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Multiple Endocrine Neoplasia Type 1

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1961. Mindfulness?based stress reduction (MBSR) for improving health, quality of life and social functioning in adults: a systematic review and meta?analysis Full Text available with Trip Pro

89 Non‐ITT Fogarty 2015 Revmatoid Arthritis DAS28‐CRP, Early morning stiffness, Pain VAS, Patient global ass, Morning stiffness, Pain, DAS28‐CR 2, 4 51 22 88 ITT Friskvold 2009 Heart disease CES‐D, PSS, DASS, BMI, PSQI, WT/Ibs, CAM 2 40 26 29 100 Non‐ITT Garland 2014 Cancer and insomnia C‐SOSI, POMS, DBAS, ISI, PSQI, SE Actigraphy, SE Diary, SOL Actigraphy, SOL Diary, TST Actigraphy, TST Diary, WASO Actigraphy, WASO Diary 5 111 18 61 ITT Gaylord 2011 Irritable Bowel Syndr. BSI, Pain Catastroph (...) Meaning, FACT EmoWB, FACT SocFamilyWB 2, 10, 22 172 26 100 Non‐ITT Hoffman 2012 Cancer (breast) POMS, FACT‐B, FACT‐ES, WHO‐5 1 229 22 100 Non‐ITT Hoge 2013 Sosal Anxiety Disorder BAI, CGI‐S, HAM‐A, SSPS, PSQI 93 20 51 Non‐ITT Hou 2014 Family care givers STAI state, STAI trait, CES‐D, PSS, CRSE‐OR, CRSE‐UT, SCS, SF‐12 MH, SF‐12 PH, FFMQ 141 16 83 ITT Huang 2015 Mental distress GHQ12, PSS, Job control, Job demands, Fatigue 1, 2 144 16 44 ITT Hughes 2013 Prehypertention Diast BP, Syst BP 56 20 89 57 ITT

2017 Campbell Collaboration

1962. Utian Translational Science Symposium report: New Ttherapies for Leiomyomas: When Surgery May Not Be the Best Option

- ingtooclosetotheuterinewall.TypeIIislessthan50%inthe cavity, and type III is outside the cavity (such as serosal or intramural in location). 12,13 A history of rapid growth of uterine leiomyomas is not necessarilyassociatedwithmalignancy.Therateofgrowthis unpredictablewithshrinkageorgrowth,withamedianof9% a year enlargement. 14,15 Although malignancy is a fear, sarcomas are more common in women aged older than 50 years and usually only diagnosed in the postoperative specimen. The rate of leiomyosarcoma varies from 0.05% to 0.28%. 16 Risk (...) transcription, translation, and cell proliferation. Through epigenetic analysis, changes in phenotype from altered gene expression because of hypermethylation have been identified. It is known that epigenetic changes have a major role in the incidence of complex diseases, including cancer, cardiovascular and respiratory diseases, metabolic syndrome, neurologic impairment, and developmental defects. Alterations of chromatin structure, gene expression, and genomic structure are major features of epigenomic

2018 The North American Menopause Society

1963. Paediatric Urology

. 182: 704. 107. Dieckmann, K.P., et al. Clinical epidemiology of testicular germ cell tumors. World J Urol, 2004. 22: 2. 108. Pettersson, A., et al. Age at surgery for undescended testis and risk of testicular cancer. N Engl J Med, 2007. 356: 1835. 109. Walsh, T.J., et al. Prepubertal orchiopexy for cryptorchidism may be associated with lower risk of testicular cancer. J Urol, 2007. 178: 1440. 110. Kapur, P., et al. Pediatric hernias and hydroceles. Pediatr Clin North Am, 1998. 45: 773. 111 (...) Paediatric Urology Paediatric Urology | Uroweb › Paediatric Urology Paediatric Urology To access the pdfs & translations of individual guidelines, please as EAU member. Non-EAU members can view the web versions. To become an EAU member, click . C. Radmayr (Chair), G. Bogaert, H.S. Dogan, R. Kočvara, J.M. Nijman (Vice-chair), R. Stein, S. Tekgül Guidelines Associates: L.A. 't Hoen, J. Quaedackers, M.S. Silay, S. Undre TABLE OF CONTENTS REFERENCES 1. Radmayr, C., et al. Management of undescended

