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Myocardial Infarction Stabilization

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241. The Stabilization Of pLaques usIng Darapladib-Thrombolysis In Myocardial Infarction 52 Trial

The Stabilization Of pLaques usIng Darapladib-Thrombolysis In Myocardial Infarction 52 Trial The Stabilization Of pLaques usIng Darapladib-Thrombolysis In Myocardial Infarction 52 Trial - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. The Stabilization Of pLaques usIng Darapladib-Thrombolysis In Myocardial Infarction 52 Trial (SOLID-TIMI 52) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01000727 Recruitment Status : Completed First Posted : October 23, 2009 Results First Posted : August 10, 2017 Last

2009 Clinical Trials

242. Long-term stability of heart rate variability in chronic stable angina pectoris, and the impact of an acute myocardial infarction. (PubMed)

Long-term stability of heart rate variability in chronic stable angina pectoris, and the impact of an acute myocardial infarction. Heart rate variability (HRV) reflects the balance between cardiac parasympathetic and sympathetic autonomic influences. Reduced HRV has adverse prognostic implications. The time course for changes in HRV over prolonged periods of time and the influence of an acute coronary event on HRV are not well established.Heart rate variability was assessed in patients (...) with chronic stable angina pectoris, who were followed for 3 years within the Angina Prognosis Study in Stockholm. Patients who suffered an acute myocardial infarction after the study were re-examined after this event. We assessed HRV by the simple geometric method differential index, and traditional time- and frequency-domain measurements of HRV.The differential index was essentially unchanged during the study (i.e. the ratio month 36/month 1 was 1.00 +/- 0.06, n = 261). Also most other time and frequency

2009 Clinical physiology and functional imaging Controlled trial quality: uncertain

243. Delivering novel therapies in the 21st century

-tumour activity and the efficacy of PD-L1 therapies. CASE STUDY 2 CASE STUDY 3 Novel treatments for chronic heart failure Modified mRNA therapies can help tissue to regenerate after injury. mRNA expressing the VEGF protein is injected directly into damaged cardiac muscle tissue where it is taken up by cells to make new proteins. A single administration improves cardiac function, repairs heart damage, and regenerates blood vessels including arteries two months after myocardial infarction in animal (...) models. Meanwhile, transplanting embryonic-stem cell derived human ventricular progenitor cells has been shown to preserve cardiac function in mouse studies following myocardial infarction. This could be combined with CRISPR genome editing to engineer progenitor cells with wider applications. Anticalin protein for respiratory disease Anticalin® proteins are smaller than antibodies, and so can be delivered into the body by inhalation. AstraZeneca is using Pieris’ Anticalin® protein platform to create

2019 Academy of Medical Sciences

244. Guidelines on Chronic Coronary Syndromes

tomography-based fractional flow reserve GEMINI- ACS A Study to Compare the Safety of Rivaroxaban Versus Acetylsalicylic Acid in Addition to Either Clopidogrel or Ticagrelor Therapy in Participants With Acute Coronary Syndrome GFR Glomerular filtration rate GLS Global longitudinal strain GOSPEL Global secondary prevention strategies to limit event recurrence after myocardial infarction HbA1c Glycated haemoglobin HF Heart failure ICA Invasive coronary angiography IMR Index of microcirculatory resistance (...) IMT Intima−media thickness IONA Impact Of Nicorandil in Angina iwFR Instantaneous wave-free ratio (instant flow reserve) LAD Left anterior descending LBBB Left bundle branch block LDL-C Low-density lipoprotein cholesterol LM Left main (coronary artery) LV Left ventricular LVEF Left ventricular ejection fraction MI Myocardial infarction MRA Mineralocorticoid receptor antagonist NOAC Non-vitamin K antagonist oral anticoagulant NT-proBNP N-terminal pro-B-type natriuretic peptide OAC Oral

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2019 European Society of Cardiology

245. Guidelines on Diabetes, Pre-Diabetes and Cardiovascular Diseases developed in collaboration with the EASD

A Diabetes Outcome Progression Trial AF Atrial fibrillation ARB Angiotensin receptor blocker ART Arterial Revascularization Trial ASCEND A Study of Cardiovascular Events iN Diabetes ASCVD Atherosclerotic cardiovascular disease ATLAS-ACS TIMI 51 Anti-Xa Therapy to Lower cardiovascular events in Addition to Standard therapy in subjects with Acute Coronary Syndromes - Thrombolysis In Myocardial Infarction 51 BARI 2D Bypass Angioplasty Revascularization Investigation 2 Diabetes BEST Randomized Comparison (...) DECLARE- TIMI 58 Dapagliflozin Effect on Cardiovascular Events−Thrombolysis In Myocardial Infarction 58 trial DES Drug-eluting stent DEVOTE Trial Comparing Cardiovascular Safety of Insulin Degludec versus Insulin Glargine in Patients with Type 2 Diabetes at High Risk of cardiovascular Events DIAD Detection of Ischaemia in Asymptomatic Diabetics DIGAMI Diabetes Mellitus Insulin-Glucose Infusion in Acute Myocardial Infarction DiRECT Diabetes Remission Clinical Trial DM Diabetes mellitus DPP4 Dipeptidyl

