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Myoclonus

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81. Low CSF 5-HIAA in Myoclonus Dystonia (PubMed)

Low CSF 5-HIAA in Myoclonus Dystonia 28949039 2019 01 14 1531-8257 32 11 2017 11 Movement disorders : official journal of the Movement Disorder Society Mov. Disord. Low CSF 5-HIAA in Myoclonus Dystonia. 1647-1649 10.1002/mds.27117 Peall Kathryn J KJ 0000-0003-4749-4944 MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff, United Kingdom. Ng Joanne J Developmental Neurosciences, UCL Great Ormond Street-Institute of Child Health, London, United Kingdom. Department of Neurology, Great

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2017 Movement disorders : official journal of the Movement Disorder Society

82. Pretreatment with Oxycodone Simultaneously Reduces Etomidate-Induced Myoclonus and Rocuronium-Induced Withdrawal Movements During RapidSequence Induction (PubMed)

Pretreatment with Oxycodone Simultaneously Reduces Etomidate-Induced Myoclonus and Rocuronium-Induced Withdrawal Movements During RapidSequence Induction BACKGROUND Etomidate and rocuronium are often paired in rapid-sequence anesthesia induction. However, the effect of pretreatment with oxycodone on myoclonic and withdrawal movements has not been previously investigated. The aim of this study was to evaluate the effects of oxycodone on the incidence and severity of etomidate-induced myoclonus (...) and rocuronium-induced nociceptive withdrawal movements during rapid-sequence anesthesia induction. MATERIAL AND METHODS We randomly divided 120 patients into the saline group (group S) and the oxycodone group (group O) (n=60 in each group). Patients received 0.05 mg/kg oxycodone or saline intravenously 2 min before administration of 0.3 mg/kg etomidate. The occurrence and severity of myoclonus were assessed after administration of etomidate, then rocuronium was injected, followed by evaluation of withdrawal

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2017 Medical science monitor : international medical journal of experimental and clinical research

83. Hypothyroidism-induced Reversible Encephalopathy as a Cause of Aggravation of Parkinsonism and Myoclonus in Parkinson’s Disease (PubMed)

Hypothyroidism-induced Reversible Encephalopathy as a Cause of Aggravation of Parkinsonism and Myoclonus in Parkinson’s Disease Myoclonus and encephalopathy are unusual in patients with Parkinson's disease (PD).We describe the case of a 59-year-old male with PD who developed myoclonus and encephalopathy. Underlying hypothyroidism was revealed after admission and treated with levothyroxine. Myoclonus and encephalopathy were completely resolved following thyroid hormone (...) replacement.Hypothyroidism can cause reversible myoclonus and encephalopathy along with unusual aggravation of parkinsonism symptoms in patients with PD.

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2017 Tremor and Other Hyperkinetic Movements

84. Opsoclonus myoclonus syndrome in a patient with Japanese encephalitis: a case report (PubMed)

Opsoclonus myoclonus syndrome in a patient with Japanese encephalitis: a case report Opsoclonus myoclonus syndrome is a rare neurological disorder that usually manifests as a paraneoplastic phenomenon. Although some viruses are reported to cause this condition, opsoclonus myoclonus syndrome by Japanese encephalitis has not been reported previously.Here we present the case of a 31-year-old Sri Lankan woman who presented with fever, altered level of consciousness, opsoclonus, and facial myoclonus (...) myoclonus syndrome can be a feature of infection with Japanese encephalitis and that it can be added to the list of viruses which cause opsoclonus. Currently there is no well-accepted treatment for opsoclonus myoclonus syndrome and intravenously administered methylprednisolone pulses and immunosuppressants can be used successfully in these patients for early recovery.

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2017 Journal of medical case reports

85. Opsoclonus-Myoclonus Syndrome during Rituximab Treatment for Autoimmune Autonomic Ganglionopathy (PubMed)

Opsoclonus-Myoclonus Syndrome during Rituximab Treatment for Autoimmune Autonomic Ganglionopathy 28740856 2018 11 13 2332-7812 4 5 2017 Sep Neurology(R) neuroimmunology & neuroinflammation Neurol Neuroimmunol Neuroinflamm Opsoclonus-Myoclonus Syndrome during Rituximab Treatment for Autoimmune Autonomic Ganglionopathy. e376 10.1212/NXI.0000000000000376 Dumitrascu Oana M OM Department of Neurology (O.M.D., L.Z., M.F.G., B.P.G.), Mayo Clinic, Phoenix, AZ; and Department of Neurology (A.M.), Mayo

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2017 Neurology® neuroimmunology & neuroinflammation

86. A Rare Instance of Levofloxacin Induced Myoclonus (PubMed)

A Rare Instance of Levofloxacin Induced Myoclonus Levofloxacin is a widely used fluoroquinolone, mainly as a respiratory antimicrobial agent. It is employed as a second line therapeutic modality in pulmonary tuberculosis as well. The drug has been in use for ages, and is known to be both efficacious and safe. However, it is not free of adverse effects. The most dangerous ones are those involving the Central Nervous System (CNS). Although rare, levofloxacin can cause involuntary movements like (...) chorea and myoclonus. Here by, we present a case of an elderly male patient who developed reversible myoclonus/chorea after a course of levofloxacin (which was initiated as part of his anti-tubercular therapy) following the development of peripheral neuropathy secondary to isoniazid.

