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Mycobacterium Avium Complex

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221. Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers Full Text available with Trip Pro

spectrometry (UHPLC-ESI-Q-TOF-MS) platform, we characterized the extracellular metabolomes of culture supernatant of nine MTB strains and nine non-tuberculous Mycobacterium (NTM) strains (four M. avium complex, one M. bovis Bacillus Calmette-Guérin (BCG), one M. chelonae, one M. fortuitum and two M. kansasii). Principal component analysis readily distinguished the metabolomes between MTB and NTM. Using multivariate and univariate analysis, 24 metabolites with significantly higher levels in MTB were (...) Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers Although previous studies have reported the use of metabolomics for Mycobacterium species differentiation, little is known about the potential of extracellular metabolites of Mycobacterium tuberculosis (MTB) as specific biomarkers. Using an optimized ultrahigh performance liquid chromatography-electrospray ionization-quadruple time of flight-mass

2015 Emerging Microbes & Infections

222. Performance Assessment of the BluePoint MycoID Plus Kit for Identification of Mycobacterium tuberculosis, Including Rifampin- and Isoniazid-resistant Isolates, and Nontuberculous Mycobacteria Full Text available with Trip Pro

were 99.7%, 99.3%, 99.0% and 99.8%, respectively. For rifampicin-resistant MTB identification, the sensitivity, specificity, PPV, and NPV of the kit were 100.0%, 99.4%, 91.3%, and 100.0%, respectively, while the corresponding values of isoniazid-resistant MTB identification were 82.6%, 99.4%, 95.0%, and 97.6%, respectively. In identifying specific NTM species, the kit correctly identified 99.3% of M. abscessus (147/148) complex, 100% of M. fortuitum (32/32), M. gordonae (38/38), M. avium (39/39), M (...) . intracellulare (90/90), M. kansasii (36/36), and M. avium complex species other than M. avium and M. intracellulare (94/94). In conclusions, the diagnostic value of the BluePoint MycoID plus kit was superior to culture method for recoveries and identification of NTM to species level. In addition, the diagnostic accuracy of BluePoint MycoID plus kit in MTB identification was similar to conventional culture method with high accuracy rate of rifampicin-resistant M. tuberculosis identification.

2015 PloS one

223. Evaluation of the Ribosomal Protein S1 Gene (rpsA) as a Novel Biomarker for Mycobacterium Species Identification Full Text available with Trip Pro

Evaluation of the Ribosomal Protein S1 Gene (rpsA) as a Novel Biomarker for Mycobacterium Species Identification To evaluate the resolution and reliability of the rpsA gene, encoding ribosomal protein S1, as a novel biomarker for mycobacteria species identification.A segment of the rpsA gene (565 bp) was amplified by PCR from 42 mycobacterial reference strains, 172 nontuberculosis mycobacteria clinical isolates, and 16 M. tuberculosis complex clinical isolates. The PCR products were sequenced (...) and aligned by using the multiple alignment algorithm in the MegAlign package (DNASTAR) and the MEGA program. A phylogenetic tree was constructed by the neighbor-joining method.Comparative sequence analysis of the rpsA gene provided the basis for species differentiation within the genus Mycobacterium. Slow- and rapid-growing groups of mycobacteria were clearly separated, and each mycobacterial species was differentiated as a distinct entity in the phylogenetic tree. The sequences discrepancy was obvious

2015 BioMed research international

224. A New Screen for Tuberculosis Drug Candidates Utilizing a Luciferase-Expressing Recombinant Mycobacterium bovis Bacillus Calmette-Guéren Full Text available with Trip Pro

, and 2 XDR-strains, respectively. Its efficacy was specific to acid-fast bacterium except for the Mycobacterium avium intracellular complex. Mass spectrometry and nuclear magnetic resonance analyses revealed that the active substance of 1904-1 was cyclomarin A. To confirm the mode of action of the 1904-1-derived compound, resistant BCG clones were used. Whole genome DNA sequence analysis showed that these clones contained a mutation in the clpc gene which encodes caseinolytic protein, an essential (...) A New Screen for Tuberculosis Drug Candidates Utilizing a Luciferase-Expressing Recombinant Mycobacterium bovis Bacillus Calmette-Guéren Tuberculosis (TB) is a serious infectious disease caused by a bacterial pathogen. Mortality from tuberculosis was estimated at 1.5 million deaths worldwide in 2013. Development of new TB drugs is needed to not only to shorten the medication period but also to treat multi-drug resistant and extensively drug-resistant TB. Mycobacterium tuberculosis (Mtb) grows

