How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

1,976 results for

Multiple Endocrine Neoplasia Type 1

by
...
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

161. Multiple Endocrine Neoplasia Type 2 and Familial Medullary Thyroid Carcinoma: An Update. (Full text)

Multiple Endocrine Neoplasia Type 2 and Familial Medullary Thyroid Carcinoma: An Update. Over the last decade, our knowledge of the multiple endocrine neoplasia (MEN) type 2 syndromes MEN2A and MEN2B and familial medullary thyroid carcinoma (FMTC) has expanded greatly. In this manuscript, we summarize how recent discoveries have enhanced our understanding of the molecular basis of these diseases and led to improvements in the diagnosis and management of affected patients.We reviewed the English (...) literature through PubMed from 2000 to the present, using the search terms medullary thyroid carcinoma, multiple endocrine neoplasia type 2, familial medullary thyroid carcinoma, RET proto-oncogene, and calcitonin.Over 70 RET mutations are known to cause MEN2A, MEN2B, or FMTC, and recent findings from studies of large kindreds with these syndromes have clouded the relationship between genotype and phenotype, primarily because of the varied clinical presentation of different families with the same RET

2013 Journal of Clinical Endocrinology and Metabolism PubMed abstract

162. Multiple endocrine neoplasia type 2A due to an exon 8 (G533C) mutation in a large North American kindred. (Abstract)

Multiple endocrine neoplasia type 2A due to an exon 8 (G533C) mutation in a large North American kindred. Medullary thyroid cancer, although most commonly sporadic, may be part of the multiple endocrine neoplasia type 2 (MEN2) syndromes, generally due to mutations in the RET proto-oncogene. The majority of these mutations are located in exons 10, 11, and 13-16. More rarely, mutations in other exons have been described. We report for the first time a family from the United States with a rare (...) missense mutation, despite initial negative screening for common mutations. We describe a family with a total of 47 individuals from five generations with multiple members affected with this mutation.Our data suggest that in patients with this mutation, pheochromocytoma is more common than previously reported, and that in some cases this mutation may be associated with a more aggressive phenotype than initially described.MEN2A due to the G533C mutation in exon 8 may be more common and more aggressive

2013 Thyroid

163. The Characterization of Pheochromocytoma and Its Impact on Overall Survival in Multiple Endocrine Neoplasia Type 2. (Full text)

The Characterization of Pheochromocytoma and Its Impact on Overall Survival in Multiple Endocrine Neoplasia Type 2. Pheochromocytoma (PHEO) occurs in 50% of patients with multiple endocrine neoplasia type 2 (MEN2). It is unknown if the presence of PHEO is associated with more aggressive medullary thyroid cancer (MTC).To present our experience with MEN2 PHEO and evaluate whether PHEO impacts MTC overall survival in patients with RET codon 634 mutations.We performed a retrospective chart review (...) of MEN2 patients at MD Anderson Cancer Center from 1960 through 2012.The study group comprised 85 patients (group 1) with MEN2-associated PHEO. Of these, 59 patients (subgroup 1) with RET codon 634 mutations were compared to 48 patients (group 2) with RET codon 634 mutations, but without MEN2-associated PHEO.Of 85 patients with MEN2 and PHEO, 70 had MEN2A and 15 had MEN2B. Median age at PHEO diagnosis was 32 years. The initial manifestation of MEN2 was MTC in 60% of patients, synchronous MTC and PHEO

2013 Journal of Clinical Endocrinology and Metabolism PubMed abstract

164. Hidden diagnosis of multiple endocrine neoplasia-1 unraveled during workup of virilization caused by adrenocortical carcinoma (Full text)

Hidden diagnosis of multiple endocrine neoplasia-1 unraveled during workup of virilization caused by adrenocortical carcinoma Multiple endocrine neoplasia-1 (MEN1) is an autosomal dominant syndrome with classic triad of parathyroid hyperplasia, pancreatic neuroendocrine tumors, and pituitary adenomas. Other recognized manifestations include carcinoid, cutaneous or adrenocortical tumors. It is commonly presented with clinical features related to parathyroid, pancreas or pituitary lesions. Here

