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1. Sensitivity and specificity of automated analysis of single-field non-mydriatic fundus photographs by Bosch DR Algorithm-Comparison with mydriatic fundus photography (ETDRS) for screening in undiagnosed diabetic retinopathy. (PubMed)

Sensitivity and specificity of automated analysis of single-field non-mydriatic fundus photographs by Bosch DR Algorithm-Comparison with mydriatic fundus photography (ETDRS) for screening in undiagnosed diabetic retinopathy. Diabetic retinopathy (DR) is a leading cause of blindness among working-age adults. Early diagnosis through effective screening programs is likely to improve vision outcomes. The ETDRS seven-standard-field 35-mm stereoscopic color retinal imaging (ETDRS) of the dilated eye (...) is elaborate and requires mydriasis, and is unsuitable for screening. We evaluated an image analysis application for the automated diagnosis of DR from non-mydriatic single-field images. Patients suffering from diabetes for at least 5 years were included if they were 18 years or older. Patients already diagnosed with DR were excluded. Physiologic mydriasis was achieved by placing the subjects in a dark room. Images were captured using a Bosch Mobile Eye Care fundus camera. The images were analyzed

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2017 PLoS ONE

2. Intracameral mydriatics versus topical mydriatics in pupil dilation for phacoemulsification cataract surgery. (PubMed)

Intracameral mydriatics versus topical mydriatics in pupil dilation for phacoemulsification cataract surgery. To evaluate the efficacy and safety of intracameral mydriatics (lidocaine 1.0% and phenylephrine 1.5%) versus topical mydriatics (phenylephrine 2.5% and tropicamide 1.0%) in pupil dilation for phacoemulsification surgery in Malaysians.Department of Ophthalmology, Penang General Hospital, Georgetown Penang, Malaysia.Prospective comparative case series.Patients with immature cataract were (...) randomized to the topical mydriatic group (topical group) or intracameral mydriatic group (intracameral group). Patients with small pupils and complicated cataracts were excluded. Pupil diameter changes were measured throughout the surgery. Additional pupil dilation maneuvers and complications were recorded.The study comprised 112 patients. There was no difference in mean pupil dilation between the intracameral group (4.86 mm ± 0.74 [SD]) and the topical group (4.88 ± 0.91 mm) (P = .86). However

2017 Journal of cataract and refractive surgery Controlled trial quality: uncertain

3. Glaucoma Screening in Nepal: Cup to Disc Estimate with Standard Mydriatic Fundus Camera Compared to Portable Non-mydriatic Camera. (PubMed)

Glaucoma Screening in Nepal: Cup to Disc Estimate with Standard Mydriatic Fundus Camera Compared to Portable Non-mydriatic Camera. To compare cup-to-disc ratio (CDR) measurements from images taken with a portable, 45-degree nonmydriatic fundus camera to images from a traditional tabletop mydriatic fundus camera.Prospective, cross-sectional, comparative instrument validation study.Setting: Clinic-based.A total of 422 eyes of 211 subjects were recruited from the Tilganga Institute (...) of Ophthalmology (Kathmandu, Nepal). Two masked readers measured CDR and noted possible evidence of glaucoma (CDR ≥ 0.7 or the presence of a notch or disc hemorrhage) from fundus photographs taken with a nonmydriatic portable camera and a mydriatic standard camera. Each image was graded twice.Effect of camera modality on CDR measurement; inter- and intraobserver agreement for each camera for the diagnosis of glaucoma.A total of 196 eyes (46.5%) were diagnosed with glaucoma by chart review; 41.2%-59.0% of eyes

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2017 American Journal of Ophthalmology

4. Topical mydriatics as adjunctive therapy for traumatic iridocyclitis and iritis [Cochrane protocol]

Topical mydriatics as adjunctive therapy for traumatic iridocyclitis and iritis [Cochrane protocol] Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external