2015 PloS one

225. Improvement in Quality of Life Following Therapy for Mycobacterium abscessus Group Lung Infection: A Prospective Cohort Study. (Abstract)

months were evaluated.Patients were 85% female and 94% white, with a mean age of 65 years. Nine (20%) had a genetic diagnosis of cystic fibrosis (none F508del homozygous). Coinfection with Mycobacterium avium complex occurred in 28% and Pseudomonas in 26%. Chest CT imaging universally indicated bronchiectasis and nodules; 51% had lung cavities. Treatment included a mean of 17 months of antibiotics, and lung resection in 34%. Seventeen patients with M. avium complex (36%) and one with Mycobacterium (...) Improvement in Quality of Life Following Therapy for Mycobacterium abscessus Group Lung Infection: A Prospective Cohort Study. Mycobacterium abscessus group lung infection is characterized by low cure rates. Improvement in quality of life may be a reasonable treatment goal.The objective of this study was to evaluate change in quality of life in response to therapy, predictors of improvement in quality of life, and association of quality of life with traditional outcome measures.Forty-seven

2015 Annals of the American Thoracic Society

226. Draft Genome Sequence of Mycobacterium vulneris DSM 45247T Full Text available with Trip Pro

Draft Genome Sequence of Mycobacterium vulneris DSM 45247T We report the draft genome sequence of Mycobacterium vulneris DSM 45247(T) strain, an emerging, opportunistic pathogen of the Mycobacterium avium complex. The genome described here is composed of 6,981,439 bp (with a G+C content of 67.14%) and has 6,653 protein-coding genes and 84 predicted RNA genes.

2014 Genome Announcements

227. Disseminated Cutaneous Infection Caused by Mycobacterium colombiense. Full Text available with Trip Pro

Qiulin Q Tang Meiyu M Wang Hong-Sheng HS eng Case Reports Journal Article Research Support, Non-U.S. Gov't Sweden Acta Derm Venereol 0370310 0001-5555 0 Anti-Bacterial Agents IM Adolescent Anti-Bacterial Agents therapeutic use Drug Therapy, Combination Humans Male Mycobacterium avium Complex drug effects isolation & purification Mycobacterium avium-intracellulare Infection diagnosis drug therapy microbiology Skin drug effects microbiology pathology Skin Diseases, Bacterial diagnosis drug therapy (...) Disseminated Cutaneous Infection Caused by Mycobacterium colombiense. 24573766 2015 07 07 2014 10 23 1651-2057 94 6 2014 Nov Acta dermato-venereologica Acta Derm. Venereol. Disseminated cutaneous infection caused by Mycobacterium colombiense. 727-8 10.2340/00015555-1828 Gao Wei W Institute of Dermatology, Chinese Academy of Medical Sciences, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, 12, Jiangwangmiao Road, Nanjing 210042, China. Chen Hao H Jiang Haiqing H Wang

2014 Acta Dermato-Venereologica

228. TGF-β-Mediated Sustained ERK1/2 Activity Promotes the Inhibition of Intracellular Growth of Mycobacterium avium in Epithelioid Cells Surrogates Full Text available with Trip Pro

TGF-β-Mediated Sustained ERK1/2 Activity Promotes the Inhibition of Intracellular Growth of Mycobacterium avium in Epithelioid Cells Surrogates Transforming growth factor beta (TGF-β) has been implicated in the pathogenesis of several diseases including infection with intracellular pathogens such as the Mycobacterium avium complex. Infection of macrophages with M. avium induces TGF-β production and neutralization of this cytokine has been associated with decreased intracellular bacterial (...) growth. We have previously demonstrated that epithelioid cell surrogates (ECs) derived from primary murine peritoneal macrophages through a process of differentiation induced by IL-4 overlap several features of epithelioid cells found in granulomas. In contrast to undifferentiated macrophages, ECs produce larger amounts of TGF-β and inhibit the intracellular growth of M. avium. Here we asked whether the levels of TGF-β produced by ECs are sufficient to induce a self-sustaining autocrine TGF-β

