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Mycobacterium Avium Complex

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121. Proton MRI for Initial Assessment of Isolated Mycobacterium avium Complex (MAC) Pneumonia. (Abstract)

Proton MRI for Initial Assessment of Isolated Mycobacterium avium Complex (MAC) Pneumonia. Computed tomographic (CT) radiography is the reference standard for imaging Mycobacterium avium complex (MAC) lung infection. Magnetic resonance imaging (MRI) has been shown to be comparable to CT for characterizing other pulmonary inflammatory conditions, but has not been rigorously tested for imaging MAC pneumonia.To determine the feasibility of pulmonary MRI for imaging MAC pneumonia and to assess

2015 Annals of the American Thoracic Society

122. Variable agreement among experts regarding Mycobacterium avium complex lung disease. (Abstract)

Variable agreement among experts regarding Mycobacterium avium complex lung disease. Data regarding many clinical aspects of pulmonary Mycobacterium avium complex (pMAC) are lacking. Guidelines rely substantially upon expert opinion, integrated through face-to-face meetings, variably weighting individual opinions. We surveyed North American non-tuberculous mycobacteria experts regarding clinical aspects of pMAC using Delphi methods. Nineteen of 26 invited experts (73%) responded, with extensive

2015 Respirology

123. Mycobacterium avium Complex Osteomyelitis in Persons With Human Immunodeficiency Virus: Case Series and Literature Review Full Text available with Trip Pro

Mycobacterium avium Complex Osteomyelitis in Persons With Human Immunodeficiency Virus: Case Series and Literature Review In persons with advanced immunosuppression, Mycobacterium avium complex (MAC) typically causes disseminated disease with systemic symptoms. We report 2 cases in which MAC caused localized osteomyelitis in human immunodeficiency virus (HIV)-infected individuals on antiretroviral therapy with rising CD4 counts. We summarize 17 additional cases of HIV-associated MAC

2015 Open forum infectious diseases

124. Characterization of mouse models of Mycobacterium avium complex infection and evaluation of drug combinations. Full Text available with Trip Pro

Characterization of mouse models of Mycobacterium avium complex infection and evaluation of drug combinations. The Mycobacterium avium complex is the most common cause of nontuberculous mycobacterial lung disease worldwide; yet, an optimal treatment regimen for M. avium complex infection has not been established. Clarithromycin is accepted as the cornerstone drug for treatment of M. avium lung disease; however, good model systems, especially animal models, are needed to evaluate the most (...) effective companion drugs. We performed a series of experiments to evaluate and use different mouse models (comparing BALB/c, C57BL/6, nude, and beige mice) of M. avium infection and to assess the anti-M. avium activity of single and combination drug regimens, in vitro, ex vivo, and in mice. In vitro, clarithromycin and moxifloxacin were most active against M. avium, and no antagonism was observed between these two drugs. Nude mice were more susceptible to M. avium infection than the other mouse strains

2015 Antimicrobial Agents and Chemotherapy

125. A M. avium complex spondylodiscitis in a middle-aged woman with diabetes Full Text available with Trip Pro

A M. avium complex spondylodiscitis in a middle-aged woman with diabetes Spondylodiscitis, the inflammation of the vertebral bodies and the intervertebral disk space, is the reason for low back pain in a minority of cases. This is caused by various pathogens. Mycobacterium tuberculosis is responsible for 17-39% of all the cases of spondylodiscitis. On the contrast, spondylodiscitis from non tuberculous mycobacteria is extremely rare in literature. We describe a 68 -year old diabetic woman (...) which is the first case of bone marrow involvement by M. intracellulare (member of M avium complex)with spondylodiscitis.

2017 Respiratory Medicine Case Reports

126. Molecular characterization and drug susceptibility profile of a Mycobacterium avium subspecies avium isolate from a dog with disseminated infection. Full Text available with Trip Pro

Molecular characterization and drug susceptibility profile of a Mycobacterium avium subspecies avium isolate from a dog with disseminated infection. Mycobacterium avium-intracellulare complex (MAC) infections have been described in many mammalian species, including humans and pets. We isolated and molecularly typed the causative agent of a rare case of disseminated mycobacteriosis in a dog. We identified the pathogen as M. avium subspecies avium by sequencing the partial genes gyrB and rpsA

2016 Journal of Medical Microbiology

127. Causative species of nontuberculous mycobacterial lung disease and comparative investigation on clinical features of Mycobacterium abscessus complex disease: A retrospective analysis for two major hospitals in a subtropical region of Japan. Full Text available with Trip Pro

