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181. Management of Stroke in Neonates and Children Full Text available with Trip Pro

health problem causing substantial morbidity and mortality, it is also an important cause of acquired brain injury in young patients, occurring most commonly in the neonate and throughout childhood. This scientific statement represents a synthesis of data and a consensus of the leading experts in childhood cardiovascular disease and stroke. Overview of Childhood and Perinatal Stroke Introduction and Definition The standard adult definition of stroke—an acute onset neurological sign or symptom (...) with AIS or CSVT, clinical trial data are lacking. Childhood Stroke Approach to a Suspected Stroke in a Child Clinical Presentation Signs and symptoms of acute stroke in children are similar to those in adults. The most common symptoms include hemiparesis and hemifacial weakness in 67% to 90%, speech or language disturbance in 20% to 50%, vision disturbance in 10% to 15%, and ataxia in 8% to 10%. Children present with nonlocalizing symptoms such as headache in 20% to 50% and altered mental status in 17

2019 American Heart Association

182. Amniotic fluid lactate measurement to predict response to syntocinon in slow labour

identified where the test has been used to guide clinical decision making. It is unlikely that sufficient evidence exists to inform decision making. HTW’s Assessment Group concluded not to progress this topic further. Page 3 of 4 June 2018 TER010 Brief literature search results Resource Results UK guidelines and guidance SIGN We did not identify any relevant evidence from this source. NICE We did not identify any relevant evidence from this source. Secondary literature and economic evaluations BMJ Best (...) Practice We did not identify any relevant evidence from this source. Cochrane library We did not identify any relevant evidence from this source. CRD database Two NIHR Horizon Scanning Centre reports were identified (2011 and 2012). Primary studies Medline 1. Wiberg-Itzel E, Pembe AB, Jarnbert-Pettersson H, et al. Lactate in Amniotic Fluid: Predictor of Labor Outcome in Oxytocin-Augmented Primiparas' Deliveries. PLoS ONE. 2016;11(10):e0161546. doi:10.1371/journal.pone.0161546. 2. Murphy M, Butler M

2019 Health Technology Wales

185. ACC/AHA/SCAI/SIR/SVM 2018 Appropriate Use Criteria for Peripheral Artery Intervention: a report of the American College of Cardiology Appropriate Use Criteria Task Force, American Heart Association, Society for Cardiovascular Angiography and Interventions

(e.g., an asymptomatic patient is truly asymptomatic for the condition under consideration and the patient has been questioned suf?ciently). 4. In this document, the term “family history” refers to ?rst-degree relatives only. 5. The indications are at times purposefully broad to cover an array of cardiovascular signs and symptoms and to account for the ordering physician’sbest judgment as to the presence of cardiovascular abnor- malities. Clear documentation of the indication for revascularization

2019 Society of Interventional Radiology

186. Suspected Spine Trauma ? Child

in children and adults that MRI following a completed cervical CT did not add any clinically significant information [7,60-64]. Some reports stated that adult cervical injuries were detected with MRI and not with CT and that these changed management [65,66]. A study of 45 patients showed that children with normal radiography and CT may have signs of traumatic cervical injury on MRI [51]. However, a recent meta-analysis showed that the pooled incidence of unstable injuries detected by MRI but missed on CT (...) , Murphy SC, Dudley N. Cervical spine computed tomography utilization in pediatric trauma patients. J Pediatr Surg 2014;49:333-7. 13. Hoffman JR, Schriger DL, Mower W, Luo JS, Zucker M. Low-risk criteria for cervical-spine radiography in blunt trauma: a prospective study. Ann Emerg Med 1992;21:1454-60. 14. Stiell IG, Clement CM, McKnight RD, et al. The Canadian C-spine rule versus the NEXUS low-risk criteria in patients with trauma. N Engl J Med 2003;349:2510-8. 15. Hoffman JR, Mower WR, Wolfson AB

