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Mycobacterium Avium Complex

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121. Opinions differ by expertise in Mycobacterium avium complex disease. Full Text available with Trip Pro

Opinions differ by expertise in Mycobacterium avium complex disease. Pulmonary Mycobacterium avium complex treatment guidelines rely largely on expert opinion. The extent to which nonexperts agree with recommendations of experts in this clinical area is unknown.We sought to compare practices and perceptions of prognosis between experts and nonexperts.We surveyed respirologists (Ontario, Canada, "nonexperts") and experts from nontuberculous mycobacterial disease centers of excellence (Canada

2014 Annals of the American Thoracic Society

122. Normal estrogen, but low dehydroepiandrosterone levels, in women with pulmonary Mycobacterium avium complex. A preliminary study. (Abstract)

Normal estrogen, but low dehydroepiandrosterone levels, in women with pulmonary Mycobacterium avium complex. A preliminary study. For unclear reasons, the phenotypical hosts for nontuberculous mycobacterial lung infection are often thin, elderly, white women without underlying lung disease. As these women are usually postmenopausal, we hypothesized that a state of relative hormone deficiency may predispose some women to pulmonary nontuberculous mycobacterial infection.To conduct a prospective (...) cross-sectional study to assess for alterations in systemic levels of sex hormones in patients with confirmed pulmonary Mycobacterium avium complex infection compared with healthy control subjects.Female patients with pulmonary M. avium complex infection (n = 35) were recruited along with similar-aged control subjects (n = 27) without lung disease from the general population of our institution. Levels of dehydroepiandrosterone-sulfate (DHEA-S), estrone, and ultrasensitive estradiol were measured

2014 Annals of the American Thoracic Society

123. Association between polyclonal and mixed mycobacterial Mycobacterium avium complex infection and environmental exposure. Full Text available with Trip Pro

Association between polyclonal and mixed mycobacterial Mycobacterium avium complex infection and environmental exposure. Polyclonal and mixed mycobacterial Mycobacterium avium complex (MAC) infection is observed in pulmonary MAC disease. Human living environments contain multiple species or genotypes of nontuberculous mycobacterial strains and are considered sources of infection.To investigate the association of environmental exposure with polyclonal and mixed mycobacterial infection

2014 Annals of the American Thoracic Society

124. Mycobacterium avium complex infection in non-cystic fibrosis bronchiectasis. (Abstract)

Mycobacterium avium complex infection in non-cystic fibrosis bronchiectasis. Reliable markers of disease progression or stability to assist in management decisions are lacking in patients with non-cystic fibrosis bronchiectasis and Mycobacterium avium complex (MAC) infection.Data from 52 adults with non-cystic fibrosis bronchiectasis and coexisting MAC infection managed at our institution over a 5-year period were retrospectively analysed. High-resolution computed tomography (HRCT) scans were

2014 Respirology

125. Draft Genome Sequence of a Mycobacterium avium Complex Isolate from a Broadbill Bird Full Text available with Trip Pro

Draft Genome Sequence of a Mycobacterium avium Complex Isolate from a Broadbill Bird We report the draft genome sequence of a Mycobacterium avium complex isolate. This isolate has an estimated genome size of 5.1 Mb with an average GC content of 68.9% and is predicted to carry 4,497 protein-encoding genes and 317 pseudogenes.

2014 Genome Announcements

126. Pilot Quasi-Randomized Controlled Study of Herbal Medicine Hochuekkito as an Adjunct to Conventional Treatment for Progressed Pulmonary Mycobacterium avium Complex Disease. Full Text available with Trip Pro

Pilot Quasi-Randomized Controlled Study of Herbal Medicine Hochuekkito as an Adjunct to Conventional Treatment for Progressed Pulmonary Mycobacterium avium Complex Disease. Hochuekkito, a traditional herbal medicine, is occasionally prescribed in Japan to treat patients with a poor general condition. We aimed to examine whether this medicine was beneficial and tolerable for patients with progressed pulmonary Mycobacterium avium complex (MAC) disease.This pilot open-label quasi-randomized