2018 European Association of Urology

1964. Neuro-urology

using The Health Improvement Network primary care database. PLoS Med, 2013. 10: e1001505. 18. Pringsheim, T., et al. The prevalence of Parkinson’s disease: a systematic review and meta-analysis. Mov Disord, 2014. 29: 1583. 19. Picillo, M., et al. The PRIAMO study: urinary dysfunction as a marker of disease progression in early Parkinson’s disease. Eur J Neurol, 2017. 24: 788. 20. Papatsoris, A.G., et al. Urinary and erectile dysfunction in multiple system atrophy (MSA). Neurourol Urodyn, 2008. 27 (...) : 22. 21. Kim, M., et al. Impaired detrusor contractility is the pathognomonic urodynamic finding of multiple system atrophy compared to idiopathic Parkinson’s disease. Parkinsonism Relat Disord, 2015. 21: 205. 22. Sakakibara, R., et al. A guideline for the management of bladder dysfunction in Parkinson’s disease and other gait disorders. Neurourol Urodyn, 2015. 23. Yamamoto, T., et al. Postvoid residual predicts the diagnosis of multiple system atrophy in Parkinsonian syndrome. J Neurol Sci, 2017

2018 European Association of Urology

1965. Male Sexual Dysfunction

and female sexual health: the Princeton III summary. J Sex Med, 2012. 9: 641. 101. Gazzaruso, C., et al. Erectile dysfunction can improve the effectiveness of the current guidelines for the screening for asymptomatic coronary artery disease in diabetes. Endocrine, 2011. 40: 273. 102. Turek, S.J., et al. Sexual dysfunction as a marker of cardiovascular disease in males with 50 or more years of type 1 diabetes. Diabetes Care, 2013. 36: 3222. 103. Vlachopoulos, C., et al. Prediction of cardiovascular events (...) of observational studies. J Sex Med 2015 12(6)1309. 39. Buvat, J., et al. Endocrine aspects of male sexual dysfunctions. J Sex Med, 2010. 7: 1627. 40. Jackson, G., et al. Cardiovascular aspects of sexual medicine. J Sex Med, 2010. 7: 1608. 41. Binmoammar, T.A., et al. The impact of poor glycaemic control on the prevalence of erectile dysfunction in men with type 2 diabetes mellitus: a systematic review. JRSM Open, 2016. 7: 2054270415622602. 42. Glina, F.P.A., et al. What Is the Impact of Bariatric Surgery

2018 European Association of Urology

1966. Management of Non-neurogenic Male LUTS

. Novara, G., et al. Critical Review of Guidelines for BPH Diagnosis and Treatment Strategy. Eur Urol Suppl 2006. 4: 418. 20. McVary, K.T., et al. Update on AUA guideline on the management of benign prostatic hyperplasia. J Urol, 2011. 185: 1793. 21. Bosch, J., et al. Etiology, Patient Assessment and Predicting Outcome from Therapy. International Consultation on Urological Diseases Male LUTS Guideline 2013. 22. Martin, R.M., et al. Lower urinary tract symptoms and risk of prostate cancer: the HUNT 2 (...) : 753. 45. Burger, M., et al. ICUD-EAU International Consultation on Bladder Cancer 2012: Non-muscle-invasive urothelial carcinoma of the bladder. Eur Urol, 2013. 63: 36. 46. Grabe, M., et al. Guidelines on Urological Infections. European Association of Urology 2013. 47. Palou, J., et al. ICUD-EAU International Consultation on Bladder Cancer 2012: Urothelial carcinoma of the prostate. Eur Urol, 2013. 63: 81. 48. Roupret, M., et al. European guidelines on upper tract urothelial carcinomas: 2013

2018 European Association of Urology

1967. Male Hypogonadism

hypogonadism and the most common numerical chromosomal aberration, with 47,XXY in 90% of cases [ ]. It arises due to non-disjunction during paternal or maternal meiotic division of germ cells [ ]. Testicular germ cell tumours are the most frequent type of cancer in young males after puberty. Risk factors are contralateral germ cell cancer, maldescended testes, gonadal dysgenesis, infertility, testicular atrophy and familial germ cell cancer. Twenty-five per cent of men with testicular tumours develop (...) , mostly obese men, with a concomitant age-related decline in testosterone levels resulting from defects in testicular as well as hypothalamic-pituitary function. Table 1: Forms of primary hypogonadism Disease Causes of deficiency Maldescended or ectopic testes Failure of testicular descent, maldevelopment of the testis [ ] Klinefelter syndrome 47,XXY Sex-chromosomal non-disjunction in germ cells Germ Cell Tumour Testicular maldevelopment Orchitis Viral or unspecific orchitis Acquired anorchia Trauma

