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Mycobacterium Avium Complex

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41. CLArithromycin Versus AZIthromycin in the Treatment of Mycobacterium Avium Complex (MAC) Lung Infections

CLArithromycin Versus AZIthromycin in the Treatment of Mycobacterium Avium Complex (MAC) Lung Infections CLArithromycin Versus AZIthromycin in the Treatment of Mycobacterium Avium Complex (MAC) Lung Infections - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. CLArithromycin Versus AZIthromycin in the Treatment of Mycobacterium Avium Complex (MAC) Lung Infections (CLAZI) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier

2017 Clinical Trials

42. Successful diagnosis of intestinal Mycobacterium avium complex infection in a kidney transplant recipient using nasogastric aspirate culture: A case report Full Text available with Trip Pro

Successful diagnosis of intestinal Mycobacterium avium complex infection in a kidney transplant recipient using nasogastric aspirate culture: A case report Intestinal Mycobacterium avium complex (MAC) infections are rare and can be challenging to diagnose. We describe a case of intestinal MAC infection in a kidney transplant recipient with 5 months of unexplained weight loss and abdominal pain who developed intestinal obstruction. Esophagoduodenoscopy with biopsies was performed

2017 Transplantation proceedings

43. Disseminated Mycobacterium avium-Intracellulare Complex Infection Presenting With Disseminated Intravascular Coagulation in an AIDS Patient Full Text available with Trip Pro

Disseminated Mycobacterium avium-Intracellulare Complex Infection Presenting With Disseminated Intravascular Coagulation in an AIDS Patient Disseminated Mycobacterium avium-intracellulare complex (MAC) infection is one of the relatively common opportunistic infections seen in severely immunocompromised AIDS patients. A constellation of clinical, laboratory, and pathological features involving multiple organ systems are often present in disseminated MAC infection but disseminated intravascular

2017 Journal of investigative medicine high impact case reports

44. Rapid pulmonary cavity formation caused by Mycobacterium avium complex in a chemotherapy patient Full Text available with Trip Pro

Rapid pulmonary cavity formation caused by Mycobacterium avium complex in a chemotherapy patient 29619321 2018 11 14 2214-2509 11 2018 IDCases IDCases Rapid pulmonary cavity formation caused by Mycobacterium avium complex in a chemotherapy patient. 39-40 10.1016/j.idcr.2017.12.007 Nakamura Ryo R Division of General Internal Medicine, Hashimoto Municipal Hospital, Hashimoto, Japan. Hashimoto Tadayuki T Division of General Internal Medicine, Hashimoto Municipal Hospital, Hashimoto, Japan. eng (...) Journal Article 2017 12 24 Netherlands IDCases 101634540 2214-2509 Chemotherapy Immunosuppressed patient Mycobacterium avium complex Pulmonary cavity lesion 2017 12 20 2017 12 21 2017 12 21 2018 4 6 6 0 2018 4 6 6 0 2018 4 6 6 1 epublish 29619321 10.1016/j.idcr.2017.12.007 S2214-2509(17)30249-4 PMC5881441 Arch Intern Med. 1976 Jan;136(1):67-70 1247337 Emerg Infect Dis. 2010 Oct;16(10):1576-83 20875283 Eur Respir J. 2017 Mar 8;49(3):null 28275170 Respir Investig. 2017 Jan;55(1):45-50 28012493 BMC Pulm

2017 IDCases

45. Pulmonary Mycobacterium Avium-Intracellulare Complex Infection in an Infant: A Silent and Coincidental Finding Full Text available with Trip Pro

Pulmonary Mycobacterium Avium-Intracellulare Complex Infection in an Infant: A Silent and Coincidental Finding An 11-month-old healthy infant girl was noted to have left lower lobe (LLL) opacities on chest X-ray (CXR) after developing desaturations during an elective cochlear implant surgery. Repeat CXR 10 days later revealed hyperexpansion of the left lung and persistent LLL opacity. Chest computerized tomography revealed enlarged mediastinal lymph nodes, left mainstem bronchial obstruction (...) , and nodular opacities. Bronchoscopic biopsy of the endobronchial tissue revealed multiple necrotizing granulomas and grew Mycobacterium avium-intracellulare, Streptococcus viridans, and Actinomyces odontolyticus. This case illustrates the potential for significant mediastinal lymphadenopathy, and endobronchial and parenchymal lesions caused by nontuberculous mycobacteria, which can present insidiously and without respiratory symptoms in otherwise healthy infants, despite advanced pulmonary disease.

2017 Pediatric allergy, immunology, and pulmonology

46. A case of bilateral hilar and mediastinal lymphadenopathy developing during treatment for Mycobacterium avium complex Full Text available with Trip Pro

A case of bilateral hilar and mediastinal lymphadenopathy developing during treatment for Mycobacterium avium complex We report a rare case of an immunocompetent patient with Mycobacterium avium complex (MAC) disease in which bilateral hilar lymphadenopathy developed during anti-MAC treatment. This case indicates that Propionibacterium acnes would be present and might be a cause of sarcoidosis even in patients with MAC.

