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Myoclonus

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161. SGCE and myoclonus dystonia: motor characteristics, diagnostic criteria and clinical predictors of genotype (PubMed)

SGCE and myoclonus dystonia: motor characteristics, diagnostic criteria and clinical predictors of genotype Myoclonus dystonia syndrome (MDS) is a young-onset movement disorder. A proportion of cases are due to mutations in the maternally imprinted SGCE gene. We assembled the largest cohort of MDS patients to date, and determined the frequency and type of SGCE mutations. The aim was to establish the motor phenotype in mutation carriers and utility of current diagnostic criteria. Eighty-nine (...) onset upper body myoclonus and dystonia, (2) early childhood onset lower limb dystonia, progressing later to more pronounced myoclonus and upper body involvement, and (3) later childhood onset upper body myoclonus and dystonia with evident cervical involvement. Five probands had large contiguous gene deletions ranging from 0.7 to 2.3 Mb in size with distinctive clinical features, including short stature, joint laxity and microcephaly. Our data confirms that SGCE mutations are most commonly

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2014 Journal of neurology

162. Myoclonus associated with concomitant ciprofloxacin and oxycodone in an older patient (PubMed)

Myoclonus associated with concomitant ciprofloxacin and oxycodone in an older patient 23879446 2015 02 07 2018 11 13 1365-2125 77 5 2014 May British journal of clinical pharmacology Br J Clin Pharmacol Myoclonus associated with concomitant ciprofloxacin and oxycodone in an older patient. 906-7 10.1111/bcp.12213 Kango Gopal Gopinath G Aged and Extended Care Services, The Queen Elizabeth Hospital, Woodville, SA, Australia. Hewton Cassie C Pazhvoor Shibu Krishnan SK eng Case Reports Letter England (...) Br J Clin Pharmacol 7503323 0306-5251 0 Analgesics, Opioid 0 Anti-Bacterial Agents 5E8K9I0O4U Ciprofloxacin CD35PMG570 Oxycodone IM Aged Aged, 80 and over Analgesics, Opioid adverse effects Anti-Bacterial Agents adverse effects Ciprofloxacin administration & dosage adverse effects Female Humans Myoclonus chemically induced Oxycodone administration & dosage adverse effects 2013 05 31 2013 07 08 2013 7 25 6 0 2013 7 25 6 0 2015 2 11 6 0 ppublish 23879446 10.1111/bcp.12213 PMC4004412 Drug Saf. 2011

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2014 British journal of clinical pharmacology

163. Dose-Dependent Olanzapine-Induced Myoclonus (PubMed)

Dose-Dependent Olanzapine-Induced Myoclonus Second-generation antipsychotics (SGA), mainly clozapine have been reported to induce myoclonus. Although olanzapine-induced myoclonus is reported, dose-dependent response has not been described. We report dose-related olanzapine-induced myoclonus in an early onset schizophrenia patient. We also suggest certain management strategies for such adverse side effects.

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2014 Toxicology international

164. Opsoclonus – Myoclonus syndrome induced by phenytoin intoxication (PubMed)

Opsoclonus – Myoclonus syndrome induced by phenytoin intoxication 25540528 2014 12 25 2018 11 13 0976-3147 5 Suppl 1 2014 Nov Journal of neurosciences in rural practice J Neurosci Rural Pract Opsoclonus - Myoclonus syndrome induced by phenytoin intoxication. S109-10 10.4103/0976-3147.145254 Verma Rajesh R Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India. Kumar Sanjeev S Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India

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2014 Journal of neurosciences in rural practice

165. Prevention of etomidate-induced myoclonus during anesthetic induction by pretreatment with dexmedetomidine (PubMed)

Prevention of etomidate-induced myoclonus during anesthetic induction by pretreatment with dexmedetomidine Myoclonus induced by etomidate during induction of general anesthesia is undesirable. This study evaluated the effect of dexmedetomidine (DEX) pretreatment on the incidence and severity of etomidate-induced myoclonus. Ninety patients undergoing elective surgical procedures were randomly allocated to three groups (n=30 each) for intravenous administration of 10 mL isotonic saline (group I (...) ), 0.5 µg/kg DEX in 10 mL isotonic saline (group II), or 1.0 µg/kg DEX in 10 mL isotonic saline (group III) over 10 min. All groups subsequently received 0.3 mg/kg etomidate by intravenous push injection. The incidence and severity of myoclonus were recorded for 1 min after etomidate administration and the incidence of cardiovascular adverse events that occurred between the administration of the DEX infusion and 1 min after tracheal intubation was recorded. The incidence of myoclonus

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2014 Brazilian Journal of Medical and Biological Research

166. BuButorphanol pre-treatment prevents myoclonus induced by etomidate: a randomised, double-blind, controlled clinical trial. (PubMed)