2014 PloS one Controlled trial quality: uncertain

127. A Case Study of Mycobacterium Avium Complex Infection Presenting with Acute Pericarditis. (Abstract)

A Case Study of Mycobacterium Avium Complex Infection Presenting with Acute Pericarditis. 24662622 2014 10 01 2014 08 09 1555-7162 127 8 2014 Aug The American journal of medicine Am. J. Med. A case study of Mycobacterium avium complex infection presenting with acute pericarditis. e9-e10 10.1016/j.amjmed.2014.03.014 S0002-9343(14)00268-X Moskowitz Robert S RS Maimonides Medical Center, Brooklyn, NY. Electronic address: rmosko@juno.com. Brickman Rebecca R Maimonides Medical Center, Brooklyn, NY (...) . Moeller Chaim C Maimonides Medical Center, Brooklyn, NY. eng Case Reports Letter 2014 03 22 United States Am J Med 0267200 0002-9343 AIM IM Aged Humans Male Mycobacterium avium Complex isolation & purification Mycobacterium avium-intracellulare Infection diagnosis pathology Pericarditis microbiology pathology 2013 12 19 2014 03 11 2014 03 11 2014 3 26 6 0 2014 3 26 6 0 2014 10 2 6 0 ppublish 24662622 S0002-9343(14)00268-X 10.1016/j.amjmed.2014.03.014

2014 American Journal of Medicine

128. Efficacy of Clarithromycin and Ethambutol for Mycobacterium avium Complex Pulmonary Disease. A Preliminary Study. (Abstract)

Efficacy of Clarithromycin and Ethambutol for Mycobacterium avium Complex Pulmonary Disease. A Preliminary Study. Patients with Mycobacterium avium complex pulmonary disease are frequently administered a combination of clarithromycin, ethambutol, and rifampicin. However, rifampicin is known to reduce the serum levels of clarithromycin. It remains unclear whether a reduction in clarithromycin serum levels influences the clinical outcome of the Mycobacterium avium complex pulmonary disease (...) treatment regimen.To compare a three-drug regimen (clarithromycin, ethambutol, and rifampicin) to a two-drug regimen (clarithromycin and ethambutol) for the treatment of Mycobacterium avium lung disease.In a preliminary open-label study, we randomly assigned newly diagnosed, but as-yet untreated, patients with disease caused by Mycobacterium avium complex without HIV infection to either the three-drug or the two-drug regimen for 12 months. The primary endpoint was the conversion of sputum cultures

2014 Annals of the American Thoracic Society Controlled trial quality: predicted high

129. Pulmonary nocardiosis caused by Nocardia cyriacigeorgica in patients with Mycobacterium avium complex lung disease: two case reports. Full Text available with Trip Pro

Pulmonary nocardiosis caused by Nocardia cyriacigeorgica in patients with Mycobacterium avium complex lung disease: two case reports. Pulmonary nocardiosis frequently occurs in immunocompromised hosts and in some immunocompetent hosts with chronic lung disease; however, few reports have described pulmonary nocardiosis with nontuberculous mycobacterial lung infection. Here we report for the first time two cases of pulmonary nocardiosis caused by Nocardia cyriacigeorgica associated (...) with Mycobacterium avium complex (MAC) lung disease caused by M. avium.Case 1 is that of a 72-year-old Japanese man with untreated MAC lung disease, who was diagnosed with rheumatoid arthritis and initiated on methotrexate. After 3 years of methotrexate therapy, the patient remained smear-negative and culture-positive for MAC, but also became smear-positive for Nocardia species. He received trimethoprim/sulfamethoxazole, and his symptoms and lung infiltrates improved. Case 2 is that of an immunocompetent 53-year

2014 BMC Infectious Diseases

130. Mycobacterium avium Complex Presenting as Lung Mass With Eosinophilic Pneumonia. (Abstract)

Mycobacterium avium Complex Presenting as Lung Mass With Eosinophilic Pneumonia.