2011 PloS one

229. Mycobacterium Kansasii (Diagnosis)

, has been reported in other countries, including Israel, Korea, [ ] Portugal, France, and Japan. Based on the analysis of identification data received by the NTM-Network European Trials Group (NET) for 20,182 patients in 30 countries across 6 continents in 2008, M kansasii was the sixth most common NTM isolated from pulmonary samples. Mycobacterium avium complex (MAC) was the most common NTM in most countries. [ ] Mortality/Morbidity The likelihood of mortality associated with M kansasii infection (...) and management of disease caused by M. avium complex, M. kansasii, and other mycobacteria. Clin Chest Med . 1989 Sep. 10(3):431-43. . Fishman JE, Schwartz DS, Sais GJ. Mycobacterium kansasii pulmonary infection in patients with AIDS: spectrum of chest radiographic findings. Radiology . 1997 Jul. 204(1):171-5. . O'Brien RJ. The epidemiology of nontuberculous mycobacterial disease. Clin Chest Med . 1989 Sep. 10(3):407-18. . Wolinsky E. Mycobacterial diseases other than tuberculosis. Clin Infect Dis . 1992 Jul

2014 eMedicine.com

230. Mycobacterium Xenopi (Follow-up)

granuloma because of infection with a novel mycobacterial species in an old FIV-positive cat. J Small Anim Pract . 2009 Mar. 50(3):143-6. . Carrillo MC1, Patsios D, Wagnetz U, Jamieson F, Marras TK. Comparison of the Spectrum of Radiologic and Clinical Manifestations of Pulmonary Disease Caused by Mycobacterium avium Complex and Mycobacterium xenopi. Can Assoc Radiol J . December 2013. 47-48. . Al Jarad N, Demertzis P, Jones DJ, et al. Comparison of characteristics of patients and treatment outcome (...) SM, Sobel H. Mycobacterium xenopi infection in a patient with acquired immunodeficiency syndrome. Chest . 1984 Jul. 86(1):145-7. . First randomised trial of treatments for pulmonary disease caused by M avium intracellulare, M malmoense, and M xenopi in HIV negative patients: rifampicin, ethambutol and isoniazid versus rifampicin and ethambutol. Thorax . 2001 Mar. 56(3):167-72. . Griffith DE, Girard WM, Wallace RJ Jr. Clinical features of pulmonary disease caused by rapidly growing mycobacteria

2014 eMedicine.com

231. Mycobacterium Kansasii (Follow-up)

A, Levell N, Munro C. Cutaneous Mycobacterium kansasii infection: case report and review. Clin Infect Dis . 1995 Apr. 20(4):812-7. . Davidson PT. The diagnosis and management of disease caused by M. avium complex, M. kansasii, and other mycobacteria. Clin Chest Med . 1989 Sep. 10(3):431-43. . Fishman JE, Schwartz DS, Sais GJ. Mycobacterium kansasii pulmonary infection in patients with AIDS: spectrum of chest radiographic findings. Radiology . 1997 Jul. 204(1):171-5. . O'Brien RJ. The epidemiology (...) Mycobacterium Kansasii (Follow-up) Mycobacterium Kansasii Treatment & Management: Medical Care, Surgical Care, Consultations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjIzMjMwLXRyZWF0bWVudA== processing

2014 eMedicine.com

232. Mycobacterium Xenopi (Overview)

-tuberculous mycobacteria in the sputum of HIV-infected patients: infection or colonization?. Int J STD AIDS . 2009 Mar. 20(3):193-5. . De Lorenzi D, Solano-Gallego L. Tracheal granuloma because of infection with a novel mycobacterial species in an old FIV-positive cat. J Small Anim Pract . 2009 Mar. 50(3):143-6. . Carrillo MC1, Patsios D, Wagnetz U, Jamieson F, Marras TK. Comparison of the Spectrum of Radiologic and Clinical Manifestations of Pulmonary Disease Caused by Mycobacterium avium Complex (...) al. Clinical and radiographic manifestations of uncommon pulmonary nontuberculous mycobacterial disease in AIDS patients. Chest . 1998 Jul. 114(1):138-45. . Eng RH, Forrester C, Smith SM, Sobel H. Mycobacterium xenopi infection in a patient with acquired immunodeficiency syndrome. Chest . 1984 Jul. 86(1):145-7. . First randomised trial of treatments for pulmonary disease caused by M avium intracellulare, M malmoense, and M xenopi in HIV negative patients: rifampicin, ethambutol and isoniazid

