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Myocardial Infarction Stabilization

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101. FAT10 attenuates hypoxia-induced cardiomyocyte apoptosis by stabilizing caveolin-3. (PubMed)

myocardial tissues and in hypoxic cardiomyocytes. Furthermore, our results demonstrated that FAT10 inhibits hypoxia-induced cardiomyocyte apoptosis by increasing Cav-3 expression. Importantly, following myocardial infarction, knockout of FAT10 aggravated cardiac dysfunction and increased cardiomyocyte apoptosis by reducing Cav-3 expression. Additionally, Cav-3 was degraded by the ubiquitin-proteasome system (UPS) in cardiomyocytes. Mechanistically, we found that FAT10 stabilizes Cav-3 expression (...) FAT10 attenuates hypoxia-induced cardiomyocyte apoptosis by stabilizing caveolin-3. FAT10, a member of the ubiquitin-like-modifier family of proteins, plays a cardioprotective role in response to hypoxic/ischemic injury. Caveolin-3 (Cav-3), a muscle-specific caveolin family member, is involved in cardiomyocyte apoptosis. However, the link between FAT10 and Cav-3 in ischemic cardiomyocytes is unclear. In the present study, we found that both FAT10 and Cav-3 were upregulated in ischemic

2018 Journal of Molecular and Cellular Cardiology

102. Study on STEMI Reperfusion Strategy Based on the Characterization of Criminal Lesions Stability

of endovascular imaging in STEMI emergency intervention strategies. Condition or disease Intervention/treatment ST Elevation Myocardial Infarction Device: optical coherence tomography Detailed Description: This study is a prospective, randomized, controlled multicenter clinical study. Twenty hundred and forty AMI patients (according to all the inclusion criteria and did not meet any exclusion criteria) who were enrolled in the culprit who had a lesion stenosis ≤70% and who had TIMI blood flow grade 3 (...) of recurrent myocardial ischemic events (angina pectoris and recurrent myocardium, infarction) or sudden death within 1 month after discharge. [ Time Frame: 1 month ] the incidence of recurrent myocardial ischemic events (angina pectoris and recurrent myocardium, infarction) or sudden death within 1 month after discharge. Secondary Outcome Measures : HF incidence [ Time Frame: 1 year ] HF incidence Stent patency and stenosis rate [ Time Frame: 1 year ] Stent patency and stenosis rate Incidence

2018 Clinical Trials

103. Delivery of progenitor cells with injectable shear-thinning hydrogel maintains geometry and normalizes strain to stabilize cardiac function after ischemia. (PubMed)

Delivery of progenitor cells with injectable shear-thinning hydrogel maintains geometry and normalizes strain to stabilize cardiac function after ischemia. The ventricle undergoes adverse remodeling after myocardial infarction, resulting in abnormal biomechanics and decreased function. We hypothesize that tissue-engineered therapy could minimize postischemic remodeling through mechanical stress reduction and retention of tensile myocardial properties due to improved endothelial progenitor cell (...) retention and intrinsic biomechanical properties of the hyaluronic acid shear-thinning gel.Endothelial progenitor cells were harvested from adult Wistar rats and resuspended in shear-thinning gel. The constructs were injected at the border zone of ischemic rat myocardium in an acute model of myocardial infarction. Myocardial remodeling, tensile properties, and hemodynamic function were analyzed: control (phosphate-buffered saline), endothelial progenitor cells, shear-thinning gel, and shear-thinning gel

2018 Journal of Thoracic and Cardiovascular Surgery

104. Characterization of cardiovascular clinical events and impact of event adjudication on the treatment effect of darapladib versus placebo in patients with stable coronary heart disease: Insights from the STABILITY trial. (PubMed)

disease.Investigators were instructed to report all potential events. Each reported event was reviewed independently by 2 reviewers according to prespecified processes and prespecified end point definitions. Concordance between reported and adjudicated cardiovascular (CV) events was evaluated, as well as event classification influence on final study results.In total, CEC reviewed 7,096 events: 1,064 deaths (696 CV deaths), 958 myocardial infarctions (MI), 433 strokes, 182 transient ischemic attacks, 2,052 coronary (...) Characterization of cardiovascular clinical events and impact of event adjudication on the treatment effect of darapladib versus placebo in patients with stable coronary heart disease: Insights from the STABILITY trial. Clinical Endpoint Classification (CEC) in clinical trials allows FOR standardized, systematic, blinded, and unbiased adjudication of investigator-reported events. We quantified the agreement rates in the STABILITY trial on 15,828 patients with stable coronary heart

