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Multinodular Goiter

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141. Gynecologic and reproductive health in patients with pathogenic germline variants in DICER1. (Abstract)

these DICER1-carrier females, DICER1-related gynecological tumors occurred during childhood or adolescence in some after which women generally experienced healthy reproductive lives. Individual education and screening for these tumors is warranted. The high rate of DICER1-related multinodular goiter resulting in pre- and post-pregnancy thyroidectomy underscores the importance of thyroid monitoring during pregnancy to ensure maternal and fetal wellbeing.Published by Elsevier Inc.

2020 Gynecologic Oncology

142. Predictors of euthyreosis in hyperthyroid patients treated with radioiodine <sup>131</sup>I<sup>-</sup>: a retrospective study. (Full text)

predictors of euthyroidism after 12 months of follow-up. The predictors of normal thyroid function have also been analyzed separately for patients with GD (Graves' disease) and TMNG (toxic multinodular goiter).The analysis showed that age (OR 1,06; 95%CI 1.025-1.096, p = 0,001), thyroid gland volume (OR 1,04; 95%CI 1,02-1,06; p < 0.001) and iodine uptake level (OR 0,952; 95%CI 0,91-0,98; p = 0,004) were significant factors of achieving normal thyroid function after RAI therapy. According to multivariate

2020 BMC Endocrine Disorders PubMed abstract

143. Measurement of anti-TSH receptor antibodies: what is the correct cut-off value? (Abstract)

, multinodular goitre, toxic adenoma, and thyroiditis. Furthermore, we included Graves' patients that were under treatment at the time of TRAb measurement.Whereas all patients with Graves' disease had positive TRAb, few patients with multinodular goitre, toxic adenoma, and thyroiditis scored positive for TRAb. ROC curve analysis revealed a cut-off value of 4.5 IU/l (compared to 3.3 IU/l established by the manufacturer). Newly diagnosed Graves' patients had higher TRAb concentrations compared to patients

2020 Netherlands Journal of Medicine

147. Unusual Cancers of Childhood Treatment (PDQ®): Health Professional Version

shown that it is possible to reduce the radiation dose to 55 Gy to 60 Gy for good responders.[ , ] Surgery. Surgery has a limited role in the management of nasopharyngeal carcinoma; the disease is usually considered unresectable because of extensive local spread. The combination of cisplatin-based chemotherapy and high doses of radiation therapy to the nasopharynx and neck are associated with a high probability of hearing loss, hypothyroidism and panhypopituitarism, trismus, xerostomia, dental

2018 PDQ - NCI's Comprehensive Cancer Database

148. AACE/ACE/AME Medical Guidelines for Clinical Practice for the Diagnosis and Management of Thyroid Nodules

goiters. • The recommendations should always be applied considering clinical setting, local medical exper- tise, available technical resources, and patient preferences [BEL 3, GRADE B]. 2. Clinical Evaluation and Diagnosis 2.1. History • We recommend that the following data be recorded: Age Personal or family history of thyroid disease or cancer Previous head or neck irradiation Rate of neck mass growth Anterior neck pain Dysphonia, dysphagia, or dyspnea Symptoms of hyper- or hypothyroidism Use (...) is not substantially different in patients with a solitary nodule versus patients with a multinodular goiter (MNG) [BEL 2, GRADE B]. 3. Thyroid Ultrasonography and Other Diagnostic Imaging Studies 3.1. When to Perform Thyroid Ultrasound • Ultrasound (US) evaluation is recommended for patients who are at risk for thyroid malignancy (see Table 3); have palpable thyroid nodules or goiter, or have neck lymphadenopathy sugges- tive of a malignant lesion [BEL 2, GRADE A]. • US evaluation is not recommended as a screen

