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Myocardial Infarction Stabilization

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281. Assessment of tachycardia

function. Differentials Sinus tachycardia Acute atrial fibrillation Chronic atrial fibrillation Atrial flutter Atrial tachycardia AV nodal re-entrant tachycardia AV re-entry tachycardia/Wolff-Parkinson-White syndrome Multifocal atrial tachycardia Junctional ectopic tachycardia Monomorphic ventricular tachycardia with prior myocardial infarction Monomorphic ventricular tachycardia with non-ischaemic cardiomyopathy Ventricular fibrillation Polymorphic ventricular tachycardia with normal QT interval (...) , are characterised by depolarisation of the ventricle and retrograde atrial activation (if present), manifested by a retrograde P wave. Arrhythmias that originate from the ventricle may originate from the distal His-Purkinje system or ventricular myocardium. The site of origin within the ventricle further defines some arrhythmias within the ventricle. Examples include right ventricular out-flow tract ventricular tachycardia and bundle branch re-entry ventricular tachycardia. Haemodynamic stability

2018 BMJ Best Practice

282. Assessment of delirium

secondary to illness or trauma, may also contribute to delirium initiation. Inouye SK. Delirium in older persons. N Engl J Med. 2006 Mar 16;354(11):1157-65. http://www.ncbi.nlm.nih.gov/pubmed/16540616?tool=bestpractice.com Differentials Dementia Pain Stroke/cerebrovascular accident and transient ischaemic attack Myocardial infarction Acute systemic infection Hypoglycaemia Hyperglycaemia Hypoxia Hypercarbia Acute urinary obstruction Medication- or illicit drug-related Alcoholic ketoacidosis Hepatic (...) . 2006 May-Jun;6(3):303-8. http://www.ncbi.nlm.nih.gov/pubmed/16826866?tool=bestpractice.com Gupta N, de Jonghe J, Schieveld J, et al. Delirium phenomenology: what can we learn from the symptoms of delirium? J Psychosom Res. 2008 Sep;65(3):215-22. http://www.ncbi.nlm.nih.gov/pubmed/18707943?tool=bestpractice.com Meagher DJ, Leonard M, Donnelly S, et al. A longitudinal study of motor subtypes in delirium: frequency and stability during episodes. J Psychosom Res. 2012 Mar;72(3):236-41. http

2018 BMJ Best Practice

283. Effectiveness of interventions to reduce homelessness: a systematic review and meta?analysis Full Text available with Trip Pro

, once per week, 2) the intervention is described as standard or broker case management, or 3) where intensity was not described. Housing programs Housing programs for homeless people typically provide accommodation and include goals such as long term residential stability, improved life‐skills and greater self‐determination (20, 21). These programs are complex and may include various forms of support and services, such as case management, work therapy, treatment of mental illness and substance abuse (...) , there have been many evaluations of housing and treatment programs for homeless individuals and/or persons at risk of homelessness. Several reviews and meta‐analyses have also been published (12, 18, 20, 28‐31). Yet, a large share of the reviews are out of date, or do not focus on homelessness and residential stability as primary outcomes, or are not systematic reviews of effectiveness. Tabol and colleagues (2010) (12) aimed to determine how clearly the supported/supportive housing model is described

2018 Campbell Collaboration

284. Performance of the Belgian health system

– Indicators specifically on population aged 75+ 74 Table 21 – Indicators on end of life care for patients with terminal cancer 77 Table 22 – Indicators on mother and newborn care 81 KCE Report 313C Performance report 2019 5 LIST OF ABBREVIATIONS ABBREVIATION DEFINITION ADL Activities of daily living AMI Acute myocardial infarction BAPCOC Belgian Antibiotic Policy Coordination Committee BCR Belgian Cancer Registry CT Computed Tomography DDD Defined Daily Dose DTP Diphtheria - Tetanus - Pertussis EBP (...) . 15 The effectiveness of primary care is measured by avoidable hospital admissions for two chronic conditions, namely asthma and complication of diabetes. Effectiveness indicators for hospital acute care are 5-year relative survival rate for cancer (breast and colorectal cancer), case fatality within 30 days after admission for acute myocardial infarction (AMI) and ischemic stroke, and case fatality within 30 days after admission for surgery for colorectal cancer. 16 Performance report 2019 KCE

