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21. Intelligence Quotient in Patients with Myelomeningocele: A Review (PubMed)

Intelligence Quotient in Patients with Myelomeningocele: A Review It has been proposed that hydrocephalus in children with myelomeningocele (MMC) can indicate a low intelligence quotient (IQ). Others have argued that it is not the mere presence of hydrocephalus but the superimposition of cerebrospinal fluid (CSF) infections, multiple shunt procedures, and other CNS complications that lead to the lowering of IQ in these patients. In this paper, we review the literature to clarify the information

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2018 Cureus

22. Effect of Custom-Made Foot Orthosis for Scoliosis with Pelvic Malalignment in a Patient with Myelomeningocele of Partial Neurological Deficit: A Case Report (PubMed)

Effect of Custom-Made Foot Orthosis for Scoliosis with Pelvic Malalignment in a Patient with Myelomeningocele of Partial Neurological Deficit: A Case Report BACKGROUND The treatment of patients with spinal deformities, such as developmental scoliosis in children with myelomeningocele, poses a formidable challenge. We observed the effects of a custom-made foot orthosis in a case of mild scoliosis with pelvic malalignment, in a patient with myelomeningocele. CASE REPORT The patient was a 5-year (...) -old female who was diagnosed with myelomeningocele and who had a partial neurological deficit. At the time of the first visit, the patient showed moderate pelvic rotation to the clockwise side during gait and severe left anterior pelvic tilting during the drooping upper body. Radiographic images revealed mild lumbar scoliosis and severe pelvic asymmetry. After applying a custom-made foot orthosis for 8 months, the patient showed moderate improvement of pelvic rotation and tilting. Clinical

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2018 The American journal of case reports

23. Alginate microparticles loaded with basic fibroblast growth factor induce tissue coverage in a rat model of myelomeningocele. (PubMed)

Alginate microparticles loaded with basic fibroblast growth factor induce tissue coverage in a rat model of myelomeningocele. We sought to develop a minimally invasive intra-amniotic therapy for prenatal treatment of myelomeningocele (MMC) in an established rat model.Time-dated pregnant rats were gavage-fed retinoic acid to induce MMC. Groups received intraamniotic injections at E17.5 with alginate particles loaded with fluorescent dye, basic fibroblast growth factor (Alg-HSA-bFGF

2018 Journal of Pediatric Surgery

24. Doppler changes in the umbilical artery and ductus venosus during fetoscopic prenatal surgical repair of myelomeningocele. (PubMed)

Doppler changes in the umbilical artery and ductus venosus during fetoscopic prenatal surgical repair of myelomeningocele. Cardiac dysfunction has been described in 60% of fetuses undergoing open myelomeningocele (MMC) repair. Routine Doppler evaluation of the umbilical artery (UA) and ductus venosus (DV) is challenging during fetal surgery. The aim of this study was to describe Doppler changes in the UA and DV in a cohort of fetuses during fetoscopic MMC repair.This was a retrospective study

2018 Ultrasound in Obstetrics and Gynecology

25. Fetal blood gas values during fetoscopic myelomeningocele repair performed under carbon dioxide insufflation. (PubMed)

Fetal blood gas values during fetoscopic myelomeningocele repair performed under carbon dioxide insufflation. Fetoscopic myelomeningocele (MMC) repair is performed using intrauterine carbon dioxide (CO2 ) insufflation. Sheep experiments have shown that CO2 insufflation is associated with significant fetal acidemia; however, corresponding data for human pregnancy are not available. We performed umbilical venous cord blood sampling in three patients during fetoscopic MMC repair at 25 + 1, 25 + 3 (...) fetoscopic myelomeningocele repair does not cause acidemia in human fetuses. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.

2018 Ultrasound in Obstetrics and Gynecology

26. In utero myelomeningocele repair and urological outcome: the first 100 cases of a prospective analysis. Is there an improvement in bladder function? (PubMed)

In utero myelomeningocele repair and urological outcome: the first 100 cases of a prospective analysis. Is there an improvement in bladder function? To evaluate the first 100 cases of in utero myelomeningocoele (MMC) repair and urological outcomes in a prospective analysis aiming to define possible improvement in bladder function.We used a protocol consisting of a detailed medical history, urinary tract ultrasonography, voiding cystourethrography, and urodynamic evaluation. Patients were

2018 BJU international

27. Fetal myelomeningocele surgery: Only treating the tip of the iceberg. (PubMed)

Fetal myelomeningocele surgery: Only treating the tip of the iceberg. Fetal myelomeningocele (fMMC) surgery improves infant outcomes when compared with postnatal surgery. Surgical selection criteria and the option of pregnancy termination, however, limit the number of cases that are eligible for prenatal surgery. We aimed to quantify what proportion of cases could ultimately benefit from fetal therapy.We retrospectively reviewed all cases of fMMC referred to a large tertiary care center over

2018 Prenatal diagnosis

28. High density placental mesenchymal stromal cells provide neuronal preservation and improve motor function following in utero treatment of ovine myelomeningocele. (PubMed)

