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41. A Case of Fatal Pulmonary Hypoplasia with Congenital Diaphragmatic Hernia, Thoracic Myelomeningocele, and Thoracic Dysplasia (PubMed)

A Case of Fatal Pulmonary Hypoplasia with Congenital Diaphragmatic Hernia, Thoracic Myelomeningocele, and Thoracic Dysplasia Background  Congenital diaphragmatic hernia (CDH) is fatal in severe cases of pulmonary hypoplasia. We experienced a fatal case of pulmonary hypoplasia due to CDH, thoracic myelomeningocele (MMC), and thoracic dysplasia. This constellation of anomalies has not been previously reported. Case Report  A male infant with a prenatal diagnosis of thoracic MMC with severe

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2017 AJP Reports

42. How much do plastic surgeons add to the closure of myelomeningoceles? (PubMed)

How much do plastic surgeons add to the closure of myelomeningoceles? This study reviews the outcomes of children undergoing myelomeningocele (MMC) repair in the paediatric neurosurgical department in Cardiff. These procedures are historically performed by paediatric neurosurgeons with occasional support from plastic surgeons for the larger lesions. We reviewed the postoperative outcomes over a 9-year period to assess the efficacy of having a plastic surgeon present at all MMC closures.Analysis

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2017 Child's Nervous System

43. Fetal Myelomeningocele After Maternal Methotrexate Administration: A Case Report. (PubMed)

Fetal Myelomeningocele After Maternal Methotrexate Administration: A Case Report. Folate supplementation in women of reproductive age has a well-established role in the prevention of neural tube defects. Methotrexate is a commonly used drug which functions by inhibiting normal folate metabolism in active cells. An association between fetal methotrexate exposure and myelomeningocele might be expected, considering this relationship. However, to our knowledge, no cases of myelomeningocele (...) equinovarus. Most interestingly, the newborn was also diagnosed with a lumbar myelomeningocele and concomitant type II Chiari malformation, as is often associated with such a neural tube defect.Methotrexate exposure may impact the fetal risk of myelomeningocele. Patients should be counseled thoroughly on the importance of follow-up care.

2017 Journal of Reproductive Medicine

44. Cognitive control and associated neural correlates in adults with spina bifida myelomeningocele (PubMed)

Cognitive control and associated neural correlates in adults with spina bifida myelomeningocele Accelerated aging can occur in adult survivors of neurodevelopmental disorders, but has been narrowly studied in spina bifida myelomeningocele (SBM). Since discrete aspects of cognitive control and related neural network macrostructure deteriorate in normal aging, the specificity and trajectory of cognition and neuropathology incurred across adulthood in SBM were examined.Adults (N = 120

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2017 Neuropsychology

45. Associations between post translational histone modifications, myelomeningocele risk, environmental arsenic exposure, and folate deficiency among participants in a case control study in Bangladesh (PubMed)

Associations between post translational histone modifications, myelomeningocele risk, environmental arsenic exposure, and folate deficiency among participants in a case control study in Bangladesh Arsenic exposure may contribute to disease risk in humans through alterations in the epigenome. Previous studies reported that arsenic exposure is associated with changes in plasma histone concentrations. Posttranslational histone modifications have been found to differ between the brain tissue (...) of human embryos with neural tube defects and that of controls. Our objectives were to investigate the relationships between plasma histone 3 levels, history of having an infant with myelomeningocele, biomarkers of arsenic exposure, and maternal folate deficiency. These studies took place in Bangladesh, a country with high environmental arsenic exposure through contaminated drinking water. We performed ELISA assays to investigate plasma concentration of total histone 3 (H3) and the histone modification

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2017 Epigenetics

46. A Comparison of Three Methods of Measuring Tibial Torsion in Children with Myelomeningocele and Normally Developing Children (PubMed)

A Comparison of Three Methods of Measuring Tibial Torsion in Children with Myelomeningocele and Normally Developing Children Abnormal tibial torsion is a common pediatric problem, and there are many existing measurement methods. The purpose of this study was to compare three methods of measuring tibial torsion for its evaluation: computed tomography, physical examination, and motion capture. Twenty healthy children and 20 children with myelomeningocele underwent measures of tibial torsion

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2017 Clinical anatomy (New York, N.Y.)

