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Myoclonus

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101. Low-Dose Ketamine Pretreatment Reduces the Incidence and Severity of Myoclonus Induced by Etomidate: A Randomized, Double-Blinded, Controlled Clinical Trial. Full Text available with Trip Pro

Low-Dose Ketamine Pretreatment Reduces the Incidence and Severity of Myoclonus Induced by Etomidate: A Randomized, Double-Blinded, Controlled Clinical Trial. Myoclonic movement induced by etomidate is a common but undesirable problem during general anesthesia induction. To investigate the influence of pretreatment with low-dose ketamine on the incidence and severity of myoclonus induced by etomidate, 104 patients were randomized allocated to 1 of 2 equally sized groups (n = 52) to receive (...) either intravenous low-dose ketamine 0.5 mg/kg (group K) or an equal volume of normal saline (group S) 1 minute before induction of anesthesia with 0.3-mg/kg etomidate. The incidence and severity of myoclonus were assessed for 2 minutes after administration of etomidate. Here, we found that the incidence and intensity of myoclonus were both significantly reduced in low-dose ketamine-treated group compared with saline-treated group. The incidence of adverse effects was low and similar between groups

2016 Medicine Controlled trial quality: uncertain

102. Clinical and Immunological Features of Opsoclonus-Myoclonus Syndrome in the Era of Neuronal Cell Surface Antibodies. Full Text available with Trip Pro

Clinical and Immunological Features of Opsoclonus-Myoclonus Syndrome in the Era of Neuronal Cell Surface Antibodies. Most studies on opsoclonus-myoclonus syndrome (OMS) in adults are based on small case series before the era of neuronal cell surface antibody discovery.To report the clinical and immunological features of idiopathic OMS (I-OMS) and paraneoplastic OMS (P-OMS), the occurrence of antibodies to cell surface antigens, and the discovery of a novel cell surface epitope.Retrospective

2016 JAMA neurology

103. Comparison of the Effects of Low-Dose Midazolam, Magnesium Sulfate, Remifentanil and Low-Dose Etomidate on Prevention of Etomidate-Induced Myoclonus in Orthopedic Surgeries. Full Text available with Trip Pro

Comparison of the Effects of Low-Dose Midazolam, Magnesium Sulfate, Remifentanil and Low-Dose Etomidate on Prevention of Etomidate-Induced Myoclonus in Orthopedic Surgeries. Etomidate is a potent hypnotic agent with several desirable advantages such as providing a stable cardiovascular profile with minimal respiratory adverse effects and better hemodynamic stability compared with other induction agents. This drug is associated, however, with myoclonic movements which is characterized (...) by a sudden, brief muscle contractions as a disturbing side-effect.The present study was designed to compare the effectiveness of low- dose midazolam, magnesium sulfate, remifentanil and low-dose etomidate to suppress etomidate-induced myoclonus in orthopedic surgery.A double-blind clinical trial study was conducted in an academic hospital from September 2014 to August 2015. Two hundred and eighty-four eligible patients, American society of anesthesiologists class I - II, scheduled for elective orthopedic

2016 Anesthesiology and pain medicine Controlled trial quality: uncertain

104. Autosomal dominant cortical tremor, myoclonus, and epilepsy (ADCME) in a unique south Indian community. Full Text available with Trip Pro

Autosomal dominant cortical tremor, myoclonus, and epilepsy (ADCME) in a unique south Indian community. Autosomal dominant cortical tremor, myoclonus, and epilepsy (ADCME)/familial adult onset myoclonic epilepsy (FAME) is a nonprogressive disorder characterized by (1) distal tremors that are usually precipitated by posture and action; (2) stimulus-sensitive myoclonus that is predominantly seen in the upper limb and is precipitated by photic stimuli, fatigue, emotional stress, and sleep

2016 Epilepsia

105. Distribution and Coexistence of Myoclonus and Dystonia as Clinical Predictors of SGCE Mutation Status: A Pilot Study Full Text available with Trip Pro

Distribution and Coexistence of Myoclonus and Dystonia as Clinical Predictors of SGCE Mutation Status: A Pilot Study Myoclonus-dystonia (M-D) is a young onset movement disorder typically involving myoclonus and dystonia of the upper body. A proportion of the cases are caused by mutations to the autosomal dominantly inherited, maternally imprinted, epsilon-sarcoglycan gene (SGCE). Despite several sets of diagnostic criteria, identification of patients most likely to have an SGCE mutation remains (...) difficult.Forty consecutive patients meeting pre-existing diagnostic clinical criteria for M-D underwent a standardized clinical examination (20 SGCE mutation positive and 20 negative). Each video was reviewed and systematically scored by two assessors blinded to mutation status. In addition, the presence and coexistence of myoclonus and dystonia was recorded in four body regions (neck, arms, legs, and trunk) at rest and with action.Thirty-nine patients were included in the study (one case was excluded owing