High density placental mesenchymal stromal cells provide neuronal preservation and improve motor function following in utero treatment of ovine myelomeningocele. The purpose of this study was to determine whether seeding density of placental mesenchymal stromal cells (PMSCs) on extracellular matrix (ECM) during in utero repair of myelomeningocele (MMC) affects motor function and neuronal preservation in the ovine model.MMC defects were surgically created in 33 fetuses and repaired following (...) with PMSCs at any density had a higher median SLR score (15 [IQR 13.5-15]) than ECM alone (6.5 [IQR 4-12.75], p = 0.036). Cross-sectional areas of spinal cord and gray matter were highest in the PMSC-ECM (167 K/cm2) group (p = 0.002 and 0.006, respectively). LN density was highest in the greatest density PMSC-ECM (250-300 K/cm2) group (p = 0.045) which positively correlated with SLR score (r = 0.807, p < 0.0001).Fetal repair of myelomeningocele with high density PMSC-ECM resulted in increased large

2018 Journal of Pediatric Surgery

29. The Management of Myelomeningocele Study: full cohort 30-month pediatric outcomes. (PubMed)

The Management of Myelomeningocele Study: full cohort 30-month pediatric outcomes. Previous reports from the Management of Myelomeningocele Study demonstrated that prenatal repair of myelomeningocele reduces hindbrain herniation and the need for cerebrospinal fluid shunting, and improves motor function in children with myelomeningocele. The trial was stopped for efficacy after 183 patients were randomized, but 30-month outcomes were only available at the time of initial publication in 134 (...) mother-child dyads. Data from the complete cohort for the 30-month outcomes are presented here. Maternal and 12-month neurodevelopmental outcomes for the full cohort were reported previously.The purpose of this study is to report the 30-month outcomes for the full cohort of patients randomized to either prenatal or postnatal repair of myelomeningocele in the original Management of Myelomeningocele Study.Eligible women were randomly assigned to undergo standard postnatal repair or prenatal repair <26

2018 American Journal of Obstetrics and Gynecology

30. Conventional physical therapy and physical therapy based on reflex stimulation showed similar results in children with myelomeningocele. (PubMed)

Conventional physical therapy and physical therapy based on reflex stimulation showed similar results in children with myelomeningocele. We aimed to investigate whether infants with myelomeningocele would improve their motor ability and functional independence after ten sessions of physical therapy and compare the outcomes of conventional physical therapy (CPT) to a physical therapy program based on reflex stimulation (RPT). Twelve children were allocated to CPT (n = 6, age 18.3 months) or RPT

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2017 Arquivos de neuro-psiquiatria

31. Fetal Myelomeningocele

Fetal Myelomeningocele Fetal Myelomeningocele - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Fetal Myelomeningocele The safety and scientific validity of this study is the responsibility of the study (...) repair of fetal myelomeningocele. Although prenatal repair is associated with improved neurologic outcomes and a decreased need for cerebrospinal fluid shunting after birth, one of the major risks is preterm delivery. This study is intended to identify maternal, fetal or intraoperative risk factors associated with preterm delivery. Condition or disease Intervention/treatment Myelomeningocele Other: Chart review Detailed Description: Myelomeningocele encompasses the most common form of spina bifida

2017 Clinical Trials

32. Ultrasound based three-dimensional medical model printing for multispecialty team surgical rehearsal prior to fetoscopic myelomeningocele repair. (PubMed)

Ultrasound based three-dimensional medical model printing for multispecialty team surgical rehearsal prior to fetoscopic myelomeningocele repair. 28850758 2018 10 29 2018 10 29 1469-0705 51 6 2018 Jun Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Ultrasound Obstet Gynecol Ultrasound-based three-dimensional printed medical model for multispecialty team surgical rehearsal prior to fetoscopic myelomeningocele

2017 Ultrasound in Obstetrics and Gynecology

33. Amniotic fluid transcriptomics reflects novel disease mechanisms in fetuses with myelomeningocele. (PubMed)

Amniotic fluid transcriptomics reflects novel disease mechanisms in fetuses with myelomeningocele. Cell-free RNA in amniotic fluid supernatant reflects developmental changes in gene expression in the living fetus, which includes genes that are specific to the central nervous system. Although it has been previously shown that central nervous system-specific transcripts are present in amniotic fluid supernatant, it is not known whether changes in the amniotic fluid supernatant transcriptome (...) reflect the specific pathophysiologic condition of fetal central nervous system disorders. In myelomeningocele, there is open communication between the central nervous system and amniotic fluid.The purpose of this study was to identify molecular pathophysiologic changes and novel disease mechanisms that are specific to myelomeningocele by the analysis of amniotic fluid supernatant cell-free RNA in fetuses with open myelomeningocele.Amniotic fluid supernatant was collected from 10 pregnant women

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2017 American Journal of Obstetrics and Gynecology

34. Fetal Surgery for Myelomeningocele: A Systematic Review and Meta-Analysis of Outcomes in Fetoscopic versus Open Repair. (PubMed)

