How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

3,334 results for

Myocardial Infarction Stabilization

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

3241. Spatially and temporally distinct expression of fibroblast connexins after sheep ventricular infarction. Full Text available with Trip Pro

Spatially and temporally distinct expression of fibroblast connexins after sheep ventricular infarction. Myocardial infarction leads to extensive changes in the organization of cardiac myocytes and fibroblasts, and changes in gap junction protein expression. In the immediate period following ischemia, reperfusion causes hypercontraction, spreading the necrotic lesion. Further progressive infarction continues over several weeks. In reperfusion injury, the nonspecific gap junction channel (...) ). Double and triple immunolabelling and confocal microscopy were used to follow changes in cardiac myocyte morphology, fibroblast content and gap junction expression after myocardial infarction. Gap junction protein levels and fibroblast numbers were quantified.Within 12 h of ischemia, myocyte viability is impaired within small islands in the ischemic region. These islands spread and fuse into larger infarct zones until 12 d post-infarction. Thereafter, surviving myocytes within the infarct

2004 Cardiovascular Research

3242. Primary stent implantation compared with primary balloon angioplasty for acute myocardial infarction: a meta-analysis of randomized clinical trials

Primary stent implantation compared with primary balloon angioplasty for acute myocardial infarction: a meta-analysis of randomized clinical trials Primary stent implantation compared with primary balloon angioplasty for acute myocardial infarction: a meta-analysis of randomized clinical trials Primary stent implantation compared with primary balloon angioplasty for acute myocardial infarction: a meta-analysis of randomized clinical trials Zhu M M, Feit A, Chadow H, Alam M, Kwan T, Clark L T (...) Authors' objectives To compare the effectiveness of coronary stenting to balloon angioplasty (PTCA) as primary revascularisation for acute myocardial infarction (AMI). Searching Searches were conducted of MEDLINE (from 1990 to December 2000) and the scientific session abstracts in Circulation, Journal of the American College of Cardiology and the European Heart Journal (from 1995 to 2000). In addition, the reference lists of identified trials and reviews were checked for relevant studies. Study

2001 DARE.

3243. The use of stabilized human umbilical vein for femoropopliteal bypass. Experience with 133 operations with 5-year follow-up. Full Text available with Trip Pro

The use of stabilized human umbilical vein for femoropopliteal bypass. Experience with 133 operations with 5-year follow-up. One hundred thirty-three femoropopliteal bypasses using stabilized human umbilical vein were performed in 116 patients during a 5-year period. The indications for operation were claudication in 35% and limb salvage in 65%. There were eight deaths in the postoperative period, all due to myocardial infarctions, and all occurring in patients operated upon for limb salvage

1984 Annals of Surgery

3244. MRI Study of Self-Perception of Postural Stability

who have substantial cognitive impairment based on mental status screening tests, history of cardiovascular disease (including angina, myocardial infarction, congestive heart failure, cerebro-vascular disease), cancer, neurological diseases, birth defects, kidney or liver disease, gastrointestinal (G.I.) disease, musculo-skeletal disorder (if they cause pathological weakness and/or chronic pain), important sensory deficits and any conditions that precludes them from being tested with standard (...) MRI Study of Self-Perception of Postural Stability MRI Study of Self-Perception of Postural Stability - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. MRI Study of Self-Perception of Postural Stability

2003 Clinical Trials

3245. Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA)

: April 23, 2012 Sponsor: Sanofi Information provided by: Sanofi Study Details Study Description Go to Brief Summary: RATIONALE: Atherothrombosis is a progressive and generalized vascular disease resulting in events leading to myocardial infarction (heart attack), stroke, and vascular death. In patients at risk for this disease, it is characterized by an unpredictable, sudden disruption of atherosclerotic plaques, which may lead to total occlusion of artery due to formation of a clot. The use (...) of cardiovascular mortality, stroke, acute myocardial infarction. STUDY EXECUTION: Some 7,600 patients per group will be recruited within two years. Patients will be observed over a maximum of 3.5 years. STUDY TERRITORY: Approximately 900 sites throughout North/South America, Europe, Asia, Australia, and South Africa. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 15603 participants Allocation: Randomized Intervention Model: Parallel

2002 Clinical Trials

3246. Triple coronary artery revascularization on the stabilized beating heart: initial experience Full Text available with Trip Pro

failure not related to the grafting technique itself, and 1 patient suffered a non-Q myocardial infarction. Early coronary angiography performed on 8 patients showed 100% graft patency, most with excellent distal runoff (21/22 grafts).In patients with adequate anatomy, performance of CAB without extracorporeal circulation can achieve excellent early results provided there is appropriate mechanical stabilization of the beating heart. (...) Triple coronary artery revascularization on the stabilized beating heart: initial experience To decrease health costs and morbidity related to extracorporeal circulation, surgeons have modified the coronary artery bypass (CAB) technique so that it can be completed without the use of extracorporeal circulation. This study summarizes initial experience with direct coronary artery revascularization on the beating heart using a coronary stabilizer.A case series.The Montreal Heart Institute

