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1. Intracameral mydriatics versus topical mydriatics in pupil dilation for phacoemulsification cataract surgery. (PubMed)

Intracameral mydriatics versus topical mydriatics in pupil dilation for phacoemulsification cataract surgery. To evaluate the efficacy and safety of intracameral mydriatics (lidocaine 1.0% and phenylephrine 1.5%) versus topical mydriatics (phenylephrine 2.5% and tropicamide 1.0%) in pupil dilation for phacoemulsification surgery in Malaysians.Department of Ophthalmology, Penang General Hospital, Georgetown Penang, Malaysia.Prospective comparative case series.Patients with immature cataract were (...) randomized to the topical mydriatic group (topical group) or intracameral mydriatic group (intracameral group). Patients with small pupils and complicated cataracts were excluded. Pupil diameter changes were measured throughout the surgery. Additional pupil dilation maneuvers and complications were recorded.The study comprised 112 patients. There was no difference in mean pupil dilation between the intracameral group (4.86 mm ± 0.74 [SD]) and the topical group (4.88 ± 0.91 mm) (P = .86). However

2017 Journal of cataract and refractive surgery

2. Glaucoma Screening in Nepal: Cup to Disc Estimate with Standard Mydriatic Fundus Camera Compared to Portable Non-mydriatic Camera. (PubMed)

Glaucoma Screening in Nepal: Cup to Disc Estimate with Standard Mydriatic Fundus Camera Compared to Portable Non-mydriatic Camera. To compare cup-to-disc ratio (CDR) measurements from images taken with a portable, 45-degree nonmydriatic fundus camera to images from a traditional tabletop mydriatic fundus camera.Prospective, cross-sectional, comparative instrument validation study.Setting: Clinic-based.A total of 422 eyes of 211 subjects were recruited from the Tilganga Institute (...) of Ophthalmology (Kathmandu, Nepal). Two masked readers measured CDR and noted possible evidence of glaucoma (CDR ≥ 0.7 or the presence of a notch or disc hemorrhage) from fundus photographs taken with a nonmydriatic portable camera and a mydriatic standard camera. Each image was graded twice.Effect of camera modality on CDR measurement; inter- and intraobserver agreement for each camera for the diagnosis of glaucoma.A total of 196 eyes (46.5%) were diagnosed with glaucoma by chart review; 41.2%-59.0% of eyes

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2017 American Journal of Ophthalmology

3. Non-mydriatic retinal photography (NMP) in persons with diabetes

Non-mydriatic retinal photography (NMP) in persons with diabetes Ap Applic Date o Context at www 1. An appl with a n people w Departm The app patients number dye inje with int angiogr 2. After co effectiv mydriat patients MSAC primary model o taking f quality by the f pplication cant: of MSAC c t for decisio w.msac.gov. Purpose o lication req non-mydriat with diabete ment of Hea plication req s with diabe rs 11215 (R ection) and travenous ey raphy. MSAC’s a onsidering t veness and c tic retinal (...) of the photography is borne by the patient. Existing MBS items for ‘retinal photography’ relate to a distinct procedure, defined as fluorescein angiography, to inform the treatment of severe DR following initial diagnosis. Health professionals in some Aboriginal Community Controlled Health Services (ACCHSs) provide RP-NMRC and screen clients in a manner that is similar to the current proposal. 5. Prerequisites to implementation of any funding advice Numerous non-mydriatic cameras have been registered

2014 Medical Services Advisory Committee

4. Diagnostic test accuracy of diabetic retinopathy screening by physician graders using a hand-held non-mydriatic retinal camera at a tertiary level medical clinic. (PubMed)

Diagnostic test accuracy of diabetic retinopathy screening by physician graders using a hand-held non-mydriatic retinal camera at a tertiary level medical clinic. The evidence on diagnostic test accuracy (DTA) of diabetic retinopathy (DR) screening utilising photographic studies by non-ophthalmologist personnel in low and middle-income country (LMIC) settings is scarce. We aimed to assess DTA of DR screening using a nonmydriatic hand-held digital camera by trained general physicians in a non (...) -ophthalmic setting.This study is a validation of a screening intervention. We selected 700 people with diabetes (PwDM) > 18 years of age, not previously screened or treated for DR, presenting at a tertiary medical clinic in Sri Lanka. Two-field retinal imaging was used to capture fundus images before and after pupil dilatation, using a hand-held non-mydriatic (Visuscout 100®-Germany) digital retinal camera. The images were captured and graded by two trained, masked independent physician graders. The DTA

