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Mycobacterium Avium Complex

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181. Sardinian Type 1 diabetes patients, Transthyretin and Mycobacterium avium subspecies paratuberculosis infection Full Text available with Trip Pro

Sardinian Type 1 diabetes patients, Transthyretin and Mycobacterium avium subspecies paratuberculosis infection Mycobacterium avium subsp. paratuberculosis (MAP) is the cause of Johne's disease, an enteric granulomatous disease. Recently, MAP has been associated with different autoimmune diseases such as Crohn's disease, type 1 diabetes (T1D) and multiple sclerosis. Transthyretin (TTR) is a plasma transport protein for thyroid hormone and forms a complex with retinol-binding protein. Reduced

2012 Gut pathogens

182. Inter- and Intra-subtype genotypic differences that differentiate Mycobacterium avium subspecies paratuberculosis strains Full Text available with Trip Pro

Inter- and Intra-subtype genotypic differences that differentiate Mycobacterium avium subspecies paratuberculosis strains Mycobacterium avium subspecies paratuberculosis (Map) is the aetiological agent of Johne's disease or paratuberculosis and is included within the Mycobacterium avium complex (MAC). Map strains are of two major types often referred to as 'Sheep' or 'S-type' and 'Cattle' or 'C-type'. With the advent of more discriminatory typing techniques it has been possible to further (...) among the S-type isolates, some of them not previously published. Both PFGE and IS900-RFLP segregated the S-type strains into types I and III and the results concurred with those of the gyr SNP analysis. Nine MIRU-VNTR genotypes were identified in these isolates. MIRU-VNTR analysis differentiated Map strains from other members of Mycobacterium avium Complex, and Map S-type from C-type but not type I from III. Pigmented Map isolates were found of type I or III.This is the largest panel of S-type

2012 BMC microbiology

183. Genome sequencing of ovine isolates of Mycobacterium avium subspecies paratuberculosis offers insights into host association Full Text available with Trip Pro

Genome sequencing of ovine isolates of Mycobacterium avium subspecies paratuberculosis offers insights into host association The genome of Mycobacterium avium subspecies paratuberculosis (MAP) is remarkably homogeneous among the genomes of bovine, human and wildlife isolates. However, previous work in our laboratories with the bovine K-10 strain has revealed substantial differences compared to sheep isolates. To systematically characterize all genomic differences that may be associated (...) the presence of 7 large inversions between the bovine and ovine genomes (~ 2.36 Mb). Whole-genome sequencing of 2 additional sheep strains of MAP (JTC1074 and JTC7565) further confirmed genomic homogeneity of the sheep isolates despite the presence of polymorphisms on the nucleotide level.Comparative sequence analysis employed here provided a better understanding of the host association, evolution of members of the M. avium complex and could help in deciphering the phenotypic differences observed among

2012 BMC genomics

184. Antibiotic susceptibility profile of Mycobacterium avium subspecies hominissuis is altered in low-iron conditions. Full Text available with Trip Pro

Antibiotic susceptibility profile of Mycobacterium avium subspecies hominissuis is altered in low-iron conditions. Antibiotic susceptibility testing of the Mycobacterium avium complex is often characterized by a lack of correlation between in vitro results and clinical response. The reason for this discrepancy might lie in the difference between in vitro susceptibility testing conditions and the actual environment experienced by mycobacteria in the host. The availability of iron is one (...) such difference, which is limited in host macrophages upon infection, but abundant in susceptibility testing media. Accordingly, the aim of our study was to determine whether iron limitation affects the antibiotic susceptibility profile of M. avium subspecies hominissuis.Susceptibilities to multiple antibiotics targeting various cellular processes were determined in media with normal- and low-iron concentrations using the resazurin microplate assay. Differences in susceptibilities were evaluated by monitoring

2012 Journal of Antimicrobial Chemotherapy

185. Comparison of methods available for the identification of Mycobacterium chimaera. Full Text available with Trip Pro

Comparison of methods available for the identification of Mycobacterium chimaera. Mycobacterium chimaera is a recently described nontuberculous mycobacterium belonging to the Mycobacterium avium complex (MAC). Because this species is implicated in a worldwide outbreak due to contaminated heater-cooler unit water tanks during open-heart surgery, it has become mandatory for clinical microbiology laboratories to be able to differentiate M. chimaera from the other MAC species, especially M (...) , GenoType Mycobacterium CM and GenoType NTM-DR) and (c) matrix-assisted desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) using Microflex LT.There was a high concordance for species determination between the reference ITS sequencing and the GenoType NTM-DR test (39/41, 95%), the INNO-LiPA Mycobacteria test (38/41, 93%) and the hsp65 sequencing (38/41, 93%). The GenoType Mycobacterium CM test did not distinguish M. chimaera from M. intracellulare. MALDI-TOF MS distinguished two M

