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Myocardial Infarction Stabilization

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261. Considerations for cardiac catheterization laboratory procedures during the COVID?19 pandemic: perspectives from the Society for Cardiovascular Angiography and Interventions Emerging Leader Mentorship (SCAI ELM) Members and Graduates (Full text)

or Person under investigation (PUI) as defined by the presence of Fever. Respiratory symptoms (cough, shortness of breath, and sore throat). Either foreign travel within 14 days to a country with a Level 2–4 travel alert health notice (centres for disease control and prevention (CDC) website) or exposure to a confirmed case or cluster of suspected COVID‐19 illness. 3 GUIDING PRINCIPLES FOR CONFIRMED OR SUSPECTED COVID‐19 PATIENTS All ST‐elevation myocardial infarction (STEMI) patients including (...) increases causing systematic and infrastructural bottlenecks for care, especially given regional variations, the primary therapeutic options may have to change (Appendix A). Alternative therapeutic options such as systemic fibrinolytic therapy may be considered for low risk STEMI (e.g., inferior STEMI without right ventricular involvement or lateral myocardial infarction without hemodynamic compromise) depending on local availability of expertise and the prevalence and effects of the COVID‐19 disease

2020 Society for Cardiovascular Angiography and Interventions PubMed abstract

262. Covid-19: Society of Family Planning interim clinical recommendations: Contraceptive provision when healthcare access is restricted due to pandemic response

, including stroke and myocardial infarction, and recommend that she schedule a non-urgent visit with a healthcare provider for blood pressure check once usual healthcare access resumes. Contraceptive counseling prior to IUD or implant placement and removal. An initial telemedicine visit can be useful for assessing potential contraindications, reviewing alternative methods, and counseling the patient as part of informed consent. This step confirms that an in-person visit is required, and minimizes (...) as substitute for clinical judgement. Due to geographic variability in both the pandemic and the legislative environment, not all recommendations will apply to all providers. This document will be revised and revisited as conditions stabilize and additional evidence emerges. Recommendations in this document may also reduce barriers to care in a post-pandemic state. References [1] Ahmed Z, Sonfield A. The COVID-19 Outbreak: Potential Fallout for Sexual and Reproductive Health and Rights. Guttmacher Institute

2020 Society of Family Planning

264. AACE Clinical Practice Guidelines for the Diagnosis and Treatment of Postmenopausal Osteoporosis

- ment (7). A recent retrospective analysis demonstrated that the annual cost of caring for osteoporotic fractures exceeds the annual costs of caring for breast cancer, myocardial infarction, or stroke in women aged 55 years and older (8). Osteoporosis is preventable and treatable, but only a small proportion of those at increased risk for fracture are evaluated and treated. Age is an important risk factor for bone loss; by age 60 years, half of white women have low bone mass (osteopenia (...) years of stability in patients with very high fracture risk (Grade B; BEL 2). R38. For zoledronate, consider a bisphosphonate holiday after 3 years in high-risk patients or until fracture risk is no longer high, and continue for up to 6 years in very-high- risk patients (Grade A; BEL 1). R39. The ending of a bisphosphonate holiday should be based on individual patient circumstances such as an increase in fracture risk, a decrease in bone mineral density beyond the least significant change (LSC

2020 American Association of Clinical Endocrinologists

265. Cardiovascular Considerations in Caring for Pregnant Patients: A Scientific Statement From the American Heart Association (Full text)

published 4 May 2020 Circulation. 2020;141:e884–e903 Abstract Cardio-obstetrics has emerged as an important multidisciplinary field that requires a team approach to the management of cardiovascular disease during pregnancy. Cardiac conditions during pregnancy include hypertensive disorders, hypercholesterolemia, myocardial infarction, cardiomyopathies, arrhythmias, valvular disease, thromboembolic disease, aortic disease, and cerebrovascular diseases. Cardiovascular disease is the primary cause (...) treatment before pregnancy. Current treatment options for pregnant women with familial hypercholesterolemia include bile acid sequestrants, which lack systemic circulation, and, as last resort, low-density lipoprotein apheresis in severe cases ( ). , Ischemic Heart Disease in Pregnancy Ischemic heart disease during pregnancy constitutes a rare but potentially fatal condition. The risk of acute myocardial infarction (MI) is 3- to 4-fold higher in pregnant women compared with their nonpregnant

