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Myelomeningocele

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1. Cerebellar herniation demonstrated by the occipitum-dens line: ultrasonography assessment of normal fetuses, fetuses with myelomeningocele, and fetuses that underwent antenatal myelomeningocele surgery. (PubMed)

Cerebellar herniation demonstrated by the occipitum-dens line: ultrasonography assessment of normal fetuses, fetuses with myelomeningocele, and fetuses that underwent antenatal myelomeningocele surgery. To establish a method to quantify the position of the cerebellum by ultrasonography in normal fetuses, fetuses with myelomeningocele (MMC), and fetuses that underwent in utero MMC repair.Reference points identifiable on ultrasound were established. The basilar portion of the occipital bone

2018 Prenatal diagnosis

2. Maternal?Fetal Surgery for Myelomeningocele

Maternal?Fetal Surgery for Myelomeningocele Maternal–Fetal Surgery for Myelomeningocele - ACOG Menu ▼ Maternal–Fetal Surgery for Myelomeningocele Page Navigation ▼ Number 720, September 2017 (Replaces Committee Opinion Number 550, January 2013) Committee on Obstetric Practice Society for Maternal–Fetal Medicine The North American Fetal Therapy Network endorses this document. This Committee Opinion was developed by the American College of Obstetricians and Gynecologists’ Committee on Obstetric (...) direct, special, indirect, or consequential damages, incurred in connection with this publication or reliance on the information presented. Maternal–Fetal Surgery for Myelomeningocele ABSTRACT: Myelomeningocele, a severe form of spina bifida, occurs in approximately 1 in 3,000 live births in the United States. The extent of disability is generally related to the level of the myelomeningocele defect, with a higher upper level of lesion generally corresponding to greater deficits. Open maternal–fetal

2017 American College of Obstetricians and Gynecologists

3. Fetal surgery for myelomeningocele: After the Management of Myelomeningocele Study (MOMS). (PubMed)

Fetal surgery for myelomeningocele: After the Management of Myelomeningocele Study (MOMS). Myelomeningocele (MMC) is the most frequently occurring congenital abnormality of the central nervous system and leads to significant physical disabilities. Historically treatment involved postnatal closure with management of the associated sequelae including ventricular shunting. The mechanism of neurologic damage that begins with abnormal neurulation followed by continued injury over the course (...) of gestation made MMC a plausible candidate for in-utero surgical repair. Animal and early human studies demonstrated the feasibility of fetal closure. The benefit of in-utero closure was debated until the results of the prospective randomized multicenter Management of Myelomeningocele Study (MOMS trial) were published, demonstrating a decreased need for shunting, reversal of hindbrain herniation, and better neurologic function in the prenatal repair group compared to postnatal repair with maternal

2017 Seminars in fetal & neonatal medicine

4. Fetal Myelomeningocele After Maternal Methotrexate Administration: A Case Report. (PubMed)

Fetal Myelomeningocele After Maternal Methotrexate Administration: A Case Report. Folate supplementation in women of reproductive age has a well-established role in the prevention of neural tube defects. Methotrexate is a commonly used drug which functions by inhibiting normal folate metabolism in active cells. An association between fetal methotrexate exposure and myelomeningocele might be expected, considering this relationship. However, to our knowledge, no cases of myelomeningocele (...) equinovarus. Most interestingly, the newborn was also diagnosed with a lumbar myelomeningocele and concomitant type II Chiari malformation, as is often associated with such a neural tube defect.Methotrexate exposure may impact the fetal risk of myelomeningocele. Patients should be counseled thoroughly on the importance of follow-up care.

2020 Journal of Reproductive Medicine

5. The Management of Myelomeningocele Study: full cohort 30-month pediatric outcomes

The Management of Myelomeningocele Study: full cohort 30-month pediatric outcomes Previous reports from the Management of Myelomeningocele Study demonstrated that prenatal repair of myelomeningocele reduces hindbrain herniation and the need for cerebrospinal fluid shunting, and improves motor function in children with myelomeningocele. The trial was stopped for efficacy after 183 patients were randomized, but 30-month outcomes were only available at the time of initial publication in 134 mother (...) -child dyads. Data from the complete cohort for the 30-month outcomes are presented here. Maternal and 12-month neurodevelopmental outcomes for the full cohort were reported previously.The purpose of this study is to report the 30-month outcomes for the full cohort of patients randomized to either prenatal or postnatal repair of myelomeningocele in the original Management of Myelomeningocele Study.Eligible women were randomly assigned to undergo standard postnatal repair or prenatal repair <26 weeks

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2018 EvidenceUpdates

6. Prenatal folic acid use associated with decreased risk of myelomeningocele: A case-control study offers further support for folic acid fortification in Bangladesh. (PubMed)