2019 Belgian Health Care Knowledge Centre

285. Bariatric surgery: an HTA report on the efficacy, safety and cost-effectiveness

mortality in the surgical group (4.5%) vs. the non- surgical group (8.5%). Pooled adjusted estimates from the non- randomized studies indicated and suggested that the surgical group had lower risk of all-cause mortality (OR 0.55, 95%CI: 0.46-0.65; 10 studies). Besides risk for CV-events (myocardial infarction: OR 0.71, 95%CI: 0.54-0.94; stroke: OR 0.66, 95%CI: 0.49-0.89; and their composite: OR 0.67, 95%CI: 0.54-0.83; 1 study), and risk of cancer (OR 0.74, 95%CI: 0.65-0.85; 2 studies) was also reduced (...) with adjusted data, bariatric surgery was associated with a significantly reduced risk of composite cardiovascular adverse events (OR 0.54, 95%CI: 0.41-0.70). Bariatric surgery was also associated with significant reduction in specific endpoints of myocardial infarction (OR 0.46 95%CI 0.30-0.69, 4 studies) and stroke (OR 0.49 95%CI: 0.32-0.75, 4 studies). ? The SR-MA by Sheng et al. 43 evaluated the LT-effect (1 RCT and 9 cohorts with FU time ranging from 5 to 15 years) of MBS in patients with type 2

2019 Belgian Health Care Knowledge Centre

286. Iron Deficiency and Anaemia in Adults

is a 75-year-old gentleman with known chronic heart failure, aetiology ischaemic heart disease having had two previous myocardial infarctions. He has been well for some time (NYHA I) but has found he has been able to do less, with his wife taking on more in the home. His deteriorating symptoms include increasing shortness of breath and fatigue and he is now NYHA II/ III. He is unable to play nine holes of golf as he once did and is feeling isolated at home, unable to get out like previously and meet (...) >500 to 1000mg 250ml 15 minutes Note: For stability reasons, dilutions to concentrations less than 2mg iron/ml are not permissible. Ferinject must not be administered by the subcutaneous or intramuscular route. Minimum observation is required (pulse and blood pressure should be checked before and after infusion). Facilities for cardiorespiratory resuscitation and equipment for handling acute anaphylactic/anaphylactoid reactions should be available, including an injectable 1:1000 adrenaline solution

2018 Royal College of Nursing

287. Statins for the primary prevention of cardiovascular events

-up time 54 4.5.3 Overall results 54 4.5.4 Sensitivity analyses 55 4.5.5 All-cause mortality 56 4.5.6 Cardiovascular mortality 56 4.5.7 Fatal and non-fatal myocardial infarction 56 4.5.8 Fatal and non-fatal stroke 57 4.5.9 Revascularization 57 4.5.10 Composite cardiovascular outcome 57 4.6 EVIDENCE ON HARMS FROM RCT’S AND OBSERVATIONAL RESEARCH 57 4.6.1 Evidence on harms from RCTs in the selected systematic review on primary prevention ... 57 4.6.2 Evidence on harms from the previous KCE report 58 (...) Atherosclerosis Prevention Study KCE Belgian Health Care Knowledge Centre (Kennis Centrum – Centre d’Expertise) LDL Low Density Lipoprotein 14 Statins in primary prevention KCE Report 306 LDL-C Low Density Lipoprotein Cholesterol LDL-P Low Density Lipoprotein Particle LY Life Year LYG Life-Year Gained MEGA Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese METEOR Measuring Effects on Intima-Media Thickness: an Evaluation of Rosuvastatin MI Myocardial Infarction MPR Mean