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2019 BMC Ophthalmology

5. Non-mydriatic retinal photography (NMP) in persons with diabetes

Non-mydriatic retinal photography (NMP) in persons with diabetes Non-mydriatic retinal photography (NMP) in persons with diabetes Non-mydriatic retinal photography (NMP) in persons with diabetes Medical Services Advisory Committee Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Medical Services Advisory Committee. Non-mydriatic retinal photography (NMP (...) ) in persons with diabetes. Canberra: Medical Services Advisory Committee (MSAC). MSAC application 1181. 2014 Authors' conclusions NMP is a non-contact, non-invasive [digital] imaging technique that provides images of the retina and optic disc. NMP provides a means for earlier detection of diabetic retinopathy and vision loss in people with diagnosed diabetes who do not attend an eyecare practitioner for a mydriatic fundus assessment. Final publication URL PubMedID Indexing Status Subject indexing assigned

2014 Health Technology Assessment (HTA) Database.

6. Pharmacodynamic profile of mydriatic agents delivered by ocular piezo-ejection microdosing compared with conventional eyedropper. (PubMed)

Pharmacodynamic profile of mydriatic agents delivered by ocular piezo-ejection microdosing compared with conventional eyedropper. Eyedroppers deliver medication volumes exceeding conjunctival absorptive capacity, causing spillage and risking ocular/systemic complications. We evaluated piezoelectric microdosing. Results/methodology: Subjects (n = 102) received precision microdroplet delivery of phenylephrine (2.5%) and tropicamide (1.0%): 1 × 1.5 μl, 1 × 6 μl or 2 × 3 μl of each (randomized 1:1

2018 Therapeutic delivery

7. Non-mydriatic chorioretinal imaging in a transmission geometry and application to retinal oximetry (PubMed)

Non-mydriatic chorioretinal imaging in a transmission geometry and application to retinal oximetry The human retina is typically imaged in a reflection geometry, where light is delivered through the pupil and images are formed from the light reflected back from the retina. In this configuration, artifacts caused by retinal surface reflex are often encountered, which complicate quantitative interpretation of the reflection images. We present an alternative illumination method, which avoids (...) these artifacts. The method uses deeply penetrating near-infrared (NIR) light delivered transcranially from the side of the head, and exploits multiple scattering to redirect a portion of the light towards the posterior eye. This unique transmission geometry simplifies absorption measurements and enables flash-free, non-mydriatic imaging as deep as the choroid. Images taken with this new transillumination approach are applied to retinal oximetry.

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2018 Biomedical optics express

8. Non-Mydriatic Fundus Retinography in Screening for Diabetic Retinopathy: Agreement Between Family Physicians, General Ophthalmologists, and a Retinal Specialist (PubMed)

Non-Mydriatic Fundus Retinography in Screening for Diabetic Retinopathy: Agreement Between Family Physicians, General Ophthalmologists, and a Retinal Specialist To determine the level of agreement between trained family physicians (FPs), general ophthalmologists (GOs), and a retinal specialist (RS) in the assessment of non-mydriatic fundus retinography in screening for diabetic retinopathy (DR) in the primary health-care setting.200 Diabetic patients were submitted to two-field non-mydriatic (...) , and 117 eyes, respectively. The agreement between the RS and the FPs with regard to DR diagnosis was substantial (FP2k = 0.69; FP3k = 0.73; FP4k = 0.71) or moderate (FP1k = 0.56). As for DR severity, the agreement between the FPs and the RS was substantial (FP2k = 0.66; FP3k = 069; FP4k = 0.64) or moderate (FP1k = 0.51). Agreement between the FPs and the RS with regard to macular edema was fair (FP1k = 0.33; FP2k = 0.39; FP3k = 0.37) or moderate (FP4k = 0.51).Non-mydriatic fundus retinography

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2018 Frontiers in endocrinology

9. Efficacy of Mydriatic Drops in Premature Infants

Efficacy of Mydriatic Drops in Premature Infants Efficacy of Mydriatic Drops in Premature Infants - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Efficacy of Mydriatic Drops in Premature Infants The safety (...) : Drug used in the examination of premature infants. to investigate side effects of eye drops used Other Name: Tropicamide and mydfline used Outcome Measures Go to Primary Outcome Measures : The mean pupillary diameter [ Time Frame: an average of 1 year ] will be measured with a ruler after 60 minutes instillation of mydriatic Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor

2018 Clinical Trials

10. Wheel Spokes Technique for Endothelial Keratoplasty for Extremely Mydriatic Bullous Keratopathy Eyes without Capsular Support (PubMed)