2019 PROSPERO

5. Reliability and reproducibility of disc-foveal angle measurements by non-mydriatic fundus photography. (PubMed)

Reliability and reproducibility of disc-foveal angle measurements by non-mydriatic fundus photography. Abnormal torsion could be associated with cyclovertical strabismus, but torsion measurements are not reliable in children. To assess an objective fundus torsion evaluation in a paediatric population, we used Non-Mydriatic Fundus photography (NMFP) in healthy and cyclovertical strabismus patients to evaluate the disc-foveal angle over time and observers.We used a retrospective set of NMFP

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2018 PLoS ONE

6. Non-mydriatic retinal photography (NMP) in persons with diabetes

Non-mydriatic retinal photography (NMP) in persons with diabetes Ap Applic Date o Context at www 1. An appl with a n people w Departm The app patients number dye inje with int angiogr 2. After co effectiv mydriat patients MSAC primary model o taking f quality by the f pplication cant: of MSAC c t for decisio w.msac.gov. Purpose o lication req non-mydriat with diabete ment of Hea plication req s with diabe rs 11215 (R ection) and travenous ey raphy. MSAC’s a onsidering t veness and c tic retinal (...) of the photography is borne by the patient. Existing MBS items for ‘retinal photography’ relate to a distinct procedure, defined as fluorescein angiography, to inform the treatment of severe DR following initial diagnosis. Health professionals in some Aboriginal Community Controlled Health Services (ACCHSs) provide RP-NMRC and screen clients in a manner that is similar to the current proposal. 5. Prerequisites to implementation of any funding advice Numerous non-mydriatic cameras have been registered

2014 Medical Services Advisory Committee

7. Diagnostic test accuracy of diabetic retinopathy screening by physician graders using a hand-held non-mydriatic retinal camera at a tertiary level medical clinic. (PubMed)

Diagnostic test accuracy of diabetic retinopathy screening by physician graders using a hand-held non-mydriatic retinal camera at a tertiary level medical clinic. The evidence on diagnostic test accuracy (DTA) of diabetic retinopathy (DR) screening utilising photographic studies by non-ophthalmologist personnel in low and middle-income country (LMIC) settings is scarce. We aimed to assess DTA of DR screening using a nonmydriatic hand-held digital camera by trained general physicians in a non (...) -ophthalmic setting.This study is a validation of a screening intervention. We selected 700 people with diabetes (PwDM) > 18 years of age, not previously screened or treated for DR, presenting at a tertiary medical clinic in Sri Lanka. Two-field retinal imaging was used to capture fundus images before and after pupil dilatation, using a hand-held non-mydriatic (Visuscout 100®-Germany) digital retinal camera. The images were captured and graded by two trained, masked independent physician graders. The DTA

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2019 BMC Ophthalmology

8. Systemic exposure to intracameral vs topical mydriatic agents: in cataract surgery. (PubMed)

Systemic exposure to intracameral vs topical mydriatic agents: in cataract surgery. The objective of this study was to compare systemic exposure to tropicamide/phenylephrine following intracameral or topical administration before cataract surgery.Mydriatics exposure was calculated in patients randomized to intracameral fixed combination of mydriatics and anesthetic ([ICMA]: tropicamide 0.02%, phenylephrine 0.31%, and lidocaine 1%, N=271) or mydriatic eye drops ([EDs]: tropicamide 0.5 (...) % and phenylephrine 10%, N=283). Additional doses were permitted if required. Mydriatic plasma levels were determined by mass spectrometric HPLC in 15 patients per group before and after administration.Most ICMA patients (73.6%) received a single dose (200 µL) representing an exposure to tropicamide of 0.04 mg and phenylephrine of 0.62 mg. None of these patients received additional mydriatics. In the control group (three administrations), the exposure was 0.45 (11.3-fold higher than ICMA) and 10.2 (16.5-fold

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2019 Clinical ophthalmology (Auckland, N.Z.) Controlled trial quality: uncertain