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2017 Journal of clinical and diagnostic research : JCDR

87. The Inter-rater Variability of Clinical Assessment in Post-anoxic Myoclonus (PubMed)

The Inter-rater Variability of Clinical Assessment in Post-anoxic Myoclonus Acute post-anoxic myoclonus (PAM) can be divided into an unfavorable (generalized/subcortical) and more favorable ((multi)focal/cortical) outcome group that could support prognostication in post-anoxic encephalopathy; however, the inter-rater variability of clinically assessing these PAM subtypes is unknown.We prospectively examined PAM patients using a standardized video protocol. Videos were rated by three (...) neurologists who classified PAM phenotype (generalized/(multi)focal), stimulus sensitivity, localization (proximal/distal/both), and severity (Clinical Global Impression-Severity Scale (CGI-S) and Unified Myoclonus Rating Scale (UMRS)).Poor inter-rater agreement was found for phenotype and stimulus sensitivity (κ=-0.05), moderate agreement for localization (κ=0.46). Substantial agreement was obtained for the CGI-S (intraclass correlation coefficient (ICC)=0.64) and almost perfect agreement for the UMRS

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2017 Tremor and Other Hyperkinetic Movements

88. Epileptic Negative Myoclonus as the First and Only Symptom in a Challenging Diagnosis of Benign Epilepsy With Centrotemporal Spikes (PubMed)

Epileptic Negative Myoclonus as the First and Only Symptom in a Challenging Diagnosis of Benign Epilepsy With Centrotemporal Spikes To investigate the clinical and neurophysiological characteristics of epileptic negative myoclonus as the first and only ictal symptom of benign epilepsy with centrotemporal spikes.Electrophysiological evaluations included polygraphic recordings with simultaneous video electroencephalogram monitoring and tests performed with patient's upper limb outstretched (...) in standing posture. Epileptic negative myoclonus manifestations, electrophysiological features, and responses to antiepileptic drugs were analyzed.The authors report 2 patients with benign epilepsy with centrotemporal spikes, who had epileptic negative myoclonus as the first and only seizure type. Video electroencephalogram monitoring results showed that their negative myoclonus seizures were emanating from the contralateral central and the parietal regions. Epileptic negative myoclonus was controlled

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2017 Child Neurology Open

89. Thymoma-associated Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM) with Myasthenia Gravis (PubMed)

Thymoma-associated Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM) with Myasthenia Gravis We report a case of a 72-year-old woman who initially presented with symptoms of bulbar myasthenia and was positive for anti-acetylcholine receptor antibodies. She subsequently developed painful muscle spasms, myoclonus, and stiffness. Thymoma was detected, and both anti-glycine receptor and anti-glutamic acid decarboxylase antibodies were found. She was diagnosed with thymoma-associated (...) progressive encephalomyelitis with rigidity and myoclonus (PERM). She experienced marked improvement after thymectomy followed by plasma exchange and intravenous immunoglobulin and prednisolone. This case suggests that thymectomy followed by sufficient immunosuppression may be useful in the treatment of thymoma-associated PERM. Myasthenia gravis may develop in thymoma-associated PERM patients.

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2017 Internal Medicine

90. Event related desynchronisation predicts functional propriospinal myoclonus (PubMed)

Event related desynchronisation predicts functional propriospinal myoclonus Recent diagnostic criteria for functional movement disorders have proposed a "laboratory supported" level of diagnostic certainty where the clinical diagnosis is supported by a positive test. For functional myoclonus the Bereitschaftspotential (BP) is generally accepted as a positive laboratory test. We hypothesised that a different EEG measure, event-related desynchronisation (ERD), might be more effective.We analysed (...) 20 patients with functional propriospinal myoclonus (fPSM) and 9 controls with organic myoclonus and performed back-averaging for BPs plus time-frequency decomposition to assess ERD and calculated sensitivity and specificity for both techniques.The BP was present in only 25% of patients with fPSM while the majority showed a significant ERD (mean 38 Hz; sensitivity 65%). ERD was significant at the group level (p < 0.001), but not the BP (p > 0.05). Both BP and ERD were absent in our control

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2016 Parkinsonism & related disorders