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2018 American Heart Journal

105. The predictive value of Cardiodynamicsgram in myocardial perfusion abnormalities. (PubMed)

. Diagnostic accuracy of CDG at presentation for myocardial perfusion abnormalities was 84.9%, sensitivity 84.0%, and specificity 89.4%. Furthermore, of the 10 patients whose SPECT MPI results are reverse redistribution, 9 patients were positive in CDG. Underlying causes of false positive CDG findings included the factors that can change the stability of cardiac electrical conduction and measurement noise. Myocardial remodeling in patients with old myocardial infarction might be the major cause of false (...) The predictive value of Cardiodynamicsgram in myocardial perfusion abnormalities. Myocardial perfusion abnormalities are the first sign of the ischemic cascade in the development of coronary artery disease (CAD). Thus, the early detection of myocardial perfusion abnormalities is significant for the prevention of CAD. Recently, a novel noninvasive method named Cardiodynamicsgram (CDG) has been proposed for early detection of CAD. This study aims to evaluate the predictive value of CDG

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2018 PLoS ONE

106. Antidiabetic gliptins in combination with G-CSF enhances myocardial function and survival after acute myocardial infarction. (PubMed)

Antidiabetic gliptins in combination with G-CSF enhances myocardial function and survival after acute myocardial infarction. Medical stimulation of endogenous progenitor cell circulation may serve as a new therapeutic tool for treatment of acute myocardial infarction. We analyzed the effects of antidiabetic gliptins plus GCSF (granulocyte colony stimulating factor) on myocardial regeneration after myocardial infarction in a mouse model.After surgical LAD-ligation (left anterior descending (...) increased mobilization and cardiac homing of bone-marrow derived stem cells by stabilization of cardiac SDF1 (stromal cell-derived factor). For Sitagliptin, it could be shown that resident cardiac stem cells were stimulated, neovascularization was enhanced and cardiac remodeling was reduced. These effects finally improved myocardial function and increased survival for both gliptins. Although gliptins as a mono therapy lead to remarkable effects in a dose dependent manner and were superior to G-CSF mono

2013 International journal of cardiology

107. Ventricular Septal Rupture Following Myocardial Infarction (Treatment)

Ventricular Septal Rupture Following Myocardial Infarction (Treatment) Postinfarction Ventricular Septal Rupture Treatment & Management: Medical Therapy, Surgical Therapy, Interventional Therapy Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) Controversy surrounds the issue of whether to perform CABG in patients undergoing emergency postinfarction VSR repair. Some authors have found no benefit to CABG in this setting and have concluded that cardiac catheterization in ill patients is time-consuming and poses a risk of contrast injury to the kidney. Others, however, have used a selective approach to cardiac catheterization. In patients who probably do not have a history of or previous myocardial infarction (MI), cardiac catheterization

2014 eMedicine Surgery

108. Complications of Myocardial Infarction (Follow-up)

Complications of Myocardial Infarction (Follow-up) Complications of Myocardial Infarction: Overview, Arrhythmic Complications of MI, Arrhythmic Complications: Supraventricular Tachyarrhythmias Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTY0OTI0LW92ZXJ2aWV3 processing > Complications of Myocardial Infarction Updated: Dec 18, 2014 Author: Ashok K Kondur, MD; Chief Editor: Eric H Yang, MD Share Email Print Feedback Close Sections Sections Complications of Myocardial Infarction Overview Overview Myocardial infarction (MI) due to coronary artery disease is a leading cause of death in the United States, where more than 1 million people have acute myocardial infarctions (AMIs) each year. [ ] The advent of coronary care units and early reperfusion

2014 eMedicine.com

109. Myocardial Infarction (Diagnosis)

Myocardial Infarction (Diagnosis) Myocardial Infarction: Practice Essentials, Background, Definitions Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTU1OTE5LW92ZXJ2aWV3 processing > Myocardial Infarction Updated (...) : Jul 19, 2018 Author: A Maziar Zafari, MD, PhD; Chief Editor: Eric H Yang, MD Share Email Print Feedback Close Sections Sections Myocardial Infarction Overview Practice Essentials Myocardial infarction (MI) (ie, heart attack) is the irreversible death (necrosis) of heart muscle secondary to prolonged lack of oxygen supply (ischemia). Approximately 1.5 million cases of MI occur annually in the United States. See the images below. Acute myocardial infarction, reperfusion type. In this case

