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Myoclonus

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81. The Inter-rater Variability of Clinical Assessment in Post-anoxic Myoclonus Full Text available with Trip Pro

The Inter-rater Variability of Clinical Assessment in Post-anoxic Myoclonus Acute post-anoxic myoclonus (PAM) can be divided into an unfavorable (generalized/subcortical) and more favorable ((multi)focal/cortical) outcome group that could support prognostication in post-anoxic encephalopathy; however, the inter-rater variability of clinically assessing these PAM subtypes is unknown.We prospectively examined PAM patients using a standardized video protocol. Videos were rated by three (...) neurologists who classified PAM phenotype (generalized/(multi)focal), stimulus sensitivity, localization (proximal/distal/both), and severity (Clinical Global Impression-Severity Scale (CGI-S) and Unified Myoclonus Rating Scale (UMRS)).Poor inter-rater agreement was found for phenotype and stimulus sensitivity (κ=-0.05), moderate agreement for localization (κ=0.46). Substantial agreement was obtained for the CGI-S (intraclass correlation coefficient (ICC)=0.64) and almost perfect agreement for the UMRS

2017 Tremor and Other Hyperkinetic Movements

82. Epileptic Negative Myoclonus as the First and Only Symptom in a Challenging Diagnosis of Benign Epilepsy With Centrotemporal Spikes Full Text available with Trip Pro

Epileptic Negative Myoclonus as the First and Only Symptom in a Challenging Diagnosis of Benign Epilepsy With Centrotemporal Spikes To investigate the clinical and neurophysiological characteristics of epileptic negative myoclonus as the first and only ictal symptom of benign epilepsy with centrotemporal spikes.Electrophysiological evaluations included polygraphic recordings with simultaneous video electroencephalogram monitoring and tests performed with patient's upper limb outstretched (...) in standing posture. Epileptic negative myoclonus manifestations, electrophysiological features, and responses to antiepileptic drugs were analyzed.The authors report 2 patients with benign epilepsy with centrotemporal spikes, who had epileptic negative myoclonus as the first and only seizure type. Video electroencephalogram monitoring results showed that their negative myoclonus seizures were emanating from the contralateral central and the parietal regions. Epileptic negative myoclonus was controlled

2017 Child Neurology Open

83. Contrast induced spinal myoclonus after percutaneous coronary intervention Full Text available with Trip Pro

Contrast induced spinal myoclonus after percutaneous coronary intervention We present a case of a 77-year-old man diagnosed with contrast-induced spinal myoclonus following primary percutaneous coronary intervention. After being admitted with a diagnosis of anteroseptal myocardial infarction, he underwent primary percutaneous coronary intervention to the left anterior descending artery and was prescribed aspirin, clopidogrel, and intravenous heparin. The following day he developed non (...) -intentional irregular jerky movements confined to the truncal area. In view of rhythmic jerking confined to muscles innervated by a restricted segment of the spinal cord, resistance to supra-spinal influences and voluntary action, and no preceding electroencephalography activity in the contralateral sensorimotor cortex, a diagnosis of spinal myoclonus was made. Spinal myoclonus is a rare entity in which myoclonic movements occur in muscles originating from few (segmental), or many adjacent spinal motor

2017 Journal of cardiology cases

84. Relative Incidence of Seizures and Myoclonus in Alzheimer’s Disease, Dementia with Lewy Bodies, and Frontotemporal Dementia Full Text available with Trip Pro

Relative Incidence of Seizures and Myoclonus in Alzheimer’s Disease, Dementia with Lewy Bodies, and Frontotemporal Dementia Patients with Alzheimer's disease (AD) are more prone to seizures and myoclonus, but relative risk of these symptoms among other dementia types is unknown.To determine incidence of seizures and myoclonus in the three most common neurodegenerative dementias: AD, dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD).Our institution's medical records were (...) reviewed for new-onset unprovoked seizures and myoclonus in patients meeting criteria for AD (n = 1,320), DLB (n = 178), and FTD (n = 348). Cumulative probabilities of developing seizures and myoclonus were compared between diagnostic groups, whereas age-stratified incidence rates were determined relative to control populations.The cumulative probability of developing seizures after disease onset was 11.5% overall, highest in AD (13.4%) and DLB (14.7%) and lowest in FTD (3.0%). The cumulative

