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Myoclonus

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182. Acute dyskinesia, myoclonus, and akathisa in an adolescent male abusing quetiapine via nasal insufflation: a case study. (PubMed)

Acute dyskinesia, myoclonus, and akathisa in an adolescent male abusing quetiapine via nasal insufflation: a case study. Although the benefits of antipsychotic pharmacotherapy can be pronounced, many patients develop unwanted adverse effects including a variety of movement disorders. Compared with the traditional antipsychotics, the atypical antipsychotics have a decreased risk for associated movement disorders. Drug-induced movement disorders can occur, however, and the risk of adverse events

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2013 BMC Pediatrics

183. [Role of target controlled infusion of remifentanil for the prevention of etomidate induced myoclonus during general anesthesia]. (PubMed)

[Role of target controlled infusion of remifentanil for the prevention of etomidate induced myoclonus during general anesthesia]. To explore the preventive effect of etomidate-induced myoclonus by different concentrations of target-controlled infusion of remifentanil.A total of 120 cases undergoing general anesthesia were randomly divided into 4 groups according to different concentrations of target controlled infusion of remifentanil using plasma target controlled infusion ( Minto model (...) ) , in which the target concentration was set as 1 f.Lg/L ( group A) , 2 f.Lg/L ( group B) , 3 f.Lg/L ( group C) , and 4 f.Lg/L ( group D) . Five minutes after the balance of effect compartment, induction with etomidate 0. 3 mglkg was conducted intravenously. The intensity and duration of myoclonus was recorded.The incidence of etomidate-induced myoclonus was 70.9%, 33.3%, 26.7%, and 0 in groups A, B, C, and D, respectively. Along with the increase of the remifentanil concentration, the incidence of severe

2013 Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

184. White Matter Degeneration with Unverricht-Lundborg Progressive Myoclonus Epilepsy: A Translational Diffusion-Tensor Imaging Study in Patients and Cystatin B-Deficient Mice. (PubMed)

White Matter Degeneration with Unverricht-Lundborg Progressive Myoclonus Epilepsy: A Translational Diffusion-Tensor Imaging Study in Patients and Cystatin B-Deficient Mice. To study white matter (WM) changes in patients with Unverricht-Lundborg progressive myoclonus epilepsy (EPM1) caused by mutations in the cystatin B gene and in the cystatin B-deficient (Cstb-/-) mouse model and to validate imaging findings with histopathologic analysis of mice.Informed consent was obtained and the study

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2013 Radiology

185. Defining the epsilon-sarcoglycan (SGCE) gene phenotypic signature in myoclonus-dystonia: A reappraisal of genetic testing criteria. (PubMed)

Defining the epsilon-sarcoglycan (SGCE) gene phenotypic signature in myoclonus-dystonia: A reappraisal of genetic testing criteria. Mutations or exon deletions of the epsilon-sarcoglycan (SGCE) gene cause myoclonus-dystonia (M-D), but a subset of M-D patients are mutation-negative and the sensitivity and specificity of current genetic testing criteria are unknown. We screened 46 newly enrolled M-D patients for SGCE mutations and deletions; moreover, 24 subjects previously testing negative

2013 Movement Disorders

186. 'North Sea' progressive myoclonus epilepsy: phenotype of subjects with GOSR2 mutation. (PubMed)

'North Sea' progressive myoclonus epilepsy: phenotype of subjects with GOSR2 mutation. We previously identified a homozygous mutation in the Golgi SNAP receptor complex 2 gene (GOSR2) in six patients with progressive myoclonus epilepsy. To define the syndrome better we analysed the clinical and electrophysiological phenotype in 12 patients with GOSR2 mutations, including six new unrelated subjects. Clinical presentation was remarkably similar with early onset ataxia (average 2 years of age (...) the North Sea, extending to the coastal region of Northern Norway. 'North Sea' progressive myoclonus epilepsy has a homogeneous clinical presentation and relentless disease course allowing ready identification from the other progressive myoclonus epilepsies.