2014 Chest

131. Monotherapy With Erythromycin for Mycobacterium avium Complex Pulmonary Disease. (Abstract)

Monotherapy With Erythromycin for Mycobacterium avium Complex Pulmonary Disease.

2014 Chest

132. Pulmonary Mycobacterium avium-intracellulare is the main driver of the rise in non-tuberculous mycobacteria incidence in England, Wales and Northern Ireland, 2007-2012. Full Text available with Trip Pro

Pulmonary Mycobacterium avium-intracellulare is the main driver of the rise in non-tuberculous mycobacteria incidence in England, Wales and Northern Ireland, 2007-2012. The incidence of non-tuberculous mycobacteria (NTM) isolation from humans is increasing worldwide. In England, Wales and Northern Ireland (EW&NI) the reported rate of NTM more than doubled between 1996 and 2006. Although NTM infection has traditionally been associated with immunosuppressed individuals or those with severe (...) culture positive isolates. Over the study period the incidence rose from 5.6/100,000 in 2007 to 7.6/100,000 in 2012 (p < 0.001). Of those with a known specimen type, 90 % were pulmonary, in whom incidence increased from 4.0/100,000 to 6.1/100,000 (p < 0.001). In extra-pulmonary specimens this fell from 0.6/100,000 to 0.4/100,000 (p < 0.001). The most frequently cultured organisms from individuals with pulmonary isolates were within the M. avium-intracellulare complex family (MAC). The incidence

2016 BMC Infectious Diseases

133. Urinary mycobacterium avium presenting as sterile pyuria Full Text available with Trip Pro

Urinary mycobacterium avium presenting as sterile pyuria A 65-year-old healthy woman presented with persistent, asymptomatic sterile pyuria detected by her family physician. While she did not have symptoms, the patient recounts that she has had cloudy urine for years. Cultures of the urine for bacteria showed no growth and no fungi were identified. First-morning urine samples were sent for both tuberculosis and nontuberculosis mycobacterium species testing. The culture grew genotypically (...) identified Mycobaterium avium complex (MAC). Mantoux skin testing was positive. No urological abnormalities were detected by ultrasound and computed tomography (CT) imaging of the urinary tract.

2016 Canadian Urological Association Journal

134. Pulmonary Mycobacterium avium infection demonstrating unusual lobar caseous pneumonia Full Text available with Trip Pro

Pulmonary Mycobacterium avium infection demonstrating unusual lobar caseous pneumonia Mycobacterium avium complex (MAC) infection is a major medical concern in Japan because of its increased prevalence and associated mortality. A common radiological feature in pulmonary MAC infection is a mixture of two basic patterns: fibrocavitary and nodular bronchiectatic; however, lobar consolidation is rare. We report an 83-year-old man with lobar caseous pneumonia caused by pulmonary MAC infection (...) . Radiological findings were predominantly composed of dense lobar consolidation and ground-glass opacity. A diagnosis was made in accordance with the clinical and microbiological criteria set by the American Thoracic Society. A histological examination of lung specimens obtained by using a bronchoscope revealed a caseous granulomatous inflammation with an appearance of Langhans cells. The patient was treated using combined mycobacterium chemotherapy with an initial positive response for 6 months; however

2016 Respirology case reports

135. Overexpression of RORγt Enhances Pulmonary Inflammation after Infection with Mycobacterium Avium Full Text available with Trip Pro

Overexpression of RORγt Enhances Pulmonary Inflammation after Infection with Mycobacterium Avium Mycobacterium avium complex (MAC) is the most common cause of nontuberculous mycobacterial disease in humans. The role of Th17 immunity in the pathogenesis of intracellular bacteria, such as MAC, is not currently understood. Transcription factor RAR-related orphan receptor gamma t (RORγt) is known as the master regulator for Th17 cell development. Here, we investigated the role of RORγt in host