2018 European Association of Urology

1968. Treatment for Bipolar Disorder in Adults: A Systematic Review

for psychosocial interventions. We were unable to address questions on subpopulations or treatments to reduce the metabolic-related side effects of first-line drug treatments. Future studies of treatments for BD will require innovative ways to increase study completion rates. References 1. Ferrari AJ, Stockings E, Khoo JP, et al. The prevalence and burden of bipolar disorder: findings from the Global Burden of Disease Study 2013. Bipolar Disord. 2016 01 Aug;18(5):440-50. doi: http://dx.doi.org/10.1111/bdi (...) ) diagnoses, including bipolar I disorder (BD-I), bipolar II disorder (BD-II), and other types. Key Messages • Acute mania treatment: Lithium, asenapine, cariprazine, olanzapine, quetiapine, risperidone, and ziprasidone may modestly improve acute mania symptoms in adults with BD-I. Participants on atypical antipsychotics, except for quetiapine, reported more extrapyramidal symptoms, and those on olanzapine reported more weight gain, compared with placebo. • Maintenance treatment: Lithium may prevent

2018 Effective Health Care Program (AHRQ)

1969. Management of Pregnancy

into account the needs of individual patients, available resources, and limitations unique to an institution or type of practice. Every healthcare professional making use of these guidelines is responsible for evaluating the appropriateness of applying them in the setting of any particular clinical situation. These guidelines are not intended to represent Department of Veterans Affairs or TRICARE policy. Further, inclusion of recommendations for specific testing and/or therapeutic interventions within (...) Health System,” by facilitating the development of clinical practice guidelines (CPGs) for the VA and DoD populations.[ ] This CPG is intended to provide healthcare providers with a framework by which to evaluate, treat, and manage the individual needs and preferences of pregnant women, thereby leading to improved clinical outcomes. 1 In 2009, the VA and DoD published a CPG for the Management of Pregnancy (2009 Pregnancy CPG), which was based on evidence reviewed through December 2007. Since

2018 VA/DoD Clinical Practice Guidelines

1970. Evaluation and Treatment of Hirsutism in Premenopausal Women Full Text available with Trip Pro

); and pelvic ultrasonography (preferably transvaginal) to detect an ovarian neoplasm in women with severe or progressive hyperandrogenism. Of note, some androgen-secreting ovarian tumors are too small to be detected by transvaginal ultrasound. Further workup to identify the origin of androgen excess may be clinically indicated because of atypical clinical or laboratory findings and may include the following: (1) measuring serum androstenedione (the immediate precursor for testosterone) ( ) or other steroid (...) additional cosmetic benefit, we suggest adding direct hair removal methods. However, for women with mild hirsutism and no evidence of an endocrine disorder, we suggest either approach. (2 |⊕OOO) 2.2. For hirsute women with obesity, including those with polycystic ovary syndrome, we also recommend lifestyle changes. (1 |⊕⊕OO) 3.0 Pharmacological treatments Initial therapies 3.1. For the majority of women with hirsutism who are not seeking fertility, we suggest oral contraceptives as initial therapy

2018 The Endocrine Society

1971. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome

hyperandrogenismneedtobe considered. Historyofsymptomonsetandprogressionis criticalin assessing for neoplasia, however, some androgen-secreting neoplasms may only induce mild to moderate increases in biochemical hyperandrogenism. _ Clinicalhyperandrogenism CCR A comprehensive history and physical examination should be completed for symptoms and signs of clinical hyperandrogenism, including acne, alopecia, and hirsutism and, in adolescents, severe acne and hirsutism. **** CCR Health professionals should be aware (...) hyperplasia and endometrial cancer is not known. A pragmatic approach could include COCP or progestin therapy in those with cycles longer than 90 days. _ 2.PREVALENCE,SCREENING,DIAGNOSTICASSESSMENTANDTREATMENTINEMOTIONALWELLBEING Qualityoflife CCR Health professionals and women should be aware of the adverse impact of PCOS on quality of life. **** Teede. International evidence-based guideline. Fertil Steril 2018. VOL.- NO.- /- 2018 7 Fertility and Sterility®TABLE 3 Continued. Category (see Table 1 for de

2018 Society for Assisted Reproductive Technology

1972. Male Infertility

be investigated. Br J Urol, 1990. 66: 642. 231. Skakkebaek, N.E. Carcinoma in situ of the testis: frequency and relationship to invasive germ cell tumours in infertile men. Histopathology, 1978. 2: 157. 232. von der Maase, H., et al. Carcinoma in situ of contralateral testis in patients with testicular germ cell cancer: study of 27 cases in 500 patients. Br Med J (Clin Res Ed), 1986. 293: 1398. 233. Jacobsen, R., et al. Risk of testicular cancer in men with abnormal semen characteristics: cohort study. BMJ (...) . 35: 439. 269. Maurer, C.A., et al. Total mesorectal excision preserves male genital function compared with conventional rectal cancer surgery. Br J Surg, 2001. 88: 1501. 270. Tournaye, H., et al. Fertility preservation in men with cancer. Lancet, 2014. 384: 1295. 271. Coward, R.M., et al. Fertility Preservation in Young Men Treated for Malignancies: Options for Precancer Treatment. Sex Med Rev, 2013. 1: 123. 272. Picton, H.M., et al. A European perspective on testicular tissue cryopreservation