2013 Indian journal of endocrinology and metabolism PubMed abstract

165. Multiple Endocrine Neoplasia Type 2

Multiple Endocrine Neoplasia Type 2 Multiple Endocrine Neoplasia Type 2 Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Multiple (...) Endocrine Neoplasia Type 2 Multiple Endocrine Neoplasia Type 2 Aka: Multiple Endocrine Neoplasia Type 2 , Multiple Endocrine Neoplasia Type II , Sipple's Syndrome , MEN II From Related Chapters II. Associated Conditions Multiple Endocrine Neoplasia Type 2 or Adrenal adenoma carcinoma Multiple Endocrine Neoplasia Type 2-A ry tumor III. Prevention: Screening in family members Identify specific gene mutation in known positive family member with MEN II Screen family members for the specific gene mutation IV

2015 FP Notebook

166. Multiple endocrine neoplasias type 2B and RET proto-oncogene (Full text)

Multiple endocrine neoplasias type 2B and RET proto-oncogene Multiple Endocrine Neoplasia type 2B (MEN 2B) is an autosomal dominant complex oncologic neurocristopathy including medullary thyroid carcinoma, pheochromocytoma, gastrointestinal disorders, marphanoid face, and mucosal multiple ganglioneuromas. Medullary thyroid carcinoma is the major cause of mortality in MEN 2B syndrome, and it often appears during the first years of life. RET proto-oncogene germline activating mutations (...) aim before 1 year of age in patients with molecular genetic diagnosis. Recent advances into the mechanisms of RET proto-oncogene signaling and pathways of RET signal transduction in the development of MEN 2 and MTC will allow new treatment possibilities.

2012 Italian journal of pediatrics PubMed abstract

167. Coexistence of Multiple Endocrine Neoplasia Type 2B and Chilaiditi Sign: A Case Report (Full text)

Coexistence of Multiple Endocrine Neoplasia Type 2B and Chilaiditi Sign: A Case Report We present a 15-year-old female patient with medullary thyroid carcinoma, marfanoid habitus, and mucosal ganglioneuromatosis. Our case had a RET protooncogene mutation ser836 polymorphism in exon 14 and ser904 polymorphism in exon 15. Our patient is thought to be atypical MEN2B due to the absence of M918T or A883F mutations. Chilaiditi sign is an incidental radiographic finding of a usually asymptomatic

2012 Case reports in endocrinology PubMed abstract

168. Ocular Signs of Multiple Endocrine Neoplasia Type 2B (MEN2B). (Full text)

Endocrinol Metab 0375362 0021-972X AIM IM Adolescent Dry Eye Syndromes etiology Eye pathology Female Humans Multiple Endocrine Neoplasia Type 2a complications diagnosis 2012 1 13 6 0 2012 1 13 6 0 2012 7 7 6 0 ppublish 22238409 jc.2011-3023 10.1210/jc.2011-3023 (...) Ocular Signs of Multiple Endocrine Neoplasia Type 2B (MEN2B). 22238409 2012 07 06 2012 03 06 1945-7197 97 3 2012 Mar The Journal of clinical endocrinology and metabolism J. Clin. Endocrinol. Metab. Ocular signs of multiple endocrine neoplasia type 2B (MEN2B). 725-6 10.1210/jc.2011-3023 Lee Richard R Worthing Hospital, Worthing, West Sussex, United Kingdom. rmhleeuk@gmail.com Hyer Jonathan J Chowdhury Haziq H Teimory Masoud M eng Case Reports Journal Article 2012 01 11 United States J Clin