2017 Journal of Alzheimer's disease : JAD

85. Update on Pharmacological Treatment of Progressive Myoclonus Epilepsies Full Text available with Trip Pro

Update on Pharmacological Treatment of Progressive Myoclonus Epilepsies Progressive myoclonus epilepsies (PMEs) are a group of rare inherited diseases featuring a combination of myoclonus, seizures and variable degree of cognitive impairment. Despite extensive investigations, a large number of PMEs remain undiagnosed. In this review, we focus on the current pharmacological approach to PMEs.References were mainly identified through PubMed search until February 2017 and backtracking of references (...) myoclonus or seizures. Lamotrigine should be used with caution due to its unpredictable effect on myoclonus. Avoidance of drugs known to aggravate myoclonus and seizures, such as carbamazepine and phenytoin, is paramount. Psychiatric (in particular depression) and other comorbidities need to be adequately managed. Although a 3- to 4-drug regimen is often necessary to control seizures and myoclonus, particular care should be paid to avoid excessive pharmacological load and neurotoxic side effects. Target

2017 Current pharmaceutical design

86. Metronidazole-Induced Craniocervical Myoclonus with Reversible Bilateral Dentate Nucleus Lesions Full Text available with Trip Pro

Metronidazole-Induced Craniocervical Myoclonus with Reversible Bilateral Dentate Nucleus Lesions 28122422 2018 11 13 2005-940X 10 1 2017 Jan Journal of movement disorders J Mov Disord Metronidazole-Induced Craniocervical Myoclonus with Reversible Bilateral Dentate Nucleus Lesions. 67-68 10.14802/jmd.16021 Lee Hyun Chang HC Department of Neurology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea. Kim Young Eun YE Department of Neurology, Hallym

2017 Journal of movement disorders

87. Multifocal Myoclonus as a Manifestation of Acute Cerebral Infarction Recovered by Carotid Arterial Stenting Full Text available with Trip Pro

Multifocal Myoclonus as a Manifestation of Acute Cerebral Infarction Recovered by Carotid Arterial Stenting 28122425 2018 11 13 2005-940X 10 1 2017 Jan Journal of movement disorders J Mov Disord Multifocal Myoclonus as a Manifestation of Acute Cerebral Infarction Recovered by Carotid Arterial Stenting. 64-66 10.14802/jmd.16040 Kim Hyangkyoung H Department of Surgery, Chung-Ang University College of Medicine, Seoul, Korea. Byun Jun Soo JS Department of Radiology, Chung-Ang University College

2017 Journal of movement disorders

88. Deep brain stimulation for myoclonus-dystonia syndrome with double mutations in DYT1 and DYT11 Full Text available with Trip Pro

Deep brain stimulation for myoclonus-dystonia syndrome with double mutations in DYT1 and DYT11 Myoclonus-dystonia syndrome (MDS) is a rare autosomal dominant inherited disorder characterized by the presentation of both myoclonic jerks and dystonia. Evidence is emerging that deep brain stimulation (DBS) may be a promising treatment for MDS. However, there are no studies reporting the effects of DBS on MDS with double mutations in DYT1 and DYT11. Two refractory MDS patients with double mutations

2017 Scientific reports

89. Botulinum Toxin A for Treatment of Diaphragmatic Myoclonus Full Text available with Trip Pro

Botulinum Toxin A for Treatment of Diaphragmatic Myoclonus 28303865 2018 09 05 2018 11 13 2542-5641 130 6 2017 Mar 20 Chinese medical journal Chin. Med. J. Botulinum Toxin A for Treatment of Diaphragmatic Myoclonus. 753-754 10.4103/0366-6999.201615 He Yi-Jing YJ Department of Neurology, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China. Li Bing B Department of Neurology, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China (...) Botulinum Toxins, Type A administration & dosage Diaphragm physiopathology Electromyography Humans Male Middle Aged Myoclonus drug therapy 2017 3 18 6 0 2017 3 18 6 0 2018 9 6 6 0 ppublish 28303865 ChinMedJ_2017_130_6_753_201615 10.4103/0366-6999.201615 PMC5358432 Neurologia. 2015 May;30(4):249-51 24011669 Mov Disord. 2009 Jul 15;24(9):1401 19373937 Handb Clin Neurol. 2011;100:617-28 21496611 Arch Dermatol. 2004 Nov;140(11):1351-4 15545544 Mov Disord. 2005 Aug;20(8):917-8 16007667

2017 Chinese medical journal

90. Opsoclonus-Myoclonus Syndrome during Rituximab Treatment for Autoimmune Autonomic Ganglionopathy Full Text available with Trip Pro

Opsoclonus-Myoclonus Syndrome during Rituximab Treatment for Autoimmune Autonomic Ganglionopathy 28740856 2018 11 13 2332-7812 4 5 2017 Sep Neurology(R) neuroimmunology & neuroinflammation Neurol Neuroimmunol Neuroinflamm Opsoclonus-Myoclonus Syndrome during Rituximab Treatment for Autoimmune Autonomic Ganglionopathy. e376 10.1212/NXI.0000000000000376 Dumitrascu Oana M OM Department of Neurology (O.M.D., L.Z., M.F.G., B.P.G.), Mayo Clinic, Phoenix, AZ; and Department of Neurology (A.M.), Mayo