2020 American Heart Association PubMed abstract

266. Call to Action to Prevent Venous Thromboembolism in Hospitalized Patients: A Policy Statement From the American Heart Association

. In an analysis of 2.5 million hospital discharges, hospitalized patients with cancer had the lowest rates of prophylaxis compared with patients with other conditions such as myocardial infarction or severe lung disease. Even when VTE prophylaxis was administered to hospitalized patients with cancer, it was frequently not targeted to those at highest risk. This practice may reflect insufficient clinical trial evidence in this patient population. Specifically, although there are emerging data evaluating (...) Previous VTE (with the exclusion of superficial vein thrombosis) 3 Reduced mobility 3 Already known thrombophilic condition 3 Recent (≤1 mo) trauma or surgery 2 Elderly age (≥70 y) 1 Heart or respiratory failure 1 Acute myocardial infarction or ischemic stroke 1 Acute infection or rheumatological disorder 1 Obesity (BMI ≥30 kg/m 2 ) 1 Ongoing hormonal treatment 1 BMI indicates body mass index; and VTE, venous thromboembolism. Adapted from Barbar et al with permission. Copyright © 2010, International

2020 American Heart Association

267. Position Statement on the Management of Cardiac Electrophysiology and Cardiac Implantable Electronic Devices in Australia During the COVID-19 Pandemic: A Living Document Version 2

in an intensive care unit. 5 In Influenza infection, cardiovascular complications include myocarditis, acute myocardial infarction (plaque rupture secondary to viral inflammation) and exacerbation of heart failure. Previous coronavirus infections have also been associated with cardiovascular complications. The risk of adverse outcomes and the severity of adverse outcomes are increased by pre-existing cardiovascular disease. SARS has previously been associated with hypotension, tachycardia, bradycardia, atrial (...) of patients admitted to ICU. 5 HRC COVID-19 9/4/2020, version 2 16 A separate single-centre retrospective analysis also from Wuhan demonstrates correlation between underlying cardiovascular disease (CVD) and myocardial injury with increased mortality and malignant arrhythmias. One third of the patients (35.3%) had previous CVD, and 52 (27.8%) patients experienced an acute myocardial injury. Troponin T (TnT) elevation likely represents myocardial injury from either myocarditis, infarction with plaque

2020 Cardiac Society of Australia and New Zealand

268. Unhealthy Drug Use: Screening

use can cause many serious health effects that vary by drug type, administration mode, amount, and frequency of use, as well as pregnancy status. Opioid use can cause drowsiness, slowed breathing, constipation, coma, and fatal overdose. Stimulants such as cocaine can cause arrhythmias, myocardial infarction, seizures, and other complications. Marijuana use is associated with slowed reaction time; problems with balance, coordination, learning, and memory; and chronic cough and frequent respiratory (...) . Treatment Treatment of drug use disorders is based on the type of drug used, the severity of drug use, and the type of use disorder. Many drug use disorders are chronic, relapsing conditions, and many persons who start treatment do not complete treatment. Therefore, treatment must often be repeated to stabilize current drug use, reduce relapse, and achieve abstinence or other treatment goals. Some patients, such as those who are pregnant, nursing, or caring for ill or healthy neonates, may require

2020 U.S. Preventive Services Task Force

269. Assessment of tachycardia

function. Differentials Sinus tachycardia Acute atrial fibrillation Chronic atrial fibrillation Atrial flutter Atrial tachycardia AV nodal re-entrant tachycardia AV re-entry tachycardia/Wolff-Parkinson-White syndrome Multifocal atrial tachycardia Junctional ectopic tachycardia Monomorphic ventricular tachycardia with prior myocardial infarction Monomorphic ventricular tachycardia with non-ischaemic cardiomyopathy Ventricular fibrillation Polymorphic ventricular tachycardia with normal QT interval (...) , are characterised by depolarisation of the ventricle and retrograde atrial activation (if present), manifested by a retrograde P wave. Arrhythmias that originate from the ventricle may originate from the distal His-Purkinje system or ventricular myocardium. The site of origin within the ventricle further defines some arrhythmias within the ventricle. Examples include right ventricular out-flow tract ventricular tachycardia and bundle branch re-entry ventricular tachycardia. Haemodynamic stability