1998 Canadian Journal of Surgery

3247. Predictors of 90-day outcome in patients stabilized after acute coronary syndromes. (Abstract)

Predictors of 90-day outcome in patients stabilized after acute coronary syndromes. We investigated predictors of 90-day risk among patients surviving the early period after an acute coronary syndrome (ACS).The study population included 15 904 stabilized ST-segment elevation or non-ST-segment elevation ACS patients randomized in SYMPHONY and 2nd SYMPHONY. We developed risk models for death, death or myocardial infarction (MI), and death, MI, or severe recurrent ischaemia (SRI) using Cox (...) , chi(2)=12.2). Higher creatinine clearance (chi(2)=17.7) and percutaneous coronary intervention between qualifying event and randomization (chi(2)=11.1) most strongly predicted lower risk. Similar characteristics entered the double and triple composite models, but HF variables and age less strongly predicted these end-points.In patients stabilized after ACS, those at highest risk over the next 90 days can be identified. Typical clinical markers are better at identifying risk of death than non-fatal

2003 European heart journal Controlled trial quality: uncertain

3248. The Octopus II stabilizing system: biochemical and neuropsychological outcomes in coronary artery bypass surgery. (Abstract)

with CPB (n = 14) or OPCAB using the Octopus II stabilizing system (n = 12), after receiving institutional approval and written consent. Exclusion criteria included previous cardiac surgery, recent myocardial infarction, and previous cerebrovascular disease. Troponin T (TnT) was measured preoperatively and at 2, 4, 6, 8, 10, 12, 24, and 72 hours after initiation of grafting. Neuropsychological assessments (10 measures) were performed in the week prior to surgery, one week, and six months after (...) The Octopus II stabilizing system: biochemical and neuropsychological outcomes in coronary artery bypass surgery. The aim of this study was to determine if coronary artery bypass graft (CABG) surgery performed utilizing the Octopus II stabilizing system provides myocardial and cerebral protection comparable to traditional CABG surgery utilizing cardiopulmonary bypass (CPB).Elective patients requiring surgery for double or triple vessel disease were randomized to receive either conventional CABG

2001 The heart surgery forum Controlled trial quality: uncertain

3249. Effects of digoxin, placebo and ibopamine on exercise tolerance and cardiac rhythm of patients with chronic post-infarct left ventricular failure. (Abstract)

Effects of digoxin, placebo and ibopamine on exercise tolerance and cardiac rhythm of patients with chronic post-infarct left ventricular failure. This study compares the effects of digoxin, placebo and ibopamine (SB-7505), the orally active 3,4-diisobutyryl ester of N-methyl-dopamine, on exercise tolerance and cardiac rhythm of 14 patients whose left ventricular heart failure (end-diastolic pressure, 26.3 +/- 5.9 mmHg; ejection fraction, 0.42 +/- 0.10%) depended on a previous myocardial (...) infarction. Patients were admitted to the study while on chronic oral digoxin treatment (serum levels between 1.1 and 1.9 ng/ml). Placebo instead of digoxin was given for the following month. Thereafter ibopamine 50 mg t.i.d. for one month was given. A sequence of one-month treatments with digoxin, placebo and ibopamine was repeated, then ibopamine was administered continuously for the next two months. The concurrent treatment (diuretics in all patients, nitroderivates in twelve, calcium antagonists

1986 Arzneimittel-Forschung

3250. Frequency of predischarge ventricular arrhythmias in postmyocardial infarction patients depends on residual left ventricular pump performance and is independent of the occurrence of acute reperfusion. The GISSI-2 Investigators. (Abstract)

study population were studied. The patients were selected on the basis of a first myocardial infarction and the availability of two-dimensional echocardiographic ejection fraction and data on the number of premature ventricular contractions per hour on Holter monitoring.It has been suggested that postthrombolytic reperfusion of the culprit vessel may be associated with an increased electrical stability of the infarcted heart, irrespective of its residual pump performance.The predischarge relation (...) Frequency of predischarge ventricular arrhythmias in postmyocardial infarction patients depends on residual left ventricular pump performance and is independent of the occurrence of acute reperfusion. The GISSI-2 Investigators. To test whether acute reperfusion of the infarct-related vessel after an acute myocardial infarction is associated with a subsequent reduction in spontaneous ventricular arrhythmias that is independent of ventricular ejection fraction, 1,944 patients from the GISSI-2

