How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

782 results for

Myelomeningocele

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

101. Fat distribution in children and adolescents with myelomeningocele. (PubMed)

Fat distribution in children and adolescents with myelomeningocele. To evaluate fat distribution in children and adolescents with myelomeningocele using dual-energy X-ray absorptiometry (DXA).Cross-sectional DXA measurements of the percentage of fat in the trunk, arms, legs, and whole body were compared between 82 children with myelomeningocele (45 males, 37 females; mean age 9y 8mo, SD 2y 7mo; 22 sacral, 13 low lumbar, 47 mid lumbar and above) and 119 comparison children (65 males, 54 females (...) ; mean age 10y 4mo, SD 2y 4mo). Differences in fat distribution between groups were evaluated using univariate and multivariate analyses.Children with myelomeningocele had higher total body fat (34% vs 31%, p=0.02) and leg fat (42% vs 35%, p<0.001) than comparison children, but no differences in trunk or arm fat after adjustment for anthropometric measures.Children with myelomeningocele have higher than normal total body and leg fat, but only children with higher level lesions have increased trunk

Full Text available with Trip Pro

2014 Developmental Medicine and Child Neurology

102. Innate healing in the fetal sheep model of myelomeningocele: A standardized defect grading system. (PubMed)

Innate healing in the fetal sheep model of myelomeningocele: A standardized defect grading system. The fetal sheep model of myelomeningocele (MMC) is well-established. While the variability of innate fetal healing of the defect at the time of the repair operation has been acknowledged, it remains poorly described. We characterized the healing within the fetal sheep MMC model and present a standardized defect grading system.Forty-three fetuses underwent surgical MMC creation at a gestational age

2014 Journal of Pediatric Surgery

103. A randomized trial of prenatal versus postnatal repair of myelomeningocele. (PubMed)

A randomized trial of prenatal versus postnatal repair of myelomeningocele. Prenatal repair of myelomeningocele, the most common form of spina bifida, may result in better neurologic function than repair deferred until after delivery. We compared outcomes of in utero repair with standard postnatal repair.We randomly assigned eligible women to undergo either prenatal surgery before 26 weeks of gestation or standard postnatal repair. One primary outcome was a composite of fetal or neonatal death (...) months. However, prenatal surgery was associated with an increased risk of preterm delivery and uterine dehiscence at delivery.Prenatal surgery for myelomeningocele reduced the need for shunting and improved motor outcomes at 30 months but was associated with maternal and fetal risks. (Funded by the National Institutes of Health; ClinicalTrials.gov number, NCT00060606.).

Full Text available with Trip Pro

2011 NEJM

104. Fetal Surgery for Myelomeningocele? (PubMed)

Fetal Surgery for Myelomeningocele? 21306233 2011 03 24 2011 03 17 1533-4406 364 11 2011 Mar 17 The New England journal of medicine N. Engl. J. Med. Fetal surgery for myelomeningocele? 1076-7 10.1056/NEJMe1101228 Simpson Joe Leigh JL Greene Michael F MF eng Comment Editorial 2011 02 09 United States N Engl J Med 0255562 0028-4793 AIM IM N Engl J Med. 2011 Mar 17;364(11):993-1004 21306277 Female Fetal Diseases surgery Fetal Therapies Fetus surgery Humans Infant, Newborn Intention to Treat

2011 NEJM

105. Myelomeningocele (Diagnosis)

Myelomeningocele (Diagnosis) Spina Bifida: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMzExMTEzLW92ZXJ2aWV3 processing > Spina Bifida Updated: Sep 21, 2018 Author: Mark R (...) a range of presentations, from stillbirth to incidental radiographic findings of spina bifida occulta. Myelomeningocele, a form of , is visible at birth (see the images below). Patients with myelomeningocele present with a spectrum of impairments, but the primary functional deficits are lower limb paralysis and sensory loss, bladder and bowel dysfunction, and cognitive dysfunction. (See Clinical Presentation.) [ ] The lumbar region of a newborn baby with myelomeningocele. The skin is intact

2014 eMedicine.com

106. Myelomeningocele (Overview)

Myelomeningocele (Overview) Spina Bifida: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMzExMTEzLW92ZXJ2aWV3 processing > Spina Bifida Updated: Sep 21, 2018 Author: Mark R (...) a range of presentations, from stillbirth to incidental radiographic findings of spina bifida occulta. Myelomeningocele, a form of , is visible at birth (see the images below). Patients with myelomeningocele present with a spectrum of impairments, but the primary functional deficits are lower limb paralysis and sensory loss, bladder and bowel dysfunction, and cognitive dysfunction. (See Clinical Presentation.) [ ] The lumbar region of a newborn baby with myelomeningocele. The skin is intact

2014 eMedicine.com

107. Myelomeningocele (Treatment)

Myelomeningocele (Treatment) Spina Bifida Treatment & Management: Approach Considerations, Bladder Management, Bowel Management Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMzExMTEzLXRyZWF0bWVudA== processing (...) is estimated to reach 70-80%. Children whose high bladder pressures are refractory to intermittent catheterization and/or medications (approximately 15-30% of patients with myelomeningocele) are candidates for surgical intervention. Various surgical techniques for augmentation cystoplasty and urinary diversion have been described in the literature. When infection occurs, antibiotics are used in combination with the usual techniques of bladder management. In general, high fluid intake is recommended