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2019 European Society of Cardiology

247. Guidelines on Supraventricular Tachycardia (for the management of patients with)

JET Junctional ectopic tachycardia LA Left atrial/atrium LAL Left anterolateral LBBB Left bundle branch block LL Left lateral LP Left posterior LPL Left posterolateral LPS Left posteroseptal LV Left ventricle/ventricular MI Myocardial infarction MRAT Macro−re-entrant atrial tachycardia MS Mid-septal NT-proBNP N-terminal pro-B-type natriuretic peptide PJRT Permanent junctional reciprocating tachycardia p.o. Per os (by mouth) POTS Postural orthostatic tachycardia syndrome PPM Permanent pacemaker (...) %. The overall incidence of atrial flutter is 88/100 000 person-years in the US population annually. Adjusted for age, the incidence of atrial flutter in men (125/100 000) is >2.5 times that of women (59/100 000) and increases exponentially with age. Patients with atrial flutter are more likely to have been smokers, have a longer PR interval, history of myocardial infarction (MI), and history of heart failure (HF). Catheter ablation is now used extensively for most varieties of SVT, and patient-reported

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2019 European Society of Cardiology

248. Diagnosis and Management of Acute Pulmonary Embolism

considerations 3.1 Epidemiology Venous thromboembolism (VTE), clinically presenting as DVT or PE, is globally the third most frequent acute cardiovascular syndrome behind myocardial infarction and stroke. In epidemiological studies, annual incidence rates for PE range from 39–115 per 100 000 population; for DVT, incidence rates range from 53–162 per 100 000 population. , Cross-sectional data show that the incidence of VTE is almost eight times higher in individuals aged ≥80 years than in the fifth decade (...) limb Hospitalization for heart failure or atrial fibrillation/flutter (within previous 3 months) Hip or knee replacement Major trauma Myocardial infarction (within previous 3 months) Previous VTE Spinal cord injury Moderate risk factors (OR 2–9) Arthroscopic knee surgery Autoimmune diseases Blood transfusion Central venous lines Intravenous catheters and leads Chemotherapy Congestive heart failure or respiratory failure Erythropoiesis-stimulating agents Hormone replacement therapy (depends

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2019 European Society of Cardiology

249. Management of Dyslipidaemias

Reduction LPL Lipoprotein lipase Lp(a) Lipoprotein(a) mAb Monoclonal antibody MACE Major adverse cardiovascular events MESA Multi-Ethnic Study of Atherosclerosis MetS Metabolic syndrome MI Myocardial infarction mRNA Messenger RNA MTP Microsomal triglyceride transfer protein NAFLD Non-alcoholic fatty liver disease NNT Number needed to treat NPC1L1 Niemann-Pick C1-like protein 1 NSTE-ACS Non-ST elevation acute coronary syndrome o.d. Once a day (omni die) ODYSSEY Outcomes Evaluation of Cardiovascular (...) SFA Saturated fatty acid SHARP Study of Heart and Renal Protection siRNA Small interfering RNA SMI Severe mental illness SPARCL Stroke Prevention by Aggressive Reduction in Cholesterol Levels STAREE STAtin Therapy for Reducing Events in the Elderly STEMI ST-elevation myocardial infarction STRENGTH Outcomes Study to Assess STatin Residual Risk Reduction with EpaNova in HiGh CV Risk PatienTs with Hypertriglyceridemia TC Total cholesterol T1DM Type 1 diabetes mellitus T2DM Type 2 diabetes mellitus

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2019 European Society of Cardiology

250. Bleeding complications with dual antiplatelet therapy among patients with stable vascular disease or risk factors for vascular disease: results from the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance (CHAR (PubMed)

year. Patients without moderate or severe bleeding during the first year were no more likely than placebo-treated patients to have bleeding thereafter. The frequency of bleeding was similar in patients with established disease and risk factors only. In multivariable analysis, the relationship between moderate bleeding and all-cause mortality was strong (hazard ratio, 2.55; 95% confidence interval, 1.71 to 3.80; P<0.0001), along with myocardial infarction (hazard ratio, 2.92; 95% confidence interval (...) Bleeding complications with dual antiplatelet therapy among patients with stable vascular disease or risk factors for vascular disease: results from the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance (CHAR Uncertainty exists about the frequency, correlates, and clinical significance of bleeding with dual antiplatelet therapy (DAPT), particularly over an extended period in a stable population. We sought to determine the frequency and time course