1994 Journal of the American College of Cardiology Controlled trial quality: uncertain

3251. The late open artery hypothesis at the crossroad. The ACTOR study: aggressive versus conservative treatment of the infarct-related artery after acute MI. ACTOR Study Group. (Abstract)

The late open artery hypothesis at the crossroad. The ACTOR study: aggressive versus conservative treatment of the infarct-related artery after acute MI. ACTOR Study Group. The purpose of this multicenter study is to test the hypothesis that opening an occluded infarct-related artery late after acute myocardial infarction in asymptomatic patients without evidence of residual ischemia would reduce cardiac events over three years of follow-up. The search for an explanation of the complex (...) relationship between the patency of the infarct-related artery and the clinical evolution of the patient who suffered an infarction led to the open-artery hypothesis, whose interpretation comprises two different components. The first component attributes the benefit to the fact that the timing and the method of reperfusion treatment induce a significant degree of myocardial salvage through early and persistent recanalization, and this is defined as the "time-dependent component" of the patent artery

1999 Giornale italiano di cardiologia

3252. Comparison of the effects of different magnesium administration times on infarct size Full Text available with Trip Pro

Comparison of the effects of different magnesium administration times on infarct size The protection of high magnesium on infarct size remains controversial.To examine the effects of magnesium administered before ischemia or early in reperfusion on infarct size in a rat model of global ischemiaIsolated rat hearts were submitted to 40 min of normothermic global ischemia and 2 h of reperfusion. After 20 min of stabilization, four protocols were performed: ischemic control (IC) hearts; 15 mM (...) % and 18+/-4%, respectively. In Mg+Ca hearts, the protection was also obtained (19+/-3%). Myocardial function also improved significantly by magnesium treatment. At the end of reperfusion, left ventricular developed pressure and maximal velocity of rise of left ventricular pressure values were 23+/-6% and 22+/-3% in MgI; and 10+/-3% and 9+/-2.6% in MgR versus 2+/-0.7% and 2.3+/-0.8% in IC hearts, respectively.The treatment with magnesium either before ischemia or early in reperfusion has an infarct

2003 Experimental & Clinical Cardiology

3253. Early revascularization and long-term survival in cardiogenic shock complicating acute myocardial infarction. Full Text available with Trip Pro

Early revascularization and long-term survival in cardiogenic shock complicating acute myocardial infarction. Cardiogenic shock remains the major cause of death for patients hospitalized with acute myocardial infarction (MI). Although survival in patients with cardiogenic shock complicating acute MI has been shown to be significantly higher at 1 year in those receiving early revascularization vs initial medical stabilization, data demonstrating long-term survival are lacking.To determine (...) if early revascularization affects long-term survival of patients with cardiogenic shock complicating acute MI.The Should We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock (SHOCK) trial, an international randomized clinical trial enrolling 302 patients from April 1993 through November 1998 with acute myocardial infarction complicated by cardiogenic shock (mean [SD] age at randomization, 66 [11] years); long-term follow-up of vital status, conducted annually until 2005, ranged from 1

2006 JAMA Controlled trial quality: predicted high

3254. Effects of Cardiac Rehabilitation on High Mobility Group Box-1 Levels After Acute Myocardial Infarction

Effects of Cardiac Rehabilitation on High Mobility Group Box-1 Levels After Acute Myocardial Infarction Effects of Cardiac Rehabilitation on High Mobility Group Box-1 Levels After Acute Myocardial Infarction - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Effects of Cardiac Rehabilitation on High Mobility Group Box-1 Levels After Acute Myocardial Infarction The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00755131 Recruitment Status : Completed First Posted : September 18, 2008 Results First Posted

2008 Clinical Trials

3255. Acute Balloon Angioplasty vs. Traditional Early Invasive Treatment of Non-ST-Elevation Myocardial Infarction

are to be treated with acute balloon angioplasty (primary PCI). B) To evaluate whether primary PCI compared with the current regimen of initial medical stabilization and sub-acute PCI results in reduction of infarct-size in NSTEMI-patients. Condition or disease Intervention/treatment Phase Myocardial Infarction Procedure: Primary Percutaneous Coronary Intervention Procedure: Coronary angiography / Percutaneous coronary intervention Not Applicable Detailed Description: Primary PCI versus Traditional Early (...) Acute Balloon Angioplasty vs. Traditional Early Invasive Treatment of Non-ST-Elevation Myocardial Infarction Acute Balloon Angioplasty vs. Traditional Early Invasive Treatment of Non-ST-Elevation Myocardial Infarction - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies

2007 Clinical Trials

3256. To Assess Safety and Efficacy of Myoblast Implantation Into Myocardium Post Myocardial Infarction

To Assess Safety and Efficacy of Myoblast Implantation Into Myocardium Post Myocardial Infarction To Assess Safety and Efficacy of Myoblast Implantation Into Myocardium Post Myocardial Infarction - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. To Assess Safety and Efficacy of Myoblast Implantation Into Myocardium Post Myocardial Infarction (MARVEL) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00526253 Recruitment Status : Active, not recruiting First Posted : September 10, 2007 Last Update

2007 Clinical Trials

3257. Racial analysis of patients with myocardial infarction complicated by heart failure and/or left ventricular dysfunction treated with valsartan, captopril, or both. Full Text available with Trip Pro

few data exist concerning the effectiveness of angiotensin receptor blockers in this population.Baseline characteristics, treatments, and outcomes of patients from the U.S. (3,390 white and 340 African-American patients) in the VALIANT (VALsartan In Acute myocardial iNfarcTion) trial were compared. This trial included patients with an acute myocardial infarction (MI) after initial stabilization and documented LVSD and/or HF. Patients were randomly assigned to receive treatment with valsartan (...) Racial analysis of patients with myocardial infarction complicated by heart failure and/or left ventricular dysfunction treated with valsartan, captopril, or both. African Americans have a high incidence of heart failure (HF). Limited retrospective observational subgroup analyses of patients with left ventricular systolic dysfunction (LVSD) suggest marginal benefit of angiotensin-converting enzyme inhibitors in the prevention of HF hospitalizations or total mortality in African Americans.Very

2008 Journal of the American College of Cardiology

3258. Biochemical Studies on the Cardioprotective Effect of Glutamine on Tissue Antioxidant Defense System in Isoprenaline-Induced Myocardial Infarction in Rats Full Text available with Trip Pro

Biochemical Studies on the Cardioprotective Effect of Glutamine on Tissue Antioxidant Defense System in Isoprenaline-Induced Myocardial Infarction in Rats Oxidative stress is one of the mechanisms with a central role involved in the pathogenesis of myocardial infarction. The protective effect of glutamine on myocardial antioxidant defense system was investigated during isoprenaline-induced myocardial infarction, an animal model of myocardial infarction of human beings. Levels of diagnostic (...) and antiperoxidative enzymes in heart tissue was also observed. Prior oral administration of glutamine significantly prevented isoprenaline-induced adverse effects and maintained myocardial antioxidant status at near normal status. The cardioprotective effect of glutamine is probably related to a strengthening of the myocardial membrane by its membrane stabilizing action, or to a counteraction of free radicals by its antioxidant property, or to its ability to maintain near to normal status the activities of free

2006 Journal of clinical biochemistry and nutrition

3259. Percutaneous Ventricular Assist Device Placement during Active Cardiopulmonary Resuscitation for Severe Refractory Cardiogenic Shock after Acute Myocardial Infarction Full Text available with Trip Pro

shock), there are limited means to rapidly provide additional hemodynamic support. We present the case of a 49-year-old man who presented with an anterior wall acute myocardial infarction complicated by cardiogenic shock. After resuscitation and stabilization with intra-aortic balloon pump and pressor support, the patient underwent successful emergent percutaneous transluminal coronary angioplasty and stenting of the left anterior descending coronary artery. Forty-eight hours later, the patient (...) Percutaneous Ventricular Assist Device Placement during Active Cardiopulmonary Resuscitation for Severe Refractory Cardiogenic Shock after Acute Myocardial Infarction Cardiogenic shock after acute myocardial infarction is associated with a high mortality rate despite modern reperfusion methods and intra-aortic balloon pump support. For myocardial infarction patients in cardiogenic shock that is refractory to intra-aortic ballon pump counterpulsation and pressors (severe refractory cardiogenic

2007 Texas Heart Institute Journal

3260. Unprotected Left Main Coronary Artery Intervention for Acute Myocardial Infarction and Cardiogenic Shock Full Text available with Trip Pro

. Percutaneous coronary intervention in the unprotected left main coronary artery can enable initial revascularization and rapid stabilization even in high-risk patients, but outcomes from the procedure since the recent advent of drug-eluting stents are still being determined. Herein, we report the successful deployment of a sirolimus-eluting stent in a 65-year-old man who had experienced acute myocardial infarction and cardiogenic shock consequent to an occluded left main coronary artery. The patient (...) Unprotected Left Main Coronary Artery Intervention for Acute Myocardial Infarction and Cardiogenic Shock Medical therapy alone often insufficiently alters the clinical course of patients who have experienced acute myocardial infarction and concomitant cardiogenic shock, and in whom the left main coronary artery is the culprit vessel. Emergency coronary artery bypass grafting is an effective yet time-consuming approach that entails the risk of extensive, irreversible myocardial damage

2007 Texas Heart Institute Journal

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>