How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

773 results for

Myelomeningocele

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

21. Prenatal folic acid use associated with decreased risk of myelomeningocele: A case-control study offers further support for folic acid fortification in Bangladesh. Full Text available with Trip Pro

Prenatal folic acid use associated with decreased risk of myelomeningocele: A case-control study offers further support for folic acid fortification in Bangladesh. Neural tube defects contribute to severe morbidity and mortality in children and adults; however, they are largely preventable through maternal intake of folic acid before and during early pregnancy. We examined the association between maternal prenatal folic acid supplement intake and risk of myelomeningocele (a severe and common (...) type of neural tube defect) in the offspring. We performed secondary analysis using data from a case-control study conducted at Dhaka Community Hospital, Bangladesh between April and November of 2013. Cases and controls included children with and without myelomeningocele, respectively, and their mothers. Cases were identified from local hospitals and rural health clinics served by Dhaka Community Hospital. Controls were selected from pregnancy registries located in the same region as the cases

2017 PLoS ONE

22. Children with myelomeningocele do not exhibit normal remodeling of tibia roundness with physical development. (Abstract)

Children with myelomeningocele do not exhibit normal remodeling of tibia roundness with physical development. Skeletal loading through daily movement is an important factor in the normal development of bones. This loading is affected by the neurological and muscle deficits that result from myelominingocele (MM). While children with MM have been shown to have atypical gait, decreased bone accrual, and increased fracture risk, it is still unclear what morphological bone differences exist

2018 Bone

23. Fetal blood gas values during fetoscopic myelomeningocele repair performed under carbon dioxide insufflation. Full Text available with Trip Pro

Fetal blood gas values during fetoscopic myelomeningocele repair performed under carbon dioxide insufflation. Fetoscopic myelomeningocele (MMC) repair is performed using intrauterine carbon dioxide (CO2 ) insufflation. Sheep experiments have shown that CO2 insufflation is associated with significant fetal acidemia; however, corresponding data for human pregnancy are not available. We performed umbilical venous cord blood sampling in three patients during fetoscopic MMC repair at 25 + 1, 25 + 3 (...) fetoscopic myelomeningocele repair does not cause acidemia in human fetuses. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.

2018 Ultrasound in Obstetrics and Gynecology

24. Doppler changes in the umbilical artery and ductus venosus during fetoscopic prenatal surgical repair of myelomeningocele. (Abstract)

Doppler changes in the umbilical artery and ductus venosus during fetoscopic prenatal surgical repair of myelomeningocele. Cardiac dysfunction has been described in 60% of fetuses undergoing open myelomeningocele (MMC) repair. Routine Doppler evaluation of the umbilical artery (UA) and ductus venosus (DV) is challenging during fetal surgery. The aim of this study was to describe Doppler changes in the UA and DV in a cohort of fetuses during fetoscopic MMC repair.This was a retrospective study

2018 Ultrasound in Obstetrics and Gynecology

25. A Study to Assess Global Availability of Fetal Surgery for Myelomeningocele. Full Text available with Trip Pro

A Study to Assess Global Availability of Fetal Surgery for Myelomeningocele. To establish the provision of fetal surgery for myelomeningocele (MMC) worldwide.Through the International Society for Prenatal Diagnosis (ISPD) Fetal Therapy Special Interest Group and the North American Fetal Therapy Network (NAFTNet), fetal therapy centres were surveyed (September 2017-June 2018) regarding availability of fetal MMC surgical repair, patient inclusion criteria, repair techniques, number of cases (...) , and outcome reporting. Responses were summarised on an interactive map on the ISPD website.Forty-four of 59 centres responded (74.6%) of which 34 centres (77.1%) currently offered fetal surgery for MMC and seven centres (15.9%) were awaiting a first case after service set up. Patient inclusion criteria were similar and based on the Management of Myelomeningocele (MOMS) trial. Five centres (14.7%) operated beyond 26 weeks' gestational age, outside the MOMS criteria. Open fetal surgery was provided in 23

2018 Prenatal diagnosis

26. Alginate microparticles loaded with basic fibroblast growth factor induce tissue coverage in a rat model of myelomeningocele. Full Text available with Trip Pro

Alginate microparticles loaded with basic fibroblast growth factor induce tissue coverage in a rat model of myelomeningocele. We sought to develop a minimally invasive intra-amniotic therapy for prenatal treatment of myelomeningocele (MMC) in an established rat model.Time-dated pregnant rats were gavage-fed retinoic acid to induce MMC. Groups received intraamniotic injections at E17.5 with alginate particles loaded with fluorescent dye, basic fibroblast growth factor (Alg-HSA-bFGF