2016 Frontiers in neurology

106. Reversible myoclonus, asterixis, and tremor associated with high dose trimethoprim-sulfamethoxazole: a case report Full Text available with Trip Pro

Reversible myoclonus, asterixis, and tremor associated with high dose trimethoprim-sulfamethoxazole: a case report Reversible myoclonus, tremor, and asterixis induced by high dose trimethoprim-sulfamethoxazole.The patient was a 66-year-old male with T9 AIS(1) C quadriplegia secondary to spinal cord compression by a tumor due to large B cell lymphoma. Subsequent to tumor resection and chemotherapy, the patient was discovered to have Pneumocystis jiroveci pneumonia (PJP). Once started on high (...) to be the first reported case of reversible myoclonus, tremor, and asterixis induced by high dose TMP-SMX in the spinal cord injury population. Early recognition of TMP-SMX induced complications were of key importance as they negatively impacted the rehabilitation process. We also recommend consideration of symptomatic treatment with levetiracetam for the duration of required TMP-SMX therapy as it appeared to mitigate the severity of our patient's movement disorders.

2016 The journal of spinal cord medicine

107. Progressive encephalomyelitis with rigidity and myoclonus (PERM): brucellosis as a possible triggering factor and long-term follow-up therapy with rituximab Full Text available with Trip Pro

Progressive encephalomyelitis with rigidity and myoclonus (PERM): brucellosis as a possible triggering factor and long-term follow-up therapy with rituximab 26788132 2016 01 20 2018 11 13 1756-2856 9 1 2016 Jan Therapeutic advances in neurological disorders Ther Adv Neurol Disord Progressive encephalomyelitis with rigidity and myoclonus (PERM): brucellosis as a possible triggering factor and long-term follow-up therapy with rituximab. 69-73 10.1177/1756285615614812 Magira Eleni E EE First

2016 Therapeutic advances in neurological disorders

108. Essential rhythmic palatal myoclonus in a 51-year-old man Full Text available with Trip Pro

Essential rhythmic palatal myoclonus in a 51-year-old man Essential palatal myoclonus is a rare movement disorder consisting of continuous rhythmic jerks of the soft palate; it usually develops secondary to brainstem or cerebellar disease called symptomatic rhythmic palatal myoclonus. Diagnosis is usually clinical, and some patients, however, fail to show evidence of a structural lesion like our patient called essential rhythmic palatal myoclonus. We report a 51-year-old man who has suffered

2016 Oxford Medical Case Reports

109. Autosomal Dominant Cortical Tremor, Myoclonus, and Epilepsy Syndrome mimicking Juvenile Myoclonic Epilepsy Full Text available with Trip Pro

Autosomal Dominant Cortical Tremor, Myoclonus, and Epilepsy Syndrome mimicking Juvenile Myoclonic Epilepsy Autosomal dominant cortical tremor, myoclonus, and epilepsy (ADCME) syndrome is a genetically heterogeneous and under-recognized disease characterized by tremulous movements mimicking essential tremor, myoclonus, and rare generalized tonic-clonic seizures. Here we described the clinical and electrophysiological features of three siblings with ADCME syndrome mimicking juvenile myoclonic (...) and wave discharges. The N20-P25 and P25-N35 amplitudes were substantially higher in the three siblings with ADCME. Although tremor frequencies were similar to those of the ET group, the siblings had mild interrupting low-amplitude myoclonus, suggestive of cortical tremor, in the accelerometric analysis.We presented a detailed clinical evaluation with electrophysiological confirmation of ADCME syndrome in a Turkish family. This rare clinical picture might be misdiagnosed as JME and should be kept

2016 Archives of Neuropsychiatry

110. Post-hypoxic Myoclonus: Current Concepts, Neurophysiology, and Treatment Full Text available with Trip Pro

Post-hypoxic Myoclonus: Current Concepts, Neurophysiology, and Treatment Myoclonus may occur after hypoxia. In 1963, Lance and Adams described persistent myoclonus with other features after hypoxia. However, myoclonus occurring immediately after hypoxia may demonstrate different syndromic features from classic Lance-Adams syndrome (LAS). The aim of this review is to provide up-to-date information about the spectrum of myoclonus occurring after hypoxia with emphasis on neurophysiological (...) features.A literature search was performed on PubMed database from 1960 to 2015. The following search terms were used: "myoclonus," "post anoxic myoclonus," "post hypoxic myoclonus," and "Lance Adams syndrome." The articles describing clinical features, neurophysiology, management, and prognosis of post-hypoxic myoclonus cases were included for review.Several reports in the literature were separated clinically into "acute post-hypoxic myoclonus," which occurred within hours of severe hypoxia