Causative species of nontuberculous mycobacterial lung disease and comparative investigation on clinical features of Mycobacterium abscessus complex disease: A retrospective analysis for two major hospitals in a subtropical region of Japan. Nontuberculous mycobacteria (NTM) lung disease is increasing globally. Although the etiological epidemiology of NTM is different across regions, Mycobacterium avium complex (MAC) is the leading cause of NTM lung disease in most countries, including mainland (...) criteria and patient epidemiology and clinical information were evaluated. Results indicate four hundred sixteen patients had bacterial cultures positive for NTM. The most common NTM was M. abscessus complex (MABC) (n = 127; 30.5%), followed by M. intracellulare (n = 85; 20.4%). NTM lung disease was diagnosed in 114 patients. Of these cases, MABC was most common (n = 41; 36.0%), followed by M. intracellulare (n = 31; 27.2%). Chronic obstructive pulmonary disease (COPD) and tracheostomy patients were

2017 PLoS ONE

128. The Role of Inflammasome in Inflammatory Macrophage in Mycobacterium Avium Complex-lung Disease and Mycobacterium Abscessus-lung Disease

The Role of Inflammasome in Inflammatory Macrophage in Mycobacterium Avium Complex-lung Disease and Mycobacterium Abscessus-lung Disease The Role of Inflammasome in Inflammatory Macrophage in Mycobacterium Avium Complex-lung Disease and Mycobacterium Abscessus-lung Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study (...) Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Role of Inflammasome in Inflammatory Macrophage in Mycobacterium Avium Complex-lung Disease and Mycobacterium Abscessus-lung Disease The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier

2013 Clinical Trials

129. Opinions differ by expertise in Mycobacterium avium complex disease. Full Text available with Trip Pro

Opinions differ by expertise in Mycobacterium avium complex disease. Pulmonary Mycobacterium avium complex treatment guidelines rely largely on expert opinion. The extent to which nonexperts agree with recommendations of experts in this clinical area is unknown.We sought to compare practices and perceptions of prognosis between experts and nonexperts.We surveyed respirologists (Ontario, Canada, "nonexperts") and experts from nontuberculous mycobacterial disease centers of excellence (Canada

2014 Annals of the American Thoracic Society

130. Normal estrogen, but low dehydroepiandrosterone levels, in women with pulmonary Mycobacterium avium complex. A preliminary study. (Abstract)

Normal estrogen, but low dehydroepiandrosterone levels, in women with pulmonary Mycobacterium avium complex. A preliminary study. For unclear reasons, the phenotypical hosts for nontuberculous mycobacterial lung infection are often thin, elderly, white women without underlying lung disease. As these women are usually postmenopausal, we hypothesized that a state of relative hormone deficiency may predispose some women to pulmonary nontuberculous mycobacterial infection.To conduct a prospective (...) cross-sectional study to assess for alterations in systemic levels of sex hormones in patients with confirmed pulmonary Mycobacterium avium complex infection compared with healthy control subjects.Female patients with pulmonary M. avium complex infection (n = 35) were recruited along with similar-aged control subjects (n = 27) without lung disease from the general population of our institution. Levels of dehydroepiandrosterone-sulfate (DHEA-S), estrone, and ultrasensitive estradiol were measured

2014 Annals of the American Thoracic Society

131. Association between polyclonal and mixed mycobacterial Mycobacterium avium complex infection and environmental exposure. Full Text available with Trip Pro

Association between polyclonal and mixed mycobacterial Mycobacterium avium complex infection and environmental exposure. Polyclonal and mixed mycobacterial Mycobacterium avium complex (MAC) infection is observed in pulmonary MAC disease. Human living environments contain multiple species or genotypes of nontuberculous mycobacterial strains and are considered sources of infection.To investigate the association of environmental exposure with polyclonal and mixed mycobacterial infection

2014 Annals of the American Thoracic Society

132. Mycobacterium avium complex infection in non-cystic fibrosis bronchiectasis. (Abstract)

Mycobacterium avium complex infection in non-cystic fibrosis bronchiectasis. Reliable markers of disease progression or stability to assist in management decisions are lacking in patients with non-cystic fibrosis bronchiectasis and Mycobacterium avium complex (MAC) infection.Data from 52 adults with non-cystic fibrosis bronchiectasis and coexisting MAC infection managed at our institution over a 5-year period were retrospectively analysed. High-resolution computed tomography (HRCT) scans were

2014 Respirology

133. Draft Genome Sequence of a Mycobacterium avium Complex Isolate from a Broadbill Bird Full Text available with Trip Pro

Draft Genome Sequence of a Mycobacterium avium Complex Isolate from a Broadbill Bird We report the draft genome sequence of a Mycobacterium avium complex isolate. This isolate has an estimated genome size of 5.1 Mb with an average GC content of 68.9% and is predicted to carry 4,497 protein-encoding genes and 317 pseudogenes.

