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Myocardial Infarction Stabilization

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3241. Pharmacological stabilization of mast cells abrogates late thrombotic events induced by diesel exhaust particles in hamsters. (Full text)

Pharmacological stabilization of mast cells abrogates late thrombotic events induced by diesel exhaust particles in hamsters. Particulate air pollution is associated with cardiovascular diseases and myocardial infarction (MI).We investigated the relationship between airway inflammation and thrombosis 24 hours after intratracheal (IT) instillation of diesel exhaust particles (DEP; 50 microg/hamster). Mild thrombosis was induced in the femoral vein by endothelial injury, and the consequences

2004 Circulation PubMed abstract

3242. Ang-1 gene therapy inhibits HIF-1{alpha}-prolyl-4-hydroxylase-2, stabilizes HIF-1{alpha} expression and normalizes immature vasculature in db/db mice. (Full text)

Ang-1 gene therapy inhibits HIF-1{alpha}-prolyl-4-hydroxylase-2, stabilizes HIF-1{alpha} expression and normalizes immature vasculature in db/db mice. Diabetic impaired angiogenesis is associated with impairment of hypoxia-inducible factor-1alpha (HIF-1alpha) as well as vasculature maturation. We investigated the potential roles and intracellular mechanisms of angiopoietin-1 (Ang-1) gene therapy on myocardial HIF-1alpha stabilization and vascular maturation in db/db mice.db/db mice were (...) systemically administrated adenovirus Ang-1 (Ad-CMV-Ang-1). Myocardial HIF-1alpha, vascular endothelial growth factor (VEGF), hemeoxygenase-1 (HO-1), endothelial nitric oxide synthase (eNOS), Akt, and HIF-1alpha-prolyl-4-hydroxylase-2 (PHD)2 expression were measured. Vasculature maturation, capillary and arteriole densities, and cardiac interstitial fibrosis were analyzed in the border zone of infarcted myocardium.Systemic administration of Ad-CMV-Ang-1 results in overexpression of Ang-1 in db/db mice

2008 Diabetes PubMed abstract

3243. Small, oral dose of clonidine reduces the incidence of intraoperative myocardial ischemia in patients having vascular surgery. (Abstract)

scheduled to have elective vascular surgical procedures to evaluate the effects of 2 micrograms/kg-1 oral clonidine (n = 145) or placebo (n = 152) on the incidence of perioperative myocardial ischemic episodes, myocardial infarction, and cardiac death. Continuous real-time S-T segment trend analysis (lead II and V5) was performed during anesthesia and surgery and correlated with arterial blood pressure and heart rate before and during ischemic events. Dose requirements for vasoactive and antiischemic (...) the incidence of perioperative myocardial ischemic episodes without affecting hemodynamic stability in patients with suspected or documented coronary artery disease.

1996 Anesthesiology Controlled trial quality: uncertain

3244. Evaluation of myocardial protection by combination of lidoflazine pretreatment and St. Thomas' Hospital cardioplegia in aorto-coronary bypass grafting. (Abstract)

Evaluation of myocardial protection by combination of lidoflazine pretreatment and St. Thomas' Hospital cardioplegia in aorto-coronary bypass grafting. The concept of pretreatment of the myocardium with a pharmacological agent protecting the cell against ischemic and reperfusion injury is very attractive. Lidoflazine, a calcium overload blocker, predominantly membrane stabilizing, is able to prevent cell damage during ischemic arrest and reperfusion. The purpose of this study was to determine (...) , incidence of myocardial infarction, low cardiac output, rhythm, and conduction disturbances. In conclusion, our data suggest that the combination of intravenous pretreatment with lidoflazine and St. Thomas' Hospital cardioplegia did not provide significant additional myocardial protection in the clinical situation.

1992 European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery Controlled trial quality: uncertain

3245. Percutaneous coronary intervention versus coronary bypass graft surgery for patients with medically refractory myocardial ischemia and risk factors for adverse outcomes with bypass: The VA AWESOME multicenter registry: comparison with the randomized clini (Abstract)

risk factors (prior heart surgery, myocardial infarction within seven days, left ventricular ejection fraction <0.35, age >70 years, intra-aortic balloon required to stabilize) were identified. By physician consensus, 1,650 patients formed a physician-directed registry assigned to CABG (692), PCI (651) or further medical therapy (307), and 781 were angiographically eligible for random allocation; 454 of these patients constitute the randomized trial, and the remaining 327 constitute a patient (...) Percutaneous coronary intervention versus coronary bypass graft surgery for patients with medically refractory myocardial ischemia and risk factors for adverse outcomes with bypass: The VA AWESOME multicenter registry: comparison with the randomized clini This study was designed to compare the three-year survival after percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery (CABG) in physician-directed and patient-choice registries with the Angina With Extremely Serious