2014 eMedicine.com

110. Complications of Myocardial Infarction (Diagnosis)

Complications of Myocardial Infarction (Diagnosis) Complications of Myocardial Infarction: Overview, Arrhythmic Complications of MI, Arrhythmic Complications: Supraventricular Tachyarrhythmias Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTY0OTI0LW92ZXJ2aWV3 processing > Complications of Myocardial Infarction Updated: Dec 18, 2014 Author: Ashok K Kondur, MD; Chief Editor: Eric H Yang, MD Share Email Print Feedback Close Sections Sections Complications of Myocardial Infarction Overview Overview Myocardial infarction (MI) due to coronary artery disease is a leading cause of death in the United States, where more than 1 million people have acute myocardial infarctions (AMIs) each year. [ ] The advent of coronary care units and early reperfusion

2014 eMedicine.com

111. Complications of Myocardial Infarction (Treatment)

Complications of Myocardial Infarction (Treatment) Complications of Myocardial Infarction: Overview, Arrhythmic Complications of MI, Arrhythmic Complications: Supraventricular Tachyarrhythmias Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTY0OTI0LW92ZXJ2aWV3 processing > Complications of Myocardial Infarction Updated: Dec 18, 2014 Author: Ashok K Kondur, MD; Chief Editor: Eric H Yang, MD Share Email Print Feedback Close Sections Sections Complications of Myocardial Infarction Overview Overview Myocardial infarction (MI) due to coronary artery disease is a leading cause of death in the United States, where more than 1 million people have acute myocardial infarctions (AMIs) each year. [ ] The advent of coronary care units and early reperfusion

2014 eMedicine.com

112. Complications of Myocardial Infarction (Overview)

Complications of Myocardial Infarction (Overview) Complications of Myocardial Infarction: Overview, Arrhythmic Complications of MI, Arrhythmic Complications: Supraventricular Tachyarrhythmias Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTY0OTI0LW92ZXJ2aWV3 processing > Complications of Myocardial Infarction Updated: Dec 18, 2014 Author: Ashok K Kondur, MD; Chief Editor: Eric H Yang, MD Share Email Print Feedback Close Sections Sections Complications of Myocardial Infarction Overview Overview Myocardial infarction (MI) due to coronary artery disease is a leading cause of death in the United States, where more than 1 million people have acute myocardial infarctions (AMIs) each year. [ ] The advent of coronary care units and early reperfusion

2014 eMedicine.com

113. Myocardial Infarction (Overview)

Myocardial Infarction (Overview) Myocardial Infarction: Practice Essentials, Background, Definitions Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTU1OTE5LW92ZXJ2aWV3 processing > Myocardial Infarction Updated (...) : Jul 19, 2018 Author: A Maziar Zafari, MD, PhD; Chief Editor: Eric H Yang, MD Share Email Print Feedback Close Sections Sections Myocardial Infarction Overview Practice Essentials Myocardial infarction (MI) (ie, heart attack) is the irreversible death (necrosis) of heart muscle secondary to prolonged lack of oxygen supply (ischemia). Approximately 1.5 million cases of MI occur annually in the United States. See the images below. Acute myocardial infarction, reperfusion type. In this case

2014 eMedicine.com

114. Myocardial Infarction (Treatment)

adjunctive use of GP II b /III a inhibitors is not recommended but may be considered in selected cases. [ , ] Previous Next: Non-ST-Elevation (NSTE) ACS Key points in the management of patients with non–ST-elevation acute coronary syndrome (NSTE-ACS) (unstable angina and non-STE myocardial infarction [NSTEMI]) is early evaluation and assessment of hemodynamic and electrical stability, estimatation of the overall risk in these patients, and guidance of therapy. There are two alternative management (...) or bivalirudin), as fondaparinux is associated with a higher risk of catheter thrombosis; this was demonstrated in the Fifth Organization to Assess Strategies in Ischemic Syndromes (OASIS-5) trial. [ , , ] Previous Next: Additional Aspects of Management and Late Hospital Care After the initial management and stabilization of the patient in the early and critical phase of acute myocardial infarction (MI), the goals of care for these patients is to restore normal activities, prevent long-term complications

2014 eMedicine.com

115. Myocardial Infarction (Follow-up)

adjunctive use of GP II b /III a inhibitors is not recommended but may be considered in selected cases. [ , ] Previous Next: Non-ST-Elevation (NSTE) ACS Key points in the management of patients with non–ST-elevation acute coronary syndrome (NSTE-ACS) (unstable angina and non-STE myocardial infarction [NSTEMI]) is early evaluation and assessment of hemodynamic and electrical stability, estimatation of the overall risk in these patients, and guidance of therapy. There are two alternative management (...) or bivalirudin), as fondaparinux is associated with a higher risk of catheter thrombosis; this was demonstrated in the Fifth Organization to Assess Strategies in Ischemic Syndromes (OASIS-5) trial. [ , , ] Previous Next: Additional Aspects of Management and Late Hospital Care After the initial management and stabilization of the patient in the early and critical phase of acute myocardial infarction (MI), the goals of care for these patients is to restore normal activities, prevent long-term complications