2017 Neurology® neuroimmunology & neuroinflammation

91. Propofol decreases etomidate-related myoclonus in gastroscopy. Full Text available with Trip Pro

Propofol decreases etomidate-related myoclonus in gastroscopy. Myoclonus, a common complication during intravenous induction with etomidate, is bothersome to both anesthesiologists and patients. This study explored the preventive effect of pretreatment with propofol on etomidate-related myoclonus.This was a prospective, double-blind, clinical, randomized controlled study. Totally, 363 patients who were scheduled for a short-duration, painless gastrointestinal endoscopy were divided into 5 (...) groups. Four groups received 0 mg/kg (E group), 0.25 mg/kg (LPE group), 0.50 mg/kg (MPE group), or 0.75 mg/kg (HPE group) propofol pretreatment before etomidate anesthesia. Another group only received 1 to 2 mg/kg of propofol (P group) as anesthesia. The incidence and severity of myoclonus, patient circulation and respiratory status, and intraoperative and postoperative complications were recorded.The incidence of myoclonus in the LPE group (26.8%), MPE group (16.4%), HPE group (14.9%), and P group

2017 Medicine Controlled trial quality: uncertain

92. Parecoxib sodium pretreatment reduces myoclonus after etomidate: A prospective, double-blind, randomized clinical trial
. (Abstract)

Parecoxib sodium pretreatment reduces myoclonus after etomidate: A prospective, double-blind, randomized clinical trial
. Myoclonus induced by etomidate during induction of general anesthesia is a common phenomenon. This prospective, randomized, saline-controlled clinical study was performed to evaluate the effect of parecoxib sodium pretreatment on the incidence and severity of etomidate-induced myoclonus.60 patients, American Society of Anesthesiologists (ASA) physical status I or II, aged 20 (...) to 60 years, who were scheduled to undergo elective laparoscopic cholecystectomy under general anesthesia, were allocated randomly into one of two groups to receive parecoxib sodium 40 mg intravenous (group P, n = 30) or the same volume of saline (group S, n = 30) 30 minutes before administration of etomidate (0.3 mg/kg). Myoclonus was assessed on a scale of 0 - 3. Postoperative side effects were recorded.The two groups were comparable with regard to baseline characteristics. The incidence

2017 International journal of clinical pharmacology and therapeutics Controlled trial quality: uncertain

93. Myoclonus epilepsy and ataxia due to KCNC1 mutation: Analysis of 20 cases and K<sup>+</sup> channel properties. (Abstract)

Myoclonus epilepsy and ataxia due to KCNC1 mutation: Analysis of 20 cases and K+ channel properties. To comprehensively describe the new syndrome of myoclonus epilepsy and ataxia due to potassium channel mutation (MEAK), including cellular electrophysiological characterization of observed clinical improvement with fever.We analyzed clinical, electroclinical, and neuroimaging data for 20 patients with MEAK due to recurrent KCNC1 p.R320H mutation. In vitro electrophysiological studies (...) were conducted using whole cell patch-clamp to explore biophysical properties of wild-type and mutant KV 3.1 channels.Symptoms began at between 3 and 15 years of age (median = 9.5), with progressively severe myoclonus and rare tonic-clonic seizures. Ataxia was present early, but quickly became overshadowed by myoclonus; 10 patients were wheelchair-bound by their late teenage years. Mild cognitive decline occurred in half. Early death was not observed. Electroencephalogram (EEG) showed generalized

2017 Annals of Neurology

94. Myoclonus

Myoclonus Myoclonus Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Myoclonus Myoclonus Aka: Myoclonus From Related Chapters II (...) . Definition Brief, sudden onset, non-rhythmic, involuntary, shock-like mucle jerking III. Causes Myoclonic Exposure Anoxia Creutzfeldt-Jacob Disease Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Myoclonus." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Myoclonus (C0027066) Definition (NCI) A sudden, involuntary contraction of a muscle or group

2018 FP Notebook

95. Combined focal myoclonus and dystonia secondary to a cerebellar hemorrhage: a case report. Full Text available with Trip Pro

Combined focal myoclonus and dystonia secondary to a cerebellar hemorrhage: a case report. Myoclonus is a clinical sign characterized by sudden, brief jerky, shock-like involuntary movements of a muscle or group of muscles. Dystonia is defined as a syndrome of sustained muscle contractions, frequently causing twisting and repetitive movements or abnormal postures. Cases of myoclonus or dystonia secondary to a structural lesion in the cerebellum have been reported. However, there has never been (...) a reported case of combined myoclonus and dystonia secondary to a cerebellar lesion.Herein, we report a 22-year-old female patient with sudden-onset myoclonic jerks, dystonic posture and mild ataxia in the right upper extremity. At age 19, she experienced sudden headache with vomiting. The neurological examination showed ataxia, myoclonus and dystonia in the right upper extremity. Brain images demonstrated a hemorrhage in the right cerebellar hemisphere secondary to a cavernous malformation. After