2014 eMedicine.com

108. Myelomeningocele (Follow-up)

Myelomeningocele (Follow-up) Spina Bifida Treatment & Management: Approach Considerations, Bladder Management, Bowel Management Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMzExMTEzLXRyZWF0bWVudA== processing (...) is estimated to reach 70-80%. Children whose high bladder pressures are refractory to intermittent catheterization and/or medications (approximately 15-30% of patients with myelomeningocele) are candidates for surgical intervention. Various surgical techniques for augmentation cystoplasty and urinary diversion have been described in the literature. When infection occurs, antibiotics are used in combination with the usual techniques of bladder management. In general, high fluid intake is recommended

2014 eMedicine.com

109. Spinal Dysraphism/Myelomeningocele

Spinal Dysraphism/Myelomeningocele Imaging in Spinal Dysraphism and Myelomeningocele: Overview, Radiography, Computed Tomography Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNDEzODk5LW92ZXJ2aWV3 processing (...) > Imaging in Spinal Dysraphism and Myelomeningocele Updated: Sep 21, 2016 Author: Ali Nawaz Khan, MBBS, FRCS, FRCP, FRCR; Chief Editor: L Gill Naul, MD Share Email Print Feedback Close Sections Sections Imaging in Spinal Dysraphism and Myelomeningocele Overview Overview Preferred examination Choosing the most appropriate modality for imaging congenital malformation of the spine (eg, spinal dysraphism/myelomeningocele) involves considering many factors. Imaging of the bony spine requires methods

2014 eMedicine Radiology

110. Functioning of peripheral Ia pathways in infants with Myelomeningocele. (PubMed)

Functioning of peripheral Ia pathways in infants with Myelomeningocele. The goal was to examine the accessibility of Ia-proprioceptive pathways to motoneurons of leg muscles associated with gait in infants with Myelomeningocele (MMC). Participants were 15 MMC infants, ages 2-10 months. We assessed over repeated trials, the tendon reflex (T-reflex), vibration-induced inhibition of T-reflex (VIM-T-reflex), and tonic vibration-induced reflex (VIR) when computer controlled stimuli were applied

2013 Infant behavior & development

111. Novel single nucleotide polymorphisms in the superoxide dismutase 1 and 2 genes among children with myelomeningocele. (PubMed)

Novel single nucleotide polymorphisms in the superoxide dismutase 1 and 2 genes among children with myelomeningocele. Excessive oxidative stress has been demonstrated as a mechanism for neural tube defects (NTDs). The current exploratory study sought to examine sequence variations in the superoxide dismutase 1 (SOD1) and 2 (SOD2) genes in patients with myelomeningocele and to identify variants altering risk for myelomeningocele.We sequenced deoxyribonucleic acid from 96 patients (...) with myelomeningocele. The 11 exons were amplified by polymerase chain reaction, and the products were sequenced with the Sanger method. Results were compared with reference sequences (NM_000454, NM_000636, and NM_001024466) obtained from University of California Santa Cruz Genome Browser. Observed alleles that differed from the reference sequences were considered novel variants.We found 1 novel variant and 1 variant only recently described in phase 1 of the 1000 Genomes Project but not yet validated. The novel

Full Text available with Trip Pro

2013 American Journal of Obstetrics and Gynecology

112. Morphology of nervous lesion in the spinal cord and bladder of fetal rats with myelomeningocele at different gestational age. (PubMed)

Morphology of nervous lesion in the spinal cord and bladder of fetal rats with myelomeningocele at different gestational age. To analyze the development and innervation of bladder smooth muscle and lesions of the spinal cord in fetal rats with meningomyelocele (MMC) at different gestational ages and to investigate interactions between spinal cord lesions and bladder.Each fetus was assigned to the MMC group or the normal group. Each group was further divided into three subgroups by gestational

2013 Journal of Pediatric Surgery

113. Anesthesia for In Utero Repair of Myelomeningocele. (PubMed)

Anesthesia for In Utero Repair of Myelomeningocele. Recently published results suggest that prenatal repair of fetal myelomeningocele is a potentially preferable alternative when compared to postnatal repair. In this article, the pathology of myelomeningocele, unique physiologic considerations, perioperative anesthetic management, and ethical considerations of open fetal surgery for prenatal myelomeningocele repair are discussed. Open fetal surgeries have many unique anesthetic issues (...) such as inducing profound uterine relaxation, vigilance for maternal or fetal blood loss, fetal monitoring, and possible fetal resuscitation. Postoperative management, including the requirement for postoperative tocolysis and maternal analgesia, are also reviewed. The success of intrauterine myelomeningocele repair relies on a well-coordinated multidisciplinary approach. Fetal surgery is an important topic for anesthesiologists to understand, as the number of fetal procedures is likely to increase as new fetal

Full Text available with Trip Pro

2013 Anesthesiology

114. Human induced pluripotent stem cell-derived neural crest stem cells integrate into the injured spinal cord in the fetal lamb model of myelomeningocele. (PubMed)