2017 Clinical Case Reports

47. Disseminated Mycobacterium Avium Complex in an Adolescent with Perinatally-Acquired HIV Infection Full Text available with Trip Pro

Disseminated Mycobacterium Avium Complex in an Adolescent with Perinatally-Acquired HIV Infection Mycobacterium avium complex (MAC) is the most frequent nontuberculous mycobacteria implicated in opportunistic infections that define acquired immunodeficiency syndrome. With highly active antiretroviral therapy, disseminated MAC (dMAC) has become a rare entity. This unique case of dMAC was diagnosed in an adolescent with newly diagnosed perinatally-acquired HIV infection whose initial CD4 cell

2017 Infectious disease reports

48. Incidence, Long-Term Outcomes, and Healthcare Utilization of Patients With Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome and Disseminated Mycobacterium avium Complex From 1992–2015 Full Text available with Trip Pro

Incidence, Long-Term Outcomes, and Healthcare Utilization of Patients With Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome and Disseminated Mycobacterium avium Complex From 1992–2015 Despite the advent of combination antiretroviral therapy (cART), patients with human immunodeficiency virus (HIV) continue to develop late-stage complications including acquired immune deficiency syndrome (AIDS), disseminated Mycobacterium avium complex (DMAC), and death.We performed (...) . Those with established HIV had a median time from HIV diagnosis to DMAC diagnosis of 7 years and were more likely to be black, rehospitalized in the 6 months after DMAC diagnosis, and die in the long term.Disseminated Mycobacterium avium complex continues to be a lethal diagnosis in the cART era, disproportionately afflicts minority populations, and reflects both delayed entry into care and failure to consistently engage care.

2017 Open forum infectious diseases

49. Characteristics of Mycobacterium avium complex (MAC) pulmonary disease in previously treated lung cancer patients Full Text available with Trip Pro

Characteristics of Mycobacterium avium complex (MAC) pulmonary disease in previously treated lung cancer patients Mycobacterium avium complex (MAC) is responsible for a large portion of non-tuberculous mycobacterial (NTM) infections worldwide. Host factors such as active malignancy, immunosuppression, chronic obstructive pulmonary disease (COPD) and bronchiectasis increase the risk of MAC infection. However, the relationship between previously treated lung cancer with subsequent development

2017 Respiratory Medicine Case Reports

50. Small bowel obstruction due to mesenteric abscess caused by Mycobacterium avium complex in an HIV patient: a case report and literature review Full Text available with Trip Pro

Small bowel obstruction due to mesenteric abscess caused by Mycobacterium avium complex in an HIV patient: a case report and literature review Small bowel obstruction in HIV patients is reportedly caused by inflammatory pseudotumor, Kaposi's sarcoma, cryptococcal lymphadenopathy and intestinal tuberculosis. The incidence of Mycobacterium avium complex (MAC) infection in HIV patients is 3% for CD4 cell count of 100-199 /mm3. MAC causing small bowel obstruction is rarely reported

2017 Journal of surgical case reports

51. A novel presentation of Mycobacterium avium complex in a recipient of a lung transplant: a case report Full Text available with Trip Pro

A novel presentation of Mycobacterium avium complex in a recipient of a lung transplant: a case report Lung transplantation remains an important potential therapeutic option for end-stage lung disease. It can improve quality of life and in some cases be a life-lengthening therapy. Despite the possible benefits, there are also many potential complications following transplantation. Here we describe a novel presentation of nontuberculous mycobacterium manifesting as an endobronchial mass (...) mycobacterium pulmonary disease is common post lung transplant and risk factors are related to immunosuppression and history of structural lung disease. Mycobacterium avium complex presenting as an endobronchial lesion in a patient post lung transplant is a novel presentation.

2017 Journal of medical case reports

52. Hemophagocytic lymphohistiocytosis (HLH): Elusive diagnosis of disseminated Mycobacterium avium complex infection Full Text available with Trip Pro

Hemophagocytic lymphohistiocytosis (HLH): Elusive diagnosis of disseminated Mycobacterium avium complex infection Hemophagocytic lymphohistiocytosis (HLH) is a clinical syndrome of hyperinflammation leading to an uncontrolled and ineffective immune response, associated with high mortality.A 26-year-old woman with acute lymphoblastic leukemia, 8 months in remission, was found to have HLH. Without any improvement, stem cell transplantation was considered. Then, Mycobacterium avium complex (MAC

2017 Germs

53. Attenuation of lymphocyte immune responses during Mycobacterium avium complex-induced lung disease due to increasing expression of programmed death-1 on lymphocytes Full Text available with Trip Pro

Attenuation of lymphocyte immune responses during Mycobacterium avium complex-induced lung disease due to increasing expression of programmed death-1 on lymphocytes Mycobacterium avium complex-induced lung disease (MAC-LD) becomes important due to its increasing prevalence. Attenuated cellular immunity associated with programmed cell death (PD)-1 may play a pathophysiological role in MAC-LD but lacks of investigation. We enrolled 80 participants in this prospective study, including 50 with MAC