2016 Tremor and Other Hyperkinetic Movements

111. Speech-activated Myoclonus Mimicking Stuttering in a Patient with Myoclonus–Dystonia Syndrome Full Text available with Trip Pro

Speech-activated Myoclonus Mimicking Stuttering in a Patient with Myoclonus–Dystonia Syndrome Acquired neurogenic stuttering has been considered a fairly uncommon clinical occurrence; speech-activated myoclonus is a rare entity that can mimic stuttering and is caused by a wide array of etiologies.Here we report a patient with myoclonus-dystonia syndrome (MDS), due to an identified disease-causing mutation, who displayed speech-activated myoclonus mimicking stuttering.In MDS, myoclonus has (...) only infrequently been reported to affect speech. This case further expands the spectrum of conditions causing the rare clinical phenomenon of speech-activated myoclonus.

2016 Tremor and Other Hyperkinetic Movements

112. Progressive myoclonus epilepsy associated with SACS gene mutations Full Text available with Trip Pro

Progressive myoclonus epilepsy associated with SACS gene mutations Pathogenic variants in the SACS gene (OMIM #604490) cause autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). ARSACS is a neurodegenerative early-onset progressive disorder, originally described in French Canadians, but later observed elsewhere.(1) Whole-exome sequencing of a large group of patients with unclassified progressive myoclonus epilepsies (PMEs) identified 2 patients bearing SACS gene mutations.(2) We

2016 Neurology: Genetics

113. Opsoclonus myoclonus ataxia syndrome due to falciparum malaria in two Indian children Full Text available with Trip Pro

Opsoclonus myoclonus ataxia syndrome due to falciparum malaria in two Indian children Opsoclonus-myoclonus ataxia (OMA) syndrome is rare in children, mostly caused by neuroblastoma. Here, we present two very rare cases presenting with OMA due to falciparum malaria. Both of them responded to a high dose of adrenocorticotrophin hormone and intravenous immunoglobulin without recurrence and complication.

2016 Indian journal of ophthalmology

114. Orthostatic myoclonus associated with Caspr2 antibodies Full Text available with Trip Pro

Orthostatic myoclonus associated with Caspr2 antibodies 26944274 2016 09 06 2018 11 13 1526-632X 86 14 2016 Apr 05 Neurology Neurology Orthostatic myoclonus associated with Caspr2 antibodies. 1353-5 10.1212/WNL.0000000000002547 Gövert Felix F From Christian-Albrecht University of Kiel (F.G., K.W., H.H., S.P., G.D., F.L.), Germany; University College London (UCL) Institute of Neurology (R.E.), UK; August Pi i Sunyer Biomedical Research Institute (IDIBAPS) (E.M.-H., J.D.), Hospital Clínic (...) administration & dosage pharmacology Male Membrane Proteins immunology Myoclonus diagnosis drug therapy Nerve Tissue Proteins immunology Posture 2015 08 18 2015 11 30 2016 3 6 6 0 2016 3 6 6 0 2016 9 7 6 0 ppublish 26944274 WNL.0000000000002547 10.1212/WNL.0000000000002547 PMC4826340 Parkinsonism Relat Disord. 2013 Nov;19(11):1013-7 23916653 Mov Disord. 2011 Jul;26(8):1563-5 21469203 Ann Neurol. 2011 Feb;69(2):303-11 21387375 Brain. 2010 Sep;133(9):2734-48 20663977 Arch Neurol. 2007 Sep;64(9):1318-22

2016 Neurology

115. Snake bite-induced myoclonus, myokymia and myospasm with leukoencephalopathy: a video presentation Full Text available with Trip Pro

Snake bite-induced myoclonus, myokymia and myospasm with leukoencephalopathy: a video presentation 27095811 2017 01 04 2018 11 13 1757-790X 2016 2016 Apr 19 BMJ case reports BMJ Case Rep Snake bite-induced myoclonus, myokymia and myospasm with leukoencephalopathy: a video presentation. 10.1136/bcr-2016-214963 10.1136/bcr-2016-214963 bcr2016214963 Ramcharan Kanterpersad K http://orcid.org/0000-0003-2937-6362 Department of Medicine, San Fernando Teaching Hospital, San Fernando, Trinidad (...) 1757-790X IM Adult Animals Bothrops Humans Leukoencephalopathies etiology Male Myoclonus etiology Myokymia etiology Snake Bites complications 2016 4 21 6 0 2016 4 21 6 0 2017 1 5 6 0 epublish 27095811 bcr-2016-214963 10.1136/bcr-2016-214963 PMC4840739 Semin Neurol. 2004 Jun;24(2):175-9 15257514 BMJ Case Rep. 2013 Jan 18;2013:null 23334491 J Postgrad Med. 2014 Jan-Mar;60(1):89-90 24625952