2018 Journal of Pediatric Surgery

27. Can Dynamic Ultrasonography Replace Urodynamics in Follow-up of Patients With Myelomeningocele

Can Dynamic Ultrasonography Replace Urodynamics in Follow-up of Patients With Myelomeningocele Can Dynamic Ultrasonography Replace Urodynamics in Follow-up of Patients With Myelomeningocele - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Can Dynamic Ultrasonography Replace Urodynamics in Follow-up of Patients With Myelomeningocele The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03550898 Recruitment Status : Completed First Posted : June 8, 2018 Last Update Posted : June 8, 2018 Sponsor: Hospital de

2018 Clinical Trials

28. Perinatal outcomes after open fetal surgery for myelomeningocele repair: a retrospective cohort study. Full Text available with Trip Pro

Perinatal outcomes after open fetal surgery for myelomeningocele repair: a retrospective cohort study. Describe outcomes of open fetal surgery for myelomeningocele (MMC) repair in two Brazilian hospitals and the impact of surgical experience on outcome.Retrospective cohort study.Sao Paulo, Brazil.237 pregnant women carrying a fetus with an open spinal defect.Surgical details, and maternal and fetal outcomes collected from all patients.Analysis of surgical and perinatal outcome parameters.Total (...) study was funded solely by institutional funds.Brazilian experience of in utero open surgery for myelomeningocele repair.© 2018 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd on behalf of Royal College of Obstetricians and Gynaecologists.

2018 BJOG

29. In utero myelomeningocele repair and urological outcome: the first 100 cases of a prospective analysis. Is there an improvement in bladder function? (Abstract)

In utero myelomeningocele repair and urological outcome: the first 100 cases of a prospective analysis. Is there an improvement in bladder function? To evaluate the first 100 cases of in utero myelomeningocoele (MMC) repair and urological outcomes in a prospective analysis aiming to define possible improvement in bladder function.We used a protocol consisting of a detailed medical history, urinary tract ultrasonography, voiding cystourethrography, and urodynamic evaluation. Patients were

2018 BJU international

30. Clusters of amniotic fluid cells and their associated early neuroepithelial markers in experimental myelomeningocele: Correlation with astrogliosis. Full Text available with Trip Pro

Clusters of amniotic fluid cells and their associated early neuroepithelial markers in experimental myelomeningocele: Correlation with astrogliosis. Myelomeningocele (MMC) is the most common and severe disabling type of spina bifida resulting in the exposure of vulnerable spinal cord to the hostile intrauterine environment. In this study, we sought to examine the cellular content of fetal amniotic fluid (AF) in MMC and explore a correlation between these cells and pathological development

2017 PLoS ONE

31. In utero fetal surgery for myelomeningocele

In utero fetal surgery for myelomeningocele In utero fetal surgery for myelomeningocele In utero fetal surgery for myelomeningocele Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation In utero fetal surgery for myelomeningocele. Lansdale: HAYES, Inc.. Directory Publication. 2012 Authors' conclusions The objective of fetal surgery for myelomeningocele (MMC

2012 Health Technology Assessment (HTA) Database.

32. How much do plastic surgeons add to the closure of myelomeningoceles? Full Text available with Trip Pro

How much do plastic surgeons add to the closure of myelomeningoceles? This study reviews the outcomes of children undergoing myelomeningocele (MMC) repair in the paediatric neurosurgical department in Cardiff. These procedures are historically performed by paediatric neurosurgeons with occasional support from plastic surgeons for the larger lesions. We reviewed the postoperative outcomes over a 9-year period to assess the efficacy of having a plastic surgeon present at all MMC closures.Analysis

2017 Child's Nervous System

33. Transpsoas cystolitholapaxy in a pediatric patient with myelomeningocele, augmented neobladder, and Mitrofanoff appendicovesicostomy Full Text available with Trip Pro

Transpsoas cystolitholapaxy in a pediatric patient with myelomeningocele, augmented neobladder, and Mitrofanoff appendicovesicostomy Recurrent urolithiasis is a common and potentially morbid complication of spina bifida. Although the size, the location, and the composition of these stones often necessitates percutaneous intervention, access is often complicated by body habitus and spinal deformity. There is little consensus regarding the approach to percutaneous lithotripsy when a clear path

2017 Radiology Case Reports

34. A Case of Fatal Pulmonary Hypoplasia with Congenital Diaphragmatic Hernia, Thoracic Myelomeningocele, and Thoracic Dysplasia Full Text available with Trip Pro

A Case of Fatal Pulmonary Hypoplasia with Congenital Diaphragmatic Hernia, Thoracic Myelomeningocele, and Thoracic Dysplasia Background  Congenital diaphragmatic hernia (CDH) is fatal in severe cases of pulmonary hypoplasia. We experienced a fatal case of pulmonary hypoplasia due to CDH, thoracic myelomeningocele (MMC), and thoracic dysplasia. This constellation of anomalies has not been previously reported. Case Report  A male infant with a prenatal diagnosis of thoracic MMC with severe

2017 AJP Reports

35. Sleep-Disordered Breathing among Newborns with Myelomeningocele. Full Text available with Trip Pro

Sleep-Disordered Breathing among Newborns with Myelomeningocele. In a matched cohort study, we report that the apnea-hypopnea index is significantly higher in neonates with myelomeningocele (34 ± 22) compared with age-matched controls (19 ± 11; P = .021). Assessment of newborns with myelomeningocele for sleep-disordered breathing may facilitate early treatment; the impact on long-term neurodevelopment is unknown.Copyright © 2017 Elsevier Inc. All rights reserved.