2018 European Association of Urology

1973. Guideline for the management of knee and hip osteoarthritis

controlled trial RR relative risk SES socioeconomic status SMD standardised mean difference SNRI serotonin and norepinephrine reuptake inhibitor TEAE treatment-emergent adverse event TENS transcutaneous electrical nerve stimulation TGA Therapeutic Goods Administration TNF-alpha tumour necrosis factor alpha TrkA tyrosine kinase receptor TRPV1 Transient Receptor Potential Vanilloid 1 VAS Visual Analog Scale WHO World Health Organization WOMAC Western Ontario and McMaster Universities Osteoarthritis Indexv (...) exercise, walking, muscle-strengthening exercise, Tai Chi) Low (all land- based, Tai Chi) Very low (walking, muscle- strengthening exercise) Land-based exercise – Hip We strongly recommend offering land-based exercise for all people with hip OA to improve pain and function, regardless of their age, structural disease severity, functional status or pain levels Exercise has also been found to be beneficial for other comorbidities and overall health The type of exercise that is most beneficial is not yet

2018 Clinical Practice Guidelines Portal

1974. Chronic Pelvic Pain

and types of nonbladder syndromes as risk factors for interstitial cystitis/painful bladder syndrome. Urology, 2011. 77: 313. 181. Peters, K.M., et al. Are ulcerative and nonulcerative interstitial cystitis/painful bladder syndrome 2 distinct diseases? A study of coexisting conditions. Urology, 2011. 78: 301. 182. Rab, M., et al. Anatomic variability of the ilioinguinal and genitofemoral nerve: implications for the treatment of groin pain. Plast Reconstr Surg, 2001. 108: 1618. 183. Eklund, A., et al (...) REFERENCES 1. Fall, M., et al., EAU Guidelines on Chronic Pelvic Pain., In: EAU Guidelines on Chronic Pelvic Pain. Presented at the 18th EAU Annual Congress Madrid 2003. 2003, European Association of Urology: Arnhem. 2. Fall, M., et al. EAU guidelines on chronic pelvic pain. Eur Urol, 2004. 46: 681. 3. Fall, M., et al., EAU Guidelines on Chronic Pelvic Pain, In: EAU Guidelines on Chronic Pelvic Pain. Presented at the 18th EAU Annual Congress Barcelona 2010. 2010, EAU: Arnhem. 4. Fall, M., et al. EAU

2018 European Association of Urology

1975. Evaluation and Management of Right-Sided Heart Failure

with HFpEF, whereas RVFAC <35% was seen in only 28%. Compared with patients with HFpEF without RVD, those with RVD were more likely to be male, to have more renal impairment, and to have a higher prevalence of atrial fibrillation and coronary artery disease. , Analogous to outcomes in HFrEF populations, RVD is associated with increased morbidity and mortality in HFpEF populations. Two-year mortality in 1 study was ≈45% for patients with RVD compared with 7% in those without RVD. Exercise intolerance (...) within days to weeks after the infarct. One-year mortality after RVMI is reported to be 18% in patients with isolated right coronary artery lesions compared to 27% in the presence of combined right and left coronary artery disease. In long-term follow-up, mortality beyond the first year remains at an additional 2%/y to 3%/y through year 10. In 1 series, mortality among patients with inferior MI with RVMI was 25% to 30% compared with 6% in patients without RVMI. Similarly, among 666 patients

2018 International Society for Heart and Lung Transplantation

1976. Bruising

of Health and Care Excellence (NICE) guideline Suspected cancer: recognition and referral [ ]. The recommendation to check a blood film is based on expert opinion in review articles that this can confirm whether there is true thrombocytopenia; and platelet and leukocyte morphology and characteristics can suggest haematological malignancies and hyperproliferative conditions [ ; ]. Pancytopenia indicates bone marrow disease [ ]. The recommendation to consider checking clotting is based on expert opinion (...) Bruising Prodigy Toggle navigation Topics Specialities A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Allergies Cancer Cardiovascular Child health Drugs and devices Ear, nose and throat Endocrine and metabolic Eyes Gastroenterology Gastrointestinal Haematology Immunizations Infections and infestations Injuries Kidney disease and urology Men's health Mental health Musculoskeletal Neurological Oral health Palliative care Poisoning Pregnancy Preventative medicine Respiratory Sexual health

