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Mycobacterium Avium Complex

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181. Mycobacterium Avium-Intracellulare Infection (Overview)

preexisting lung disease. Sputum culture grew Mycobacterium avium complex. The diagnosis was Lady Windermere syndrome. An interesting case reported in 2012 involved in a child with complete interferon (IFN)–γ receptor-1 deficiency interrupting the interleukin (IL)–12/IFN-γ pathway and resulting in granulomatous skin papules and plaques and lower extremity edema. In this child, recurrent infection with MAI, Mycobacterium tuberculosis , Mycobacterium bovis , and Mycobacterium fortuitum all occurred. [ ] MAI (...) complex involving osteomyelitis, DRESS syndrome has been reported to occur. [ ] MAI olecranon bursitis resolving without surgical or antimicrobial intervention has been noted to occur. [ ] Previous Next: Workup Considerations Primary cutaneous Mycobacterium avium-intracellulare (MAI, or MAC) infection is rare, but it does not necessarily mandate a workup for immunosuppression. Biopsy should be performed for suspected dermatologic manifestations of MAI infection. Tissue samples of cutaneous lesions may

2014 eMedicine.com

182. Mycobacterium Avium-Intracellulare (Follow-up)

Mycobacterium Avium-Intracellulare (Follow-up) Mycobacterium Avium Complex (MAC) (Mycobacterium Avium-Intracellulare [MAI]) Treatment & Management: Approach Considerations, Pulmonary MAC Infection in Immunocompetent Patients, Disseminated MAC Infection in Patients with AIDS Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px (...) /getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjIyNjY0LXRyZWF0bWVudA== processing > Mycobacterium Avium Complex (MAC) (Mycobacterium Avium-Intracellulare [MAI]) Treatment & Management Updated: Oct 18, 2018 Author: Janak Koirala, MD, MPH, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD Share Email Print Feedback Close Sections Sections Mycobacterium Avium Complex (MAC) (Mycobacterium Avium-Intracellulare [MAI]) Treatment Approach Considerations

2014 eMedicine.com

183. Mycobacterium Avium-Intracellulare Infection (Follow-up)

preexisting lung disease. Sputum culture grew Mycobacterium avium complex. The diagnosis was Lady Windermere syndrome. An interesting case reported in 2012 involved in a child with complete interferon (IFN)–γ receptor-1 deficiency interrupting the interleukin (IL)–12/IFN-γ pathway and resulting in granulomatous skin papules and plaques and lower extremity edema. In this child, recurrent infection with MAI, Mycobacterium tuberculosis , Mycobacterium bovis , and Mycobacterium fortuitum all occurred. [ ] MAI (...) complex involving osteomyelitis, DRESS syndrome has been reported to occur. [ ] MAI olecranon bursitis resolving without surgical or antimicrobial intervention has been noted to occur. [ ] Previous Next: Workup Considerations Primary cutaneous Mycobacterium avium-intracellulare (MAI, or MAC) infection is rare, but it does not necessarily mandate a workup for immunosuppression. Biopsy should be performed for suspected dermatologic manifestations of MAI infection. Tissue samples of cutaneous lesions may

2014 eMedicine.com

184. Pathogenicity of Mycolicibacterium phlei, a non-pathogenic nontuberculous mycobacterium in an immunocompetent host carrying anti-interferon gamma autoantibodies: a case report. Full Text available with Trip Pro

Pathogenicity of Mycolicibacterium phlei, a non-pathogenic nontuberculous mycobacterium in an immunocompetent host carrying anti-interferon gamma autoantibodies: a case report. Mycolicibacterium phlei (M. phlei) is known to be a non-pathogenic nontuberculous mycobacterium (NTM) which rarely causes diseases in humans. A disseminated NTM infection is mostly caused by the Mycobacterium avium complex (MAC) and is known to develop in immunocompromised hosts, like those with acquired immune

2019 BMC Infectious Diseases

185. Antimicrobial Susceptibility of Clinical and Environmental <i>Mycobacterium chimaera</i> isolates. Full Text available with Trip Pro

Antimicrobial Susceptibility of Clinical and Environmental Mycobacterium chimaera isolates. Mycobacterium chimaera is a slow-growing nontuberculous Mycobacterium species belonging to the Mycobacterium avium Complex (MAC). It has been identified globally as the cause of a large outbreak of cardiovascular infections following open heart surgery, but can also cause respiratory infections in individuals with underlying structural pulmonary disease. Invasive M. chimaera infections

2019 Antimicrobial Agents and Chemotherapy

186. Mycobacterium arosiense, an unexpected cause of osteomyelitis in a patient with sarcoidosis: a case report. Full Text available with Trip Pro