9. Non-mydriatic retinal photography (NMP) in persons with diabetes

Non-mydriatic retinal photography (NMP) in persons with diabetes Non-mydriatic retinal photography (NMP) in persons with diabetes Non-mydriatic retinal photography (NMP) in persons with diabetes Medical Services Advisory Committee Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Medical Services Advisory Committee. Non-mydriatic retinal photography (NMP (...) ) in persons with diabetes. Canberra: Medical Services Advisory Committee (MSAC). MSAC application 1181. 2014 Authors' conclusions NMP is a non-contact, non-invasive [digital] imaging technique that provides images of the retina and optic disc. NMP provides a means for earlier detection of diabetic retinopathy and vision loss in people with diagnosed diabetes who do not attend an eyecare practitioner for a mydriatic fundus assessment. Final publication URL PubMedID Indexing Status Subject indexing assigned

2014 Health Technology Assessment (HTA) Database.

10. Pharmacodynamic profile of mydriatic agents delivered by ocular piezo-ejection microdosing compared with conventional eyedropper. (PubMed)

Pharmacodynamic profile of mydriatic agents delivered by ocular piezo-ejection microdosing compared with conventional eyedropper. Eyedroppers deliver medication volumes exceeding conjunctival absorptive capacity, causing spillage and risking ocular/systemic complications. We evaluated piezoelectric microdosing. Results/methodology: Subjects (n = 102) received precision microdroplet delivery of phenylephrine (2.5%) and tropicamide (1.0%): 1 × 1.5 μl, 1 × 6 μl or 2 × 3 μl of each (randomized 1:1

2018 Therapeutic delivery Controlled trial quality: uncertain

11. Non-Mydriatic Fundus Retinography in Screening for Diabetic Retinopathy: Agreement Between Family Physicians, General Ophthalmologists, and a Retinal Specialist (PubMed)

Non-Mydriatic Fundus Retinography in Screening for Diabetic Retinopathy: Agreement Between Family Physicians, General Ophthalmologists, and a Retinal Specialist To determine the level of agreement between trained family physicians (FPs), general ophthalmologists (GOs), and a retinal specialist (RS) in the assessment of non-mydriatic fundus retinography in screening for diabetic retinopathy (DR) in the primary health-care setting.200 Diabetic patients were submitted to two-field non-mydriatic (...) , and 117 eyes, respectively. The agreement between the RS and the FPs with regard to DR diagnosis was substantial (FP2k = 0.69; FP3k = 0.73; FP4k = 0.71) or moderate (FP1k = 0.56). As for DR severity, the agreement between the FPs and the RS was substantial (FP2k = 0.66; FP3k = 069; FP4k = 0.64) or moderate (FP1k = 0.51). Agreement between the FPs and the RS with regard to macular edema was fair (FP1k = 0.33; FP2k = 0.39; FP3k = 0.37) or moderate (FP4k = 0.51).Non-mydriatic fundus retinography

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2018 Frontiers in endocrinology

12. Non-mydriatic chorioretinal imaging in a transmission geometry and application to retinal oximetry (PubMed)

Non-mydriatic chorioretinal imaging in a transmission geometry and application to retinal oximetry The human retina is typically imaged in a reflection geometry, where light is delivered through the pupil and images are formed from the light reflected back from the retina. In this configuration, artifacts caused by retinal surface reflex are often encountered, which complicate quantitative interpretation of the reflection images. We present an alternative illumination method, which avoids (...) these artifacts. The method uses deeply penetrating near-infrared (NIR) light delivered transcranially from the side of the head, and exploits multiple scattering to redirect a portion of the light towards the posterior eye. This unique transmission geometry simplifies absorption measurements and enables flash-free, non-mydriatic imaging as deep as the choroid. Images taken with this new transillumination approach are applied to retinal oximetry.