2014 eMedicine.com

116. Myocardial Infarction in Childhood (Follow-up)

Myocardial Infarction in Childhood (Follow-up) Myocardial Infarction in Childhood Treatment & Management: Approach Considerations, Initial Supportive Measures, Surgical Revascularization Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvODk3NDUzLXRyZWF0bWVudA== processing > Myocardial Infarction in Childhood Treatment & Management Updated: May 23, 2014 Author: Louis I Bezold, MD; Chief Editor: Stuart Berger, MD Share Email Print Feedback Close Sections Sections Myocardial Infarction in Childhood Treatment Approach Considerations Medical care for a disease or condition that predisposes children to acute myocardial infarction (AMI) is discussed more fully elsewhere (see and ). The primary treatment in patients with anomalous left coronary artery (LCA

2014 eMedicine Pediatrics

117. Myocardial Infarction in Childhood (Treatment)

Myocardial Infarction in Childhood (Treatment) Myocardial Infarction in Childhood Treatment & Management: Approach Considerations, Initial Supportive Measures, Surgical Revascularization Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvODk3NDUzLXRyZWF0bWVudA== processing > Myocardial Infarction in Childhood Treatment & Management Updated: May 23, 2014 Author: Louis I Bezold, MD; Chief Editor: Stuart Berger, MD Share Email Print Feedback Close Sections Sections Myocardial Infarction in Childhood Treatment Approach Considerations Medical care for a disease or condition that predisposes children to acute myocardial infarction (AMI) is discussed more fully elsewhere (see and ). The primary treatment in patients with anomalous left coronary artery (LCA

2014 eMedicine Pediatrics

118. Myocardial Infarction (Treatment)

adjunctive use of GP II b /III a inhibitors is not recommended but may be considered in selected cases. [ , ] Previous Next: Non-ST-Elevation (NSTE) ACS Key points in the management of patients with non–ST-elevation acute coronary syndrome (NSTE-ACS) (unstable angina and non-STE myocardial infarction [NSTEMI]) is early evaluation and assessment of hemodynamic and electrical stability, estimatation of the overall risk in these patients, and guidance of therapy. There are two alternative management (...) or bivalirudin), as fondaparinux is associated with a higher risk of catheter thrombosis; this was demonstrated in the Fifth Organization to Assess Strategies in Ischemic Syndromes (OASIS-5) trial. [ , , ] Previous Next: Additional Aspects of Management and Late Hospital Care After the initial management and stabilization of the patient in the early and critical phase of acute myocardial infarction (MI), the goals of care for these patients is to restore normal activities, prevent long-term complications

2014 eMedicine Emergency Medicine

119. Myocardial Infarction (Overview)

Myocardial Infarction (Overview) Myocardial Infarction: Practice Essentials, Background, Definitions Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTU1OTE5LW92ZXJ2aWV3 processing > Myocardial Infarction Updated (...) : Jul 19, 2018 Author: A Maziar Zafari, MD, PhD; Chief Editor: Eric H Yang, MD Share Email Print Feedback Close Sections Sections Myocardial Infarction Overview Practice Essentials Myocardial infarction (MI) (ie, heart attack) is the irreversible death (necrosis) of heart muscle secondary to prolonged lack of oxygen supply (ischemia). Approximately 1.5 million cases of MI occur annually in the United States. See the images below. Acute myocardial infarction, reperfusion type. In this case

2014 eMedicine Emergency Medicine

120. Ventricular Septal Rupture Following Myocardial Infarction (Follow-up)

Ventricular Septal Rupture Following Myocardial Infarction (Follow-up) Postinfarction Ventricular Septal Rupture Treatment & Management: Medical Therapy, Surgical Therapy, Interventional Therapy Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) Controversy surrounds the issue of whether to perform CABG in patients undergoing emergency postinfarction VSR repair. Some authors have found no benefit to CABG in this setting and have concluded that cardiac catheterization in ill patients is time-consuming and poses a risk of contrast injury to the kidney. Others, however, have used a selective approach to cardiac catheterization. In patients who probably do not have a history of or previous myocardial infarction (MI), cardiac catheterization

2014 eMedicine Surgery

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