Mycobacterium arosiense, an unexpected cause of osteomyelitis in a patient with sarcoidosis: a case report. Nontuberculous mycobacteria belonging to the Mycobacterium avium complex are recognized as opportunistic pathogens to humans. Mycobacterium arosiense is one of the novel members of the Mycobacterium avium complex. The organism has only rarely been reported in human clinical cases and may be routinely misidentified.An adult male with a history of a discus prolapse and sarcoidosis presented (...) with high fever and a strong back pain with projection to the extremities. A Magnetic Resonance Imaging scan of columna revealed a tumor suspect process at thoracic vertebrae 11/12 with changes at the second lumbar vertebra, which was partly removed by laminectomy. Biopsy smears revealed acid-fast bacilli and turned out to be Mycobacterium tuberculosis complex PCR negative. The routine line probe assay INNO-LiPa v2 (INNOGENETICS NV, Gent), which differentiates 16 mycobacterial species indicated

2019 BMC Infectious Diseases

187. Altered Toll-Like Receptor 9 Signaling in Mycobacterium avium subsp. paratuberculosis-Infected Bovine Monocytes Reveals Potential Therapeutic Targets Full Text available with Trip Pro

Altered Toll-Like Receptor 9 Signaling in Mycobacterium avium subsp. paratuberculosis-Infected Bovine Monocytes Reveals Potential Therapeutic Targets Mycobacterium avium subsp. paratuberculosis is the causative agent of Johne's disease in cattle. The complex, multifaceted interaction of M. avium subsp. paratuberculosis with its host includes dampening the ability of infected cells to respond to stimuli that promote M. avium subsp. paratuberculosis clearance. By disrupting host defenses, M (...) . avium subsp. paratuberculosis creates an intracellular environment that favors the establishment and maintenance of infection. Toll-like receptors (TLRs) are important sensors that initiate innate immune responses to microbial challenge and are also immunotherapeutic targets. For example, TLR9 contributes to host defense against M. avium subsp. paratuberculosis, and its agonists (CpG oligodeoxynucleotides [ODNs]) are under investigation for treatment of Johne's disease and other infections. Here we

2013 Infection and immunity

188. Fast update of undetected Mycobacterium chimaera infections to reveal unsuspected cases. (Abstract)

retrospective Mycobacterium avium-Mycobacterium intracellulare complex isolates, which corresponded to a patient who had undergone heart valve replacement in a different institution. Whole-genome sequencing demonstrated that he was the first case in Spain with involvement of the strain responsible for the global outbreak. These results highlight the relevance of retrospective tracking for undetected M. chimaera infections.Copyright © 2018 The Healthcare Infection Society. Published by Elsevier Ltd. All (...) Fast update of undetected Mycobacterium chimaera infections to reveal unsuspected cases. Mycobacterium chimaera is involved in a worldwide alert due to contaminated heater-cooler units. A real-time polymerase chain reaction (RT-PCR)-based procedure was implemented to survey undetected cases of M. chimaera infection. PCR was negative in the 59 prosthetic heart valves from patients with PCR-16SrRNA-negative infective endocarditis. PCR identified M. chimaera in one of 15 clinically significant

2018 Journal of Hospital Infection

189. Non-tuberculous Mycobacterium species causing mycobacteriosis in farmed aquatic animals of South Africa Full Text available with Trip Pro

, Mycobacterium fortuitum, a member of the Mycobacterium avium complex, and Mycobacterium szulgai. Phylogenetic analysis of mycobacteria, based on esxA and esxB genes, separated slow growing from rapidly growing mycobacteria as well as pathogenic from non-pathogenic mycobacteria in some cases.Isolation of the different NTM species from samples presenting granuloma suggests the significance of these NTM species in causing mycobacteriosis in these aquatic animals. The study also revealed the potential of esxA (...) Non-tuberculous Mycobacterium species causing mycobacteriosis in farmed aquatic animals of South Africa Mycobacteriosis caused by non-tuberculous mycobacteria (NTM), is among the most chronic diseases of aquatic animals. In addition, fish mycobacteriosis has substantial economic consequences especially in the aquaculture and fisheries industry as infections may significantly decrease production and trade. Some fish NTM pathogens are highly virulent and zoonotic; as such, infection of aquaria

2018 BMC microbiology

190. Evaluation of the Vitek MS v3.0 Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry System for Identification of Mycobacterium and Nocardia Species Full Text available with Trip Pro

. abscessus, and M. avium complexes and within the M. fortuitum and M. mucogenicum groups could be differentiated. Among the 312 Nocardia isolates tested, 236 (76%) were correctly identified to the species level, with an additional 44 (14%) correctly identified to the complex level. Species within the N. nova and N. transvalensis complexes could not always be differentiated. Eleven percent of the isolates (103/963) underwent repeat testing in order to get a final result. Identification of a representative (...) Evaluation of the Vitek MS v3.0 Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry System for Identification of Mycobacterium and Nocardia Species This multicenter study was designed to assess the accuracy and reproducibility of the Vitek MS v3.0 matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry system for identification of Mycobacterium and Nocardia species compared to DNA sequencing. A total of 963 clinical isolates