Prenatal folic acid use associated with decreased risk of myelomeningocele: A case-control study offers further support for folic acid fortification in Bangladesh. Neural tube defects contribute to severe morbidity and mortality in children and adults; however, they are largely preventable through maternal intake of folic acid before and during early pregnancy. We examined the association between maternal prenatal folic acid supplement intake and risk of myelomeningocele (a severe and common (...) type of neural tube defect) in the offspring. We performed secondary analysis using data from a case-control study conducted at Dhaka Community Hospital, Bangladesh between April and November of 2013. Cases and controls included children with and without myelomeningocele, respectively, and their mothers. Cases were identified from local hospitals and rural health clinics served by Dhaka Community Hospital. Controls were selected from pregnancy registries located in the same region as the cases

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2017 PLoS ONE

7. Protocol for open spinal dysraphism - myelomeningocele

Protocol for open spinal dysraphism - myelomeningocele Protocol for open spinal dysraphism - myelomeningocele | Great Ormond Street Hospital Google Tag Manager Navigation Search Search You are here Protocol for open spinal dysraphism - myelomeningocele Protocol for open spinal dysraphism - myelomeningocele Policies and legal statements Follow Us Great Ormond Street Hospital Tel: 020 7405 9200 Great Ormond Street Hospital for Children NHS Foundation Trust Great Ormond Street London WC1N 3JH ©

2015 Publication 1593

8. Protocol for open spinal dysraphism - myelomeningocele

Protocol for open spinal dysraphism - myelomeningocele Protocol for open spinal dysraphism - myelomeningocele | Great Ormond Street Hospital Google Tag Manager Navigation Search Search You are here Protocol for open spinal dysraphism - myelomeningocele Protocol for open spinal dysraphism - myelomeningocele Policies and legal statements Follow Us Great Ormond Street Hospital Tel: 020 7405 9200 Great Ormond Street Hospital for Children NHS Foundation Trust Great Ormond Street London WC1N 3JH ©

2015 Publication 1593

9. Systematic review of scoliosis treatment among individuals living with myelomeningocele or spina bifida in Asia

Systematic review of scoliosis treatment among individuals living with myelomeningocele or spina bifida in Asia Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

10. Effect of Prenatal Repair of Myelomeningocele on Urological Outcomes at School Age. (PubMed)

Effect of Prenatal Repair of Myelomeningocele on Urological Outcomes at School Age. To investigate longer-term urological outcomes in patients enrolled in the Management of Myelomeningocele Study (MOMS).Women who participated in the original trial were asked for consent to their child being followed-up at 6 years or older in a single comprehensive study visit to a MOMS center. Participating children underwent urologic and radiologic procedures to provide objective evidence of current bladder (...) volitionally. Augmentation cystoplasty, vesicostomy, and urethral dilation did not differ between the two groups. Aside from a larger post residual urodynamic catheterization volume, there were no other statistical differences in video-urodynamic data or findings on renal/bladder ultrasound.Prenatal closure of myelomeningocele resulted in less reported CIC at school-age. The mechanism for this is unclear. Although most children are in diapers or on CIC, parental reports showed children who underwent

2019 Journal of Urology

11. Two-Port Fetoscopic Repair of Myelomeningocele in Fetal Lambs. (PubMed)

Two-Port Fetoscopic Repair of Myelomeningocele in Fetal Lambs. The aim of this study was to assess the feasibility and the effectiveness of a fetoscopic myelomeningocele (MMC) repair with a running single suture using a 2-port access in the sheep model.Eighteen fetuses underwent surgical creation of a MMC defect at day 75. Fetuses were then randomized into 3 groups. Four fetuses remained untreated (control group). In the other 14 fetuses, a prenatal repair was performed at day 90: 7 fetuses had

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2019 Fetal diagnosis and therapy

12. Heated humidified carbon dioxide for partial uterine insufflation in fetoscopic myelomeningocele repair: insights from animal model. (PubMed)

Heated humidified carbon dioxide for partial uterine insufflation in fetoscopic myelomeningocele repair: insights from animal model. Linked Comment: Ultrasound Obstet Gynecol 2018; 53: 340-347.Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.

2019 Ultrasound in Obstetrics and Gynecology

13. Subsequent Pregnancy Outcomes After Open Maternal-Fetal Surgery for Myelomeningocele. (PubMed)

Subsequent Pregnancy Outcomes After Open Maternal-Fetal Surgery for Myelomeningocele. Open maternal-fetal surgery for fetal myelomeningocele results in reduction in neonatal morbidity related to spina bifida but may be associated with fetal, neonatal, and maternal complications in subsequent pregnancies.The objective of this study was to ascertain obstetric risk in subsequent pregnancies after open maternal-fetal surgery for fetal myelomeningocele closure.An international multicenter (...) prospective observational registry created to track and report maternal, obstetric, fetal/neonatal, and subsequent pregnancy outcomes following open maternal-fetal surgery for fetal myelomeningocele was evaluated for subsequent pregnancy outcome variables. Institutional Review Board approval was obtained for the registry.From 693 cases of open maternal-fetal surgery for fetal myelomeningocele closure entered into the registry, 77 subsequent pregnancies in 60 women were identified. The overall live birth

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2019 American Journal of Obstetrics and Gynecology