2014 eMedicine.com

233. Mycobacterium Kansasii (Overview)

, has been reported in other countries, including Israel, Korea, [ ] Portugal, France, and Japan. Based on the analysis of identification data received by the NTM-Network European Trials Group (NET) for 20,182 patients in 30 countries across 6 continents in 2008, M kansasii was the sixth most common NTM isolated from pulmonary samples. Mycobacterium avium complex (MAC) was the most common NTM in most countries. [ ] Mortality/Morbidity The likelihood of mortality associated with M kansasii infection (...) and management of disease caused by M. avium complex, M. kansasii, and other mycobacteria. Clin Chest Med . 1989 Sep. 10(3):431-43. . Fishman JE, Schwartz DS, Sais GJ. Mycobacterium kansasii pulmonary infection in patients with AIDS: spectrum of chest radiographic findings. Radiology . 1997 Jul. 204(1):171-5. . O'Brien RJ. The epidemiology of nontuberculous mycobacterial disease. Clin Chest Med . 1989 Sep. 10(3):407-18. . Wolinsky E. Mycobacterial diseases other than tuberculosis. Clin Infect Dis . 1992 Jul

2014 eMedicine.com

234. Mycobacterium Xenopi (Treatment)

. . Carrillo MC1, Patsios D, Wagnetz U, Jamieson F, Marras TK. Comparison of the Spectrum of Radiologic and Clinical Manifestations of Pulmonary Disease Caused by Mycobacterium avium Complex and Mycobacterium xenopi. Can Assoc Radiol J . December 2013. 47-48. . Al Jarad N, Demertzis P, Jones DJ, et al. Comparison of characteristics of patients and treatment outcome for pulmonary non-tuberculous mycobacterial infection and pulmonary tuberculosis. Thorax . 1996 Feb. 51(2):137-9. . American Thoracic Society (...) Mycobacterium Xenopi (Treatment) Mycobacterium Xenopi Treatment & Management: Medical Care, Surgical Care, Consultations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjIzNDgwLXRyZWF0bWVudA== processing

2014 eMedicine.com

235. Mycobacterium Kansasii (Treatment)

A, Levell N, Munro C. Cutaneous Mycobacterium kansasii infection: case report and review. Clin Infect Dis . 1995 Apr. 20(4):812-7. . Davidson PT. The diagnosis and management of disease caused by M. avium complex, M. kansasii, and other mycobacteria. Clin Chest Med . 1989 Sep. 10(3):431-43. . Fishman JE, Schwartz DS, Sais GJ. Mycobacterium kansasii pulmonary infection in patients with AIDS: spectrum of chest radiographic findings. Radiology . 1997 Jul. 204(1):171-5. . O'Brien RJ. The epidemiology (...) Mycobacterium Kansasii (Treatment) Mycobacterium Kansasii Treatment & Management: Medical Care, Surgical Care, Consultations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjIzMjMwLXRyZWF0bWVudA== processing

2014 eMedicine.com

236. Mycobacterium Xenopi (Diagnosis)

-tuberculous mycobacteria in the sputum of HIV-infected patients: infection or colonization?. Int J STD AIDS . 2009 Mar. 20(3):193-5. . De Lorenzi D, Solano-Gallego L. Tracheal granuloma because of infection with a novel mycobacterial species in an old FIV-positive cat. J Small Anim Pract . 2009 Mar. 50(3):143-6. . Carrillo MC1, Patsios D, Wagnetz U, Jamieson F, Marras TK. Comparison of the Spectrum of Radiologic and Clinical Manifestations of Pulmonary Disease Caused by Mycobacterium avium Complex (...) al. Clinical and radiographic manifestations of uncommon pulmonary nontuberculous mycobacterial disease in AIDS patients. Chest . 1998 Jul. 114(1):138-45. . Eng RH, Forrester C, Smith SM, Sobel H. Mycobacterium xenopi infection in a patient with acquired immunodeficiency syndrome. Chest . 1984 Jul. 86(1):145-7. . First randomised trial of treatments for pulmonary disease caused by M avium intracellulare, M malmoense, and M xenopi in HIV negative patients: rifampicin, ethambutol and isoniazid