2012 Journal of Clinical Endocrinology and Metabolism PubMed abstract

169. RET Proto-Oncogene Genetic Screening of Families with Multiple Endocrine Neoplasia Type 2 Optimizes Diagnostic and Clinical Management in China. (Abstract)

RET Proto-Oncogene Genetic Screening of Families with Multiple Endocrine Neoplasia Type 2 Optimizes Diagnostic and Clinical Management in China. Genetic screening for germline mutations in the RET proto-oncogene has been extensively exploited worldwide to optimize the diagnostic and clinical management of multiple endocrine neoplasia type 2 (MEN2) patients and their relatives. However, a distinct lag period exists not only in the recognition but also in the medical treatment of patients (...) , mutation types, tumor histopathologic features, and follow-up records were systematically analyzed.The RET mutations p.C634Y (n=34), p.C634R (n=6), p.C618S (n=13), p.V292M/R67H/R982C (n=7), p.L790F (n=2), and p.C634Y/V292M/R67H/R982C (n=1) were confirmed in 31 index cases and then identified in 32 at-risk relatives (mutation carriers), with MEN2A as the most common clinical subtype. The overall penetrance of PHEO in patients with MEN2A was 46.7%. A total of 50 patients underwent thyroidectomy

2012 Thyroid

170. Multiple endocrine neoplasia type 2: achievements and current challenges (Full text)

Multiple endocrine neoplasia type 2: achievements and current challenges Incremental advances in medical technology, such as the development of sensitive hormonal assays for routine clinical care, are the drivers of medical progress. This principle is exemplified by the creation of the concept of multiple endocrine neoplasia type 2, encompassing medullary thyroid cancer, pheochromocytoma, and primary hyperparathyroidism, which did not emerge before the early 1960s. This review sets out (...) to highlight key achievements, such as joint biochemical and DNA-based screening of individuals at risk of developing multiple endocrine neoplasia type 2, before casting a spotlight on current challenges which include: (i) ill-defined upper limits of calcitonin assays for infants and young children, rendering it difficult to implement the biochemical part of the integrated DNA-based/biochemical concept; (ii) our increasingly mobile society in which different service providers are caring for one individual

2012 Clinics PubMed abstract

171. Genotype-phenotype correlation in multiple endocrine neoplasia type 2 (Full text)

Genotype-phenotype correlation in multiple endocrine neoplasia type 2 Multiple endocrine neoplasia type 2 is an autosomal-dominant hereditary cancer syndrome caused by missense gain-of-function mutations of the rearranged during transfection proto-oncogene, which encodes the receptor tyrosine kinase, on chromosome 10. It has a strong penetrance of medullary thyroid carcinomas and can be associated with bilateral pheochromocytoma and primary hyperparathyroidism. Multiple endocrine neoplasia type (...) 2 is divided into three varieties depending on its clinical features: multiple endocrine neoplasia type 2A, multiple endocrine neoplasia type 2B, and familial medullary thyroid carcinoma. The specific rearranged during transfection mutation may suggest a predilection toward a particular phenotype and clinical course of medullary thyroid carcinoma, with strong genotype-phenotype correlations. Offering rearranged during transfection testing is the best practice for the clinical management

2012 Clinics PubMed abstract

172. Surgical approach to medullary thyroid carcinoma associated with multiple endocrine neoplasia type 2 (Full text)

Surgical approach to medullary thyroid carcinoma associated with multiple endocrine neoplasia type 2 We briefly review the surgical approaches to medullary thyroid carcinoma associated with multiple endocrine neoplasia type 2 (medullary thyroid carcinoma/multiple endocrine neoplasia type 2). The recommended surgical approaches are usually based on the age of the affected carrier/patient, tumor staging and the specific rearranged during transfection codon mutation. We have focused mainly

2012 Clinics PubMed abstract

173. RET Proto-oncogene Genetic Screening of Families with Multiple Endocrine Neoplasia Type 2 Optimizes Diagnostic and Clinical Management in China. (Abstract)

RET Proto-oncogene Genetic Screening of Families with Multiple Endocrine Neoplasia Type 2 Optimizes Diagnostic and Clinical Management in China.