2019 Belgian Health Care Knowledge Centre

288. Allopurinol / lesinurad (Duzallo) - Gout

are within the specifications and consistent from batch to batch and demonstrated the equivalence of the two processes. Stability Stability data on three pilot scale batches of lesinurad stored in the intended commercial packaging from the first manufacturer and three commercial scale batches from the second manufacturer were provided. In addition data from two pilot batches from the first manufacturer using process II were also provided as supportive data. Results for up to 36 months under long term (...) conditions (25.0 ± 2.0 °C / 60.0 % RH ± 5.0 %) and for up to 6 months under accelerated conditions (40.0 ± 2.0 °C / 75.0 % RH ± 5.0 %) were provided according to the ICH guidelines. Samples were tested for appearance, assay, organic impurities, water content, physical form by XRPD, thermal analysis by DSC and particle size distribution. The test methods are stability indicating. All tested parameters consistently meet the specifications under both accelerated and long-term conditions. No significant

2018 European Medicines Agency - EPARs

289. Management of Cardiovascular Diseases during Pregnancy Full Text available with Trip Pro

ratio ACS Acute coronary syndromes AF Atrial fibrillation AHF Acute heart failure AMI Acute myocardial infarction aPTT Activated partial thromboplastin time ARB Angiotensin receptor blocker ARNI Angiotensin receptor neprilysin inhibitor AS Aortic stenosis ASD Atrial septal defect ASI Aortic size index AT Atrial tachycardia AUC Area under the curve AV Atrioventricular BMI Body mass index BP Blood pressure BSA Body surface area CAD Coronary artery disease CARPREG CARdiac disease in PREGnancy CCB (...) 5-HT1A 5-hydroxytryptamine (serotonin) HTAD Heritable thoracic aortic disease ICD Implantable cardioverter-defibrillator ICU Intensive care unit IE Infective endocarditis INR International normalized ratio i.v. Intravenous KLH Keyhole limpet haemocyanin LMWH Low molecular weight heparin LQTS Long QT syndrome LV Left ventricular LVEF Left ventricular ejection fraction MCS Mechanical circulatory support mGy Milligray MI Myocardial infarction MR Mitral regurgitation MRA Mineralocorticoid receptor

2018 European Society of Cardiology

290. Ezetimibe

of major adverse cardiovascular events (including cardiac death, spontaneous myocardial infarction, unplanned 2017 2. Prevention of Stroke with the Addition of Ezetimibe to Statin Therapy in Patients With Acute Coronary Syndrome in IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial) 28972004 2017 12 26 2017 12 26 1524-4539 136 25 2017 Dec 19 Circulation Circulation Prevention of Stroke with the Addition of Ezetimibe to Statin Therapy in Patients With Acute Coronary (...) of cardiovascular events, but whether the addition of ezetimibe , a nonstatin drug that reduces intestinal cholesterol absorption (...) (40 mg) and ezetimibe (10 mg) (simvastatin- ezetimibe ) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization (≥30 days after randomization), or nonfatal stroke. The median follow-up was 6

2018 Trip Latest and Greatest

291. Diltiazem

Comparison of Diltiazem and Metoprolol in the Management of Acute Atrial Fibrillation or Atrial Flutter (DiME (...) complications such as congestive heart failure, hypotension, ventricular ectopy, respiratory failure, angina and myocardial infarction. Both beta-blocking agents and calcium channel blockers are commonly used to treat AFF in the ED. Metoprolol is the most commonly used beta-blocker; and diltiazem is the most frequently used calcium channel antagonist.[8] Diltiazem was released by the FDA (...) intravenous NTG. Both groups had similar baseline features and the endpoints of treatment were recurrence of angina, myocardial infarction 1995 11. [Intraoperative cortical PO2 measurement in kidney transplantation. the effect of the calcium antagonist diltiazem ]. 7974930 1994 12 23 1994 12 23 2013 11 21 0340-2592 33 5 1994 Sep Der Urologe. Ausg. A Urologe A [Intraoperative cortical PO2 measurement in kidney transplantation. the effect of the calcium antagonist diltiazem ]. 415-21 A local measurement