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2013 Brain

187. Transitory stapedial myoclonus in a patient with benign fasciculation syndrome. (PubMed)

Transitory stapedial myoclonus in a patient with benign fasciculation syndrome. We report a previously undescribed association between transitory stapedial myoclonus, objective tinnitus and benign fasciculation syndrome.Case report and review of the world literature regarding stapedial myoclonus.A 30-year-old man with a diagnosis of benign fasciculation syndrome abruptly developed severe, low-pitched tinnitus on the right side. Otoscopic examination revealed rhythmic movement of the tympanic (...) membrane, which was synchronous with the tinnitus. No palatal spasm was noted on nasopharyngeal examination. Brain magnetic resonance imaging and pure tone audiometry were unremarkable. Based on these findings, a diagnosis of objective tinnitus due to stapedial myoclonus was made. The objective tinnitus spontaneously disappeared within 48 hours of its appearance, but in the following days the patient suffered frequent, brief episodes of objective tinnitus lasting only a few seconds.The occurrence

2013 Journal of Laryngology & Otology

188. A descriptive study of myoclonus associated with etomidate procedural sedation in the ED. (PubMed)

A descriptive study of myoclonus associated with etomidate procedural sedation in the ED. Myoclonus is a well-recognized side effect of etomidate when given in induction doses for rapid sequence intubation. Most of the data reported on myoclonus with emergency department (ED) sedation doses are reported as a secondary finding.Our objective was to prospectively quantify the incidence and duration of myoclonus associated with the administration of etomidate in the lower doses given for procedural (...) sedation in the ED.This was a prospective descriptive study performed between September 2008 and September 2010 at an urban teaching hospital ED with approximately 50000 patient visits per year. Procedural sedation was performed at the discretion of the treating emergency physician, and adult patients receiving etomidate were eligible for enrollment. The occurrence and duration of myoclonus were observed and recorded. Any interference of myoclonus with the ability to complete the procedure was recorded

2013 American Journal of Emergency Medicine

189. Metabolic changes in DYT11 myoclonus-dystonia. (PubMed)

Metabolic changes in DYT11 myoclonus-dystonia. To identify brain regions with metabolic changes in DYT11 myoclonus-dystonia (DYT11-MD) relative to control subjects and to compare metabolic abnormalities in DYT11-MD with those found in other forms of hereditary dystonia and in posthypoxic myoclonus.[(18)F]-fluorodeoxyglucose PET was performed in 6 subjects with DYT11-MD (age 30.5 ± 10.1 years) and in 6 nonmanifesting DYT11 mutation carriers (NM-DYT11; age 59.1 ± 8.9 years) representing (...) increases in the inferior pons and in the posterior thalamus as well as reductions in the ventromedial prefrontal cortex. Significant phenotype-related increases were present in the parasagittal cerebellum. This latter abnormality was shared with posthypoxic myoclonus, but not with other forms of dystonia. By contrast, all dystonia cohorts exhibited significant metabolic increases in the superior parietal lobule.The findings are consistent with a subcortical myoclonus generator in DYT11-MD, likely

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2013 Neurology

190. Efficacy Trial of Zonisamide for Myoclonus Dystonia

Efficacy Trial of Zonisamide for Myoclonus Dystonia Efficacy Trial of Zonisamide for Myoclonus Dystonia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Efficacy Trial of Zonisamide for Myoclonus Dystonia (...) Details Study Description Go to Brief Summary: Myoclonus Dystonia is a disease in which myoclonus distort the precision of movements and so cause a handicap in the movements of the everyday life. Response to oral medications may be incomplete and surgery may cause operating risk. Zonisamide is an antiepileptic drug which could bring a therapeutic profit in Myoclonus Dystonia on the severity of the myoclonus. Condition or disease Intervention/treatment Phase Myoclonus Dystonia Drug: zonegran Drug

2013 Clinical Trials

191. Comparison of effects of fentanyl and remifentanil on hemodynamic response to endotracheal intubation and myoclonus in elderly patients with etomidate induction (PubMed)

Comparison of effects of fentanyl and remifentanil on hemodynamic response to endotracheal intubation and myoclonus in elderly patients with etomidate induction Etomidate has a stable hemodynamic profile after induction, but hypertension and tachycardia are frequent after intubation as well as myoclonus. We compared the effects of fentanyl and remifentanil on the hemodynamic response to intubation and myoclonus during etomidate induction in elderly patients.Ninety ASA I or II patients aged over (...) of myoclonus were recorded.After intubation, group R showed significant decreases compared with groups C and F for all of the hemodynamic variables measured. The incidences of increases in SBP and HR of more than 30% of the baseline levels, SBP of > 200 mmHg, and HR of > 120 beats/min were significantly lower in group R (0%, 10%, 0%, and 0%, respectively) compared with groups C (83%, 83%, 30%, and 13%, respectively) and F (63%, 77%, 13%, and 7%, respectively). The frequency and intensity of myoclonus were