2017 Clinical Microbiology and Infection

186. Draft Genome Sequence of Mycobacterium chimaera Type Strain Fl-0169 Full Text available with Trip Pro

Draft Genome Sequence of Mycobacterium chimaera Type Strain Fl-0169 We report here the draft genome sequence of the type strain Mycobacterium chimaera Fl-0169, a member of the Mycobacterium avium complex (MAC). M. chimaera Fl-0169T was isolated from a patient in Italy and is highly similar to strains of M. chimaera isolated in Ireland, although Fl-0169T possesses unique virulence genes.Copyright © 2017 Pfaller et al.

2017 Genome Announcements

187. Disseminated Cutaneous Infection of Mycobacterium colombiense in a Patient with Myelodysplastic Syndrome Full Text available with Trip Pro

Disseminated Cutaneous Infection of Mycobacterium colombiense in a Patient with Myelodysplastic Syndrome Mycobacterium colombiense (M. colombiense) is a member of the Mycobacterium avium complex (MAC). To our knowledge, this is the third case report of an M. colombiense infection. An 80-year-old man, immunocompromised by myelodysplastic syndrome (MDS), developed a skin rash with exfoliation and eruption on his face and scalp. Mycobacteria were detected in pus samples. Broad-range polymerase (...) chain reaction (PCR) revealed the mycobacteria to be M. colombiense. The lesions resolved after daily administration of rifampicin, ethambutol, and clarithromycin. In conclusion, broad-range PCR identified this rare mycobacterium, allowing for the administration of appropriate combination antibiotic therapy.

2017 Internal Medicine

188. Insights from the Genome Sequence of Mycobacterium lepraemurium: Massive Gene Decay and Reductive Evolution Full Text available with Trip Pro

might be related to Mycobacterium avium In this study, the complete genome of M. lepraemurium was sequenced using a combination of PacBio and Illumina sequencing. Phylogenomic analyses confirmed that M. lepraemurium is a distinct species within the M. avium complex (MAC). The M. lepraemurium genome is 4.05 Mb in length, which is considerably smaller than other MAC genomes, and it comprises 2,682 functional genes and 1,139 pseudogenes, which indicates that M. lepraemurium has undergone genome (...) Insights from the Genome Sequence of Mycobacterium lepraemurium: Massive Gene Decay and Reductive Evolution Mycobacterium lepraemurium is the causative agent of murine leprosy, a chronic, granulomatous disease similar to human leprosy. Due to the similar clinical manifestations of human and murine leprosy and the difficulty of growing both bacilli axenically, Mycobacterium leprae and M. lepraemurium were once thought to be closely related, although it was later suggested that M. lepraemurium

2017 mBio

189. Disseminated Mycobacterium chimaera Presenting as Vertebral Osteomyelitis Full Text available with Trip Pro

Disseminated Mycobacterium chimaera Presenting as Vertebral Osteomyelitis Mycobacterium chimaera, a member of the Mycobacterium avium complex, is a slow-growing, nontuberculous mycobacterium associated with outbreaks in cardiac-surgery patients supported on heart-lung machines. We report a case of an elderly woman on chronic prednisone who presented with a six-month history of worsening chronic back pain, recurrent low-grade fevers, and weight loss. Imaging identified multilevel vertebral

2017 Case reports in infectious diseases

190. Development of a One-Step Multiplex PCR Assay for Differential Detection of Major Mycobacterium Species Full Text available with Trip Pro

. The aims of this assay were to (i) discriminate between the Mycobacterium tuberculosis complex (MTBC) and NTM using rv0577 or RD750, (ii) differentiate M. tuberculosis (M. tuberculosis) from MTBC using RD9, (iii) selectively identify the widespread M. tuberculosis Beijing genotype by targeting mtbk_20680, and (iv) simultaneously detect five clinically important NTM (M. avium, M. intracellulare, M. abscessus, M. massiliense, and M. kansasii) by targeting IS1311, DT1, mass_3210, and mkan_rs12360 (...) Development of a One-Step Multiplex PCR Assay for Differential Detection of Major Mycobacterium Species The prevalence of tuberculosis continues to be high, and nontuberculous mycobacterial (NTM) infection has also emerged worldwide. Moreover, differential and accurate identification of mycobacteria to the species or subspecies level is an unmet clinical need. Here, we developed a one-step multiplex PCR assay using whole-genome analysis and bioinformatics to identify novel molecular targets