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2018 Biomedical optics express

13. Wheel Spokes Technique for Endothelial Keratoplasty for Extremely Mydriatic Bullous Keratopathy Eyes without Capsular Support (PubMed)

Wheel Spokes Technique for Endothelial Keratoplasty for Extremely Mydriatic Bullous Keratopathy Eyes without Capsular Support We describe a new technique to prevent an endothelial donor graft from dropping into the vitreous cavity during non-Descemet stripping automated endothelial keratoplasty (nDSAEK) for extremely mydriatic bullous keratopathy (BK) eyes without capsular support. The patient was a 79-year-old woman who underwent nDSAEK for an extremely mydriatic BK eye with an incomplete (...) barrier between the anterior and posterior chambers. She had undergone argon laser iridotomy for acute glaucoma at the age of 59 years and cataract surgery 3 years later. The pupil was extremely mydriatic as a result of iris sphincter muscle damage associated with an acute glaucoma attack and cataract surgery. After cataract surgery, the dislocated intraocular lens (IOL) sometimes touched the corneal endothelium. Despite simultaneous surgery to remove the dislocated IOL and lens capsule, vitrectomy

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2018 Case reports in ophthalmology

14. Efficacy of Mydriatic Drops in Premature Infants

Efficacy of Mydriatic Drops in Premature Infants Efficacy of Mydriatic Drops in Premature Infants - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Efficacy of Mydriatic Drops in Premature Infants The safety (...) : Drug used in the examination of premature infants. to investigate side effects of eye drops used Other Name: Tropicamide and mydfline used Outcome Measures Go to Primary Outcome Measures : The mean pupillary diameter [ Time Frame: an average of 1 year ] will be measured with a ruler after 60 minutes instillation of mydriatic Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor

2018 Clinical Trials

15. Non-mydriatic ultrawide field scanning laser ophthalmoscopy compared with dilated fundal examination for assessment of diabetic retinopathy and diabetic macular oedema in Chinese individuals with diabetes mellitus. (PubMed)

Non-mydriatic ultrawide field scanning laser ophthalmoscopy compared with dilated fundal examination for assessment of diabetic retinopathy and diabetic macular oedema in Chinese individuals with diabetes mellitus. To evaluate the performance of ultrawide field scanning laser ophthalmoscopy (UWF-SLO) for assessing diabetic retinopathy (DR) and diabetic macular oedema (DME) in a Chinese population, compared with clinical examination.This is a retrospective cohort study. A series of 322 eyes from (...) 164 patients with DM were included. Each patient underwent both dilated fundal examination with DR and DME grading by retina specialist and non-mydriatic 200° UWF-SLO (Daytona, Optos, Dunfermline, UK). The severity of DR and DME from UWF-SLO images was further graded by ophthalmologists, according to both international clinical DR and DME disease severity scales and the standard 7-field Early Treatment Diabetic Retinopathy Study (ETDRS) scale. Any DR, DME and vision-threatening DR (VTDR) were

2018 British Journal of Ophthalmology

16. Pupil dilation dynamics with an intracameral fixed combination of mydriatics and anesthetic during cataract surgery. (PubMed)

Pupil dilation dynamics with an intracameral fixed combination of mydriatics and anesthetic during cataract surgery. To compare the pupil dynamics of an intracameral combination of 2 mydriatics and 1 anesthetic (Mydrane) to a standard topical regimen for cataract surgery.Sixty-two centers in Europe and 6 centers in Algeria.Prospective case series.Pupil size measurements were performed in 2 randomized studies (phase 2 and phase 3) under masked conditions (recorded videography, masked reading (...) diameter remained stable in the intracameral combination group and decreased in the topical group. The mean change in pupil size just before capsulorhexis to the end of surgery (just before cefuroxime injection) was -0.22 ± 0.72 mm and -1.67 ± 0.98 mm, respectively. No clinically significant change in pupil diameter (change <1.0 mm) occurred in the majority of the intracameral combination group (89.3%) compared with the topical group (26.8%).Intracameral combination of 2 mydriatics and 1 anesthetic

