilaterally myringotomized and divided randomly into four groups, each including five rats. Group I received no treatment, Group II was treated with topical saline solution, Group III (...) received topical L-NAME and Group IV received intraperitoneally administered L-NAME. After 2 weeks, the tympanic membranes were examined and scored by otomicroscopy regarding the extent of the myringosclerosis. Then the tympanic membranes were harvested and evaluated histopathologically by light microscopy. The intensity of inflammation and degree of myringosclerosis were evaluated, the mean thickness of tympanic membranes were also measured.The tympanic membranes of Groups I and II showed extensive

2011 International Journal of Pediatric Otorhinolaryngology

15. The effect of topical sodium thiosulfate in experimentally induced myringosclerosis. (PubMed)

The effect of topical sodium thiosulfate in experimentally induced myringosclerosis. The purpose of this study was to investigate the effect of topical sodium thiosulfate (STS) in experimentally induced myringosclerosis (MS).A prospective experimental animal study.Thirty Wistar albino rats were bilaterally myringotomized. The right ears were treated with STS or saline daily, and the left ears were left untreated and used as controls. The tympanic membranes were observed by otoendoscopy weekly (...) , and tympanometric measurements were performed. All animals were histopathologically examined for myringosclerotic plaques.Under otoendoscopy, myringosclerosis were observed around the handle of the malleus and near the annular region. The numbers of myringosclerotic ears were significantly more frequent in control and saline groups compared with the STS group (P < .05), and the formation of MS was more severe in control and saline groups compared with STS group (P < .05). Using tympanometric measurement

2010 Laryngoscope

16. Influence of coexisting myringosclerosis on myringoplasty outcomes in children. (PubMed)

Influence of coexisting myringosclerosis on myringoplasty outcomes in children. To obtain information on the success rate of tympanoplasty with concomitant myringosclerosis.The medical records of 40 children with myringosclerosis (23 girls, 17 boys; age range six to 16 years, mean age 9.85 years) who had undergone primary tympanoplasty were retrospectively studied. Surgical success was defined as the perforation remaining closed 12 months post-operatively.Sclerotic plaques occupied whole (...) remnant eardrums in 17 patients, and were located in various parts of the eardrum in 23. Tympanosclerosis associated with myringosclerosis was present in six patients. The success rate of primary tympanoplasty was 92.5 per cent. All three surgical failures were observed in girls with marginal perforations. These children underwent successful revision procedures for their residual perforations, variously at four, eight and 10 months after the initial surgery.Appropriate freshening of the perforation

2009 Journal of Laryngology & Otology

17. Tympanostomy Tubes in Children with Otitis Media

? Speech and language outcomes ? Educational achievement ? Behavioral outcomes Adverse events • Anesthetic and surgical • Otorrhea • Blockage of tube lumen • Granulation tissue • Premature extrusion • TT displacement into middle ear • Persistent perforation • Myringosclerosis • Atrophy, atelectasis or retraction • Worsened hearing thresholds Tympanostomy tube placement (+/- adenoidectomy) (KQ 3) Intermediate outcomes ? Middle ear effusion prevalence (KQ 1) ? Recurrent AOM/otorrhea (KQ 2) ? Hearing (...) and parental quality of life, speech and language outcomes, educational achievement, behavioral outcomes such as disobedience, enuresis, or tantrums. The following outcomes were extracted for KQ 3: Intraoperative and immediate postoperative anesthetic and surgical adverse events, otorrhea beyond the postoperative period, blockage of the tube lumen, granulation tissue, premature extrusion, TT displacement into the middle ear, persistent perforation of the tympanic membrane, myringosclerosis, tympanic

2017 Effective Health Care Program (AHRQ)

19. Pediatric lateral graft tympanoplasty A review of 78 cases. (PubMed)

. Primary and secondary outcomes were graft failure rate and hearing outcomes, respectively.78 cases were analyzed. The mean age at time of surgery was 10.3 years (range 5-18 years). Mean follow-up was 11.0 months; 27 patients had follow-up >1 yr. Most patients were non-syndromic (85.9%), had a history of bilateral Eustachian tube dysfunction (ETD) (59%) and presented with marked myringosclerosis (73.1%). Thirty-three percent of cases were revision tympanoplasties. A learner surgeon (resident or fellow (...) ) was present in 89.7% of cases. Successful closure of the TM was achieved in 97.4% (76/78) of cases and 92.6% (25/27) of cases with >1-year follow-up. No obvious difference in graft failure was noted with regards to age at time of surgery, perforation size, history of bilateral ETD, presence of a learner surgeon, myringosclerosis, presence of syndromic features, or history of prior tympanoplasty. Ninety-one percent of patients either improved hearing or preserved their conductive hearing deficit. Poorer

2019 International Journal of Pediatric Otorhinolaryngology

20. Evaluation of Prognostic Factors in Tympanoplasty

descriptors. Black introduced the surgical, prosthetic, infection, tissues, and eustachian tube system (SPITE), and more recently Kartush developed middle ear risk index (MERI). Smoking is added as a middle ear risk. Furthermore, cholesteatoma and granulation tissue or effusion risk value has been increased in MERI 2001. Prognostic factors such as age, sex, presence of systemic diseases, location and size of perforation, duration of dry period, presence of myringosclerosis, presence of septal and conchal (...) of the surgical management whenever done. [ Time Frame: One year ] Prognostic factors such as age, sex, presence of systemic diseases, location and size of perforation, duration of dry period, presence of myringosclerosis, presence of septal and conchal pathology and status of the opposite ear and middle ear risk index will be investigated. Evaluation of middle ear risk index in tympanoplasty [ Time Frame: One year ] Each risk parameter will take a numerical value; Ear discharge: 0-3, Perforation: 0-2

2018 Clinical Trials

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