2016 American Association of Clinical Endocrinologists

149. Consensus statement: using laryngeal electromyography for the diagnosis and treatment of vocal cord paralysis

of postoperative complications after total thy- roidectomy for multinodular goiters by surgeons with experience in endocrine surgery. Ann Surg 2004;240:18–25. 9. Steurer M, Passler C, Denk DM, Schneider B, Niederele B, Bigenzahn W. Advantages of recurrent laryngeal nerve identi?cation in thyroidectomy and parathyroidectomy and the importance of pre- operative and postoperative laryngoscopic examination in more than 1000 nerves at risk. Laryngoscope 2002;112:124–133. 10. Weddell G, Feinstein B, Pattle RE

2016 American Academy of Neurology

150. Consensus Statement: Using Laryngeal Electromyography for the Diagnosis and Treatment of Vocal Cord Paralysis

of postoperative complications after total thy- roidectomy for multinodular goiters by surgeons with experience in endocrine surgery. Ann Surg 2004;240:18–25. 9. Steurer M, Passler C, Denk DM, Schneider B, Niederele B, Bigenzahn W. Advantages of recurrent laryngeal nerve identi?cation in thyroidectomy and parathyroidectomy and the importance of pre- operative and postoperative laryngoscopic examination in more than 1000 nerves at risk. Laryngoscope 2002;112:124–133. 10. Weddell G, Feinstein B, Pattle RE

2016 American Association of Neuromuscular & Electrodiagnostic Medicine

153. SLC26A4-linked CEVA haplotype correlates with phenotype in patients with enlargement of the vestibular aqueduct. (Full text)

SLC26A4-linked CEVA haplotype correlates with phenotype in patients with enlargement of the vestibular aqueduct. Recessive mutations of coding regions and splice sites of the SLC26A4 gene cause hearing loss with enlargement of the vestibular aqueduct (EVA). Some patients also have a thyroid iodination defect that can lead to multinodular goiter as part of Pendred syndrome. A haplotype of variants upstream of SLC26A4, called CEVA, acts as a pathogenic recessive allele in trans to mutations

2019 BMC Medical Genetics PubMed abstract

154. The utility of intact parathyroid hormone level in managing hypocalcemia after thyroidectomy in children. (Abstract)

patients up to 18 years of age who underwent total or completion thyroidectomy from 1/1/2010 to 12/31/2016 at a tertiary pediatric academic center. Patient demographics, pathology, postoperative PTH, serum calcium, and length of stay were analyzed.The median age was 14.3 years (range of 4.3-18.4 years) with 84.2% being female. Thyroid malignancy was noted in 25 patients, and 13 had benign pathology including 8 patients with multinodular goiter and 5 with Grave's disease. In this serie, 63.2% (24/38

2019 International Journal of Pediatric Otorhinolaryngology

155. Children are at a High Risk of Hypocalcaemia and Hypoparathyroidism after Total Thyroidectomy. (Abstract)

' disease in 52 children (49.1%), Multiple Endocrine Neoplasia type-2 in 36 (33.9%), multinodular goiter in 3 (2.8%) and follicular/papillary thyroid carcinoma in 15 (14.2%). Neck dissection was performed in 23 children (18.9%). In 14 children (13.2%), autotransplantation was performed; in 31 (29.2%), ≥1 glands were found in the specimen. Hypocalcaemia within 24 h of thyroidectomy was observed in 63 children (59.4%) and 52 (49.3%) were discharged on supplements. Hypoparathyroidism at 6 months persisted

2019 Journal of Pediatric Surgery

156. miR-222 expression is correlated with the ATA risk stratifications in papillary thyroid carcinomas. (Full text)

miR-222 expression is correlated with the ATA risk stratifications in papillary thyroid carcinomas. miR-222 is one of the most consistently overexpressed miRNAs in papillary thyroid carcinoma (PTC). Previous studies demonstrated that miR-222 overexpression conferred high-risk features in PTC patients, suggesting its value in risk-stratification. However, studies in term of miR-222's utility on stratifying PTCs are lacking.One hundred patients including 10 with multinodular goiter and 90 (...) with PTC were enrolled. Formalin-fixed paraffin-embedded samples were exploited for miR-222 quantitative reverse transcriptase- polymerase chain reaction (RT-PCR) analysis. Correlations between miR-222 expression and different clinicopathological features, Tumor-node-metastasis (TNM) staging and ATA risk level were analyzed.miR-222 expression of the PTC group was significantly higher than that of the goiter group (P < .001). Furthermore, miR-222 expression was significantly higher in PTCs with advanced