2018 BMJ Best Practice

270. Assessment of delirium

secondary to illness or trauma, may also contribute to delirium initiation. Inouye SK. Delirium in older persons. N Engl J Med. 2006 Mar 16;354(11):1157-65. Differentials Dementia Pain Stroke/cerebrovascular accident and transient ischaemic attack Myocardial infarction Acute systemic infection Hypoglycaemia Hyperglycaemia Hypoxia Hypercarbia Acute urinary obstruction Medication- or illicit drug-related Alcoholic ketoacidosis Hepatic (...) . 2006 May-Jun;6(3):303-8. Gupta N, de Jonghe J, Schieveld J, et al. Delirium phenomenology: what can we learn from the symptoms of delirium? J Psychosom Res. 2008 Sep;65(3):215-22. Meagher DJ, Leonard M, Donnelly S, et al. A longitudinal study of motor subtypes in delirium: frequency and stability during episodes. J Psychosom Res. 2012 Mar;72(3):236-41. http

2018 BMJ Best Practice

271. Effectiveness of interventions to reduce homelessness: a systematic review and meta?analysis (Full text)

, once per week, 2) the intervention is described as standard or broker case management, or 3) where intensity was not described. Housing programs Housing programs for homeless people typically provide accommodation and include goals such as long term residential stability, improved life‐skills and greater self‐determination (20, 21). These programs are complex and may include various forms of support and services, such as case management, work therapy, treatment of mental illness and substance abuse (...) , there have been many evaluations of housing and treatment programs for homeless individuals and/or persons at risk of homelessness. Several reviews and meta‐analyses have also been published (12, 18, 20, 28‐31). Yet, a large share of the reviews are out of date, or do not focus on homelessness and residential stability as primary outcomes, or are not systematic reviews of effectiveness. Tabol and colleagues (2010) (12) aimed to determine how clearly the supported/supportive housing model is described

2018 Campbell Collaboration PubMed abstract

272. Performance of the Belgian health system

– Indicators specifically on population aged 75+ 74 Table 21 – Indicators on end of life care for patients with terminal cancer 77 Table 22 – Indicators on mother and newborn care 81 KCE Report 313C Performance report 2019 5 LIST OF ABBREVIATIONS ABBREVIATION DEFINITION ADL Activities of daily living AMI Acute myocardial infarction BAPCOC Belgian Antibiotic Policy Coordination Committee BCR Belgian Cancer Registry CT Computed Tomography DDD Defined Daily Dose DTP Diphtheria - Tetanus - Pertussis EBP (...) . 15 The effectiveness of primary care is measured by avoidable hospital admissions for two chronic conditions, namely asthma and complication of diabetes. Effectiveness indicators for hospital acute care are 5-year relative survival rate for cancer (breast and colorectal cancer), case fatality within 30 days after admission for acute myocardial infarction (AMI) and ischemic stroke, and case fatality within 30 days after admission for surgery for colorectal cancer. 16 Performance report 2019 KCE