Fetal Surgery for Myelomeningocele: A Systematic Review and Meta-Analysis of Outcomes in Fetoscopic versus Open Repair. The Management of Myelomeningocele (MMC) Study (MOMS) showed that prenatal repair of MMC resulted in improved neurological outcomes but was associated with high rates of obstetrical complications. This study compares outcomes of open and fetoscopic MMC repair.PubMed and Embase studies reporting outcomes of fetal MMC repair published since the completion of the MOMS.We analyzed

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2017 Fetal diagnosis and therapy

35. Sleep-Disordered Breathing among Newborns with Myelomeningocele. (PubMed)

Sleep-Disordered Breathing among Newborns with Myelomeningocele. In a matched cohort study, we report that the apnea-hypopnea index is significantly higher in neonates with myelomeningocele (34 ± 22) compared with age-matched controls (19 ± 11; P = .021). Assessment of newborns with myelomeningocele for sleep-disordered breathing may facilitate early treatment; the impact on long-term neurodevelopment is unknown.Copyright © 2017 Elsevier Inc. All rights reserved.

2017 Journal of Pediatrics

36. Placental mesenchymal stromal cells seeded on clinical grade extracellular matrix improve ambulation in ovine myelomeningocele. (PubMed)

Placental mesenchymal stromal cells seeded on clinical grade extracellular matrix improve ambulation in ovine myelomeningocele. The purpose of this study was to investigate the effects of placental mesenchymal stromal cells (PMSCs) seeded on a clinical grade porcine small intestinal submucosa (SIS)-derived extracellular matrix (ECM) on hindlimb motor function in an ovine fetal repair model of myelomeningocele (MMC).MMC defects were surgically created in 21 fetuses at median gestational age 78

2017 Journal of Pediatric Surgery

37. Fetal surgical repair with placenta-derived mesenchymal stromal cell engineered patch in a rodent model of myelomeningocele. (PubMed)

Fetal surgical repair with placenta-derived mesenchymal stromal cell engineered patch in a rodent model of myelomeningocele. The purpose of this study is to determine the feasibility of fetal surgical repair of myelomeningocele (MMC) in a rodent model using human placental mesenchymal stromal cells (PMSCs) seeded onto extracellular matrix (ECM) and to characterize the resulting changes in spinal cord tissue.Fetal rodents with retinoic acid (RA) induced MMC underwent surgical repair of the MMC

2017 Journal of Pediatric Surgery

38. Committee Opinion No. 720 Summary: Maternal-Fetal Surgery for Myelomeningocele. (PubMed)

Committee Opinion No. 720 Summary: Maternal-Fetal Surgery for Myelomeningocele. Myelomeningocele, a severe form of spina bifida, occurs in approximately 1 in 3,000 live births in the United States. The extent of disability is generally related to the level of the myelomeningocele defect, with a higher upper level of lesion generally corresponding to greater deficits. Open maternal-fetal surgery for myelomeningocele repair is a major procedure for the woman and her affected fetus. Although (...) there is demonstrated potential for fetal and pediatric benefit, there are significant maternal implications and complications that may occur acutely, postoperatively, for the duration of the pregnancy, and in subsequent pregnancies. Women with pregnancies complicated by fetal myelomeningocele who meet established criteria for in utero repair should be counseled in a nondirective fashion regarding all management options, including the possibility of open maternal-fetal surgery. Maternal-fetal surgery

2017 Obstetrics and Gynecology

39. Committee Opinion No. 720: Maternal-Fetal Surgery for Myelomeningocele. (PubMed)

Committee Opinion No. 720: Maternal-Fetal Surgery for Myelomeningocele. Myelomeningocele, a severe form of spina bifida, occurs in approximately 1 in 3,000 live births in the United States. The extent of disability is generally related to the level of the myelomeningocele defect, with a higher upper level of lesion generally corresponding to greater deficits. Open maternal-fetal surgery for myelomeningocele repair is a major procedure for the woman and her affected fetus. Although (...) there is demonstrated potential for fetal and pediatric benefit, there are significant maternal implications and complications that may occur acutely, postoperatively, for the duration of the pregnancy, and in subsequent pregnancies. Women with pregnancies complicated by fetal myelomeningocele who meet established criteria for in utero repair should be counseled in a nondirective fashion regarding all management options, including the possibility of open maternal-fetal surgery. Maternal-fetal surgery

2017 Obstetrics and Gynecology

40. Transpsoas cystolitholapaxy in a pediatric patient with myelomeningocele, augmented neobladder, and Mitrofanoff appendicovesicostomy (PubMed)

Transpsoas cystolitholapaxy in a pediatric patient with myelomeningocele, augmented neobladder, and Mitrofanoff appendicovesicostomy Recurrent urolithiasis is a common and potentially morbid complication of spina bifida. Although the size, the location, and the composition of these stones often necessitates percutaneous intervention, access is often complicated by body habitus and spinal deformity. There is little consensus regarding the approach to percutaneous lithotripsy when a clear path

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2017 Radiology Case Reports

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