2002 Journal of the American College of Cardiology Controlled trial quality: uncertain

3246. Effect of surgical revascularization of a right coronary artery tributary of an infarcted nonischemic territory on the outcome of patients with three-vessel disease: a prospective randomized trial. (Full text)

coronary artery bypass grafting with 3-vessel coronary disease and a dominant right coronary artery tributary of an infarcted nonischemic territory, 154 were randomized to right coronary artery revascularization and 149 to no right coronary artery grafting. In all cases, standard on-pump surgical myocardial revascularization was performed.Overall hospital mortality was 2 of 154 versus 1 of 149 (P =.97); no difference in in-hospital outcome was observed between the 2 groups. At follow-up, cardiac event (...) , and less left ventricular dilatation than did the non-right coronary artery revascularized series.Surgical grafting of a right coronary artery tributary of an infarcted nonischemic territory in patients with 3-vessel coronary artery disease submitted to coronary artery bypass grafting improved late electric stability, ventricular geometry, and event-free survival but did not affect in-hospital or 10-year survival.

2004 The Journal of thoracic and cardiovascular surgery Controlled trial quality: uncertain PubMed abstract

3247. Spatially and temporally distinct expression of fibroblast connexins after sheep ventricular infarction. (Full text)

Spatially and temporally distinct expression of fibroblast connexins after sheep ventricular infarction. Myocardial infarction leads to extensive changes in the organization of cardiac myocytes and fibroblasts, and changes in gap junction protein expression. In the immediate period following ischemia, reperfusion causes hypercontraction, spreading the necrotic lesion. Further progressive infarction continues over several weeks. In reperfusion injury, the nonspecific gap junction channel (...) ). Double and triple immunolabelling and confocal microscopy were used to follow changes in cardiac myocyte morphology, fibroblast content and gap junction expression after myocardial infarction. Gap junction protein levels and fibroblast numbers were quantified.Within 12 h of ischemia, myocyte viability is impaired within small islands in the ischemic region. These islands spread and fuse into larger infarct zones until 12 d post-infarction. Thereafter, surviving myocytes within the infarct

2004 Cardiovascular Research PubMed abstract

3248. Primary stent implantation compared with primary balloon angioplasty for acute myocardial infarction: a meta-analysis of randomized clinical trials

Primary stent implantation compared with primary balloon angioplasty for acute myocardial infarction: a meta-analysis of randomized clinical trials Primary stent implantation compared with primary balloon angioplasty for acute myocardial infarction: a meta-analysis of randomized clinical trials Primary stent implantation compared with primary balloon angioplasty for acute myocardial infarction: a meta-analysis of randomized clinical trials Zhu M M, Feit A, Chadow H, Alam M, Kwan T, Clark L T (...) Authors' objectives To compare the effectiveness of coronary stenting to balloon angioplasty (PTCA) as primary revascularisation for acute myocardial infarction (AMI). Searching Searches were conducted of MEDLINE (from 1990 to December 2000) and the scientific session abstracts in Circulation, Journal of the American College of Cardiology and the European Heart Journal (from 1995 to 2000). In addition, the reference lists of identified trials and reviews were checked for relevant studies. Study

2001 DARE.

3249. The use of stabilized human umbilical vein for femoropopliteal bypass. Experience with 133 operations with 5-year follow-up. (Full text)

The use of stabilized human umbilical vein for femoropopliteal bypass. Experience with 133 operations with 5-year follow-up. One hundred thirty-three femoropopliteal bypasses using stabilized human umbilical vein were performed in 116 patients during a 5-year period. The indications for operation were claudication in 35% and limb salvage in 65%. There were eight deaths in the postoperative period, all due to myocardial infarctions, and all occurring in patients operated upon for limb salvage

1984 Annals of Surgery PubMed abstract

3250. MRI Study of Self-Perception of Postural Stability

who have substantial cognitive impairment based on mental status screening tests, history of cardiovascular disease (including angina, myocardial infarction, congestive heart failure, cerebro-vascular disease), cancer, neurological diseases, birth defects, kidney or liver disease, gastrointestinal (G.I.) disease, musculo-skeletal disorder (if they cause pathological weakness and/or chronic pain), important sensory deficits and any conditions that precludes them from being tested with standard (...) MRI Study of Self-Perception of Postural Stability MRI Study of Self-Perception of Postural Stability - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. MRI Study of Self-Perception of Postural Stability

2003 Clinical Trials

3251. Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA)