2017 Prodigy

1977. CRACKCast E140 – Accidental Hypothermia

of epinephrine 1 mg if in arrest (knowing that below 30 degrees it will not be very effective and may be prodysrhythmic) Trial single defibrillation attempt at 360 J If unsuccessful don’t re-attempt until the patient has been warmed 1-2 degrees Celsius; then attempts may resume again. Key point: don’t make the patient with bradycardia go into VF! Avoid disturbing the moderate/severely hypothermic patient! Avoid multiple attempts at defibrillation with 360 J for patients with temperatures < 28 degrees Celsuis (...) Used primarily for moderate to severe hypothermia Required for moderate to severe hypothermia where cardiovascular instability is present Two types of active rewarming are: Active External Rewarming Active Core Rewarming [9] What are five indications for active rewarming? Describe 6 techniques for active rewarming See Box 132.3 in Rosen’s 9 th Edition for the list of indications for active rewarming in the hypothermic patient Five Indications for Active Rewarming 1. Cardiovascular instability 2

2018 CandiEM

1978. Guidelines on autopsy practice: Sudden death with likely cardiac pathology

? Obesity-associated cardiomyopathy ? Idiopathic myocardial fibrosis ? Cardiac amyloid ? Storage disorders ? Connective tissue disorders (rheumatoid disease, lupus (SLE), sickle cell (HbSS), endocrine; hypothyroid/hyperthyroid states). Congenital heart disease (+/- corrected), also known as GUCH (grown-up congenital heart disease). CEff 200715 6 V6 Final Cardiac tumour This is mostly cardiac myxoma, but rarely may be a primary malignant lesion (sarcoma). Metastasis from other tumour sites should (...) be sought. Cardiac tumours are rarely encountered and their significance should be balanced against the ante-mortem history and other autopsy findings. Cardiomyopathies deserve special mention.These include dilated cardiomyopathy (DCM; multiple causes being recognised), hypertrophic cardiomyopathy (HCM), arrhythmogenic (right ventricular) cardiomyopathy (ARVC) and other degenerative cardiomyopathies (mitochondrial, muscular dystrophy, etc.). These cardiomyopathies are usually associated with progressive

2017 Royal College of Pathologists

1979. Guidelines for the investigation of chronic diarrhoea in adults

disease, etc as well as stool tests for inflammation (Grade of evidence level 1, Strength of recommendation strong). ? We recommend making a positive diagnosis of irritable bowel syndrome (IBS) following basic blood and stool screening tests (Grade of evidence level 2, Strength of recommendation strong). cancer or inflammation ? We recommend excluding colorectal cancer in those with altered bowel habit±rectal bleeding by colonoscopy (Grade of evidence level 1, Strength of recommendation strong). ? We (...) functional bowel disorder from organic/ inflammatory bowel disease (Grade of evidence level 1, Strength of recommendation strong). ? In patients with typical symptoms of functional bowel disease, normal physical examination and normal screening blood and faecal tests (calprotectin), a positive diagnosis of IBS can be made (Grade of evidence level 2, Strength of recommendation strong). ? For those with lower gastrointestinal symptoms suspicious of colon cancer (without rectal bleeding), we suggest faecal

2018 British Society of Gastroenterology

1980. CRACKCast E181 – Approach to the Geriatric Patient

Focal Weakness Acute Focal Causes ICH Ischemic Stroke SAH Tumor Acute Bilateral Causes Brainstem stroke SCI trauma infection neoplasm inflammatory Guillain-Barre Non-Focal Weakness Acute Non-Focal Causes cardiac delirium metabolic infection Chronic Non-Focal Causes anemia meds inflammation neurologic deconditioning malignancy [6] List 8 predisposing risk factors for sepsis in the elderly. See Figure 183.4 Delirium and Dementia Decreased gag and cough reflex (aspiration risk) Endocrine deficiency (...) CRACKCast E181 – Approach to the Geriatric Patient CRACKCast E181 - Approach to the Geriatric Patient - CanadiEM CRACKCast E181 – Approach to the Geriatric Patient In , , by Adam Thomas May 28, 2018 This episode of CRACKCast covers Rosen’s chapter 183, approach to the geriatric patient. Our geriatric patients can often mask serious diagnoses with vague presentations and multiple co-morbidities. Shownotes– Rosen’s In Perspective Taking care of the elderly is hard! Given the Silver-Tsunami

2018 CandiEM

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