Wheel Spokes Technique for Endothelial Keratoplasty for Extremely Mydriatic Bullous Keratopathy Eyes without Capsular Support We describe a new technique to prevent an endothelial donor graft from dropping into the vitreous cavity during non-Descemet stripping automated endothelial keratoplasty (nDSAEK) for extremely mydriatic bullous keratopathy (BK) eyes without capsular support. The patient was a 79-year-old woman who underwent nDSAEK for an extremely mydriatic BK eye with an incomplete (...) barrier between the anterior and posterior chambers. She had undergone argon laser iridotomy for acute glaucoma at the age of 59 years and cataract surgery 3 years later. The pupil was extremely mydriatic as a result of iris sphincter muscle damage associated with an acute glaucoma attack and cataract surgery. After cataract surgery, the dislocated intraocular lens (IOL) sometimes touched the corneal endothelium. Despite simultaneous surgery to remove the dislocated IOL and lens capsule, vitrectomy

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2018 Case reports in ophthalmology

11. Non-mydriatic ultrawide field scanning laser ophthalmoscopy compared with dilated fundal examination for assessment of diabetic retinopathy and diabetic macular oedema in Chinese individuals with diabetes mellitus. (PubMed)

Non-mydriatic ultrawide field scanning laser ophthalmoscopy compared with dilated fundal examination for assessment of diabetic retinopathy and diabetic macular oedema in Chinese individuals with diabetes mellitus. To evaluate the performance of ultrawide field scanning laser ophthalmoscopy (UWF-SLO) for assessing diabetic retinopathy (DR) and diabetic macular oedema (DME) in a Chinese population, compared with clinical examination.This is a retrospective cohort study. A series of 322 eyes from (...) 164 patients with DM were included. Each patient underwent both dilated fundal examination with DR and DME grading by retina specialist and non-mydriatic 200° UWF-SLO (Daytona, Optos, Dunfermline, UK). The severity of DR and DME from UWF-SLO images was further graded by ophthalmologists, according to both international clinical DR and DME disease severity scales and the standard 7-field Early Treatment Diabetic Retinopathy Study (ETDRS) scale. Any DR, DME and vision-threatening DR (VTDR) were

2018 British Journal of Ophthalmology

12. Pupil dilation dynamics with an intracameral fixed combination of mydriatics and anesthetic during cataract surgery. (PubMed)

Pupil dilation dynamics with an intracameral fixed combination of mydriatics and anesthetic during cataract surgery. To compare the pupil dynamics of an intracameral combination of 2 mydriatics and 1 anesthetic (Mydrane) to a standard topical regimen for cataract surgery.Sixty-two centers in Europe and 6 centers in Algeria.Prospective case series.Pupil size measurements were performed in 2 randomized studies (phase 2 and phase 3) under masked conditions (recorded videography, masked reading (...) diameter remained stable in the intracameral combination group and decreased in the topical group. The mean change in pupil size just before capsulorhexis to the end of surgery (just before cefuroxime injection) was -0.22 ± 0.72 mm and -1.67 ± 0.98 mm, respectively. No clinically significant change in pupil diameter (change <1.0 mm) occurred in the majority of the intracameral combination group (89.3%) compared with the topical group (26.8%).Intracameral combination of 2 mydriatics and 1 anesthetic

2018 Journal of cataract and refractive surgery

13. Quality and Diagnostic Utility of Mydriatic Fundus Plenoptic Photography

Quality and Diagnostic Utility of Mydriatic Fundus Plenoptic Photography Quality and Diagnostic Utility of Mydriatic Fundus Plenoptic Photography - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Quality (...) and Diagnostic Utility of Mydriatic Fundus Plenoptic Photography (PORT) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03037268 Recruitment Status : Suspended (Device is being refined by the engineers) First Posted : January 31, 2017 Last Update Posted : March 29, 2018 Sponsor: Wills Eye Collaborator: Mid

2017 Clinical Trials

14. Telemedicine screening of retinal diseases with a handheld portable non-mydriatic fundus camera. (PubMed)

Telemedicine screening of retinal diseases with a handheld portable non-mydriatic fundus camera. We modified and reconstructed a high image quality portable non-mydriatic fundus camera and compared it with the tabletop fundus camera to evaluate the efficacy of the new camera in detecting retinal diseases.We designed and built a novel portable handheld fundus camera with telemedicine system. The image quality of fundus cameras was compared to that of existing commercial tabletop cameras (...) % (53/400) were fair, and 3.25% (13/400) were inadequate. Common retinal diseases were easily identified from fundus images obtained from the portable fundus camera.The new type of non-mydriatic portable fundus camera was qualified to have professional quality of fundus images. The revolutionary screening camera provides a foundational platform which can potentially improve the accessibility of retinal screening programmes.

