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Myelomeningocele

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41. Fetal surgical repair with placenta-derived mesenchymal stromal cell engineered patch in a rodent model of myelomeningocele. (Abstract)

Fetal surgical repair with placenta-derived mesenchymal stromal cell engineered patch in a rodent model of myelomeningocele. The purpose of this study is to determine the feasibility of fetal surgical repair of myelomeningocele (MMC) in a rodent model using human placental mesenchymal stromal cells (PMSCs) seeded onto extracellular matrix (ECM) and to characterize the resulting changes in spinal cord tissue.Fetal rodents with retinoic acid (RA) induced MMC underwent surgical repair of the MMC

2017 Journal of Pediatric Surgery

42. Maternal Gene-Micronutrient Interactions Related to One-Carbon Metabolism and the Risk of Myelomeningocele Among Offspring Full Text available with Trip Pro

Maternal Gene-Micronutrient Interactions Related to One-Carbon Metabolism and the Risk of Myelomeningocele Among Offspring Few studies have evaluated interactions between maternal genetic variation in 5,10-methylenetetrahydrofolate reductase (MTHFR) and micronutrient intake on the risk of myelomeningocele (MM) in offspring. Therefore, we sought to determine if the role of maternal MTHFR C677T and A1298C on MM risk is altered by maternal intake of micronutrients related to one-carbon

2017 Birth Defects Research

43. Cognitive control and associated neural correlates in adults with spina bifida myelomeningocele Full Text available with Trip Pro

Cognitive control and associated neural correlates in adults with spina bifida myelomeningocele Accelerated aging can occur in adult survivors of neurodevelopmental disorders, but has been narrowly studied in spina bifida myelomeningocele (SBM). Since discrete aspects of cognitive control and related neural network macrostructure deteriorate in normal aging, the specificity and trajectory of cognition and neuropathology incurred across adulthood in SBM were examined.Adults (N = 120

2017 Neuropsychology

44. Associations between post translational histone modifications, myelomeningocele risk, environmental arsenic exposure, and folate deficiency among participants in a case control study in Bangladesh Full Text available with Trip Pro

Associations between post translational histone modifications, myelomeningocele risk, environmental arsenic exposure, and folate deficiency among participants in a case control study in Bangladesh Arsenic exposure may contribute to disease risk in humans through alterations in the epigenome. Previous studies reported that arsenic exposure is associated with changes in plasma histone concentrations. Posttranslational histone modifications have been found to differ between the brain tissue (...) of human embryos with neural tube defects and that of controls. Our objectives were to investigate the relationships between plasma histone 3 levels, history of having an infant with myelomeningocele, biomarkers of arsenic exposure, and maternal folate deficiency. These studies took place in Bangladesh, a country with high environmental arsenic exposure through contaminated drinking water. We performed ELISA assays to investigate plasma concentration of total histone 3 (H3) and the histone modification

2017 Epigenetics

45. Tibial derotational osteotomies in two neuromuscular populations: comparing cerebral palsy with myelomeningocele Full Text available with Trip Pro

Tibial derotational osteotomies in two neuromuscular populations: comparing cerebral palsy with myelomeningocele To review the outcomes of tibial derotational osteotomies (TDOs) as a function of complication and revision surgery rates comparing a cohort of children with myelodysplasia to a cohort with cerebral palsy (CP).A chart review was completed on TDOs performed in a tertiary referral centre on patients with myelodysplasia or CP between 1985 and 2013 in patients aged > 5 years with > 2

2017 Journal of children's orthopaedics

46. Histological evidence of reparative activity in chorioamniotic membrane following open fetal surgery for myelomeningocele Full Text available with Trip Pro

Histological evidence of reparative activity in chorioamniotic membrane following open fetal surgery for myelomeningocele An increased understanding of the reparative process in fetal membrane following surgical techniques may be helpful to decrease the risks to mother and fetus and avoid adverse pregnancy outcomes. The present study discusses histological evaluation of the fetal membrane following open fetal surgery. Chorioamniotic membranes (n=10) were obtained following birth from (...) pregnancies that underwent open fetal surgery for myelomeningocele. The collagen distribution was quantified using picrosirius-polarization method comparing the suture site with non-suture site. The differences between the collagen fiber percentages at the two sites was evaluated by the paired t-test with P<0.05. The mean gestational age of fetal surgery was 26.09±0.3 and 33.81±0.82 weeks at birth. The picrosirius red sign was more intense at the suture site, primarily associated with collagen type 1

2017 Experimental and therapeutic medicine

47. In utero repair of fetal rat myelomeningocele affects neuromuscular development in the bladder Full Text available with Trip Pro