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2010 Circulation Controlled trial quality: predicted high

251. Will the universal definition of myocardial infarction criteria result in an overdiagnosis of myocardial infarction? (PubMed)

Will the universal definition of myocardial infarction criteria result in an overdiagnosis of myocardial infarction? The Universal Definition of Myocardial Infarction (acute myocardial infarction [AMI]) requires detection of increasing or decreasing cardiac biomarkers (preferably cardiac troponin) with >or=1 value >99(th) percentile, together with either clinical symptoms, new ischemic electrocardiographic changes, or typical imaging findings indicative of myocardial necrosis as diagnostic (...) criteria for AMI. However, a small cardiac troponin elevation together with ST-T segment abnormalities may also occur in clinically stable populations. Accordingly, 0.6% of elderly subjects from a community sample (PIVUS Study) and 6.7% of patients stabilized after an acute coronary syndrome (FRISC II Study) would have been labeled AMI following the Universal Definition of AMI when diagnostic classification had been based on a single cardiac troponin I result. In conclusion, our results emphasized

2009 American Journal of Cardiology

252. Assessment of delirium

secondary to illness or trauma, may also contribute to delirium initiation. Inouye SK. Delirium in older persons. N Engl J Med. 2006 Mar 16;354(11):1157-65. http://www.ncbi.nlm.nih.gov/pubmed/16540616?tool=bestpractice.com Differentials Dementia Pain Stroke/cerebrovascular accident and transient ischaemic attack Myocardial infarction Acute systemic infection Hypoglycaemia Hyperglycaemia Hypoxia Hypercarbia Acute urinary obstruction Medication- or illicit drug-related Alcoholic ketoacidosis Hepatic (...) . 2006 May-Jun;6(3):303-8. http://www.ncbi.nlm.nih.gov/pubmed/16826866?tool=bestpractice.com Gupta N, de Jonghe J, Schieveld J, et al. Delirium phenomenology: what can we learn from the symptoms of delirium? J Psychosom Res. 2008 Sep;65(3):215-22. http://www.ncbi.nlm.nih.gov/pubmed/18707943?tool=bestpractice.com Meagher DJ, Leonard M, Donnelly S, et al. A longitudinal study of motor subtypes in delirium: frequency and stability during episodes. J Psychosom Res. 2012 Mar;72(3):236-41. http

2018 BMJ Best Practice

253. Assessment of tachycardia

function. Differentials Sinus tachycardia Acute atrial fibrillation Chronic atrial fibrillation Atrial flutter Atrial tachycardia AV nodal re-entrant tachycardia AV re-entry tachycardia/Wolff-Parkinson-White syndrome Multifocal atrial tachycardia Junctional ectopic tachycardia Monomorphic ventricular tachycardia with prior myocardial infarction Monomorphic ventricular tachycardia with non-ischaemic cardiomyopathy Ventricular fibrillation Polymorphic ventricular tachycardia with normal QT interval (...) , are characterised by depolarisation of the ventricle and retrograde atrial activation (if present), manifested by a retrograde P wave. Arrhythmias that originate from the ventricle may originate from the distal His-Purkinje system or ventricular myocardium. The site of origin within the ventricle further defines some arrhythmias within the ventricle. Examples include right ventricular out-flow tract ventricular tachycardia and bundle branch re-entry ventricular tachycardia. Haemodynamic stability

2018 BMJ Best Practice

254. Statins for the primary prevention of cardiovascular events

-up time 54 4.5.3 Overall results 54 4.5.4 Sensitivity analyses 55 4.5.5 All-cause mortality 56 4.5.6 Cardiovascular mortality 56 4.5.7 Fatal and non-fatal myocardial infarction 56 4.5.8 Fatal and non-fatal stroke 57 4.5.9 Revascularization 57 4.5.10 Composite cardiovascular outcome 57 4.6 EVIDENCE ON HARMS FROM RCT’S AND OBSERVATIONAL RESEARCH 57 4.6.1 Evidence on harms from RCTs in the selected systematic review on primary prevention ... 57 4.6.2 Evidence on harms from the previous KCE report 58 (...) Atherosclerosis Prevention Study KCE Belgian Health Care Knowledge Centre (Kennis Centrum – Centre d’Expertise) LDL Low Density Lipoprotein 14 Statins in primary prevention KCE Report 306 LDL-C Low Density Lipoprotein Cholesterol LDL-P Low Density Lipoprotein Particle LY Life Year LYG Life-Year Gained MEGA Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese METEOR Measuring Effects on Intima-Media Thickness: an Evaluation of Rosuvastatin MI Myocardial Infarction MPR Mean