2018 Trip Latest and Greatest

292. Allopurinol

disease. Methods We conducted a multicenter, double-blind, noninferiority trial involving patients with gout (...) and cardiovascular disease; patients were randomly assigned to receive febuxostat or allopurinol and were stratified according to kidney function. The trial had a prespecified noninferiority margin of 1.3 for the hazard ratio for the primary end point (a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or unstable angina with urgent revascularization (...) ), allopurinol and febuxostat, are the mainstay of urate lowering treatment for gout and may have different effects on cardiovascular risk in patients with gout. Methods -Using U.S. Medicare claims data (2008-2013), we conducted a cohort study for comparative cardiovascular safety of initiating febuxostat versus allopurinol among gout patients aged ≥65 years. The primary outcome was a composite endpoint of hospitalization for myocardial infarction (MI) or stroke 2018 16. Does Allopurinol Prolong a Treated

2018 Trip Latest and Greatest

293. Lansoprazole

, lansoprazole can treat or prevent incident tuberculosis (TB) disease. METHODS AND FINDINGS: We studied a cohort (...) of new users of lansoprazole , omeprazole, or pantoprazole from the United Kingdom Clinical Practice Research Datalink to determine whether lansoprazole users have a lower incidence of TB disease than omeprazole or pantoprazole users. Negative control outcomes of myocardial infarction (MI) and herpes zoster were also studied. Multivariable Cox proportional hazards regression was used (...) . This study seeks to determine if the medication is equally distributed within the tablet to allow for accurate dosing. METHODS: Ten 15-mg Prevacid SoluTabs were divided. Each (...) ). CONCLUSIONS: There are statistically significant differences in the amount of lansoprazole -containing microgranules within each half of a divided tablet. Clinicians must determine whether this difference is clinically relevant when prescribing "divided" medication to children. 2015 16. A Novel, Validated Stability

2018 Trip Latest and Greatest

294. Adalimumab (Hefiya) - Juvenile Rheumatoid Arthritis, Hidradenitis Suppurativa, Psoriasis, Ankylosing Spondylitis, Uveitis

. Assessment report EMA/CHMP/520007/2018 Page 18/128 Release and periodical retests for both, the primary reference and the working reference standard have been submitted and are considered acceptable. For the primary reference standard a panel of analytical methods for additional characterisation has been presented. Stability The proposed shelf life of Hefiya active substance when stored at the recommended conditions is based on long-term stability data. The results demonstrate that Hefiya active (...) substance is stable under the recommended conditions. Supporting information on accelerated and stress stability data and data from thermal freeze/thaw cycles as well as photo-stability data have been provided. Comparability exercise for Active Substance The development activities include the initial development of the AS manufacturing process, the following scale up and transfer from the pilot scale to the manufacturing scale at different plants and lines. Comparability was demonstrated in data between

2018 European Medicines Agency - EPARs

295. Adalimumab (Halimatoz) - Juvenile Rheumatoid Arthritis, Psoriatic Arthritis, Rheumatoid Arthritis, Hidradenitis Suppurativa, Psoriasis, Ankylosing Spondylitis, Uveitis

standards as well as the concept for introduction of future in-house reference standards has been briefly outlined. Release and periodical retests for both, the primary reference and the working reference standard have been submitted and are considered acceptable. For the primary reference standard a panel of analytical methods for additional characterisation has been presented. Stability The proposed shelf life of Halimatoz active substance when stored at the recommended conditions is based on long (...) -term stability data. The results demonstrate that Halimatoz active substance is stable under the recommended conditions. Supporting information on accelerated and stress stability data and data from thermal freeze/thaw cycles as well as photo-stability data have been provided. Comparability exercise for Active Substance The development activities include the initial development of the AS manufacturing process, the following scale up and transfer from the pilot scale to the manufacturing scale