2014 Genome Announcements

134. Pilot Quasi-Randomized Controlled Study of Herbal Medicine Hochuekkito as an Adjunct to Conventional Treatment for Progressed Pulmonary Mycobacterium avium Complex Disease. Full Text available with Trip Pro

Pilot Quasi-Randomized Controlled Study of Herbal Medicine Hochuekkito as an Adjunct to Conventional Treatment for Progressed Pulmonary Mycobacterium avium Complex Disease. Hochuekkito, a traditional herbal medicine, is occasionally prescribed in Japan to treat patients with a poor general condition. We aimed to examine whether this medicine was beneficial and tolerable for patients with progressed pulmonary Mycobacterium avium complex (MAC) disease.This pilot open-label quasi-randomized

2014 PloS one Controlled trial quality: uncertain

135. Mycobacterium avium Complex Empyema in a Patient with Interferon Gamma Autoantibodies Full Text available with Trip Pro

Mycobacterium avium Complex Empyema in a Patient with Interferon Gamma Autoantibodies Interferon gamma (IFN-γ) autoantibodies are a relatively recently discovered clinical entity, which have been shown to be associated with disseminated non-tuberculous mycobacterial (NTM) infections and other opportunistic infections. Interestingly, isolated NTM infections (without disseminated NTM infection) have not been shown to be a good predictor of the presence of IFN-γ autoantibodies. This case describes

2014 Hawai'i Journal of Medicine & Public Health

136. Pulmonary nocardiosis caused by Nocardia cyriacigeorgica in patients with Mycobacterium avium complex lung disease: two case reports. Full Text available with Trip Pro

Pulmonary nocardiosis caused by Nocardia cyriacigeorgica in patients with Mycobacterium avium complex lung disease: two case reports. Pulmonary nocardiosis frequently occurs in immunocompromised hosts and in some immunocompetent hosts with chronic lung disease; however, few reports have described pulmonary nocardiosis with nontuberculous mycobacterial lung infection. Here we report for the first time two cases of pulmonary nocardiosis caused by Nocardia cyriacigeorgica associated (...) with Mycobacterium avium complex (MAC) lung disease caused by M. avium.Case 1 is that of a 72-year-old Japanese man with untreated MAC lung disease, who was diagnosed with rheumatoid arthritis and initiated on methotrexate. After 3 years of methotrexate therapy, the patient remained smear-negative and culture-positive for MAC, but also became smear-positive for Nocardia species. He received trimethoprim/sulfamethoxazole, and his symptoms and lung infiltrates improved. Case 2 is that of an immunocompetent 53-year

2014 BMC Infectious Diseases

137. Mycobacterium avium Complex Presenting as Lung Mass With Eosinophilic Pneumonia. (Abstract)

Mycobacterium avium Complex Presenting as Lung Mass With Eosinophilic Pneumonia.

2014 Chest

138. A Case Study of Mycobacterium Avium Complex Infection Presenting with Acute Pericarditis. (Abstract)

A Case Study of Mycobacterium Avium Complex Infection Presenting with Acute Pericarditis. 24662622 2014 10 01 2014 08 09 1555-7162 127 8 2014 Aug The American journal of medicine Am. J. Med. A case study of Mycobacterium avium complex infection presenting with acute pericarditis. e9-e10 10.1016/j.amjmed.2014.03.014 S0002-9343(14)00268-X Moskowitz Robert S RS Maimonides Medical Center, Brooklyn, NY. Electronic address: rmosko@juno.com. Brickman Rebecca R Maimonides Medical Center, Brooklyn, NY (...) . Moeller Chaim C Maimonides Medical Center, Brooklyn, NY. eng Case Reports Letter 2014 03 22 United States Am J Med 0267200 0002-9343 AIM IM Aged Humans Male Mycobacterium avium Complex isolation & purification Mycobacterium avium-intracellulare Infection diagnosis pathology Pericarditis microbiology pathology 2013 12 19 2014 03 11 2014 03 11 2014 3 26 6 0 2014 3 26 6 0 2014 10 2 6 0 ppublish 24662622 S0002-9343(14)00268-X 10.1016/j.amjmed.2014.03.014

2014 American Journal of Medicine

139. Efficacy of Clarithromycin and Ethambutol for Mycobacterium avium Complex Pulmonary Disease. A Preliminary Study. (Abstract)

Efficacy of Clarithromycin and Ethambutol for Mycobacterium avium Complex Pulmonary Disease. A Preliminary Study. Patients with Mycobacterium avium complex pulmonary disease are frequently administered a combination of clarithromycin, ethambutol, and rifampicin. However, rifampicin is known to reduce the serum levels of clarithromycin. It remains unclear whether a reduction in clarithromycin serum levels influences the clinical outcome of the Mycobacterium avium complex pulmonary disease (...) treatment regimen.To compare a three-drug regimen (clarithromycin, ethambutol, and rifampicin) to a two-drug regimen (clarithromycin and ethambutol) for the treatment of Mycobacterium avium lung disease.In a preliminary open-label study, we randomly assigned newly diagnosed, but as-yet untreated, patients with disease caused by Mycobacterium avium complex without HIV infection to either the three-drug or the two-drug regimen for 12 months. The primary endpoint was the conversion of sputum cultures

2014 Annals of the American Thoracic Society Controlled trial quality: predicted high

140. Monotherapy With Erythromycin for Mycobacterium avium Complex Pulmonary Disease. (Abstract)

Monotherapy With Erythromycin for Mycobacterium avium Complex Pulmonary Disease.

2014 Chest

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