2016 BMC Neurology

96. A randomized, controlled, double-blind, crossover trial of zonisamide in myoclonus-dystonia. (Abstract)

A randomized, controlled, double-blind, crossover trial of zonisamide in myoclonus-dystonia. To evaluate the efficacy and safety of zonisamide in patients with myoclonus-dystonia.We conducted a randomized, double-blind, placebo-controlled crossover trial of zonisamide (300 mg/d) in 24 patients with myoclonus-dystonia. Each treatment period consisted of a 6-week titration phase followed by a 3-week fixed-dose phase. The periods were separated by a 5-week washout period. The co-primary outcomes (...) were action myoclonus severity (section 4 of the Unified Myoclonus Rating Scale [UMRS 4]) and myoclonus-related functional disability (UMRS 5). Secondary outcomes included dystonia severity, assessed with the movement and disability subscales of the Burke-Fahn-Marsden-Dystonia Rating Scale (BFM), the Clinical Global Impression-Improvement scale (CGI), and safety measures. Wilcoxon signed-rank tests for paired data were used to analyze treatment effects.Twenty-three patients (11 men, 12 women) were

2016 Neurology Controlled trial quality: predicted high

97. Clinically distinct electroencephalographic phenotypes of early myoclonus after cardiac arrest. Full Text available with Trip Pro

Clinically distinct electroencephalographic phenotypes of early myoclonus after cardiac arrest. We tested the hypothesis that there are readily classifiable electroencephalographic (EEG) phenotypes of early postanoxic multifocal myoclonus (PAMM) that develop after cardiac arrest.We studied a cohort of consecutive comatose patients treated after cardiac arrest from January 2012 to February 2015. For patients with clinically evident myoclonus before awakening, 2 expert physicians reviewed (...) and classified all EEG recordings. Major categories included: Pattern 1, suppression-burst background with high-amplitude polyspikes in lockstep with myoclonic jerks; and Pattern 2, continuous background with narrow, vertex spike-wave discharges in lockstep with myoclonic jerks. Other patterns were subcortical myoclonus and unclassifiable. We compared population characteristics and outcomes across these EEG subtypes.Overall, 401 patients were included, of whom 69 (16%) had early myoclonus. Among

2016 Annals of Neurology

98. KIF5A mutations cause an infantile onset phenotype including severe myoclonus with evidence of mitochondrial dysfunction. Full Text available with Trip Pro

KIF5A mutations cause an infantile onset phenotype including severe myoclonus with evidence of mitochondrial dysfunction. Missense mutations in kinesin family member 5A (KIF5A) cause spastic paraplegia 10. We report on 2 patients with de novo stop-loss frameshift variants in KIF5A resulting in a novel phenotype that includes severe infantile onset myoclonus, hypotonia, optic nerve abnormalities, dysphagia, apnea, and early developmental arrest. We propose that alteration and elongation

2016 Annals of Neurology

99. A Rare Cause of Myoclonus: A Cupric Conundrum. Full Text available with Trip Pro

A Rare Cause of Myoclonus: A Cupric Conundrum. A woman aged 22 years presented with a 3-year history of jerks when brushing her teeth and a tremor when carrying drinks. Examination revealed a bilateral jerky tremor, stimulus-sensitive myoclonus, and difficulty with tandem gait. Thyroid and liver function test results were normal, but she had rapidly progressive renal failure. Serum copper, ceruloplasmin, and manganese levels were normal, but her urinary copper level was elevated on 2 occasions

2016 JAMA neurology

100. [Effect of gabapentin pretreatment on myoclonus after etomidate: a randomized, double-blind, placebo-controlled study]. Full Text available with Trip Pro

[Effect of gabapentin pretreatment on myoclonus after etomidate: a randomized, double-blind, placebo-controlled study]. To evaluate the effects of three different doses of gabapentin pretreatment on the incidence and severity of myoclonic movements linked to etomidate injection.One hundered patients, between 18 and 60 years of age and risk category American Society of Anesthesiologists I-II, with planned elective surgery under general anesthetic were included in the study. The patients were (...) . Two minutes after induction, 2μgkg(-1) fentanyl and 0.8mgkg(-1) rocuronium were administered for tracheal intubation.Demographic data were similar. Incidence and severity of myoclonus in Group G1200 and Group G800 were significantly lower than in Group P; sedation incidence and level were appreciably higher compared to Group P and Group G400. While there was no difference in the incidence of myoclonus between Group P and Group G400, the severity of myoclonus in Group G400 was lower than

2016 Revista brasileira de anestesiologia Controlled trial quality: uncertain

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