In utero repair of fetal rat myelomeningocele affects neuromuscular development in the bladder Fetal repair of myelomeningocele (MMC) has been proven to be beneficial for the central nervous system development; however, the effect of fetal MMC repair on bladder function remains controversial. The objective of the present study was to establish an early timepoint for in utero MMC repair using a rat model, and to investigate the changes in bladder development subsequent to that intervention

2017 Experimental and therapeutic medicine

48. Methotrexate and Valproic Acid Affect Early Neurogenesis of Human Amniotic Fluid Stem Cells from Myelomeningocele Full Text available with Trip Pro

Methotrexate and Valproic Acid Affect Early Neurogenesis of Human Amniotic Fluid Stem Cells from Myelomeningocele Myelomeningocele (MMC) is a severe type of neural tube defect (NTD), in which the backbone and spinal canal do not close completely during early embryonic development. This condition results in serious morbidity and increased mortality after birth. Folic acid significantly reduces, and conversely, folate antagonist methotrexate (MTX) and valproic acid (VPA) increase the occurrence

2017 Stem Cells International

49. Mutations in Folate Transporter Genes and Risk for Human Myelomeningocele Full Text available with Trip Pro

Mutations in Folate Transporter Genes and Risk for Human Myelomeningocele The molecular mechanisms linking folate deficiency and neural tube defect (NTD) risk in offspring remain unclear. Folate transporters (SLC19A1, SLC46A1, SLC25A32, and FOLH1) and folate receptors (FOLR1, FOLR2, and FOLR3) are suggested to play essential roles in transporting folate from maternal intestinal lumen to the developing embryo. Loss of function variants in these genes may affect folate availability and contribute (...) to NTD risk. This study examines whether variants within the folate transporter and receptor genes are associated with an increased risk for myelomeningocele (MM). Exons and their flanking intron sequences of 348 MM subjects were sequenced using the Sanger sequencing method and/or next generation sequencing to identify variants. Frequencies of alleles of single nucleotide polymorphisms (SNPs) in MM subjects were compared to those from ethnically matched reference populations to evaluate alleles

2017 American journal of medical genetics. Part A

50. Fetal Therapy Model of Myelomeningocele with Three-Dimensional Skin Using Amniotic Fluid Cell-Derived Induced Pluripotent Stem Cells Full Text available with Trip Pro

Fetal Therapy Model of Myelomeningocele with Three-Dimensional Skin Using Amniotic Fluid Cell-Derived Induced Pluripotent Stem Cells Myelomeningocele (MMC) is a congenital disease without genetic abnormalities. Neurological symptoms are irreversibly impaired after birth, and no effective treatment has been reported to date. Only surgical repairs have been reported so far. In this study, we performed antenatal treatment of MMC with an artificial skin using induced pluripotent stem cells (iPSCs

2017 Stem cell reports

51. A Comparison of Three Methods of Measuring Tibial Torsion in Children with Myelomeningocele and Normally Developing Children Full Text available with Trip Pro

A Comparison of Three Methods of Measuring Tibial Torsion in Children with Myelomeningocele and Normally Developing Children Abnormal tibial torsion is a common pediatric problem, and there are many existing measurement methods. The purpose of this study was to compare three methods of measuring tibial torsion for its evaluation: computed tomography, physical examination, and motion capture. Twenty healthy children and 20 children with myelomeningocele underwent measures of tibial torsion

2017 Clinical anatomy (New York, N.Y.)

52. Conventional physical therapy and physical therapy based on reflex stimulation showed similar results in children with myelomeningocele. Full Text available with Trip Pro

Conventional physical therapy and physical therapy based on reflex stimulation showed similar results in children with myelomeningocele. We aimed to investigate whether infants with myelomeningocele would improve their motor ability and functional independence after ten sessions of physical therapy and compare the outcomes of conventional physical therapy (CPT) to a physical therapy program based on reflex stimulation (RPT). Twelve children were allocated to CPT (n = 6, age 18.3 months) or RPT

2017 Arquivos de neuro-psiquiatria Controlled trial quality: uncertain

53. Systematic review of scoliosis treatment among individuals living with myelomeningocele or spina bifida in Asia

Systematic review of scoliosis treatment among individuals living with myelomeningocele or spina bifida in Asia Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