: April 23, 2012 Sponsor: Sanofi Information provided by: Sanofi Study Details Study Description Go to Brief Summary: RATIONALE: Atherothrombosis is a progressive and generalized vascular disease resulting in events leading to myocardial infarction (heart attack), stroke, and vascular death. In patients at risk for this disease, it is characterized by an unpredictable, sudden disruption of atherosclerotic plaques, which may lead to total occlusion of artery due to formation of a clot. The use (...) of cardiovascular mortality, stroke, acute myocardial infarction. STUDY EXECUTION: Some 7,600 patients per group will be recruited within two years. Patients will be observed over a maximum of 3.5 years. STUDY TERRITORY: Approximately 900 sites throughout North/South America, Europe, Asia, Australia, and South Africa. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 15603 participants Allocation: Randomized Intervention Model: Parallel

2002 Clinical Trials

3252. Triple coronary artery revascularization on the stabilized beating heart: initial experience (Full text)

failure not related to the grafting technique itself, and 1 patient suffered a non-Q myocardial infarction. Early coronary angiography performed on 8 patients showed 100% graft patency, most with excellent distal runoff (21/22 grafts).In patients with adequate anatomy, performance of CAB without extracorporeal circulation can achieve excellent early results provided there is appropriate mechanical stabilization of the beating heart. (...) Triple coronary artery revascularization on the stabilized beating heart: initial experience To decrease health costs and morbidity related to extracorporeal circulation, surgeons have modified the coronary artery bypass (CAB) technique so that it can be completed without the use of extracorporeal circulation. This study summarizes initial experience with direct coronary artery revascularization on the beating heart using a coronary stabilizer.A case series.The Montreal Heart Institute

1998 Canadian Journal of Surgery PubMed abstract

3253. Predictors of 90-day outcome in patients stabilized after acute coronary syndromes. (Abstract)

Predictors of 90-day outcome in patients stabilized after acute coronary syndromes. We investigated predictors of 90-day risk among patients surviving the early period after an acute coronary syndrome (ACS).The study population included 15 904 stabilized ST-segment elevation or non-ST-segment elevation ACS patients randomized in SYMPHONY and 2nd SYMPHONY. We developed risk models for death, death or myocardial infarction (MI), and death, MI, or severe recurrent ischaemia (SRI) using Cox (...) , chi(2)=12.2). Higher creatinine clearance (chi(2)=17.7) and percutaneous coronary intervention between qualifying event and randomization (chi(2)=11.1) most strongly predicted lower risk. Similar characteristics entered the double and triple composite models, but HF variables and age less strongly predicted these end-points.In patients stabilized after ACS, those at highest risk over the next 90 days can be identified. Typical clinical markers are better at identifying risk of death than non-fatal

2003 European heart journal Controlled trial quality: uncertain

3254. The Octopus II stabilizing system: biochemical and neuropsychological outcomes in coronary artery bypass surgery. (Abstract)

with CPB (n = 14) or OPCAB using the Octopus II stabilizing system (n = 12), after receiving institutional approval and written consent. Exclusion criteria included previous cardiac surgery, recent myocardial infarction, and previous cerebrovascular disease. Troponin T (TnT) was measured preoperatively and at 2, 4, 6, 8, 10, 12, 24, and 72 hours after initiation of grafting. Neuropsychological assessments (10 measures) were performed in the week prior to surgery, one week, and six months after (...) The Octopus II stabilizing system: biochemical and neuropsychological outcomes in coronary artery bypass surgery. The aim of this study was to determine if coronary artery bypass graft (CABG) surgery performed utilizing the Octopus II stabilizing system provides myocardial and cerebral protection comparable to traditional CABG surgery utilizing cardiopulmonary bypass (CPB).Elective patients requiring surgery for double or triple vessel disease were randomized to receive either conventional CABG

2001 The heart surgery forum Controlled trial quality: uncertain

3255. Effects of digoxin, placebo and ibopamine on exercise tolerance and cardiac rhythm of patients with chronic post-infarct left ventricular failure. (Abstract)

Effects of digoxin, placebo and ibopamine on exercise tolerance and cardiac rhythm of patients with chronic post-infarct left ventricular failure. This study compares the effects of digoxin, placebo and ibopamine (SB-7505), the orally active 3,4-diisobutyryl ester of N-methyl-dopamine, on exercise tolerance and cardiac rhythm of 14 patients whose left ventricular heart failure (end-diastolic pressure, 26.3 +/- 5.9 mmHg; ejection fraction, 0.42 +/- 0.10%) depended on a previous myocardial (...) infarction. Patients were admitted to the study while on chronic oral digoxin treatment (serum levels between 1.1 and 1.9 ng/ml). Placebo instead of digoxin was given for the following month. Thereafter ibopamine 50 mg t.i.d. for one month was given. A sequence of one-month treatments with digoxin, placebo and ibopamine was repeated, then ibopamine was administered continuously for the next two months. The concurrent treatment (diuretics in all patients, nitroderivates in twelve, calcium antagonists