2019 American College of Radiology

187. ShortGUIDE: Instrumental vaginal birth

for some low and most mid-cavity forceps birth Episiotomy · Evidence about episiotomy and reducing the risk of perineal injury is unclear—use clinical judgement for each birth 1,2,19,30 o Refer to Queensland Clinical Guidelines: Perineal care 31 · Strongly consider episiotomy if first vaginal birth and forceps are used 31 o If episiotomy is indicated, perform mediolateral Maternal and fetal observation · Provide continuous one-to-one midwifery support · Monitor vital signs as per second stage of labour (...) observations o Avoid hats and bonnets so changing head shape or size can be identified 32 o Assess for signs and symptoms of instrument-related injury o Refer to Queensland Clinical Guideline Routine newborn assessment 33 o In the presence of poor feeding, pallor or other concerns, increase frequency of monitoring and seek timely medical review 32 Maternal observations · Routine postnatal observations as per individual clinical circumstances/local protocols Perineal care · Perform a comprehensive perineal

2019 Queensland Health

188. BTS Guideline for Bronchiectasis in adults

(USA) P Wolters (USA) Statistical Editors A Douiri (UK) C Flach (UK) C Jackson (UK) S Stanojevic (USA) R Szczesniak (USA) B Wagner (USA) Y Wang (UK) Journal Club Editor P Murphy (UK) President, British Thoracic Society Dr M Elliott Editorial Office Thorax, BMA House, Tavistock Square, London WC1H 9JR, UK T: +44 (0)20 7383 6373 E: Twitter: @ThoraxBMJ ISSN: 0040-6376 (print) ISSN: 1468-3296 (online) Disclaimer: Thorax is owned and published by the British Thoracic Society and BMJ (...) pulmonary artery) º Lack of tapering º Airway visibility within 1cm of costal pleural surface or touching mediastinal pleura. ? The following indirect signs are commonly associated with bronchiectasis: º Bronchial wall thickening º Mucus impaction º Mosaic perfusion / air trapping on expir- atory CT General ? CT scanning can also aid in identifying an aeti- ology of bronchiectasis eg Allergic bronchopul- monary aspergillosis (ABPA), Non-tuberculous mycobacteria (NTM), primary ciliary dyski- nesia, alpha

2019 British Thoracic Society

189. Acute Mental Status Change, Delirium, and New Onset Psychosis

yield may be low in the absence of a focal neurological deficit or signs of trauma [2,17,27,29,36]. No prospectively validated clinical rule or scoring system is available to help define which of these patients benefit the most from imaging. Therefore, determining the clinical need and value of brain imaging in this scenario relies on the evaluating clinician’s judgement. Unresponsive patients may have higher rates of acute findings on CT [29]. Contrast-enhanced CT examinations are usually (...) Appropriateness Criteria ® topic on “Seizures and Epilepsy” [19], ACR Appropriateness Criteria ® topic on “Head Trauma” [20], or the ACR Appropriateness Criteria ® topic on “Headache” [21]. CT Head The reported detection of treatment-altering findings on head CT is very low in elderly patients with new onset delirium unless one of the following risk factors is present: focal neurologic deficit, history of recent falls or head injury, anticoagulation therapy, signs of elevated intracranial pressure

2019 American College of Radiology

191. Optimal Care Pathway for Aboriginal and Torres Strait Islander people with cancer

to the follow- up plan (travel or cost) and strategies or referrals to support services to address these • a process for rapid re-entry to medical services for suspected recurrence. Support and communication – lead clinician to: • explain the treatment summary and follow-up care plan to the patient/carer • provide culturally appropriate information about the signs and symptoms of recurrent disease, secondary prevention and healthy living • discuss the follow-up care plan with the general practitioner

2018 Cancer Australia

192. Neonatal seizures

is variable and clinical features of a seizure are often absent or non-specific. 6,7 This has led to under-diagnosis and occasional over-diagnosis 7 of neonatal seizures. Newborn babies can have movements that can be mistaken for seizures, where the electroencephalogram (EEG) is normal. 7 The majority of seizures demonstrated on video EEG monitoring do not have overt clinical signs. 6 Neonatal seizures encompass events that have a proven underlying epileptic mechanism detected by an EEG. 6 They most (...) commonly occur due to neonatal encephalopathy often due to brain hypoxic ischemia. 9 Subclinical seizures may manifest as apnoea in the term baby however when it is the sole sign of a seizure it is not usually accompanied by bradycardia. 10,11 Seizure are a sign of neurological dysfunction and neonates 12 are at especially high risk of seizures compared to other age groups. 13 They reflect different pre-, peri-, or postnatal disorders of the central nervous system (CNS). 9 The reasons