2018 European Medicines Agency - EPARs

296. Nitroglycerin

ration via nasogastric tube. In 4 groups of 5 horses each, saline (0.9% NaCl) solution or ET receptor antagonist (10(5)M 2006 2. Prehospital Nitroglycerin Safety in Inferior ST Elevation Myocardial Infarction. Patients with inferior ST elevation myocardial infarction (STEMI), associated with right ventricular infarction, are thought to be at higher risk of developing hypotension when administered nitroglycerin (NTG). However, current basic life support (BLS) protocols do not differentiate location (...) (or ) are indicated as first line agents in most other cases of III. Preparation Mix 50 mg in 250 ml D5W IV. Dosing: Acute Myocardial Ischemia or Infarction Bolus: 12.5 to 25 mcg 2015 16. Nitroglycerin Nitroglycerin Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies

2018 Trip Latest and Greatest

297. Quinapril

angiotensin (...) -converting enzyme inhibition (ACE-I) (i.e., quinapril ) prevents transient ischemia (exertional and spontaneous) in patients with coronary artery disease (CAD). It is known that ACE-I reduces the risk of death, myocardial infarction (MI), and other CAD-related outcomes in high-risk patients. Numerous studies have confirmed that ACE-I improves coronary flow and endothelial function. Whether ACE-I also decreases transient ischemia is unclear, because no studies have been adequately (...) of systematic reviews, clinical guidelines 2018 12. Effects of quinapril , losartan and hydralazine on cardiac hypertrophy and β-adrenergic neuroeffector mechanisms in transgenic (mREN2)27 rats 9504380 1998 04 13 1998 04 13 2015 11 19 0007-1188 123 3 1998 Feb British journal of pharmacology Br. J. Pharmacol. Effects of quinapril , losartan and hydralazine on cardiac hypertrophy and beta-adrenergic neuroeffector mechanisms in transgenic (mREN2)27 rats. 405-12 1. Desensitization of the myocardial beta

2018 Trip Latest and Greatest

298. ESC/ESH Management of Arterial Hypertension Full Text available with Trip Pro

Rosuvastatin LDH Lactate dehydrogenase LDL-C LDL cholesterol LEAD Lower extremity artery disease LIFE Losartan Intervention For Endpoint reduction in hypertension LV Left ventricular LVH Left ventricular hypertrophy MAP Mean arterial pressure MI Myocardial infarction MR Magnetic resonance MRA Mineralocorticoid receptor antagonist MRI Magnetic resonance imaging MUCH Masked uncontrolled hypertension NORDIL Nordic Diltiazem NS Non-significant NT-proBNP N-terminal pro-B natriuretic peptide o.d. Omni die (every (...) million), and ischaemic stroke (1.5 million). Both office BP and out-of-office BP have an independent and continuous relationship with the incidence of several CV events [haemorrhagic stroke, ischaemic stroke, myocardial infarction, sudden death, heart failure, and peripheral artery disease (PAD)], as well as end-stage renal disease. Accumulating evidence is closely linking hypertension with an increased risk of developing atrial fibrillation (AF), and evidence is emerging that links early elevations

2018 European Society of Cardiology

300. Sodium zirconium cyclosilicate (Lokelma) - Hyperkalemia

are usually between 3.5 and 5.0 mmol/L, which is considered the normal range for adults. However, a number of recent retrospective studies have shown the risk of mortality is increased even with only modest elevations of S-K. Mortality risk has been shown to be significantly higher in chronic kidney disease (CKD) patients with S-K levels > 5.0 mmol/L. In acute myocardial infarction patients, a mean postadmission S-K = 5.5 mmol/L during hospitalisation corresponded to a 12-fold increase in death compared (...) of the active substance are provided. The results are within the specifications and consistent from batch to batch. The active substance specifications are based on the active substance critical quality attributes (CQA). Stability Stability data on six commercial scale batches of the active substance from the proposed manufacturer stored in a container closure system representative of that intended for commercial production were provided. Data on three batches was provided for 24 months under long term

2018 European Medicines Agency - EPARs

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