1986 Arzneimittel-Forschung

3256. Frequency of predischarge ventricular arrhythmias in postmyocardial infarction patients depends on residual left ventricular pump performance and is independent of the occurrence of acute reperfusion. The GISSI-2 Investigators. (Abstract)

study population were studied. The patients were selected on the basis of a first myocardial infarction and the availability of two-dimensional echocardiographic ejection fraction and data on the number of premature ventricular contractions per hour on Holter monitoring.It has been suggested that postthrombolytic reperfusion of the culprit vessel may be associated with an increased electrical stability of the infarcted heart, irrespective of its residual pump performance.The predischarge relation (...) Frequency of predischarge ventricular arrhythmias in postmyocardial infarction patients depends on residual left ventricular pump performance and is independent of the occurrence of acute reperfusion. The GISSI-2 Investigators. To test whether acute reperfusion of the infarct-related vessel after an acute myocardial infarction is associated with a subsequent reduction in spontaneous ventricular arrhythmias that is independent of ventricular ejection fraction, 1,944 patients from the GISSI-2

1994 Journal of the American College of Cardiology Controlled trial quality: uncertain

3257. The late open artery hypothesis at the crossroad. The ACTOR study: aggressive versus conservative treatment of the infarct-related artery after acute MI. ACTOR Study Group. (Abstract)

The late open artery hypothesis at the crossroad. The ACTOR study: aggressive versus conservative treatment of the infarct-related artery after acute MI. ACTOR Study Group. The purpose of this multicenter study is to test the hypothesis that opening an occluded infarct-related artery late after acute myocardial infarction in asymptomatic patients without evidence of residual ischemia would reduce cardiac events over three years of follow-up. The search for an explanation of the complex (...) relationship between the patency of the infarct-related artery and the clinical evolution of the patient who suffered an infarction led to the open-artery hypothesis, whose interpretation comprises two different components. The first component attributes the benefit to the fact that the timing and the method of reperfusion treatment induce a significant degree of myocardial salvage through early and persistent recanalization, and this is defined as the "time-dependent component" of the patent artery

1999 Giornale italiano di cardiologia

3258. Comparison of the effects of different magnesium administration times on infarct size (Full text)

Comparison of the effects of different magnesium administration times on infarct size The protection of high magnesium on infarct size remains controversial.To examine the effects of magnesium administered before ischemia or early in reperfusion on infarct size in a rat model of global ischemiaIsolated rat hearts were submitted to 40 min of normothermic global ischemia and 2 h of reperfusion. After 20 min of stabilization, four protocols were performed: ischemic control (IC) hearts; 15 mM (...) % and 18+/-4%, respectively. In Mg+Ca hearts, the protection was also obtained (19+/-3%). Myocardial function also improved significantly by magnesium treatment. At the end of reperfusion, left ventricular developed pressure and maximal velocity of rise of left ventricular pressure values were 23+/-6% and 22+/-3% in MgI; and 10+/-3% and 9+/-2.6% in MgR versus 2+/-0.7% and 2.3+/-0.8% in IC hearts, respectively.The treatment with magnesium either before ischemia or early in reperfusion has an infarct

2003 Experimental & Clinical Cardiology PubMed abstract

3259. Early revascularization and long-term survival in cardiogenic shock complicating acute myocardial infarction. (Full text)

Early revascularization and long-term survival in cardiogenic shock complicating acute myocardial infarction. Cardiogenic shock remains the major cause of death for patients hospitalized with acute myocardial infarction (MI). Although survival in patients with cardiogenic shock complicating acute MI has been shown to be significantly higher at 1 year in those receiving early revascularization vs initial medical stabilization, data demonstrating long-term survival are lacking.To determine (...) if early revascularization affects long-term survival of patients with cardiogenic shock complicating acute MI.The Should We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock (SHOCK) trial, an international randomized clinical trial enrolling 302 patients from April 1993 through November 1998 with acute myocardial infarction complicated by cardiogenic shock (mean [SD] age at randomization, 66 [11] years); long-term follow-up of vital status, conducted annually until 2005, ranged from 1

2006 JAMA Controlled trial quality: predicted high PubMed abstract

3260. Effects of Cardiac Rehabilitation on High Mobility Group Box-1 Levels After Acute Myocardial Infarction

Effects of Cardiac Rehabilitation on High Mobility Group Box-1 Levels After Acute Myocardial Infarction Effects of Cardiac Rehabilitation on High Mobility Group Box-1 Levels After Acute Myocardial Infarction - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Effects of Cardiac Rehabilitation on High Mobility Group Box-1 Levels After Acute Myocardial Infarction The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00755131 Recruitment Status : Completed First Posted : September 18, 2008 Results First Posted

2008 Clinical Trials

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