2016 BMJ case reports

116. Giant early components of somatosensory evoked potentials to tibial nerve stimulation in cortical myoclonus Full Text available with Trip Pro

Giant early components of somatosensory evoked potentials to tibial nerve stimulation in cortical myoclonus Enlarged cortical components of somatosensory evoked potentials (giant SEPs) recorded by electroencephalography (EEG) and abnormal somatosensory evoked magnetic fields (SEFs) recorded by magnetoencephalography (MEG) are observed in the majority of patients with cortical myoclonus (CM). Studies on simultaneous recordings of SEPs and SEFs showed that generator mechanism of giant SEPs

2016 NeuroImage : Clinical

117. Opioid-induced myoclonus and hyperalgesia following a short course of low-dose oral morphine Full Text available with Trip Pro

Opioid-induced myoclonus and hyperalgesia following a short course of low-dose oral morphine A 76-year-old man was admitted to hospital with a right-sided fractured neck of femur requiring repair via a cemented hemiarthroplasty. Intraoperatively he received 10 mg of intravenous morphine. Post-operatively he received a short course of low-dose oral opioids and subsequently developed myoclonic jerks and hyperalgesia. The opioids were discontinued and both adverse effects resolved. This case (...) report discusses the concurrent development of myoclonus and hyperalgesia following a low dose of opioids and explores possible management options.

2016 British journal of pain

118. Ataxia, dystonia and myoclonus in adult patients with Niemann-Pick type C Full Text available with Trip Pro

Ataxia, dystonia and myoclonus in adult patients with Niemann-Pick type C Niemann-Pick type C (NP-C) is a rare autosomal recessive progressive neurodegenerative disorder caused by mutations in the NP-C 1 or 2 gene. Besides visceral symptoms, presentation in adolescent and adult onset variants is often with neurological symptoms. The most frequently reported presenting symptoms of NP-C in adulthood are psychiatric symptoms (38 %), cognitive decline (23 %) and ataxia (20 %). Myoclonus can (...) was evaluated by questionnaires (Rand-36, SIP-68, HAQ). In four of the five patients with myoclonic jerks simultaneous EEG with EMG was performed.A movement disorder was the initial neurological symptom in six patients: three with myoclonus and three with ataxia. Two others presented with psychosis. Four experienced cognitive deficits early in the course of the disease. Patients showed cognitive deficits in all investigated domains. Five patients showed myoclonic jerks, including negative myoclonus. In all

2016 Orphanet journal of rare diseases

119. The clinical heterogeneity of drug-induced myoclonus: an illustrated review Full Text available with Trip Pro

The clinical heterogeneity of drug-induced myoclonus: an illustrated review A wide variety of drugs can cause myoclonus. To illustrate this, we first discuss two personally observed cases, one presenting with generalized, but facial-predominant, myoclonus that was induced by amantadine; and the other presenting with propriospinal myoclonus triggered by an antibiotic. We then review the literature on drugs that may cause myoclonus, extracting the corresponding clinical phenotype and suggested (...) underlying pathophysiology. The most frequently reported classes of drugs causing myoclonus include opiates, antidepressants, antipsychotics, and antibiotics. The distribution of myoclonus ranges from focal to generalized, even amongst patients using the same drug, which suggests various neuro-anatomical generators. Possible underlying pathophysiological alterations involve serotonin, dopamine, GABA, and glutamate-related processes at various levels of the neuraxis. The high number of cases of drug

2016 Journal of neurology

120. Brain inflammation is accompanied by peripheral inflammation in Cstb−/− mice, a model for progressive myoclonus epilepsy Full Text available with Trip Pro

Brain inflammation is accompanied by peripheral inflammation in Cstb−/− mice, a model for progressive myoclonus epilepsy Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) is an autosomal recessively inherited childhood-onset neurodegenerative disorder, characterized by myoclonus, seizures, and ataxia. Mutations in the cystatin B gene (CSTB) underlie EPM1. The CSTB-deficient (Cstb -/- ) mouse model recapitulates key features of EPM1, including myoclonic seizures. The mice

2016 Journal of neuroinflammation

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