2019 Queensland Health

193. Adult and Pediatric Antibiotic Prophylaxis during Vascular and IR Procedures: A Society of Interventional Radiology Practice Parameter Update Endorsed by the Cardiovascular and Interventional Radological Society of Europe and the Canadian Association for

drainage or percutaneous nephrostomy drainage of pyonephrosis Colonization: Normal bacterial ?ora, ie, organisms that reside on a host surface without inciting an in?ammatory response Staphylococcus epidermidis is a common inhabitant of skin and typically does not cause in?ammation Bacteremia: Presence of bacteria within the bloodstream without signs and/or symptoms of clinical infection – Clinical infection: Signs and symptoms of in?ammation as a response to infectious organism or its toxins – Sepsis

2019 Society of Interventional Radiology

194. Post-Treatment Follow-up and Active Surveillance of Clinically Localized Renal Cell Cancer.

nephrectomy or nephron-sparing surgery. We do not deal with patients who are undergoing systemic therapy for known recurrent RCC, patients in whom specific symptoms, signs, or laboratory studies suggest recurrent malignancy at a specific site, or patients for whom surgery is known to have left a residual tumor [1-6]; we do not address the imaging of nononcologic complications of surgery. Follow-up is important for patients who have had radical or partial nephrectomy for RCC. Although patients may have (...) Nephrol. 2002;57(1):56-62. 40. Blacher E, Johnson DE, Haynie TP. Value of routine radionuclide bone scans in renal cell carcinoma. Urology. 1985;26(5):432-434. 41. Chancellor MB, Konnak JW, Grossman HB. Diagnostic value of routine bone scintigraphy renal imaging in renal cell carcinoma. Urology. 1989;33(5):440-442. 42. Rosen PR, Murphy KG. Bone scintigraphy in the initial staging of patients with renal-cell carcinoma: concise communication. J Nucl Med. 1984;25(3):289-291. 43. Sohaib SA, Cook G, Allen

2019 American College of Radiology

195. Sexual Assault

exposure to a variety of interpersonal violence scenarios, including sexual assault. The trauma experienced by individuals can have lasting adverse effects on their functioning and mental, physical, social, and emotional well-being ( ). The trauma-informed approach to care uses a framework that acknowledges the effect of trauma, recognizes signs and symptoms of trauma, responds by integrating knowledge about trauma into practices, and seeks to resist retraumatization. The key principles of trauma (...) . Department of Justice, Office of Justice Programs. National best practices for sexual assault kits: a multidisciplinary approach. Washington, DC: DOJ; 2017. Available at: . Retrieved October 18, 2018. Lamba H, Murphy SM. Sexual assault and sexually transmitted infections: an updated review. Int J STD AIDS 2000; 11:487–91. Workowski KA, Bolan GA. Sexually transmitted diseases treatment guidelines, 2015. Centers for Disease Control and Prevention [published erratum appears in MMWR Recomm Rep. 2015;64:924

2019 American College of Obstetricians and Gynecologists

196. Post-Treatment Surveillance of Bladder Cancer.

obstruction has been associated with a decreased 5-year survival rate. Patients with bilateral hydronephrosis had a 5-year survival rate of 31%, compared with 45% for those who had unilateral involvement and 63% for those with no hydronephrosis [20]. 7. Lymphatic invasion: Invasion of the lamina propria is a very poor prognostic sign [21], and most patients so affected die within 6 years [14]. Solid (nonpapillary) lesions have a greater tendency for lymphatic invasion [17]. 8. TCC involvement (...) . Campbell's urology. 7th ed. Philadelphia: W.B. Saunders Co.; 1998:2327-2408. 32. Babjuk M, Oosterlinck W, Sylvester R, Kaasinen E, Bohle A, Palou-Redorta J. EAU guidelines on non- muscle-invasive urothelial carcinoma of the bladder. Eur Urol. 2008;54(2):303-314. 33. Schmidbauer J, Lindenau G. Follow-up of nonmuscle invasive transitional cell carcinoma of the bladder: how and how often? Curr Opin Urol. 2008;18(5):504-507. 34. Browne RF, Murphy SM, Grainger R, Hamilton S. CT cystography and virtual