2017 Scientific reports

54. Levels of Antibody against Glycopeptidolipid Core as a Marker for Monitoring Treatment Response in Mycobacterium avium Complex Pulmonary Disease: a Prospective Cohort Study Full Text available with Trip Pro

Levels of Antibody against Glycopeptidolipid Core as a Marker for Monitoring Treatment Response in Mycobacterium avium Complex Pulmonary Disease: a Prospective Cohort Study The diagnosis of Mycobacterium avium complex pulmonary disease (MAC-PD) is sometimes complicated and time-consuming. A serodiagnostic kit that measures the serum levels of IgA antibodies against the glycopeptidolipid (GPL) core is commercially available and has good diagnostic accuracy for MAC-PD. However, the significance

2017 Journal of clinical microbiology

55. Infection Sources of a Common Non-tuberculous Mycobacterial Pathogen, Mycobacterium avium Complex Full Text available with Trip Pro

Infection Sources of a Common Non-tuberculous Mycobacterial Pathogen, Mycobacterium avium Complex Numerous studies have revealed a continuous increase in the worldwide incidence and prevalence of non-tuberculous mycobacteria (NTM) diseases, especially pulmonary Mycobacterium avium complex (MAC) diseases. Although it is not clear why NTM diseases have been increasing, one possibility is an increase of mycobacterial infection sources in the environment. Thus, in this review, we focused (...) with frequent human contact, such as soil and bathrooms, indicating that individuals may carry NTM organisms that concomitantly attach to their household belongings. To explore the mechanisms associated with the global spread of infection and MAC transmission routes, an epidemiological population-wide genotyping survey would be very useful. A good example of the power of genotyping comes from M. avium subsp. hominissuis, where close genetic relatedness was found between isolates of it from European patients

2017 Frontiers in medicine

56. Impact of chronic Pseudomonas aeruginosa infection on health-related quality of life in Mycobacterium avium complex lung disease. Full Text available with Trip Pro

Impact of chronic Pseudomonas aeruginosa infection on health-related quality of life in Mycobacterium avium complex lung disease. In bronchiectasis patients, chronic Pseudomonas aeruginosa (PA) infection has been associated with worse health-related quality of life (HRQL), but little is known about Mycobacterium avium complex lung disease (MACLD) patients in this context. This study aimed to evaluate HRQL and investigate the impact of chronic PA infection in MACLD patients.This cross-sectional

2017 BMC pulmonary medicine

57. Outcomes of <i>Mycobacterium avium</i> complex lung disease based on clinical phenotype. Full Text available with Trip Pro

Outcomes of Mycobacterium avium complex lung disease based on clinical phenotype. The effect of the clinical phenotype of Mycobacterium avium complex (MAC) lung disease on treatment outcome and redevelopment of nontuberculous mycobacterial (NTM) lung disease after treatment completion has not been studied systematically.We evaluated 481 treatment-naïve patients with MAC lung disease who underwent antibiotic treatment for ≥12 months between January 2002 and December 2013.Out of 481

2017 European Respiratory Journal

58. Natural history of <i>Mycobacterium avium</i> complex lung disease in untreated patients with stable course. Full Text available with Trip Pro

Natural history of Mycobacterium avium complex lung disease in untreated patients with stable course. Little is known about the long-term natural history of Mycobacterium avium complex lung disease (MAC-LD) in untreated patients with stable course.The aim of this study was to investigate the natural course of untreated stable MAC-LD, with a focus on factors associated with clinical deterioration, spontaneous sputum conversion and prognosis.Of 488 patients diagnosed with MAC-LD between

2017 European Respiratory Journal

59. Tedizolid is highly bactericidal in the treatment of pulmonary Mycobacterium avium complex disease. Full Text available with Trip Pro

Tedizolid is highly bactericidal in the treatment of pulmonary Mycobacterium avium complex disease. To determine if tedizolid is effective for pulmonary Mycobacterium avium complex (MAC) disease, and to use pharmacokinetics/pharmacodynamics to design optimal doses.We performed an exposure-response experiment in the hollow-fibre system model of intracellular MAC (HFS-MAC). We mimicked the tedizolid concentration-time profiles achieved in the lungs of patients treated once daily for 28 days

2017 Journal of Antimicrobial Chemotherapy

60. A 'shock and awe' thioridazine and moxifloxacin combination-based regimen for pulmonary Mycobacterium avium-intracellulare complex disease. Full Text available with Trip Pro

A 'shock and awe' thioridazine and moxifloxacin combination-based regimen for pulmonary Mycobacterium avium-intracellulare complex disease. To develop a thioridazine/moxifloxacin-based combination regimen for treatment of pulmonary infection due to Mycobacterium avium-intracellulare complex (MAC) that kills bacteria faster than the standard treatment regimen.Monocytes were infected with MAC and inoculated into the hollow-fibre system model for pulmonary MAC disease (HFS-MAC). We co-administered

2017 Journal of Antimicrobial Chemotherapy

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