2018 Journal of clinical microbiology

191. Characterization of non-tuberculous mycobacterium from humans and water in an Agropastoral area in Zambia. Full Text available with Trip Pro

Characterization of non-tuberculous mycobacterium from humans and water in an Agropastoral area in Zambia. The non-tuberculous mycobacteria include those mycobacterium species that are not members of the Mycobacterium tuberculosis complex, the causative agent of pulmonary tuberculosis and Mycobacterium leprae. In Zambia, Non-tuberculous Mycobacteria are gaining recognition as pathogens of public health significance. However, there is scanty information on the isolation and speciation (...) water, Borehole water, rivers, wells and streams. Standard TB culture methods were employed to isolate Non-tuberculous Mycobacteria and later 16S-23S internal transcribed spacer region Sequencing was employed to characterize NTM.Seven (7, 4.6%) NTM species were identified from humans with M. arupense (3, 42.9%) being the most common organism, while twenty three (23, 15.4%) NTM were identified from water with the common species being Mycobacterium gordonae (5, 21.7%). Mycobacterium avium

2018 BMC Infectious Diseases

192. Mycobacterium triplex Pulmonary Disease with Acquired Macrolide Resistance in Immunocompetent Patients. Full Text available with Trip Pro

Anti-Bacterial Agents 0 Macrolides 0 RNA, Ribosomal, 16S IM Anti-Bacterial Agents adverse effects pharmacology therapeutic use Drug Resistance, Multiple, Bacterial Female Humans Immunocompetence Lung diagnostic imaging microbiology Lung Diseases drug therapy Macrolides adverse effects therapeutic use Middle Aged Mycobacterium Infections, Nontuberculous diagnosis drug therapy Mycobacterium avium Complex drug effects Nontuberculous Mycobacteria drug effects genetics isolation & purification RNA (...) Mycobacterium triplex Pulmonary Disease with Acquired Macrolide Resistance in Immunocompetent Patients. 29309938 2018 11 08 2018 11 08 1469-0691 24 6 2018 Jun Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases Clin. Microbiol. Infect. Mycobacterium triplex pulmonary disease with acquired macrolide resistance in immunocompetent patients. 671-672 S1198-743X(17)30713-9 10.1016/j.cmi.2017.12.018 Matsuda S S

2018 Clinical Microbiology and Infection

193. Endobronchial Non-Tuberculosis Mycobacterium Infection Presenting in a Healthy Child. (Abstract)

Endobronchial Non-Tuberculosis Mycobacterium Infection Presenting in a Healthy Child. To describe a safe and effective treatment for endobronchial Mycobacterium avium complex.Case report and literature review.We present a case of endobronchial M. avium complex in a healthy child treated with serial carbon-dioxide laser excisions and antibiotic triple therapy using azithromycin, rifampin, and ethambutol. No current guideline for the treatment of these lesions in the pediatric population

2018 Rhinology and Laryngology

194. Mycobacterium chimaera Hepatitis: A New Disease Entity. (Abstract)

Mycobacterium chimaera Hepatitis: A New Disease Entity. Mycobacterium chimaera was identified as a species within the Mycobacterium avium complex in 2004. Until recently, it was predominantly seen in immunocompromised patients. In 2015, an outbreak of disseminated M. chimaera disease was described in European patients after undergoing open-heart surgery in which contaminated heater-cooler water units were used. Using whole genomic sequencing and phylogenetic analysis, investigators found

2018 American Journal of Surgical Pathology

195. Mycobacterium Biofilms Full Text available with Trip Pro

. Biofilm-forming mycobacteria have been reported in many environmental studies, especially in water systems. NTM cause respiratory disease in patients with underlying diseases, such as old tuberculosis scars, bronchiectasis, and cystic fibrosis. Pathogens can be either slowly growing mycobacteria, such as Mycobacterium avium complex, or rapidly growing species, such as Mycobacterium abscessus. Another important biofilm-related group of infections are those associated with biomaterials (...) Mycobacterium Biofilms The genus Mycobacterium includes human pathogens (Mycobacterium tuberculosis and Mycobacterium leprae) and environmental organisms known as non-tuberculous mycobacteria (NTM) that, when associated with biomaterials and chronic disease, can cause human infections. A common pathogenic factor of mycobacteria is the formation of biofilms. Various molecules are involved in this process, including glycopeptidolipids, shorter-chain mycolic acids, and GroEL1 chaperone. Nutrients