2019 Belgian Health Care Knowledge Centre

256. Bariatric surgery: an HTA report on the efficacy, safety and cost-effectiveness

mortality in the surgical group (4.5%) vs. the non- surgical group (8.5%). Pooled adjusted estimates from the non- randomized studies indicated and suggested that the surgical group had lower risk of all-cause mortality (OR 0.55, 95%CI: 0.46-0.65; 10 studies). Besides risk for CV-events (myocardial infarction: OR 0.71, 95%CI: 0.54-0.94; stroke: OR 0.66, 95%CI: 0.49-0.89; and their composite: OR 0.67, 95%CI: 0.54-0.83; 1 study), and risk of cancer (OR 0.74, 95%CI: 0.65-0.85; 2 studies) was also reduced (...) with adjusted data, bariatric surgery was associated with a significantly reduced risk of composite cardiovascular adverse events (OR 0.54, 95%CI: 0.41-0.70). Bariatric surgery was also associated with significant reduction in specific endpoints of myocardial infarction (OR 0.46 95%CI 0.30-0.69, 4 studies) and stroke (OR 0.49 95%CI: 0.32-0.75, 4 studies). ? The SR-MA by Sheng et al. 43 evaluated the LT-effect (1 RCT and 9 cohorts with FU time ranging from 5 to 15 years) of MBS in patients with type 2

2019 Belgian Health Care Knowledge Centre

257. Performance of the Belgian health system

– Indicators specifically on population aged 75+ 74 Table 21 – Indicators on end of life care for patients with terminal cancer 77 Table 22 – Indicators on mother and newborn care 81 KCE Report 313C Performance report 2019 5 LIST OF ABBREVIATIONS ABBREVIATION DEFINITION ADL Activities of daily living AMI Acute myocardial infarction BAPCOC Belgian Antibiotic Policy Coordination Committee BCR Belgian Cancer Registry CT Computed Tomography DDD Defined Daily Dose DTP Diphtheria - Tetanus - Pertussis EBP (...) . 15 The effectiveness of primary care is measured by avoidable hospital admissions for two chronic conditions, namely asthma and complication of diabetes. Effectiveness indicators for hospital acute care are 5-year relative survival rate for cancer (breast and colorectal cancer), case fatality within 30 days after admission for acute myocardial infarction (AMI) and ischemic stroke, and case fatality within 30 days after admission for surgery for colorectal cancer. 16 Performance report 2019 KCE

2019 Belgian Health Care Knowledge Centre

258. Guidelines on Diagnosis and Management of Syncope

- ventricular Structural cardiac: aortic stenosis, acute myocardial infarction/ischaemia, hypertrophic cardiomyopathy, cardiac masses (atrial myxoma, tumours, etc.), pericardial disease/tamponade, congenital anomalies of coronary arteries, prosthetic valve dysfunction Cardiopulmonary and great vessels: pulmonary embolus, acute aortic dissection, pulmonary hypertension Remarks All forms of syncope, but mostly reflex syncope and OH, are more likely to occur or are more severe when various factors are present (...) autonomic failure (neurogenic OH): - diabetes, amyloidosis, spinal cord injuries, auto-immune autonomic neuropathy, paraneoplastic autonomic neuropathy, kidney failure Cardiac syncope Arrhythmia as primary cause: Bradycardia: - sinus node dysfunction (including bradycardia/tachycardia syndrome) - atrioventricular conduction system disease Tachycardia: - supraventricular - ventricular Structural cardiac: aortic stenosis, acute myocardial infarction/ischaemia, hypertrophic cardiomyopathy, cardiac masses

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2018 European Society of Cardiology

260. Heart Disease and Stroke Statistics

after myocardial infarction (MI), lower risk of atrial fibrillation, and greater positive psychological functioning (dispositional optimism). Among children, from 1999 to 2000 to 2015 to 2016, prevalence of nonsmoking, ideal total cholesterol, and ideal BP improved. For example, nonsmoking among children aged 12 to 19 years went from 76% to 94%. However, meeting ideal levels for physical activity, body mass index (BMI), and blood glucose did not improve. For example, prevalence of ideal BMI declined

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2019 American Heart Association

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