BuButorphanol pre-treatment prevents myoclonus induced by etomidate: a randomised, double-blind, controlled clinical trial. Myoclonic movements are common problems during induction of anaesthesia with etomidate. The myoclonus occurring after etomidate administration may represent a form of seizure. Agonistic modulation of the κ opiate receptor may reduce seizures, and butorphanol acts in such a manner. The aim of this randomised, double-blind, placebo-controlled clinical trial was to test our (...) hypothesis that pre-treatment with butorphanol might reduce the incidence and severity of myoclonus induced by etomidate.Patients (108) with American Society of Anaesthesiologists physical status I or II were randomly assigned to one of two groups to receive either 0.015 mg/kg of butorphanol (n = 54) or saline (n = 54) intravenously. At two minutes after infusion of butorphanol or saline, 0.3 mg/kg etomidate was given. The occurrence and severity (observational score of 0-3) of myoclonus was assessed

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2014 Swiss medical weekly

167. Autosomal dominant cortical tremor, myoclonus, and epilepsy (ADCME): Probable first family from India (PubMed)

Autosomal dominant cortical tremor, myoclonus, and epilepsy (ADCME): Probable first family from India Autosomal dominant cortical tremor, myoclonus, and epilepsy (ADCME) is an extremely rare syndrome characterized by familial occurrence of postural and action-induced tremors of the hands but showing electrophysiologic findings of cortical reflex myoclonus. Patients also have cognitive decline and tonic-clonic seizures, often precipitated by sleep deprivation or photic stimulation. We describe

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2014 Annals of Indian Academy of Neurology

168. Palato-pharyngo-laryngeal myoclonus … an unusual cause of dysphagia. (PubMed)

Palato-pharyngo-laryngeal myoclonus … an unusual cause of dysphagia. Dysphagia is a common problem in the elderly patient. Palato-pharyngo-laryngeal myoclonus, however, is a rare cause of this. We report a case of a 78-year-old man with dysphagia due to palato-pharngo-laryngeal myoclonus that was ultimately managed conservatively with a good functional outcome. © The Author 2014. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved

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2014 Age and ageing

169. Propriospinal myoclonus: The spectrum of clinical and neurophysiological phenotypes. (PubMed)

Propriospinal myoclonus: The spectrum of clinical and neurophysiological phenotypes. Propriospinal myoclonus (PSM) is a rare type of spinal myoclonus characterized by muscle jerks that usually start in the midthoracic segments and then slowly propagate up and down into the spinal cord, resulting in repetitive and irregular jerky flexion, or extension of the trunk, neck, knees and hips. PSM can be symptomatic, but up to 80% of reported cases appear idiopathic. PSM tends to occur especially while

2014 Sleep medicine reviews

170. Increased cortical hyperexcitability and exaggerated myoclonus with aging in benign adult familial myoclonus epilepsy. (PubMed)

Increased cortical hyperexcitability and exaggerated myoclonus with aging in benign adult familial myoclonus epilepsy. The clinical implications of enlarged early cortical components of somatosensory evoked potentials in benign adult familial myoclonus epilepsy remain unknown. Somatosensory evoked potentials following electrical stimulation of the median nerve at the wrist were studied in 16 patients with a clinical diagnosis of benign adult familial myoclonus epilepsy (7 men and 9 women; mean (...) potential examination and N20, P25, and N35 amplitudes, both in the patient and in the control groups (P < 0.05). The linear regression gradient of the N35 amplitude with respect to age was significantly larger in the patient group than in the control group (P = 0.04). Furthermore, regression analysis showed a significant positive relationship between the myoclonus rating scale and age at time of somatosensory evoked potential examination (R = 0.645, P = 0.007). Somatosensory evoked potential amplitude

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2011 Movement Disorders

171. Reticular reflex myoclonus: a physiological type of human post-hypoxic myoclonus. (PubMed)

Reticular reflex myoclonus: a physiological type of human post-hypoxic myoclonus. A patient with post-hypoxic myoclonus, sensitive to therapy with 5-hydroxytryptophan and clonazepam, was subjected to detailed electrophysiological investigation. Brief generalised jerks followed the critical stimulus of muscle stretch. The electroencephalogram showed generalised spikes that were associated with, but not time locked to, the myoclonus. The cranial nerve nuclei were activated upward. Analysis (...) of the findings suggests that the mechanism of the myoclonus is hyperactivity of a reflex mediated in the reticular formation of the medulla oblongata.

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1977 Journal of neurology, neurosurgery, and psychiatry

172. Uraemic myoclonus: an example of reticular reflex myoclonus? (PubMed)

Uraemic myoclonus: an example of reticular reflex myoclonus? Two patients are described who developed action, reflex myoclonus during acute renal failure. In both cases the myoclonus was abolished after the intravenous administration of clonazepam. We suggest that the characteristic action myoclonus, which occurs in both acute renal failure and postanoxic encephalopathy, is caused by a disturbance of function in the lower brainstem reticular formation.