2018 Frontiers in microbiology

196. Rare case of Mycobacterium nebraskense presenting as asymptomatic cavitary lung lesion Full Text available with Trip Pro

4.5 cm pleural-based opacity in right lung base with a small cavity. Sputum smear for Acid-fast bacilli was positive. Mycobacterial culture reported positive growth of M. nebraskense, while polymerase chain reaction returned negative for Mycobacterium gordonae, Mycobacterium kansasii, Mycobacterium avium complex and Mycobacterium tuberculosis. With the patient asymptomatic and her constipation improved, she was discharged with plans for close follow-up as outpatient. Conclusion: M. nebraskense (...) Rare case of Mycobacterium nebraskense presenting as asymptomatic cavitary lung lesion Introduction: Mycobacterium Nebraskense is a rare nontuberculous mycobacterial infection. The first isolate of the species was from human sputum at University of Nebraska Medical Center. There are only a few cases have been reported and the exact behavior of the disease is not clearly described. Here, we present a case from New York City incidentally found to have a cavitary lung lesion due to M

2018 Journal of community hospital internal medicine perspectives

197. The Presence of Coexisting Lung Cancer and Non-Tuberculous Mycobacterium in a Solitary Mass Full Text available with Trip Pro

. avium complex was detected in the cancer tissue culture. CONCLUSIONS Physicians should suspect the co-existent lung cancer and NTM infection in patients with solitary lung masses that yield a positive mycobacterium culture result for sputum or bronchial lavage fluid. (...) The Presence of Coexisting Lung Cancer and Non-Tuberculous Mycobacterium in a Solitary Mass BACKGROUND Whereas non-tuberculous mycobacterium (NTM) pulmonary disease can mimic lung cancer as a solitary pulmonary nodule or mass, the coexistence of lung cancer and NTM pulmonary disease in a single nodule or mass is rare. We report such a rare case, highlighting that during a bronchoscopes examination which comprises taking a transbronchial lung biopsy (TBLB), bronchial brushing, and bronchial

2018 The American journal of case reports

198. Mycobacterium avium-intracellulare brain abscess in HIV-positive patient Full Text available with Trip Pro

Mycobacterium avium-intracellulare brain abscess in HIV-positive patient Mycobacterial opportunistic infections are a major cause of morbidity and mortality among patients living with HIV (PLHIV) worldwide. Nontuberculous mycobacterial (NTM) infection is one of the leading causes of opportunistic infection in patients with advanced acquired immunodeficiency syndrome i.e., with CD4 count less than 50/cu.mm. Mycobacterium avium complex (MAC) is among the most common opportunistic bacterial (...) infections in those patients with advanced immunodeficiency apart from cryptococcal meningitis, progressive multifocal leukoencephalopathy, etc. Common presentations of mycobacterium avium complex are fever, lymphadenitis and respiratory disease. Immune reconstitution disease is also known to manifest with MAC infections in PLHIV on highly active antiretroviral therapy. Very few cases of central nervous system involvement due to NTM infection have been described. We are reporting a case of advanced

2012 Annals of Indian Academy of Neurology

199. Lactase persistence, NOD2 status and Mycobacterium avium subsp. paratuberculosis infection associations to Inflammatory Bowel Disease Full Text available with Trip Pro

Lactase persistence, NOD2 status and Mycobacterium avium subsp. paratuberculosis infection associations to Inflammatory Bowel Disease Inflammatory Bowel Disease (IBD), which includes both Crohn's disease (CD) and ulcerative colitis (UC), is caused by a complex interplay involving genetic predisposition, environmental factors and an infectious agent. Mycobacterium avium subsp. paratuberculosis (MAP) is a promising pathogen candidate since it produces a chronic intestinal inflammatory disease

2012 Gut pathogens

200. Characterization of Clinical and Environmental Mycobacterium avium Spp. Isolates and Their Interaction with Human Macrophages Full Text available with Trip Pro

Characterization of Clinical and Environmental Mycobacterium avium Spp. Isolates and Their Interaction with Human Macrophages Members of the Mycobacterium avium complex (MAC) are naturally occurring bacteria in the environment. A link has been suggested between M. avium strains in drinking water and clinical isolates from infected individuals. There is a need to develop new screening methodologies that can identify specific virulence properties of M. avium isolates found in water that predict (...) a level of risk to exposed individuals. In this work we have characterized 15 clinical and environmental M. avium spp. isolates provided by the US Environmental Protection Agency (EPA) to improve our understanding of the key processes involved in the binding, uptake and survival of these isolates in primary human macrophages. M. avium serovar 8 was predominant among the isolates studied. Different amounts and exposure of mannose-capped lipoarabinomannan (ManLAM) and glycopeptidolipids (GPLs), both

2012 PloS one

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