2016 PloS one

136. Mycobacterium avium Infection of Nasal Septum in a Diabetic Adult: A Case Report Full Text available with Trip Pro

Mycobacterium avium Infection of Nasal Septum in a Diabetic Adult: A Case Report Mycobacterium avium complex (MAC) is primarily a pulmonary pathogen that affects individuals who are immune deficient or immunocompromised. In this report, we describe a very rare case of MAC infection clinically presenting as a nasal polyp in a patient with type 2 diabetes mellitus. This case illustrates an atypical anatomic location for MAC, the anterior nasal septum in nasal cavity, as well as often overlooked

2016 Head and neck pathology

137. Seroreactivity against Specific L5P Antigen from Mycobacterium avium subsp. paratuberculosis in Children at Risk for T1D Full Text available with Trip Pro

Seroreactivity against Specific L5P Antigen from Mycobacterium avium subsp. paratuberculosis in Children at Risk for T1D Although numerous environmental agents have been investigated over the years as possible triggers of type 1 diabetes (T1D), its causes remain unclear. We have already demonstrated an increased prevalence of antibodies against peptides derived from Mycobacterium avuim subsp. paratuberculosis (MAP) homologous to human zinc transporter 8 protein (ZnT8) and proinsulin in Italian (...) with a stable immunity against MAP antigens. The overall coincidence in positivity to L5P and the four MAP epitopes both in children at risk for T1D and HC exceeded 90%.MAP-derived homologs may cross-react with ZnT8 and proinsulin peptides inducing immune responses at a young age in subjects predisposed for T1D. Thus, L5P may have a diagnostic value to immediately indicate the presence of anti-MAP seroreactivity when evaluation of a more complex antibody status is not required. Almost complete coincidence

2016 PloS one

138. Mycobacterium avium MAV2054 protein induces macrophage apoptosis by targeting mitochondria and reduces intracellular bacterial growth Full Text available with Trip Pro

Mycobacterium avium MAV2054 protein induces macrophage apoptosis by targeting mitochondria and reduces intracellular bacterial growth Mycobacterium avium complex induces macrophage apoptosis. However, the M. avium components that inhibit or trigger apoptosis and their regulating mechanisms remain unclear. We recently identified the immunodominant MAV2054 protein by fractionating M. avium culture filtrate protein by multistep chromatography; this protein showed strong immuno-reactivity in M (...) . avium complex pulmonary disease and in patients with tuberculosis. Here, we investigated the biological effects of MAV2054 on murine macrophages. Recombinant MAV2054 induced caspase-dependent macrophage apoptosis. Enhanced reactive oxygen species production and JNK activation were essential for MAV2054-mediated apoptosis and MAV2054-induced interleukin-6, tumour necrosis factor, and monocyte chemoattractant protein-1 production. MAV2054 was targeted to the mitochondrial compartment of macrophages

2016 Scientific reports

139. Production of Multivalent Fluorescent Antisera for Identification of Organisms in the Mycobacterium avium-Mycobacterium intracellulare Complex Full Text available with Trip Pro

Production of Multivalent Fluorescent Antisera for Identification of Organisms in the Mycobacterium avium-Mycobacterium intracellulare Complex Antisera to ten strains of mycobacteria in the Mycobacterium avium-Mycobacterium intracellulare group were obtained by injecting rabbits with ultraviolet light-killed cells. The antisera were conjugated with fluorescein isothiocyanate and used in the direct fluorescent antibody test. Individual antisera reacted specifically with the mycobacterial

1974 Applied microbiology

140. Heat inactivation of Mycobacterium avium-Mycobacterium intracellulare complex organisms in aqueous suspension. Full Text available with Trip Pro

Heat inactivation of Mycobacterium avium-Mycobacterium intracellulare complex organisms in aqueous suspension. Isolants from swine and from humans representing serotypes 1, 2, 4, 8, and 10 of the Mycobacterium avium-Mycobacterium intracellulare complex were compared for heat tolerance in aqueous suspension. The most heat-resistant isolant found was a serovar 10 isolated from a human. This isolant was examined further to determine the rate of kill at various temperatures and pH's, the effect

1979 Applied and environmental microbiology

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