2019 Belgian Health Care Knowledge Centre

273. Bariatric surgery: an HTA report on the efficacy, safety and cost-effectiveness

mortality in the surgical group (4.5%) vs. the non- surgical group (8.5%). Pooled adjusted estimates from the non- randomized studies indicated and suggested that the surgical group had lower risk of all-cause mortality (OR 0.55, 95%CI: 0.46-0.65; 10 studies). Besides risk for CV-events (myocardial infarction: OR 0.71, 95%CI: 0.54-0.94; stroke: OR 0.66, 95%CI: 0.49-0.89; and their composite: OR 0.67, 95%CI: 0.54-0.83; 1 study), and risk of cancer (OR 0.74, 95%CI: 0.65-0.85; 2 studies) was also reduced (...) with adjusted data, bariatric surgery was associated with a significantly reduced risk of composite cardiovascular adverse events (OR 0.54, 95%CI: 0.41-0.70). Bariatric surgery was also associated with significant reduction in specific endpoints of myocardial infarction (OR 0.46 95%CI 0.30-0.69, 4 studies) and stroke (OR 0.49 95%CI: 0.32-0.75, 4 studies). ? The SR-MA by Sheng et al. 43 evaluated the LT-effect (1 RCT and 9 cohorts with FU time ranging from 5 to 15 years) of MBS in patients with type 2

2019 Belgian Health Care Knowledge Centre

274. Iron Deficiency and Anaemia in Adults

is a 75-year-old gentleman with known chronic heart failure, aetiology ischaemic heart disease having had two previous myocardial infarctions. He has been well for some time (NYHA I) but has found he has been able to do less, with his wife taking on more in the home. His deteriorating symptoms include increasing shortness of breath and fatigue and he is now NYHA II/ III. He is unable to play nine holes of golf as he once did and is feeling isolated at home, unable to get out like previously and meet (...) >500 to 1000mg 250ml 15 minutes Note: For stability reasons, dilutions to concentrations less than 2mg iron/ml are not permissible. Ferinject must not be administered by the subcutaneous or intramuscular route. Minimum observation is required (pulse and blood pressure should be checked before and after infusion). Facilities for cardiorespiratory resuscitation and equipment for handling acute anaphylactic/anaphylactoid reactions should be available, including an injectable 1:1000 adrenaline solution

2018 Royal College of Nursing

275. Statins for the primary prevention of cardiovascular events

-up time 54 4.5.3 Overall results 54 4.5.4 Sensitivity analyses 55 4.5.5 All-cause mortality 56 4.5.6 Cardiovascular mortality 56 4.5.7 Fatal and non-fatal myocardial infarction 56 4.5.8 Fatal and non-fatal stroke 57 4.5.9 Revascularization 57 4.5.10 Composite cardiovascular outcome 57 4.6 EVIDENCE ON HARMS FROM RCT’S AND OBSERVATIONAL RESEARCH 57 4.6.1 Evidence on harms from RCTs in the selected systematic review on primary prevention ... 57 4.6.2 Evidence on harms from the previous KCE report 58 (...) Atherosclerosis Prevention Study KCE Belgian Health Care Knowledge Centre (Kennis Centrum – Centre d’Expertise) LDL Low Density Lipoprotein 14 Statins in primary prevention KCE Report 306 LDL-C Low Density Lipoprotein Cholesterol LDL-P Low Density Lipoprotein Particle LY Life Year LYG Life-Year Gained MEGA Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese METEOR Measuring Effects on Intima-Media Thickness: an Evaluation of Rosuvastatin MI Myocardial Infarction MPR Mean

2019 Belgian Health Care Knowledge Centre

276. Allopurinol / lesinurad (Duzallo) - Gout

are within the specifications and consistent from batch to batch and demonstrated the equivalence of the two processes. Stability Stability data on three pilot scale batches of lesinurad stored in the intended commercial packaging from the first manufacturer and three commercial scale batches from the second manufacturer were provided. In addition data from two pilot batches from the first manufacturer using process II were also provided as supportive data. Results for up to 36 months under long term (...) conditions (25.0 ± 2.0 °C / 60.0 % RH ± 5.0 %) and for up to 6 months under accelerated conditions (40.0 ± 2.0 °C / 75.0 % RH ± 5.0 %) were provided according to the ICH guidelines. Samples were tested for appearance, assay, organic impurities, water content, physical form by XRPD, thermal analysis by DSC and particle size distribution. The test methods are stability indicating. All tested parameters consistently meet the specifications under both accelerated and long-term conditions. No significant