2014 eMedicine.com

237. Mycobacterium yongonense in Pulmonary Disease, Italy Full Text available with Trip Pro

Infect Dis 9508155 1080-6040 IM Aged Female Genes, Bacterial Humans Italy Molecular Sequence Data Mycobacterium avium Complex genetics isolation & purification Mycobacterium avium-intracellulare Infection diagnosis Sequence Analysis, DNA Tuberculosis, Pulmonary diagnosis Italy MAC Mycobacterium avium complex Mycobacterium yongonense bacteria cavitary pulmonary disease pulmonary disease respiratory infections tuberculosis and other mycobacteria 2013 11 12 6 0 2013 11 12 6 0 2014 6 10 6 0 ppublish (...) Mycobacterium yongonense in Pulmonary Disease, Italy 24206761 2014 06 09 2018 11 13 1080-6059 19 11 2013 Nov Emerging infectious diseases Emerging Infect. Dis. Mycobacterium yongonense in pulmonary disease, Italy. 1902-4 10.3201/eid1911.130911 Tortoli Enrico E Mariottini Alessandro A Pierotti Piera P Simonetti Tullia M TM Rossolini Gian Maria GM eng GENBANK KF224989 KF224990 KF224991 KF224992 KF224993 KF224994 KF224995 KF224996 KF224997 KF224998 KF224999 Case Reports Letter United States Emerg

2013 Emerging Infectious Diseases

238. Complete Genome Sequence of Mycobacterium intracellulare Strain ATCC 13950T Full Text available with Trip Pro

Complete Genome Sequence of Mycobacterium intracellulare Strain ATCC 13950T Here we report the first complete genome sequence of Mycobacterium intracellulare ATCC 13950(T), a Mycobacterium avium complex (MAC) strain. This genome sequence will serve as a valuable reference for understanding the epidemiologic, biological, and pathogenic aspects of the disparity between MAC members.

2012 Journal of bacteriology

239. Massive gene acquisitions in Mycobacterium indicus pranii provide a perspective on mycobacterial evolution Full Text available with Trip Pro

significance. Evolutionarily, it is the progenitor of opportunistic pathogens belonging to M. avium complex and is endowed with features that place it between saprophytic and pathogenic species. Herein, we have sequenced the complete MIP genome to understand its unique life style, basis of immunomodulation and habitat diversification in mycobacteria. As a case of massive gene acquisitions, 50.5% of MIP open reading frames (ORFs) are laterally acquired. We show, for the first time for Mycobacterium (...) Massive gene acquisitions in Mycobacterium indicus pranii provide a perspective on mycobacterial evolution Understanding the evolutionary and genomic mechanisms responsible for turning the soil-derived saprophytic mycobacteria into lethal intracellular pathogens is a critical step towards the development of strategies for the control of mycobacterial diseases. In this context, Mycobacterium indicus pranii (MIP) is of specific interest because of its unique immunological and evolutionary

2012 Nucleic acids research

240. Characterization of a Mycobacterium chimaera variant. Full Text available with Trip Pro

within the Mycobacterium avium complex (MAC). However, the cell-wall mycolic acid pattern, analysed by HPLC, and the partial sequences of the hsp65 and rpoB genes were identical to those of M. chimaera. We concluded that the isolates represent a novel variant of M. chimaera. The results of this analysis have led us to question the currently used methods of species definition for members of the genus Mycobacterium, which are based largely on 16S rRNA or rpoB gene sequencing. Definitions based (...) Characterization of a Mycobacterium chimaera variant. In this study, nonchromogenic mycobacteria were isolated from pulmonary samples of three patients in the Netherlands. All isolates had identical, unique 16S rRNA gene and 16S-23S ITS sequences, which were closely related to those of Mycobacterium chimaera and Mycobacterium marseillense. The biochemical features of the isolates differed slightly from those of M. chimaera, suggesting that the isolates may represent a possible separate species

2012 Journal of Medical Microbiology

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