2019 American College of Radiology

197. Child Abuse, Elder Abuse, and Intimate Partner Violence

Trauma 25 g. Abdominal Injuries 28 h. Skeletal Injuries 30 i. Laboratory Screening 34 j. Imaging for Suspected Child Abuse 36 3. Intervention 43 a. Communicating with Families 43 b. Trauma-Informed Care 44 c. Teamwork 48 d. Mandated Reporting 50 Best Practices Guidelines for Trauma Center Recognition: Elder Abuse 51 1. Overview 52 2. Assessment 55 a. Identifying High-Risk Patients 55 b. Physical Signs 59 c. Screening 61 d. Laboratory Screening 62 e Imaging for Suspected Elder Abuse 63 3. Intervention (...) features present, sensitivity was 72.3% and specificity was 85.7% Pittsburgh Infant Brain Injury Score (PIBIS) 9 Well appearing infants (i.e. less than 1 year of age) presenting to an ED with no history of trauma and a high-risk sign or symptom (e.g., acute life-threatening event [ALTE]/ brief resolved unexplained event [BRUE], seizure, vomiting without diarrhea, irritable, bump on scalp, bruising) Having a previously abnormal head computed tomography (CT) The 5-point PIBIS scale is weighted: 2 points

2019 American College of Surgeons

198. Use of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes in Preclinical Cancer Drug Cardiotoxicity Testing: A Scientific Statement From the American Heart Association Full Text available with Trip Pro

aspects of immaturity have proved more challenging than this natural maturation strategy can accomplish, including the abolition of the pacemaker potential and appearance of a fully developed t-tubule system. Although the abolition of intrinsic pacemaking activity is an electrophysiological sign of cardiomyocyte maturity, the presence of pacemaker (nodal) cells in 2D constructs will always conveniently produce monolayers with spontaneous activity (thus avoiding the need for electric or optogenetic (...) tools for hazard identification or, in the case of more developed or qualified biomarkers, for risk assessment. When qualified, a biomarker is linked to a specific interpretation and application for drug discovery or regulatory purposes within a stated context of use. Evaluating concordance between preclinical and clinical cardiotoxicity biomarkers is made difficult by variability in detecting and defining subclinical and clinical contractile dysfunction, which is often the first sign of evolving

2019 American Heart Association

199. Diagnosis and staging of patients with ovarian cancer

Ireland and Honorary Professor in Gynecological Pathology of Queen’s University of Belfast, Northern Ireland) and Professor Evis Sala (Professor of Oncological Imaging at the University of Cambridge, UK). We would like in addition to thank Louise Murphy for her editorial support during preparation for publication. A full list of members of the Guideline Development Group is available in the previous pages. ____________________________ ____________________________ Signed by the Chairs: Dr Josephine (...) Radiology Dr Josephine Barry Consultant Radiologist, CUH Co-chair & writing member Dr Tony Geoghegan Consultant Radiologist, MMUH Writing member Dr Joan Heneghan Consultant Radiologist, UHW Writing member Dr Anne Carroll Radiology Specialist Registrar, SVUH Writing member Dr Laura Murphy Radiology Specialist Registrar, CUH Writing member Dr Charles Sullivan Radiology Specialist Registrar, SJH Writing member Dr Zoe Hutchinson Radiology Specialist Registrar, SVUH Writing member Dr Conor Houlihan Radiology

2019 HIQA Guidelines

200. Pruritus

. Dr. Joanna Wallengren, Lund (Sweden) Prof. Dr. Ekin Savk, Aydin (Turkey) Prof. Dr. Uwe Gieler, Gießen (Germany) Prof. Dr. Julien Lambert, Antwerp (Belgium) Dr. Simone Garcovich, Rome (Italy) Members of EDF Guideline Committee: Prof. Dr. Werner Aberer, Graz (Austria) Prof. Dr. Gillian Murphy, Dublin (Ireland) Prof. Dr. Martine Bagot, Paris (France) Prof. Dr. Alexander Nast, Berlin (Germany) Prof. Dr. Nicole Basset-Seguin, Paris (France) Prof. Dr. Martino Neumann, Rotterdam (Netherlands) Prof. Dr (...) , CP is defined as pruritus lasting 6 weeks or longer (Ständer, Weisshaar et al. 2007). This is a practical distinction defined by clinicians in order to facilitate the decision to perform a diagnostic work-up. In some cases, pruritus may precede the diagnosis of the underlying disease by years (premonitory pruritus); in others, it is the early sign of a neoplastic disease such as Hodgkin lymphoma (paraneoplastic disease). In line with the IFSI, the term “pruritus sine materia” will not be used

2019 European Dermatology Forum

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