2017 Journal of Pediatrics

36. Ultrasound based three-dimensional medical model printing for multispecialty team surgical rehearsal prior to fetoscopic myelomeningocele repair. Full Text available with Trip Pro

Ultrasound based three-dimensional medical model printing for multispecialty team surgical rehearsal prior to fetoscopic myelomeningocele repair. 28850758 2018 10 29 2018 10 29 1469-0705 51 6 2018 Jun Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Ultrasound Obstet Gynecol Ultrasound-based three-dimensional printed medical model for multispecialty team surgical rehearsal prior to fetoscopic myelomeningocele

2017 Ultrasound in Obstetrics and Gynecology

37. Committee Opinion No. 720 Summary: Maternal-Fetal Surgery for Myelomeningocele. (Abstract)

Committee Opinion No. 720 Summary: Maternal-Fetal Surgery for Myelomeningocele. Myelomeningocele, a severe form of spina bifida, occurs in approximately 1 in 3,000 live births in the United States. The extent of disability is generally related to the level of the myelomeningocele defect, with a higher upper level of lesion generally corresponding to greater deficits. Open maternal-fetal surgery for myelomeningocele repair is a major procedure for the woman and her affected fetus. Although (...) there is demonstrated potential for fetal and pediatric benefit, there are significant maternal implications and complications that may occur acutely, postoperatively, for the duration of the pregnancy, and in subsequent pregnancies. Women with pregnancies complicated by fetal myelomeningocele who meet established criteria for in utero repair should be counseled in a nondirective fashion regarding all management options, including the possibility of open maternal-fetal surgery. Maternal-fetal surgery

2017 Obstetrics and Gynecology

38. Committee Opinion No. 720: Maternal-Fetal Surgery for Myelomeningocele. (Abstract)

Committee Opinion No. 720: Maternal-Fetal Surgery for Myelomeningocele. Myelomeningocele, a severe form of spina bifida, occurs in approximately 1 in 3,000 live births in the United States. The extent of disability is generally related to the level of the myelomeningocele defect, with a higher upper level of lesion generally corresponding to greater deficits. Open maternal-fetal surgery for myelomeningocele repair is a major procedure for the woman and her affected fetus. Although (...) there is demonstrated potential for fetal and pediatric benefit, there are significant maternal implications and complications that may occur acutely, postoperatively, for the duration of the pregnancy, and in subsequent pregnancies. Women with pregnancies complicated by fetal myelomeningocele who meet established criteria for in utero repair should be counseled in a nondirective fashion regarding all management options, including the possibility of open maternal-fetal surgery. Maternal-fetal surgery

2017 Obstetrics and Gynecology

39. Amniotic fluid transcriptomics reflects novel disease mechanisms in fetuses with myelomeningocele. Full Text available with Trip Pro

Amniotic fluid transcriptomics reflects novel disease mechanisms in fetuses with myelomeningocele. Cell-free RNA in amniotic fluid supernatant reflects developmental changes in gene expression in the living fetus, which includes genes that are specific to the central nervous system. Although it has been previously shown that central nervous system-specific transcripts are present in amniotic fluid supernatant, it is not known whether changes in the amniotic fluid supernatant transcriptome (...) reflect the specific pathophysiologic condition of fetal central nervous system disorders. In myelomeningocele, there is open communication between the central nervous system and amniotic fluid.The purpose of this study was to identify molecular pathophysiologic changes and novel disease mechanisms that are specific to myelomeningocele by the analysis of amniotic fluid supernatant cell-free RNA in fetuses with open myelomeningocele.Amniotic fluid supernatant was collected from 10 pregnant women

2017 American Journal of Obstetrics and Gynecology

40. Placental mesenchymal stromal cells seeded on clinical grade extracellular matrix improve ambulation in ovine myelomeningocele. (Abstract)

Placental mesenchymal stromal cells seeded on clinical grade extracellular matrix improve ambulation in ovine myelomeningocele. The purpose of this study was to investigate the effects of placental mesenchymal stromal cells (PMSCs) seeded on a clinical grade porcine small intestinal submucosa (SIS)-derived extracellular matrix (ECM) on hindlimb motor function in an ovine fetal repair model of myelomeningocele (MMC).MMC defects were surgically created in 21 fetuses at median gestational age 78

2017 Journal of Pediatric Surgery

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>