14. A Comparison of Dressing Techniques for Presurgical Closure of Myelomeningocele in the Neonate. (PubMed)

A Comparison of Dressing Techniques for Presurgical Closure of Myelomeningocele in the Neonate. Myelomeningoceles are routinely closed surgically within 24 to 48 hours after birth; the defect and exposed placode must be protected from further damage from excoriation and contamination until surgery.Two methods to keep the defect moist and clean are used at our large Midwestern children's hospital: the occlusive and the drip. There was no agreement between the neonatal and neurosurgical teams

2019 The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses Controlled trial quality: uncertain

15. Heritable Spina Bifida in Sheep: A Potential Model for Fetal Repair of Myelomeningocele. (PubMed)

Heritable Spina Bifida in Sheep: A Potential Model for Fetal Repair of Myelomeningocele. In 2004, a heritable occurrence of spina bifida was reported in sheep on a farm in the United States. We maintained and characterized the spina bifida phenotype in this flock to assess its potential as an alternative surgical model.A breeding strategy was developed in which the sheep were crossed to maintain or increase the occurrence of spina bifida. Measurements and observations were recorded regarding (...) displayed a range of ambulatory and urological deficits which could be used to evaluate new fetal repair methodologies. Finally, affected lambs were shown to demonstrate severe Chiari malformations and hydrocephalus.We have determined that use of these sheep as a natural source for spina bifida fetuses is feasible and could supplement the deficits of current sheep models for myelomeningocele repair.Level IV.Copyright © 2019 Elsevier Inc. All rights reserved.

2019 Journal of Pediatric Surgery

16. Does Kyphectomy Improve the Quality of Life of Patients With Myelomeningocele? (PubMed)

Does Kyphectomy Improve the Quality of Life of Patients With Myelomeningocele? Lumbar kyphosis is a complex spinal deformity occurring in approximately 8% to 20% of patients with myelomeningocele. The resulting gibbosity may cause pressure ulcers, difficulty lying down in the supine position and sitting on the ischia without support, decreasing quality of life (QOL). Surgery is generally performed to correct kyphosis and maintain vertebral alignment, but high complication rates have been (...) reported. Despite satisfactory radiological results, the impact of surgery and its complications on health-related QOL (HRQOL) has not yet been established.Among children with myelomeningocele undergoing corrective surgery for lumbar kyphosis: (1) What is the risk of complications and reoperation after this procedure? (2) Does this procedure improve HRQOL scores in these patients?Between 2012 and 2013, five surgeons at three centers treated 32 patients for myelomeningocele-related kyphosis

2019 Clinical Orthopaedics and Related Research

17. Maternal, fetal, neonatal and childhood outcomes for pregnancies complicated by fetal myelomeningocele (spina bifida): a systematic review to develop a core outcome set

Maternal, fetal, neonatal and childhood outcomes for pregnancies complicated by fetal myelomeningocele (spina bifida): a systematic review to develop a core outcome set Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation

2018 PROSPERO

18. Intelligence Quotient in Patients with Myelomeningocele: A Review (PubMed)

Intelligence Quotient in Patients with Myelomeningocele: A Review It has been proposed that hydrocephalus in children with myelomeningocele (MMC) can indicate a low intelligence quotient (IQ). Others have argued that it is not the mere presence of hydrocephalus but the superimposition of cerebrospinal fluid (CSF) infections, multiple shunt procedures, and other CNS complications that lead to the lowering of IQ in these patients. In this paper, we review the literature to clarify the information

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2018 Cureus

19. Effect of Custom-Made Foot Orthosis for Scoliosis with Pelvic Malalignment in a Patient with Myelomeningocele of Partial Neurological Deficit: A Case Report (PubMed)

Effect of Custom-Made Foot Orthosis for Scoliosis with Pelvic Malalignment in a Patient with Myelomeningocele of Partial Neurological Deficit: A Case Report BACKGROUND The treatment of patients with spinal deformities, such as developmental scoliosis in children with myelomeningocele, poses a formidable challenge. We observed the effects of a custom-made foot orthosis in a case of mild scoliosis with pelvic malalignment, in a patient with myelomeningocele. CASE REPORT The patient was a 5-year (...) -old female who was diagnosed with myelomeningocele and who had a partial neurological deficit. At the time of the first visit, the patient showed moderate pelvic rotation to the clockwise side during gait and severe left anterior pelvic tilting during the drooping upper body. Radiographic images revealed mild lumbar scoliosis and severe pelvic asymmetry. After applying a custom-made foot orthosis for 8 months, the patient showed moderate improvement of pelvic rotation and tilting. Clinical

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2018 The American journal of case reports

20. Myelomeningocele with Unilateral Right Renal Agenesis: A Case Report (PubMed)

Myelomeningocele with Unilateral Right Renal Agenesis: A Case Report Congenital anomalies of the spine may occur with malformations of the central nervous, cardiovascular, gastrointestinal, respiratory, and genitourinary systems. This is a case of myelomeningocele with unilateral right renal agenesis in a newborn. The patient suffered complications of cerebrospinal fluid leak and meningitis, but was successfully treated and discharged on day 86. In this case, unilateral right renal agenesis

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2018 AJP Reports

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