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2013 Korean journal of anesthesiology

192. Manual Quantitative Assessment of Amplitude and Sleep Stage Distribution of Excessive Fragmentary Myoclonus (PubMed)

Manual Quantitative Assessment of Amplitude and Sleep Stage Distribution of Excessive Fragmentary Myoclonus Excessive fragmentary myoclonus (EFM) consists of brief, asynchronous, twitch-like movements appearing asymmetrically in sleep. The new AASM Manual for the Scoring of Sleep and Associated Events identifies some EFM scoring criteria but does not provide amplitude criteria for scoring EFM. Older observational series have used 50 μVs. We report data from various amplitude criteria using

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2013 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

193. Jerky Periods: Myoclonus Occurring Solely During Menses (PubMed)

Jerky Periods: Myoclonus Occurring Solely During Menses In this case report, we describe an unusual case of a patient with myoclonus only occurring during menses.A 41-year-old female, known to have neurological sequelae after a car accident 1 year earlier, presented with myoclonic movements of the right arm and hand only during menses. Brain magnetic resonance imaging is compatible with head trauma. Electromyography shows brief irregular bursts with a duration of about 20 ms.This appears (...) to be the first description of myoclonus appearing only during menses. We suggest a cortical origin for myoclonus.

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2013 Tremor and Other Hyperkinetic Movements

194. Middle Ear Myoclonus: Two Informative Cases and a Systematic Discussion of Myogenic Tinnitus (PubMed)

Middle Ear Myoclonus: Two Informative Cases and a Systematic Discussion of Myogenic Tinnitus The term middle ear myoclonus (mem) has been invoked to explain symptoms of tinnitus presumably caused by the dysfunctional movement of either of the two muscles that insert in the middle ear: tensor tympani and stapedius. MEM has been characterized through heterogeneous case reports in the otolaryngology literature, where clinical presentation is variable, phenomenology is scarcely described

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2013 Tremor and Other Hyperkinetic Movements

195. Surgical treatment of myoclonus dystonia syndrome. (PubMed)

Surgical treatment of myoclonus dystonia syndrome. Myoclonus dystonia (M-D) syndrome is a heritable movement disorder characterized by myoclonic jerks and dystonia primarily of the upper extremities. M-D remains poorly responsive to pharmacological treatment. Emerging reports suggest good response to DBS of the internal globus pallidus (GPi) and ventral intermediate nucleus (VIM) of the thalamus. This study aimed to appraise the value of these two DBS targets by evaluating reports available (...) in the literature. A systematic search of published case reports and case series was performed on Medline and Embase. Responses to DBS were evaluated. Myoclonus was assessed with the Unified Myoclonus Rating Scale (UMRS) and dystonia by the Burke-Fahn-Marsden dystonia rating scale (BFMDRS). The primary outcome of interest was the relative improvements noted with GPi, compared to VIM stimulation. A total of 17 publications yielded 40 unique cases, with mean follow-up of 27.2 months. All patients demonstrated

2013 Movement Disorders

196. Prevention of etomidate-related myoclonus in anesthetic induction by pretreatment with magnesium. (PubMed)

Prevention of etomidate-related myoclonus in anesthetic induction by pretreatment with magnesium. Etomidate frequently leads to myoclonic jerks during anesthetic induction. This study aimed to detect if pretreatment with magnesium decreases myoclonus incidence.A hundred ASA (the American Society of Anesthesiologists) I-II patients were included and randomized into 2 groups. Three minutes before etomidate induction of anesthesia (by 0.3 mg/kg intravenous etomidate), Group M received 2.48 mmol (...) (60 mg) intravenous magnesium sulphate and Group P received equal volume of intravenous saline. Myoclonus was evaluated as "present/absent".The rate of myoclonus was significantly lower in Group M than in Group P (p < 0.01). Hemodynamic parameters revealed no significant difference between the two groups.Low dose magnesium pretreatment before etomidate induction of anesthesia significantly reduces unwanted myoclonic jerks and also protects the hemodynamic stability.