2017 Journal of clinical microbiology

191. Evaluation of GenoType NTM-DR Assay for Identification of Mycobacterium chimaera Full Text available with Trip Pro

Evaluation of GenoType NTM-DR Assay for Identification of Mycobacterium chimaera Identification of species within the Mycobacterium avium complex (MAC) is difficult, and most current diagnostic laboratory tests cannot distinguish between species included in the complex. Differentiation of species within the MAC is important, as Mycobacterium chimaera has recently emerged as a major cause of invasive cardiovascular infections following open heart surgery. A new commercial diagnostic assay (...) assay was in agreement with 16S rRNA and 16S-23S ITS gene sequencing results. Misidentification occurred with 16 isolates which belonged to four species included in the MAC that are rarely encountered in clinical specimens. Despite some limitations of this assay, GenoType NTM-DR had 100% specificity for identifying M. chimaera This novel assay will enable diagnostic laboratories to differentiate species belonging to the Mycobacterium avium complex and to accurately identify M. chimaera It can

2017 Journal of clinical microbiology

192. Target-Specific Assay for Rapid and Quantitative Detection of Mycobacterium chimaera DNA Full Text available with Trip Pro

Target-Specific Assay for Rapid and Quantitative Detection of Mycobacterium chimaera DNA Mycobacterium chimaera is an opportunistic environmental mycobacterium belonging to the Mycobacterium avium-M. intracellulare complex. Although most commonly associated with pulmonary disease, there has been growing awareness of invasive M. chimaera infections following cardiac surgery. Investigations suggest worldwide spread of a specific M. chimaera clone, associated with contaminated hospital heater

2017 Journal of clinical microbiology

193. Complete Genome Sequence of Mycobacterium chimaera SJ42, a Nonoutbreak Strain from an Immunocompromised Patient with Pulmonary Disease Full Text available with Trip Pro

Complete Genome Sequence of Mycobacterium chimaera SJ42, a Nonoutbreak Strain from an Immunocompromised Patient with Pulmonary Disease Mycobacterium chimaera, a nontuberculous mycobacterium (NTM) belonging to the Mycobacterium avium complex (MAC), is an opportunistic pathogen that can cause respiratory and disseminated disease. We report the complete genome sequence of a strain, SJ42, isolated from an immunocompromised male presenting with MAC pneumonia, assembled from Illumina and Oxford

2017 Genome Announcements

194. Mycobacterium chimaera Isolates from Heater–Cooler Units, United Kingdom Full Text available with Trip Pro

Chimera Humans Mycobacterium Infections, Nontuberculous microbiology Mycobacterium avium Complex Nontuberculous Mycobacteria isolation & purification United Kingdom Mycobacterium chimaera United Kingdom bacteria cardiac surgical procedures cross-infection disease outbreaks equipment contamination genome heater–cooler units nontuberculous mycobacteria tuberculosis and other mycobacteria 2017 6 20 6 0 2017 6 20 6 0 2017 11 14 6 0 ppublish 28628453 10.3201/eid2307.170442 PMC5512474 Clin Infect Dis. 2017 (...) Mycobacterium chimaera Isolates from Heater–Cooler Units, United Kingdom 28628453 2017 11 13 2018 12 02 1080-6059 23 7 2017 07 Emerging infectious diseases Emerging Infect. Dis. Mycobacterium chimaera Isolates from Heater-Cooler Units, United Kingdom. 1227 10.3201/eid2307.170442 Hedge Jessica J Lamagni Theresa T Moore Ginny G Walker James J Crook Derrick D Chand Meera M eng Letter Comment United States Emerg Infect Dis 9508155 1080-6040 IM Emerg Infect Dis. 2017 Mar;23 (3):507-509 28035898

2017 Emerging Infectious Diseases

195. Mycobacterium kansasii Isolated from Tuberculin-positive Rhesus Macaques (Macaca mulatta) in the Absence of Disease Full Text available with Trip Pro