54. Fetal Myelomeningocele

Fetal Myelomeningocele Fetal Myelomeningocele - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Fetal Myelomeningocele The safety and scientific validity of this study is the responsibility of the study (...) repair of fetal myelomeningocele. Although prenatal repair is associated with improved neurologic outcomes and a decreased need for cerebrospinal fluid shunting after birth, one of the major risks is preterm delivery. This study is intended to identify maternal, fetal or intraoperative risk factors associated with preterm delivery. Condition or disease Intervention/treatment Myelomeningocele Other: Chart review Detailed Description: Myelomeningocele encompasses the most common form of spina bifida

2017 Clinical Trials

55. Impact on family and parental stress of prenatal vs postnatal repair of myelomeningocele Full Text available with Trip Pro

Impact on family and parental stress of prenatal vs postnatal repair of myelomeningocele The Management of Myelomeningocele Study was a multicenter, randomized controlled trial that compared prenatal repair with standard postnatal repair for fetal myelomeningocele.We sought to describe the long-term impact on the families of the women who participated and to evaluate how the timing of repair influenced the impact on families and parental stress.Randomized women completed the 24-item Impact

2016 EvidenceUpdates Controlled trial quality: uncertain

56. Bladder Function After Fetal Surgery for Myelomeningocele Full Text available with Trip Pro

Bladder Function After Fetal Surgery for Myelomeningocele A substudy of the Management of Myelomeningocele Study evaluating urological outcomes was conducted.Pregnant women diagnosed with fetal myelomeningocele were randomly assigned to either prenatal or standard postnatal surgical repair. The substudy included patients randomly assigned after April 18, 2005. The primary outcome was defined in their children as death or the need for clean intermittent catheterization (CIC) by 30 months of age (...) . The implications of these findings are unclear now, but support the need for long-term urologic follow-up of patients with myelomeningocele regardless of type of surgical repair.Copyright © 2015 by the American Academy of Pediatrics.

2015 EvidenceUpdates Controlled trial quality: predicted high

57. Myelomeningocele

Myelomeningocele Myelomeningocele Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Myelomeningocele Myelomeningocele Aka (...) : Myelomeningocele , Severe Spina Bifida From Related Chapters II. Epidemiology Occurs in 1 per 1000 live births III. Risk Factors Maternal Prior history of child with Myelomeningocele (4% risk) (1-2% risk if taken during pregnancy) IV. Pathophysiology Severe form of Affects lumbosacral region in 75% of cases Associated with dysfunction of multiple organ systems V. Signs of lower extremities es absent VI. Associated Conditions (80% of cases) Neurogenic VII. Management Supportive care may be appropriate in severe

2018 FP Notebook

58. Maternal, fetal, neonatal and childhood outcomes for pregnancies complicated by fetal myelomeningocele (spina bifida): a systematic review to develop a core outcome set

Maternal, fetal, neonatal and childhood outcomes for pregnancies complicated by fetal myelomeningocele (spina bifida): a systematic review to develop a core outcome set Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation

2018 PROSPERO

59. Lack of efficacy of an intradural somatic-to-autonomic nerve anastomosis (Xiao procedure) for bladder control in children with myelomeningocele and lipomyelomeningocele: results of a prospective, randomized, double-blind study. Full Text available with Trip Pro

Lack of efficacy of an intradural somatic-to-autonomic nerve anastomosis (Xiao procedure) for bladder control in children with myelomeningocele and lipomyelomeningocele: results of a prospective, randomized, double-blind study. OBJECTIVE Xiao et al. and other investigators have studied an intradural somatic-to-autonomic (e.g., L-5 to S3-4) nerve transfer as a method to create a reflex arc to allow bladder emptying in response to cutaneous stimulation (the Xiao procedure). In previous clinical (...) children with myelomeningocele (MM), lipomyelomeningocele (LMM), and neurogenic bladder dysfunction who were scheduled for spinal cord detethering (DT) for the usual indications. At the time of DT, patients were randomized between 2 arms of the study: half of the patients underwent a standard spinal cord DT procedure alone (DT group) and half underwent DT as well as the Xiao procedure (DT+X group). Patients, families, and study investigators, all of whom were blinded to the surgical details, analyzed

2016 Journal of neurosurgery. Pediatrics Controlled trial quality: predicted high

60. Prenatal surgery for myelomeningocele. (Abstract)

Prenatal surgery for myelomeningocele. This review summarizes outcomes of fetal surgery for myelomeningocele (MMC) as they compare to postnatal MMC repair and provides insights into areas of investigation to improve fetal MMC repair.Recent studies confirm the findings of the Management of Myelomeningocele Study and support the decreased need for postnatal ventricular shunts, improved hindbrain herniation, and improved neurofunctional outcome following open fetal repair compared to postnatal

2016 Current Opinion in Obstetrics and Gynecology

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