2012 Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

197. A proof-of-concept trial of the whey protein alfa-lactalbumin in chronic cortical myoclonus. (PubMed)

A proof-of-concept trial of the whey protein alfa-lactalbumin in chronic cortical myoclonus. 22025266 2012 02 28 2015 11 19 1531-8257 26 14 2011 Dec Movement disorders : official journal of the Movement Disorder Society Mov. Disord. A proof-of-concept trial of the whey protein alfa-lactalbumin in chronic cortical myoclonus. 2573-5 10.1002/mds.23908 Errichiello Luca L Pezzella Marianna M Santulli Lia L Striano Salvatore S Zara Federico F Minetti Carlo C Mainardi Paolo P Striano Pasquale P eng (...) Letter Randomized Controlled Trial 2011 10 24 United States Mov Disord 8610688 0885-3185 0 Milk Proteins 0 Whey Proteins 9013-90-5 Lactalbumin IM Adult Chronic Disease Feasibility Studies Female Humans Lactalbumin administration & dosage Male Middle Aged Milk Proteins administration & dosage Myoclonus drug therapy Treatment Failure Whey Proteins Young Adult 2011 04 28 2011 06 16 2011 07 18 2011 10 26 6 0 2011 10 26 6 0 2012 3 1 6 0 ppublish 22025266 10.1002/mds.23908

2012 Movement disorders : official journal of the Movement Disorder Society

198. Severe pruritus and myoclonus following intrathecal morphine administration in a dog (PubMed)

Severe pruritus and myoclonus following intrathecal morphine administration in a dog During epidural needle placement in a 32-kg dog the subarachnoid space was punctured and half the intended dose of lidocaine, bupivacaine, and morphine was injected. After recovery from anesthesia the dog showed signs of severe pruritus of the tail base and limbs and myoclonus of the tail and hind limbs. Methadone, acepromazine, ketamine, buprenorphine, and butorphanol were administered to control myoclonus (...) and pruritus, but were unsuccessful. Diazepam was used to control myoclonus until the effects of morphine abated.During epidural needle placement in a 32-kg dog the subarachnoid space was punctured and half the intended dose of lidocaine, bupivacaine, and morphine was injected. After recovery from anesthesia the dog showed signs of severe pruritus of the tail base and limbs and myoclonus of the tail and hind limbs. Methadone, acepromazine, ketamine, buprenorphine, and butorphanol were administered

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2012 The Canadian Veterinary Journal

199. Systematic review of management strategies for middle ear myoclonus.

Systematic review of management strategies for middle ear myoclonus. Middle ear myoclonus is a rare condition with distinct characteristics at presentation. Diagnosis is based primarily on history, clinical examination, and long-time-based tympanometry. No consensus exists regarding treatment at present. This review was designed to identify relevant studies on current investigation and management.A systematic electronic literature search of MEDLINE, Embase, Cumulative Index to Nursing (...) and Allied Health Literature (CINAHL), Cochrane Trials register, and Web of Science was conducted for articles describing middle ear myoclonus through to May 2011. English- and non-English-language articles that focused on investigation and treatment were considered for review.Two authors independently reviewed the articles for study design, treatment, intervention, and outcome. Data from human and experimental studies were considered.A total of 21 articles were identified for this review. Most studies

2012 Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

200. Acute posthypoxic myoclonus after cardiopulmonary resuscitation. (PubMed)

Acute posthypoxic myoclonus after cardiopulmonary resuscitation. Acute posthypoxic myoclonus (PHM) can occur in patients admitted after cardiopulmonary resuscitation (CPR) and is considered to have a poor prognosis. The origin can be cortical and/or subcortical and this might be an important determinant for treatment options and prognosis. The aim of the study was to investigate whether acute PHM originates from cortical or subcortical structures, using somatosensory evoked potential (SEP (...) ) and electroencephalogram (EEG).Patients with acute PHM (focal myoclonus or status myoclonus) within 72 hours after CPR were retrospectively selected from a multicenter cohort study. All patients were treated with hypothermia. Criteria for cortical origin of the myoclonus were: giant SEP potentials; or epileptic activity, status epilepticus, or generalized periodic discharges on the EEG (no back-averaging was used). Good outcome was defined as good recovery or moderate disability after 6 months.Acute PHM was reported

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2012 BMC Neurology

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