91. Autosomal Dominant Cortical Tremor, Myoclonus, and Epilepsy Syndrome mimicking Juvenile Myoclonic Epilepsy (PubMed)

Autosomal Dominant Cortical Tremor, Myoclonus, and Epilepsy Syndrome mimicking Juvenile Myoclonic Epilepsy Autosomal dominant cortical tremor, myoclonus, and epilepsy (ADCME) syndrome is a genetically heterogeneous and under-recognized disease characterized by tremulous movements mimicking essential tremor, myoclonus, and rare generalized tonic-clonic seizures. Here we described the clinical and electrophysiological features of three siblings with ADCME syndrome mimicking juvenile myoclonic (...) and wave discharges. The N20-P25 and P25-N35 amplitudes were substantially higher in the three siblings with ADCME. Although tremor frequencies were similar to those of the ET group, the siblings had mild interrupting low-amplitude myoclonus, suggestive of cortical tremor, in the accelerometric analysis.We presented a detailed clinical evaluation with electrophysiological confirmation of ADCME syndrome in a Turkish family. This rare clinical picture might be misdiagnosed as JME and should be kept

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2016 Archives of Neuropsychiatry

92. Progressive Myoclonus Epilepsies: The Gene-Empowered Era (PubMed)

Progressive Myoclonus Epilepsies: The Gene-Empowered Era 27694067 2017 03 14 2017 11 18 1950-6945 18 S2 2016 Sep 01 Epileptic disorders : international epilepsy journal with videotape Epileptic Disord Progressive Myoclonus Epilepsy: The Gene-Empowered Era. 1-2 Minassian Berge A BA Striano Pasquale P Avanzini Giuliano G eng P01 NS097197 NS NINDS NIH HHS United States Introductory Journal Article Progressive Myoclonus Epilepsy: The Gene-Empowered Era. France Epileptic Disord 100891853 1294-9361

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2016 Epileptic disorders : international epilepsy journal with videotape

93. Post-modern therapeutic approaches for progressive myoclonus epilepsy (PubMed)

Post-modern therapeutic approaches for progressive myoclonus epilepsy While the PME are arguably the severest epilepsies and neurological disorders, the vast majority are monogenic. Additionally, many affect straightforward biochemical pathways. Finally, by definition, they occur in previously healthy and well-developed brains. As such, their therapies should be easier than in complex, albeit often less severe, neurological developmental disorders where the complex, poorly understood

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2016 Epileptic disorders : international epilepsy journal with videotape

94. The History of Progressive Myoclonus Epilepsies (PubMed)

The History of Progressive Myoclonus Epilepsies The history of the progressive myoclonus epilepsies (PMEs) spans more than a century. However, the recent history of PMEs begins with a consensus statement published in the wake of the Marseille PME workshop in 1989 (Marseille Consensus Group, 1990). This consensus helped define the various types of PME known at the time and set the agenda for a new era of genetic research which soon lead to the discovery of many PME genes. Prior to the Marseille

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2016 Epileptic disorders : international epilepsy journal with videotape

95. Essential rhythmic palatal myoclonus in a 51-year-old man (PubMed)

Essential rhythmic palatal myoclonus in a 51-year-old man Essential palatal myoclonus is a rare movement disorder consisting of continuous rhythmic jerks of the soft palate; it usually develops secondary to brainstem or cerebellar disease called symptomatic rhythmic palatal myoclonus. Diagnosis is usually clinical, and some patients, however, fail to show evidence of a structural lesion like our patient called essential rhythmic palatal myoclonus. We report a 51-year-old man who has suffered

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2016 Oxford Medical Case Reports

96. Post-hypoxic Myoclonus: Current Concepts, Neurophysiology, and Treatment (PubMed)

Post-hypoxic Myoclonus: Current Concepts, Neurophysiology, and Treatment Myoclonus may occur after hypoxia. In 1963, Lance and Adams described persistent myoclonus with other features after hypoxia. However, myoclonus occurring immediately after hypoxia may demonstrate different syndromic features from classic Lance-Adams syndrome (LAS). The aim of this review is to provide up-to-date information about the spectrum of myoclonus occurring after hypoxia with emphasis on neurophysiological (...) features.A literature search was performed on PubMed database from 1960 to 2015. The following search terms were used: "myoclonus," "post anoxic myoclonus," "post hypoxic myoclonus," and "Lance Adams syndrome." The articles describing clinical features, neurophysiology, management, and prognosis of post-hypoxic myoclonus cases were included for review.Several reports in the literature were separated clinically into "acute post-hypoxic myoclonus," which occurred within hours of severe hypoxia

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2016 Tremor and Other Hyperkinetic Movements

97. Comparison of the Effects of Low-Dose Midazolam, Magnesium Sulfate, Remifentanil and Low-Dose Etomidate on Prevention of Etomidate-Induced Myoclonus in Orthopedic Surgeries. (PubMed)