2019 Medicine PubMed abstract

157. Association between Hashimoto's thyroiditis and papillary thyroid carcinoma: a retrospective analysis of 305 patients. (Full text)

of multinodular goiter, which was a significant difference (p <  0.001). In the second group, the association with PTC was found in 43 (40,2%) cases of HT nodular variant and in 3 cases (8,1%) of HT diffuse variant (p <  0.001).The relationship between HT and PTC is still far from clear and represents an unresolved issue. Our own study has underlined the frequent coexistence of these two pathologies, an aspect not to be neglected in clinical practice. Patients receiving HT diagnosis should undergo careful (...) group made up of 142 patients undergoing surgery for differentiated thyroid carcinoma was compared to a control group of 142 analogous subjects operated for normofunctioning goiter. A second group was made up of 163 patients who had undergone total thyroidectomy (TT) with pre-operative diagnosis of HT.In the first group of patients an association with HT was found in 28,6% of the patients with final histopathological diagnosis of PTC versus 7,7% of the patients with histopathological diagnosis

2019 BMC Endocrine Disorders PubMed abstract

158. Analysis of the PD-1/PD-L1 axis in human autoimmune thyroid disease: Insights into pathogenesis and clues to immunotherapy associated thyroid autoimmunity. (Abstract)

the analysis of the expression of PD-1, PD-L1 and PD-L2 in PBMCs, infiltrating thyroid lymphocytes (ITLs) and in thyroid follicular cells (TFCs) in GD, HT and multinodular goiter (MNG) patients and healthy controls PBMCs (HC). By combining flow cytometry, tissue immunofluorescence and induction experiments on primary and thyroid cell line cultures, we show that: 1) while PD-1+ T cells are moderately expanded in PBMCs from GD vs HC, approximately half of T cells in the infiltrate are PD-1+ including some PD

2019 Journal of autoimmunity

159. Follicular proliferation TIR3B: the role of total thyroidectomy vs lobectomy. (Full text)

), focusing mainly on the observed rate of malignancy. Chi-squared test and Fisher's exact probability test were used for analysis, considering a P values less than 0.05 as significant.Out of 52 patients 49 underwent TT and 3 L. In TT group a multinodular goiter was associated in 67.3% of patients. Malignancy rate was 81.6 and 33.3% respectively after TT and L (P 0.003). Multicentric and contralateral tumors were detected respectively in 36.7% and in 32.6% of patients underwent TT. No main post-operative (...) complications were registered.Ultrasound and elastography are useful to define within the TIR3B group those lesions at higher risk and therefore requiring a more radical approach. TT seems an appropriate approach to TIR3B lesions, especially in multinodular goiter, considering the incidence of malignancy with probably higher rate than previously reported.

2019 BMC Surgery PubMed abstract

160. The association of other autoimmune diseases in patients with Graves' disease (with or without ophthalmopathy): Review of the literature and report of a large series. (Abstract)

reported in the literature about the possible associations. Here, we review the association of GD and other autoimmune syndromes. Furthermore, we report the results of our prospective study that investigated the prevalence of other autoimmune disorders in 3209 GD patients (984 with Graves' ophthalmopathy), with respect to 1069 healthy controls, or 1069 patients with AT, or 1069 with multinodular goiter (matched by age, gender, coming from the same area, with a similar iodine intake). On the whole, 16.7 (...) The association of other autoimmune diseases in patients with Graves' disease (with or without ophthalmopathy): Review of the literature and report of a large series. Graves' disease (GD) and autoimmune thyroiditis (AT) are the two main clinical presentations of AITD, and their clinical hallmarks are thyrotoxicosis and hypothyroidism, respectively. GD, and AT, can be associated with other organ specific, or systemic autoimmune diseases in the same patient. However discordant results have been

2019 Autoimmunity reviews

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