2018 European Medicines Agency - EPARs

277. Management of Cardiovascular Diseases during Pregnancy (Full text)

ratio ACS Acute coronary syndromes AF Atrial fibrillation AHF Acute heart failure AMI Acute myocardial infarction aPTT Activated partial thromboplastin time ARB Angiotensin receptor blocker ARNI Angiotensin receptor neprilysin inhibitor AS Aortic stenosis ASD Atrial septal defect ASI Aortic size index AT Atrial tachycardia AUC Area under the curve AV Atrioventricular BMI Body mass index BP Blood pressure BSA Body surface area CAD Coronary artery disease CARPREG CARdiac disease in PREGnancy CCB (...) 5-HT1A 5-hydroxytryptamine (serotonin) HTAD Heritable thoracic aortic disease ICD Implantable cardioverter-defibrillator ICU Intensive care unit IE Infective endocarditis INR International normalized ratio i.v. Intravenous KLH Keyhole limpet haemocyanin LMWH Low molecular weight heparin LQTS Long QT syndrome LV Left ventricular LVEF Left ventricular ejection fraction MCS Mechanical circulatory support mGy Milligray MI Myocardial infarction MR Mitral regurgitation MRA Mineralocorticoid receptor

2018 European Society of Cardiology PubMed abstract

278. Ezetimibe

of major adverse cardiovascular events (including cardiac death, spontaneous myocardial infarction, unplanned 2017 2. Prevention of Stroke with the Addition of Ezetimibe to Statin Therapy in Patients With Acute Coronary Syndrome in IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial) 28972004 2017 12 26 2017 12 26 1524-4539 136 25 2017 Dec 19 Circulation Circulation Prevention of Stroke with the Addition of Ezetimibe to Statin Therapy in Patients With Acute Coronary (...) of cardiovascular events, but whether the addition of ezetimibe , a nonstatin drug that reduces intestinal cholesterol absorption (...) (40 mg) and ezetimibe (10 mg) (simvastatin- ezetimibe ) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization (≥30 days after randomization), or nonfatal stroke. The median follow-up was 6

2018 Trip Latest and Greatest

279. Diltiazem

Comparison of Diltiazem and Metoprolol in the Management of Acute Atrial Fibrillation or Atrial Flutter (DiME (...) complications such as congestive heart failure, hypotension, ventricular ectopy, respiratory failure, angina and myocardial infarction. Both beta-blocking agents and calcium channel blockers are commonly used to treat AFF in the ED. Metoprolol is the most commonly used beta-blocker; and diltiazem is the most frequently used calcium channel antagonist.[8] Diltiazem was released by the FDA (...) intravenous NTG. Both groups had similar baseline features and the endpoints of treatment were recurrence of angina, myocardial infarction 1995 11. [Intraoperative cortical PO2 measurement in kidney transplantation. the effect of the calcium antagonist diltiazem ]. 7974930 1994 12 23 1994 12 23 2013 11 21 0340-2592 33 5 1994 Sep Der Urologe. Ausg. A Urologe A [Intraoperative cortical PO2 measurement in kidney transplantation. the effect of the calcium antagonist diltiazem ]. 415-21 A local measurement

2018 Trip Latest and Greatest

280. Allopurinol

disease. Methods We conducted a multicenter, double-blind, noninferiority trial involving patients with gout (...) and cardiovascular disease; patients were randomly assigned to receive febuxostat or allopurinol and were stratified according to kidney function. The trial had a prespecified noninferiority margin of 1.3 for the hazard ratio for the primary end point (a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or unstable angina with urgent revascularization (...) ), allopurinol and febuxostat, are the mainstay of urate lowering treatment for gout and may have different effects on cardiovascular risk in patients with gout. Methods -Using U.S. Medicare claims data (2008-2013), we conducted a cohort study for comparative cardiovascular safety of initiating febuxostat versus allopurinol among gout patients aged ≥65 years. The primary outcome was a composite endpoint of hospitalization for myocardial infarction (MI) or stroke 2018 16. Does Allopurinol Prolong a Treated

2018 Trip Latest and Greatest

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