47. Fetal Therapy Model of Myelomeningocele with Three-Dimensional Skin Using Amniotic Fluid Cell-Derived Induced Pluripotent Stem Cells (PubMed)

Fetal Therapy Model of Myelomeningocele with Three-Dimensional Skin Using Amniotic Fluid Cell-Derived Induced Pluripotent Stem Cells Myelomeningocele (MMC) is a congenital disease without genetic abnormalities. Neurological symptoms are irreversibly impaired after birth, and no effective treatment has been reported to date. Only surgical repairs have been reported so far. In this study, we performed antenatal treatment of MMC with an artificial skin using induced pluripotent stem cells (iPSCs

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2017 Stem cell reports

48. Tibial derotational osteotomies in two neuromuscular populations: comparing cerebral palsy with myelomeningocele (PubMed)

Tibial derotational osteotomies in two neuromuscular populations: comparing cerebral palsy with myelomeningocele To review the outcomes of tibial derotational osteotomies (TDOs) as a function of complication and revision surgery rates comparing a cohort of children with myelodysplasia to a cohort with cerebral palsy (CP).A chart review was completed on TDOs performed in a tertiary referral centre on patients with myelodysplasia or CP between 1985 and 2013 in patients aged > 5 years with > 2

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2017 Journal of children's orthopaedics

49. Histological evidence of reparative activity in chorioamniotic membrane following open fetal surgery for myelomeningocele (PubMed)

Histological evidence of reparative activity in chorioamniotic membrane following open fetal surgery for myelomeningocele An increased understanding of the reparative process in fetal membrane following surgical techniques may be helpful to decrease the risks to mother and fetus and avoid adverse pregnancy outcomes. The present study discusses histological evaluation of the fetal membrane following open fetal surgery. Chorioamniotic membranes (n=10) were obtained following birth from (...) pregnancies that underwent open fetal surgery for myelomeningocele. The collagen distribution was quantified using picrosirius-polarization method comparing the suture site with non-suture site. The differences between the collagen fiber percentages at the two sites was evaluated by the paired t-test with P<0.05. The mean gestational age of fetal surgery was 26.09±0.3 and 33.81±0.82 weeks at birth. The picrosirius red sign was more intense at the suture site, primarily associated with collagen type 1

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2017 Experimental and therapeutic medicine

50. In utero repair of fetal rat myelomeningocele affects neuromuscular development in the bladder (PubMed)

In utero repair of fetal rat myelomeningocele affects neuromuscular development in the bladder Fetal repair of myelomeningocele (MMC) has been proven to be beneficial for the central nervous system development; however, the effect of fetal MMC repair on bladder function remains controversial. The objective of the present study was to establish an early timepoint for in utero MMC repair using a rat model, and to investigate the changes in bladder development subsequent to that intervention

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2017 Experimental and therapeutic medicine

51. Maternal Gene-Micronutrient Interactions Related to One-Carbon Metabolism and the Risk of Myelomeningocele Among Offspring (PubMed)

Maternal Gene-Micronutrient Interactions Related to One-Carbon Metabolism and the Risk of Myelomeningocele Among Offspring Few studies have evaluated interactions between maternal genetic variation in 5,10-methylenetetrahydrofolate reductase (MTHFR) and micronutrient intake on the risk of myelomeningocele (MM) in offspring. Therefore, we sought to determine if the role of maternal MTHFR C677T and A1298C on MM risk is altered by maternal intake of micronutrients related to one-carbon

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2017 Birth Defects Research

52. Methotrexate and Valproic Acid Affect Early Neurogenesis of Human Amniotic Fluid Stem Cells from Myelomeningocele (PubMed)

Methotrexate and Valproic Acid Affect Early Neurogenesis of Human Amniotic Fluid Stem Cells from Myelomeningocele Myelomeningocele (MMC) is a severe type of neural tube defect (NTD), in which the backbone and spinal canal do not close completely during early embryonic development. This condition results in serious morbidity and increased mortality after birth. Folic acid significantly reduces, and conversely, folate antagonist methotrexate (MTX) and valproic acid (VPA) increase the occurrence

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2017 Stem Cells International

53. Mutations in Folate Transporter Genes and Risk for Human Myelomeningocele (PubMed)

Mutations in Folate Transporter Genes and Risk for Human Myelomeningocele The molecular mechanisms linking folate deficiency and neural tube defect (NTD) risk in offspring remain unclear. Folate transporters (SLC19A1, SLC46A1, SLC25A32, and FOLH1) and folate receptors (FOLR1, FOLR2, and FOLR3) are suggested to play essential roles in transporting folate from maternal intestinal lumen to the developing embryo. Loss of function variants in these genes may affect folate availability and contribute (...) to NTD risk. This study examines whether variants within the folate transporter and receptor genes are associated with an increased risk for myelomeningocele (MM). Exons and their flanking intron sequences of 348 MM subjects were sequenced using the Sanger sequencing method and/or next generation sequencing to identify variants. Frequencies of alleles of single nucleotide polymorphisms (SNPs) in MM subjects were compared to those from ethnically matched reference populations to evaluate alleles

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2017 American journal of medical genetics. Part A