2018 Journal of cataract and refractive surgery

17. Evaluation of the efficacy and safety of a standardised intracameral combination of mydriatics and anaesthetics for cataract surgery. (PubMed)

Evaluation of the efficacy and safety of a standardised intracameral combination of mydriatics and anaesthetics for cataract surgery. To compare the efficacy and safety of intracameral (IC) administration at the beginning of cataract surgery, of Mydrane, a standardised ophthalmic combination of tropicamide 0.02%, phenylephrine 0.31% and lidocaine 1%, to a standard topical regimen.In this international phase III, prospective, randomised study, the selected eye of 555 patients undergoing (...) phacoemulsification with intraocular lens (IOL) implantation received 200 μL of Mydrane (Mydrane group) just after the first incision or a topical regimen of one drop each of tropicamide 0.5% and phenylephrine 10% repeated three times (reference group). The primary efficacy variable was achievement of capsulorhexis without additional mydriatics. The non-inferiority of Mydrane to the topical regimen was tested. The main outcome measures were pupil size, patient perception of ocular discomfort

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2017 The British journal of ophthalmology Controlled trial quality: uncertain

18. Changes in intraocular pressure and horizontal pupil diameter during use of topical mydriatics in the canine eye (PubMed)

Changes in intraocular pressure and horizontal pupil diameter during use of topical mydriatics in the canine eye The objective of this study was to determine the effects of topical 0.5% tropicamide, 1% atropine sulphate and 10% phenylephrine hydrochloride ophthalmic solutions on intraocular pressure (IOP) and horizontal pupil diameter (HPD) in the dog during the first hour after treatment. Forty clinically and ophthalmologically normal canine patients (between the ages of 2 and 6 years (...) , but the HPD of the - untreated eye slightly decreased at 15 minutes, but this change only reached statistical significance at 40 min post- treatment (P<0.05). Normal saline showed no influence on IOP or HPD. The drugs investigated here show a significant increase in IOP after mydriatics.

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2017 Open veterinary journal

19. Predictors of Photographic Quality with a Handheld Non-Mydriatic Fundus Camera used for Screening of Vision Threatening Diabetic Retinopathy (PubMed)

Predictors of Photographic Quality with a Handheld Non-Mydriatic Fundus Camera used for Screening of Vision Threatening Diabetic Retinopathy To analyze predictors of image quality for a handheld nonmydriatic fundus camera used for screening of vision-threatening diabetic retinopathy.An ophthalmic photographer at an Aravind Eye Hospital obtained nonmydriatic and mydriatic fundus images from 3 fields in 275 eyes of 155 participants over 13 months using a Smartscope camera (Optomed, Oulu, Finland (...) ) and a Topcon tabletop fundus camera (Topcon, Tokyo, Japan). Two fellowship-trained retina specialists graded the images. Repeated-measures logistic regression assessed predictors of the main outcome measure: gradability of the fundus images.Of 2,475 images, 76.2% of the Smartscope nonmydriatic images, 90.1% of the Smartscope mydriatic images, and 92.0% of the Topcon mydriatic images were gradable. Eyes with vitreous hemorrhage (OR = 0.24, p < 0.0001) or advanced cataract (OR = 0.08, p < 0.0001) had

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2017 Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde

20. Quality and learning curve of handheld versus stand-alone non-mydriatic cameras (PubMed)

Quality and learning curve of handheld versus stand-alone non-mydriatic cameras Nowadays, complex digital imaging systems allow detailed retinal imaging without dilating patients' pupils. These so-called non-mydriatic cameras have advantages in common circumstances (eg, for screening or emergency purposes) but present limitations in terms of image quality and field of view. We compare the usefulness of two non-mydriatic camera systems (ie, a handheld versus a stand-alone device) for fundus

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2017 Clinical ophthalmology (Auckland, N.Z.)

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