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1979 Journal of neurology, neurosurgery, and psychiatry

173. Somatostatin receptor positron emission tomography/computed tomography (PET/CT) in the evaluation of opsoclonus-myoclonus ataxia syndrome (PubMed)

Somatostatin receptor positron emission tomography/computed tomography (PET/CT) in the evaluation of opsoclonus-myoclonus ataxia syndrome Opsoclonus-myoclonus ataxia (OMA) syndrome is the most common paraneoplastic neurological syndrome of childhood, associated with occult neuroblastoma in 20%-50% of all cases. OMA is the initial presentation of neuroblastoma in 1%-3% of children. Conventional radiological imaging approaches include chest radiography and abdominal computed tomography (CT

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2013 Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India

174. Antiglycine receptor antibody and encephalomyelitis with rigidity and myoclonus (PERM) related to small cell lung cancer (PubMed)

Antiglycine receptor antibody and encephalomyelitis with rigidity and myoclonus (PERM) related to small cell lung cancer A 39-year-old man (a lifetime non-smoker) presented with a locked left jaw and leg myoclonus. Clinical and electromyographic findings were in keeping with progressive encephalomyelitis with rigidity and myoclonus (PERM) syndrome. A thoracic CT scan demonstrated a 19 mm right hilar nodule, which was proven to be small cell lung cancer on bronchoscopic biopsy. Serological

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2013 BMJ case reports

175. Middle ear myoclonus cured by selective tenotomy of the tensor tympani: strategies for targeted intervention for middle ear muscles. (PubMed)

Middle ear myoclonus cured by selective tenotomy of the tensor tympani: strategies for targeted intervention for middle ear muscles. To describe a case of middle ear myoclonus that was successfully cured by selective transection of the tensor tympani (TT) without sectioning the stapedius tendon (ST) and to review previously reported cases, elucidating precipitating factors for interventions targeting middle ear muscles.One case we encountered and a recent systematic review published in 2012 (...) .In addition to our case, 23 cases identified by the previous systematic review regarding middle ear myoclonus in which surgical interventions were conducted.Outcomes for selective tenotomy of TT or ST were analyzed focusing on the following 6 preoperative factors: 1) history of facial palsy, 2) provoking factors for tinnitus, 3) auscultation of the ear, 4) movement of the ear drum, 5) complication with palatal myoclonus, and 6) confirmation of myoclonus during surgery. Among these, the first 2 factors

2013 Otology and Neurotology

176. The α<sub>2B</sub> adrenergic receptor is mutant in cortical myoclonus and epilepsy. (PubMed)

The α2B adrenergic receptor is mutant in cortical myoclonus and epilepsy. Autosomal dominant cortical myoclonus and epilepsy (ADCME) is characterized by distal, fairly rhythmic myoclonus and epilepsy with variable severity. We have previously mapped the disease locus on chromosome 2p11.1-q12.2 by genome-wide linkage analysis. Additional pedigrees affected by similar forms of epilepsy have been associated with chromosomes 8q, 5p, and 3q, but none of the causing genes has been

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2013 Annals of Neurology

177. Clinical diagnosis of propriospinal myoclonus is unreliable: An electrophysiologic study. (PubMed)

Clinical diagnosis of propriospinal myoclonus is unreliable: An electrophysiologic study. Propriospinal myoclonus is a rare movement disorder that is hypothesized to arise from a spinal generator that transmits activity up and down the spinal cord via long propriospinal pathways. Polymyography is mandatory for the diagnosis, but the typical electrophysiological pattern described for propriospinal myoclonus has been also found in patients with psychogenic axial jerks, supported by the presence (...) of a Bereitschaftspotential (BP; from German, "readiness potential," also called the premotor potential). We evaluated polymyographic findings in 65 patients referred to us with a clinical diagnosis of propriospinal myoclonus and also looked for the presence of the BP, as detected by jerk-locked back-averaging. At clinical reassessment by a movement disorder specialist, nearly one-half of the patients had clinical clues suggestive of a psychogenic cause of the jerks. Electrophysiological studies were carried out on all

2013 Movement Disorders

180. Clinical characteristics and therapeutic response of objective tinnitus due to middle ear myoclonus: A large case series. (PubMed)

Clinical characteristics and therapeutic response of objective tinnitus due to middle ear myoclonus: A large case series. To evaluate the clinical characteristics and therapeutic response of tinnitus due to middle ear myoclonus (MEM) and to suggest appropriate diagnostic methods.Retrospective chart review.This study included 58 patients with tinnitus diagnosed with MEM, who were seen from January 2004 to July 2011. Clinical and audiological characteristics were investigated. The therapeutic (...) with forceful eyelid closure was observed in 15% of patients. Impedance audiogram and otoendoscopic examinations of the tympanic membrane were helpful tools for diagnosing MEM. With medical therapy, more than 75% of patients exhibited complete or partial remission of their tinnitus. Patients with intractable MEM who underwent sectioning of the middle ear tendons had very good outcomes.Tinnitus due to middle ear myoclonus seems to occur in young patients and to be related to stress or noise. Information

2013 Laryngoscope

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