54. The Management of Myelomeningocele Study: Full cohort 30 month pediatric outcomes. (PubMed)

The Management of Myelomeningocele Study: Full cohort 30 month pediatric outcomes. Previous reports from the Management of Myelomeningocele Study demonstrated that prenatal repair of myelomeningocele reduces hindbrain herniation and the need for cerebrospinal fluid shunting, and improves motor function in children with myelomeningocele. The trial was stopped for efficacy after 183 patients were randomized, but 30-month outcomes were only available at the time of initial publication in 134 (...) mother-child dyads. Data from the complete cohort for the 30-month outcomes are presented here. Maternal and 12-month neurodevelopmental outcomes for the full cohort were reported previously.The purpose of this study is to report the 30-month outcomes for the full cohort of patients randomized to either prenatal or postnatal repair of myelomeningocele in the original Management of Myelomeningocele Study.Eligible women were randomly assigned to undergo standard postnatal repair or prenatal repair <26

2017 American Journal of Obstetrics and Gynecology

55. In utero fetal surgery for myelomeningocele

In utero fetal surgery for myelomeningocele In utero fetal surgery for myelomeningocele In utero fetal surgery for myelomeningocele Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation In utero fetal surgery for myelomeningocele. Lansdale: HAYES, Inc.. Directory Publication. 2012 Authors' conclusions The objective of fetal surgery for myelomeningocele (MMC

2012 Health Technology Assessment (HTA) Database.

56. Walking Activity during Daily Living in Children with Myelomeningocele (PubMed)

Walking Activity during Daily Living in Children with Myelomeningocele To quantify the walking activity of children with myelomeningocele during daily living.Walking activity was measured using a StepWatch activity monitor over one week in 47 children with myelomeningocele (27 males; 9 years 11 months SD 2 years 7 months; 18 sacral, 9 low lumbar, 20 mid-high lumbar) and seven children with typical development (5 males; 11 years 1 month SD 1 year 11 months) in a prospective, cross-sectional (...) study. Average total steps per day, number of steps and minutes spent at low, medium and high intensity stepping were evaluated. Groups were compared using t-tests and chi-squared tests with Bonferroni post-hoc adjustment.Children with sacral and low lumbar myelomeningocele exhibited no significant differences in demographic characteristics or walking performance compared to typically developing children. Children with mid-high lumbar myelomeningocele exhibited higher BMI percentile than the control

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2016 Disability and rehabilitation

57. Genetic Association of the Glycine Cleavage System Genes and Myelomeningocele (PubMed)

Genetic Association of the Glycine Cleavage System Genes and Myelomeningocele Neural tube defects (NTDs) are one of the most common congenital birth defects, with myelomeningocele (MM) being the most severe form compatible with life. Recent studies show a link between mitochondrial folate one carbon metabolism and NTDs by means of the glycine cleavage system (GCS). We hypothesize that single nucleotide polymorphisms and novel variants in the coding regions of the GCS genes increase the risk

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2016 Birth defects research. Part A, Clinical and molecular teratology

58. Can We Further Improve the Quality of Nephro-Urological Care in Children with Myelomeningocele? (PubMed)

Can We Further Improve the Quality of Nephro-Urological Care in Children with Myelomeningocele? Myelomeningocele (MMC) results from a failure of normal neural tube fusion in early fetal development. Retrospective, observational study of medical data of 54 children treated in Pediatric Nephrology and Urology Clinics for five years was performed. The following data were analyzed: serum creatinine, eGFR, urine analysis, renal scintigraphy (RS), renal ultrasound, and urodynamics. Mean age

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2016 International journal of environmental research and public health

59. A rare case of giant multiseptated thoracic myelomeningocele with segmental placode: Commentary (PubMed)

A rare case of giant multiseptated thoracic myelomeningocele with segmental placode: Commentary 27274401 2016 06 09 2018 11 13 2229-5097 7 Suppl 12 2016 Surgical neurology international Surg Neurol Int A rare case of giant multiseptated thoracic myelomeningocele with segmental placode: Commentary. S305-6 10.4103/2152-7806.182390 Beuriat Pierre-Aurelien PA Department of Pediatric Neurosurgery, Neurological and Neurosurgical Hospital Pierre Wertheimer, Lyon, France. Szathmari Alexandru

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2016 Surgical neurology international

60. Extended Criteria For Fetal Myelomeningocele Repair

Extended Criteria For Fetal Myelomeningocele Repair Extended Criteria For Fetal Myelomeningocele Repair - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Extended Criteria For Fetal Myelomeningocele Repair (...) Information provided by (Responsible Party): KuoJen Tsao, The University of Texas Health Science Center, Houston Study Details Study Description Go to Brief Summary: The purpose of this study is to offer pre-natal Myelomeningocele (MMC) repair surgery to pregnant women with one of the former surgery exclusion factors A BMI of 35-40 kg/m2 Diabetes; patients will require good glycemic control History a previous preterm birth, as long as it was followed by a full term birth Structural abnormality

2016 Clinical Trials

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