2012 Thyroid

174. Importance of surveillance for multiple endocrine neoplasia-1 and surgery in patients with sporadic Zollinger-Ellison syndrome. (Abstract)

review of patients with ZES associated with multiple endocrine neoplasia type 1 (MEN-1) (n = 16) and those with sporadic ZES (n = 33) seen at a tertiary care center from August 1994 to January 2012. Cox proportional hazards modeling was used to compare survival times among groups, based on treatment with surgery (n = 34) and the presence of MEN-1 (n = 9 with surgery; n = 7 without surgery). Differences were compared using the unpaired Student t test and the Fisher exact test.Patients with MEN-1 (...) Importance of surveillance for multiple endocrine neoplasia-1 and surgery in patients with sporadic Zollinger-Ellison syndrome. Zollinger-Ellison syndrome (ZES) is a rare disorder characterized by gastrin-secreting tumors of the gastrointestinal tract and gastric acid hypersecretion. There is controversy over the best way to manage these patients; we investigated outcomes of patients with different forms of the disease, who did and did not undergo surgery.We performed a retrospective chart

2012 Clinical Gastroenterology and Hepatology

175. Oncogenetic testing, diagnosis and follow-up in Birt-Hogg-Dubé syndrome, familial atypical multiple mole melanoma syndrome and neurofibromatosis 1 and 2

syndrome, FAMMM and Neurofibromatosis 1/2 KCE Report 243Cs 4.4. Neurofibromatosis type 2 Neurofibromatosis type 2 is a multiple neoplasia syndrome that results from a mutation in the NF2 tumour suppressor gene. The genotype occurs in one in 25 000 live births and is inherited as an autosomal dominant trait. It has wide phenotypic variability. The penetrance is nearly 100% by 60 years of age. Improvements in diagnosis and treatment have led to a rise in the diagnostic prevalence to one in 100 000 people (...) are largely based on the opinion of experts in the field. 3. METHODS 3.1. Clinical research questions The current guideline addresses the following clinical questions: Among patients with suspicion of Birt-Hogg-Dubé syndrome or Familial atypical multiple mole melanoma syndrome or Neurofibromatosis 1 and Neurofibromatosis 2, either based on symptoms or family history: ? Who should undergo genetic testing? ? What type of follow-up should patients undergo, depending on test results and diagnosis? 3.2

2015 Belgian Health Care Knowledge Centre

176. Aggressive Medullary Thyroid Carcinoma in a 10-Year-Old Patient with Multiple Endocrine Neoplasia 2B due to the A883F Mutation. (Abstract)

Aggressive Medullary Thyroid Carcinoma in a 10-Year-Old Patient with Multiple Endocrine Neoplasia 2B due to the A883F Mutation. 25244518 2015 09 10 2015 01 10 1557-9077 25 1 2015 Jan Thyroid : official journal of the American Thyroid Association Thyroid Aggressive medullary thyroid carcinoma in a ten-year-old patient with multiple endocrine neoplasia 2B due to the A883F mutation. 139-40 10.1089/thy.2014.0177 Mathiesen Jes Sloth JS 1 Department of ENT Head & Neck Surgery, Odense University (...) Hospital , Odense C, Denmark . Stochholm Kirstine K Poulsen Per Loegstrup PL Vestergaard Else Marie EM Christiansen Peer P Vestergaard Peter P eng Case Reports Letter United States Thyroid 9104317 1050-7256 EC 2.7.10.1 Proto-Oncogene Proteins c-ret IM Carcinoma, Medullary genetics pathology Child Humans Male Multiple Endocrine Neoplasia Type 2b genetics pathology Mutation Proto-Oncogene Proteins c-ret genetics Thyroid Neoplasms genetics pathology 2014 9 23 6 0 2014 9 23 6 0 2015 9 12 6 0 ppublish