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2017 BMC Ophthalmology

15. A randomised trial of non-mydriatic ultra-wide field retinal imaging versus usual care to screen for diabetic eye disease: rationale and protocol for the Clearsight trial. (PubMed)

A randomised trial of non-mydriatic ultra-wide field retinal imaging versus usual care to screen for diabetic eye disease: rationale and protocol for the Clearsight trial. Suboptimal screening for diabetic eye disease is a major cause of preventable vision loss. Screening barriers include mydriasis and the extra time patients need to attend dedicated eye screening appointments. In the Clearsight trial, we are testing whether screening by non-mydriatic ultra-wide field (NM UWF) imaging

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2017 BMJ open

16. Systematic review: Can non-mydriatic cameras accurately detect diabetic retinopathy? (PubMed)

Systematic review: Can non-mydriatic cameras accurately detect diabetic retinopathy? Diabetes puts many individuals at risk for developing diabetic retinopathy (DR). Non-mydriatic (NM) retinal photography without pharmacological pupil dilation can be used to detect DR, however, its value in a general clinical setting has not been established. The objective of this review is to evaluate the validity of NM retinal photos, as compared to the reference standard of seven standard stereoscopic 30

2017 Diabetes research and clinical practice

17. Evaluation of the efficacy and safety of a standardised intracameral combination of mydriatics and anaesthetics for cataract surgery. (PubMed)

Evaluation of the efficacy and safety of a standardised intracameral combination of mydriatics and anaesthetics for cataract surgery. To compare the efficacy and safety of intracameral (IC) administration at the beginning of cataract surgery, of Mydrane, a standardised ophthalmic combination of tropicamide 0.02%, phenylephrine 0.31% and lidocaine 1%, to a standard topical regimen.In this international phase III, prospective, randomised study, the selected eye of 555 patients undergoing (...) phacoemulsification with intraocular lens (IOL) implantation received 200 μL of Mydrane (Mydrane group) just after the first incision or a topical regimen of one drop each of tropicamide 0.5% and phenylephrine 10% repeated three times (reference group). The primary efficacy variable was achievement of capsulorhexis without additional mydriatics. The non-inferiority of Mydrane to the topical regimen was tested. The main outcome measures were pupil size, patient perception of ocular discomfort

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2017 The British journal of ophthalmology

18. Quality and learning curve of handheld versus stand-alone non-mydriatic cameras (PubMed)

Quality and learning curve of handheld versus stand-alone non-mydriatic cameras Nowadays, complex digital imaging systems allow detailed retinal imaging without dilating patients' pupils. These so-called non-mydriatic cameras have advantages in common circumstances (eg, for screening or emergency purposes) but present limitations in terms of image quality and field of view. We compare the usefulness of two non-mydriatic camera systems (ie, a handheld versus a stand-alone device) for fundus

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2017 Clinical ophthalmology (Auckland, N.Z.)

19. Predictors of Photographic Quality with a Handheld Non-Mydriatic Fundus Camera used for Screening of Vision Threatening Diabetic Retinopathy (PubMed)

Predictors of Photographic Quality with a Handheld Non-Mydriatic Fundus Camera used for Screening of Vision Threatening Diabetic Retinopathy To analyze predictors of image quality for a handheld nonmydriatic fundus camera used for screening of vision-threatening diabetic retinopathy.An ophthalmic photographer at an Aravind Eye Hospital obtained nonmydriatic and mydriatic fundus images from 3 fields in 275 eyes of 155 participants over 13 months using a Smartscope camera (Optomed, Oulu, Finland (...) ) and a Topcon tabletop fundus camera (Topcon, Tokyo, Japan). Two fellowship-trained retina specialists graded the images. Repeated-measures logistic regression assessed predictors of the main outcome measure: gradability of the fundus images.Of 2,475 images, 76.2% of the Smartscope nonmydriatic images, 90.1% of the Smartscope mydriatic images, and 92.0% of the Topcon mydriatic images were gradable. Eyes with vitreous hemorrhage (OR = 0.24, p < 0.0001) or advanced cataract (OR = 0.08, p < 0.0001) had

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2017 Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde

20. Mydriatic insert and intracameral injections compared with mydriatic eyedrops in cataract surgery: controlled studies. (PubMed)

Mydriatic insert and intracameral injections compared with mydriatic eyedrops in cataract surgery: controlled studies. Mydriatic eyedrops are the standard method for pupil dilation in cataract surgery, but their limitations have prompted a search for alternative techniques. Two alternatives-an ophthalmic insert containing phenylephrine and tropicamide and intracameral injections of various combinations of lidocaine, cyclopentolate, and phenylephrine, with or without epinephrine (...) in the irrigating solution-have been assessed in prospective controlled studies, including randomized controlled trials (RCTs). We reviewed the safety and efficacy of mydriatic ophthalmic inserts and intracameral mydriatic injections compared with the safety and efficacy of mydriatic eyedrops using a systematic PubMed search (1963 to 2014). We identified 9 prospective studies (7 RCTs, 637 patients) of the mydriatic ophthalmic insert and 15 prospective studies (14 RCTs, 1020 patients) of intracameral mydriatic

2015 Journal of cataract and refractive surgery

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