. avium complex organism. One macaque from the contract quarantine facility tested culture positive for M. kansasii. Genomic testing and target gene RNA expression analysis of the 2 M. kansasii isolates were performed to evaluate possible kinship and affected genes that might contribute to susceptibility to mycobacterial infection. Genotyping of the 2 isolates revealed 2 genetically distinct strains (strains 1 and 4). The presence of positive tuberculin skin tests in the absence of disease raises (...) Mycobacterium kansasii Isolated from Tuberculin-positive Rhesus Macaques (Macaca mulatta) in the Absence of Disease Mycobacterial infections are of primary health concern in NHP colonies in biomedical research. NHP are constantly monitored and screened for Mycobacterium spp. We report 6 Chinese-origin rhesus macaques infected with Mycobacterium kansasii that exhibited positive tuberculin skin tests in the absence of disease. Two of these macaques were being used for research purposes

2017 Comparative medicine

196. Molecular analysis of clinical isolates previously diagnosed as Mycobacterium intracellulare reveals incidental findings of "Mycobacterium indicus pranii" genotypes in human lung infection. Full Text available with Trip Pro

Molecular analysis of clinical isolates previously diagnosed as Mycobacterium intracellulare reveals incidental findings of "Mycobacterium indicus pranii" genotypes in human lung infection. Mycobacterium intracellulare is a major cause of Mycobacterium avium complex lung disease in many countries. Molecular studies have revealed several new Mycobacteria species that are closely related to M. intracellulare. The aim of this study was to re-identify and characterize clinical isolates from (...) patients previously diagnosed with M. intracellulare lung disease at the molecular level.Mycobacterial isolates from 77 patients, initially diagnosed with M. intracellulare lung disease were re-analyzed by multi-locus sequencing and pattern of insertion sequences.Among the 77 isolates, 74 (96 %) isolates were designated as M. intracellulare based on multigene sequence-based analysis. Interestingly, the three remaining strains (4 %) were re-identified as "Mycobacterium indicus pranii" according

2015 BMC Infectious Diseases

197. An unusual cause of chest pain: Mycobacterium avium complex and the immune reconstitution inflammatory syndrome. (Abstract)

An unusual cause of chest pain: Mycobacterium avium complex and the immune reconstitution inflammatory syndrome. The HIV-associated immune reconstitution inflammatory syndrome usually manifests as new infections or worsening of pre-existing infections during the first few months of initiating anti-retroviral therapy. It is commonly associated with local or systemic inflammation, presumably due to rapid reconstitution of host immune system. Here we describe a unique case of the immune (...) reconstitution inflammatory syndrome presenting as acute pericarditis and pericardial effusion caused by mycobacterium avium complex. We also demonstrate that judicious use of steroids, along with pathogen specific antimicrobial therapy, can prevent local complications of the inflammatory response.Copyright © 2010 Society of Hospital Medicine.

2011 Journal of Hospital Medicine

198. Environmental risk factors for pulmonary Mycobacterium avium-intracellulare complex disease. Full Text available with Trip Pro

Environmental risk factors for pulmonary Mycobacterium avium-intracellulare complex disease. Mycobacterium avium-intracellulare complex (MAC) is a ubiquitous pathogen found in soil and water. Environmental exposure is the primary route for MAC infection. However, specific environmental risk factors have been poorly determined in immunocompetent patients with pulmonary MAC disease.A case-control study was performed with 106 patients with pulmonary MAC disease (men [women], 23 [83]; age, 64.3

2011 Chest

199. Evaluation of a rapid detection method of clarithromycin resistance genes in Mycobacterium avium complex isolates. Full Text available with Trip Pro

Evaluation of a rapid detection method of clarithromycin resistance genes in Mycobacterium avium complex isolates. Clarithromycin is the key drug in the various treatment regimens of Mycobacterium avium complex (MAC) diseases, and is the only drug for which drug susceptibility has been shown to correlate with clinical response in these diseases. A point mutation at either positions 2058 or 2059 of the 23S rRNA gene has been reported to occur in high-level clarithromycin-resistant isolates

2011 Journal of Antimicrobial Chemotherapy

200. Radical surgical debridement alone for treatment of carpal tunnel syndrome caused by mycobacterium avium complex flexor tenosynovitis: case report. (Abstract)

Radical surgical debridement alone for treatment of carpal tunnel syndrome caused by mycobacterium avium complex flexor tenosynovitis: case report. We present a case of proliferative flexor tenosynovitis caused by Mycobacterium avium complex resulting in recurrent symptoms of median nerve compression. The patient was treated with radical tenosynovectomy and release of the carpal tunnel without antimicrobial therapy. She remains symptom-free and is apparently disease-free more than 2 years after

2011 Journal of Hand Surgery - American

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