Human induced pluripotent stem cell-derived neural crest stem cells integrate into the injured spinal cord in the fetal lamb model of myelomeningocele. Neurological function in patients with myelomeningocele (MMC) is limited even after prenatal repair. Neural crest stem cells (NCSCs) can improve neurological function in models of spinal cord injury. We aimed to evaluate the survival, integration, and differentiation of human NCSCs derived from induced pluripotent stem cells (iPSC-NCSCs

2013 Journal of Pediatric Surgery

115. Prenatal Surgical Repair of Fetal Myelomeningocele

Prenatal Surgical Repair of Fetal Myelomeningocele Prenatal Surgical Repair of Fetal Myelomeningocele - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Prenatal Surgical Repair of Fetal Myelomeningocele (...) Information provided by (Responsible Party): Assistance Publique - Hôpitaux de Paris Study Details Study Description Go to Brief Summary: The open surgical repair of myelomeningoceles before 26 weeks gestational age provides a correction of the anomaly of Chiarri, reduces the incidence of ventriculomegaly (defined as a measure of the ventricles at the crossroads ≥ 10 mm), and get a lower of injury than one corresponding to the anatomical defect (as defined by the last upper normal vertebra before

2013 Clinical Trials

116. Single-Access Fetal Endoscopy (SAFE) for myelomeningocele in sheep model I: amniotic carbon dioxide gas approach. (PubMed)

Single-Access Fetal Endoscopy (SAFE) for myelomeningocele in sheep model I: amniotic carbon dioxide gas approach. This study aimed to assess the feasibility of single-access fetal endoscopy (SAFE) for the management of myelomeningocele (MMC) using intrauterine carbon dioxide as a distension medium in a sheep model.This prospective experimental case-control study investigated 12 lamb fetuses that had a myelomeningocele-like defect surgically created on the 75th day of gestation. Four fetuses

2013 Surgical endoscopy

117. Family-Based Association Study Between SLC2A1, HK1, and LEPR Polymorphisms With Myelomeningocele in Chile (PubMed)

Family-Based Association Study Between SLC2A1, HK1, and LEPR Polymorphisms With Myelomeningocele in Chile Obese/diabetic mothers present a higher risk to develop offspring with myelomeningocele (MM), evidence supporting the role of energy homeostasis-related genes in neural tube defects. Using polymerase chain reaction-restriction fragment length polymorphism, we have genotyped SLC2A1, HK1, and LEPR single-nucleotide polymorphisms in 105 Chilean patients with MM and their parents in order

Full Text available with Trip Pro

2013 Reproductive Sciences

118. Open fetal surgery for myelomeningocele. (PubMed)

Open fetal surgery for myelomeningocele. In a recently completed randomized, prospective clinical trial, fetal repair for myelomeningocele was shown to result in reduced rates of hydrocephalus requiring placement of a ventriculoperitoneal shunt, improvement in Chiari malformation Type II, and improvement in neurological function compared with standard postnatal repair. Successful fetal surgery requires the active participation and interaction of several clinical teams. Each group has a specific (...) role, and overlap is often required at different points of the treatment plan. Extensive multispecialty discussions with the patient and family are necessary before informed consent can be obtained. Fetal surgery carries significant risks to the mother and fetus and these must be carefully considered prior to a final treatment decision. This review will summarize the evaluation and treatment of patients undergoing fetal repair for myelomeningocele at one institution.

Full Text available with Trip Pro

2012 Journal of neurosurgery. Pediatrics

119. Maternal, fetal, and neonatal care in open fetal surgery for myelomeningocele. (PubMed)

Maternal, fetal, and neonatal care in open fetal surgery for myelomeningocele. Fetal myelomeningocele closure (fMMC) was demonstrated in a randomized, prospective clinical trial to improve outcomes for children diagnosed prenatally. Complex care of the maternal/fetal dyad undergoing fetal surgery requires a well-coordinated multidisciplinary team. Nurses in many roles are essential members of the team that cares for these women across the continuum. In this article we discuss the care

2012 Journal of obstetric, gynecologic, and neonatal nursing : JOGNN / NAACOG

120. Transcutaneous interferential electrical stimulation for management of neurogenic bowel dysfunction in children with myelomeningocele. (PubMed)

Transcutaneous interferential electrical stimulation for management of neurogenic bowel dysfunction in children with myelomeningocele. We describe the efficacy of transcutaneous interferential (IF) electrical stimulation on constipation symptoms in children with myelomeningocele (MMC).MMC children (30, comprising of 17 girls and 13 boys), mean age 6.7 ± 2.9, with moderate to severe intractable constipation were enrolled in this study. They were divided into treatment (IF stimulation, 15 (...) in 53% patients, they persisted for 6 months. Frequency of defecation increased statistically significant from 2.5 ± 1.1 per week before treatment to 4.7 ± 2.3 per week after treatment (P < .001).This pilot study showed that IF therapy is safe, noninvasive, and effective modality to improve constipation symptoms and anorectal manometry parameters in children with history of myelomeningocele.

2012 International journal of colorectal disease

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>