2014 Thyroid

177. The early diagnosis of medullary carcinoma of the thyroid gland in patients with multiple endocrine neoplasia type II. (Full text)

The early diagnosis of medullary carcinoma of the thyroid gland in patients with multiple endocrine neoplasia type II. Pentagastrin is a potent stimulator of thyrocalcitonin secretion from "C" cells. Since medulllary carcinoma of the thyroid gland (MCT) is a tumor composed of "C" cells, pentagastrin was used to screen a large kindred with multiple endocrine neoplasia type II (MCT, pheochromocytoma (s), and parathyroid hyperplasia). Four children with no thyroid abnormalities evident on physical (...) elevations in thyrocalcitonin secretion. This test has great diagnostic utility, especially in screening patients with multiple endocrine neoplasia type II.

1975 Annals of Surgery PubMed abstract

178. Multiple Endocrine Neoplasia (Treatment)

Multiple Endocrine Neoplasia (Treatment) Pediatric Multiple Endocrine Neoplasia Treatment & Management: Approach Considerations, Surgery for Type 1 MEN, Surgery or Type 2 MEN Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvOTIzMjY5LXRyZWF0bWVudA== processing > Pediatric Multiple Endocrine Neoplasia Treatment & Management Updated: Oct 11, 2017 Author: Alicia Diaz-Thomas, MD, MPH; Chief Editor: Robert P Hoffman, MD Share Email Print Feedback Close Sections Sections Pediatric Multiple Endocrine Neoplasia Treatment Approach Considerations Treatments for the various conditions associated with multiple endocrine neoplasia (MEN) include the following: Hypercalcemia - For patients with type 1 MEN who have hypercalcemia, surgery

2014 eMedicine Pediatrics

179. Multiple Endocrine Neoplasia (Overview)

Multiple Endocrine Neoplasia Updated: Oct 11, 2017 Author: Alicia Diaz-Thomas, MD, MPH; Chief Editor: Robert P Hoffman, MD Share Email Print Feedback Close Sections Sections Pediatric Multiple Endocrine Neoplasia Overview Background First reported in 1963 by Wermer, multiple endocrine neoplasia (MEN) syndromes, found in pediatric and adult patients, consist of rare, autosomal dominant mutations in genes that regulate cell growth. [ ] Current classification recognizes type 1 and , with the latter being (...) mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states. Hum Mol Genet . 1997 Jul. 6(7):1169-75. . Trouillas J, Labat-Moleur F, Sturm N, Kujas M, Heymann MF, Figarella-Branger D, et al. Pituitary tumors and hyperplasia in multiple endocrine neoplasia type 1 syndrome (MEN1): a case-control study in a series of 77 patients versus 2509 non-MEN1 patients. Am J Surg Pathol . 2008 Apr. 32(4):534-43. . Kloos RT, Eng C, Evans DB, et al. Medullary thyroid cancer: management

2014 eMedicine Pediatrics

180. Multiple Endocrine Neoplasia (Follow-up)

Multiple Endocrine Neoplasia (Follow-up) Pediatric Multiple Endocrine Neoplasia Treatment & Management: Approach Considerations, Surgery for Type 1 MEN, Surgery or Type 2 MEN Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvOTIzMjY5LXRyZWF0bWVudA== processing > Pediatric Multiple Endocrine Neoplasia Treatment & Management Updated: Oct 11, 2017 Author: Alicia Diaz-Thomas, MD, MPH; Chief Editor: Robert P Hoffman, MD Share Email Print Feedback Close Sections Sections Pediatric Multiple Endocrine Neoplasia Treatment Approach Considerations Treatments for the various conditions associated with multiple endocrine neoplasia (MEN) include the following: Hypercalcemia - For patients with type 1 MEN who have hypercalcemia, surgery

2014 eMedicine Pediatrics

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>