Comparison of the Effects of Low-Dose Midazolam, Magnesium Sulfate, Remifentanil and Low-Dose Etomidate on Prevention of Etomidate-Induced Myoclonus in Orthopedic Surgeries. Etomidate is a potent hypnotic agent with several desirable advantages such as providing a stable cardiovascular profile with minimal respiratory adverse effects and better hemodynamic stability compared with other induction agents. This drug is associated, however, with myoclonic movements which is characterized (...) by a sudden, brief muscle contractions as a disturbing side-effect.The present study was designed to compare the effectiveness of low- dose midazolam, magnesium sulfate, remifentanil and low-dose etomidate to suppress etomidate-induced myoclonus in orthopedic surgery.A double-blind clinical trial study was conducted in an academic hospital from September 2014 to August 2015. Two hundred and eighty-four eligible patients, American society of anesthesiologists class I - II, scheduled for elective orthopedic

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2016 Anesthesiology and pain medicine

98. Snake bite-induced myoclonus, myokymia and myospasm with leukoencephalopathy: a video presentation (PubMed)

Snake bite-induced myoclonus, myokymia and myospasm with leukoencephalopathy: a video presentation 27095811 2017 01 04 2018 11 13 1757-790X 2016 2016 Apr 19 BMJ case reports BMJ Case Rep Snake bite-induced myoclonus, myokymia and myospasm with leukoencephalopathy: a video presentation. 10.1136/bcr-2016-214963 10.1136/bcr-2016-214963 bcr2016214963 Ramcharan Kanterpersad K http://orcid.org/0000-0003-2937-6362 Department of Medicine, San Fernando Teaching Hospital, San Fernando, Trinidad (...) 1757-790X IM Adult Animals Bothrops Humans Leukoencephalopathies etiology Male Myoclonus etiology Myokymia etiology Snake Bites complications 2016 4 21 6 0 2016 4 21 6 0 2017 1 5 6 0 epublish 27095811 bcr-2016-214963 10.1136/bcr-2016-214963 PMC4840739 Semin Neurol. 2004 Jun;24(2):175-9 15257514 BMJ Case Rep. 2013 Jan 18;2013:null 23334491 J Postgrad Med. 2014 Jan-Mar;60(1):89-90 24625952

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2016 BMJ case reports

99. Distribution and Coexistence of Myoclonus and Dystonia as Clinical Predictors of SGCE Mutation Status: A Pilot Study (PubMed)

Distribution and Coexistence of Myoclonus and Dystonia as Clinical Predictors of SGCE Mutation Status: A Pilot Study Myoclonus-dystonia (M-D) is a young onset movement disorder typically involving myoclonus and dystonia of the upper body. A proportion of the cases are caused by mutations to the autosomal dominantly inherited, maternally imprinted, epsilon-sarcoglycan gene (SGCE). Despite several sets of diagnostic criteria, identification of patients most likely to have an SGCE mutation remains (...) difficult.Forty consecutive patients meeting pre-existing diagnostic clinical criteria for M-D underwent a standardized clinical examination (20 SGCE mutation positive and 20 negative). Each video was reviewed and systematically scored by two assessors blinded to mutation status. In addition, the presence and coexistence of myoclonus and dystonia was recorded in four body regions (neck, arms, legs, and trunk) at rest and with action.Thirty-nine patients were included in the study (one case was excluded owing

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2016 Frontiers in neurology

100. Late-onset Juvenile Myoclonic Epilepsy or Frontal Lobe Epilepsy with Myoclonus (PubMed)

Late-onset Juvenile Myoclonic Epilepsy or Frontal Lobe Epilepsy with Myoclonus 27748348 2017 02 27 2018 12 02 2542-5641 129 20 2016 10 20 Chinese medical journal Chin. Med. J. Late-onset Juvenile Myoclonic Epilepsy or Frontal Lobe Epilepsy with Myoclonus. 2508-2509 10.4103/0366-6999.191829 Zhang Xin-Yue XY Department of Neurology, Neuroscience Center, First Hospital of Jilin University, Changchun, Jilin 130021, China. Yu Jin-Bei JB Department of Neurology, Neuroscience Center, First Hospital (...) Anticonvulsants 33CM23913M Carbamazepine VZI5B1W380 Oxcarbazepine IM Adult Anticonvulsants therapeutic use Brain drug effects pathology physiopathology Carbamazepine analogs & derivatives therapeutic use Electroencephalography Epilepsy, Frontal Lobe diagnosis drug therapy Female Humans Myoclonic Epilepsy, Juvenile diagnosis drug therapy Myoclonus diagnosis drug therapy Oxcarbazepine 2016 10 18 6 0 2016 10 18 6 0 2017 2 28 6 0 ppublish 27748348 ChinMedJ_2016_129_20_2508_191829 10.4103/0366-6999.191829

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2016 Chinese medical journal

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