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Multinodular Goiter

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121. Levothyroxine

in uninodular non-toxic goiter, whereas only few controlled trials enrolled patients with multinodular disease. The aim of the present study (...) is to evaluate the short term effects of levothyroxine treatment in never treated, pre-menopausal women affected by thyroid multinodular disease. Seventy-one pre-menopausal women with thyroid multinodular disease, still presenting normal TSH levels, from Latina area were randomly assigned to a levothyroxine treated or control group. Biochemical (...) of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com Top results for levothyroxine 1. Treatment of hypothyroidism with levothyroxine plus liothyronine: a randomized, double-blind, crossover study. 27982198 2016 12 16 2017 02 08 2359-4292 60 6 2016 Nov-Dec Archives of endocrinology and metabolism Arch Endocrinol Metab Treatment of hypothyroidism with levothyroxine plus liothyronine: a randomized, double-blind, crossover study. 562-572 S2359-39972016000600562

2018 Trip Latest and Greatest

122. Thyroid Function Testing in the Diagnosis and Monitoring of Thyroid Function Disorder

hypertension Thyroid Gland • GoitreGoitre Thermoregulation • Diminished sweating • Cold intolerance • Increased sweating • Heat intolerance Ophthalmologic • Blurred or double vision • Dry eyes, conjunctivitis, proptosis or dysconjugate gaze Gastrointestinal • Constipation • Increased frequency of stools Pituitary Function • Menorrhagia • Amenorrhea/oligomenorrhea A. Hypothyroidism rarely causes weight gain in pediatric populations. 93 BCGuidelines.ca: Thyroid Function Testing in the Diagnosis (...) not generally change clinical management. In specific circumstances it may be helpful in further clinical decision making. In patients with a goitre or mildly elevated TSH, anti-TPO measurement is used to evaluate whether the cause is autoimmune thyroiditis. 13 TPO antibody positivity increases the risk of developing hypothyroidism in patients with subclinical hypothyroidism, autoimmune diseases (e.g., type 1 diabetes), chromosomal disorders (e.g., Turner syndrome and Down syndrome) or patients who

2018 Clinical Practice Guidelines and Protocols in British Columbia

123. Thyroid Disease

gland. It typically occurs over many years and is more common in women in their fifth and sixth decades of life. Enlargement of the gland can occur with or without nodules and can involve the whole gland symmetrically or predominantly affect one lobe. Thyrotoxicosis is a condition of elevated thyroid hormone production. The most common causes are intrinsic to the thyroid and include Graves disease, toxic adenoma, toxic multinodular goiter, and subacute thyroiditis. Pituitary causes of thyrotoxicosis (...) goiter is made of thyroid tissue, in a multinodular goiter the scan should be compared to an US to identify hypofunctioning or isofunctioning nodules to be targeted for biopsy [16]. Variant 3: Thyrotoxicosis. Initial imaging. Thyrotoxicosis may present with symptoms of hyperthyroidism, such as heat intolerance, tachycardia, anxiety, and weight loss, or be subclinical and found as an incidental laboratory abnormality (low TSH). The most common causes of thyrotoxicosis are Graves disease, toxic adenoma

2019 American College of Radiology

124. Regorafenib (Stivarga) indicated as monotherapy for the treatment of adult patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib treatment

be caused by chronic infections with hepatitis B virus (HBV) or hepatitis C virus (HCV), chronic alcohol consumption, non-alcoholic ste- atohepatitis, or diabetes [11] There are many other risk factors but with lower importance, such as haemochromatosis, aflatoxin B1, tyrosinaemia, galactosaemia, fructosaemia, alpha 1 anti-trypsin deficiency, genetic predisposition, anabolising hormones, oestrogen contraceptives, obesity, and hypothyroidism. Based on a non-interventional surveillance study in 479 (...) of this disease should be global, taking into account the general state of patients and the underlying disease. When diagnosed at an early stage, patients may be eligible for curative treatments mainly repre- sented by surgical resection, radiofrequency ablation or liver transplantation. At an intermediate (multinodular) stage or for patients who progress to an intermediate stage, transcatheter arterial chemoembolisation (TACE) is generally the preferred option. For patients diagnosed with an ad- vanced

2018 EUnetHTA

126. Ultrasound-guided percutaneous radiofrequency ablation for benign thyroid nodules

, adenomatous or cancerous. The majority of thyroid nodules are benign and they are often asymptomatic. There may be a single thyroid nodule (solitary nodule) or multiple thyroid nodules (multinodular goitre). Thyroid nodules can cause an overactive thyroid, which affects the normal production of thyroxine or triiodothyronine. 2.2 Treatment of benign thyroid nodules may be necessary if they are symptomatic or causing cosmetic problems. Conventional treatment includes suppressive levothyroxine therapy (...) randomised to no treatment (27.5±22.1 ml at baseline and 27.8±22.1 ml at 6-month follow-up). In an RCT of 80 patients with solid, compressive, non-functioning benign thyroid nodules treated by RFA or no treatment, the median percentage volume changes were 71% reduction and 3% increase respectively (p=0.0001). In a non-randomised comparative study of 400 patients with nodular goitre treated by RFA or surgery there was a mean percentage volume reduction of 85(±17.1)% after RFA at 12-month follow-up (p

2016 National Institute for Health and Clinical Excellence - Interventional Procedures

127. Hyperthyroidism. (Abstract)

Hyperthyroidism. Thyrotoxicosis is a general term for excess circulating and tissue thyroid hormone levels, whereas hyperthyroidism specifically denotes disorders involving a hyperactive thyroid gland (Graves disease, toxic multinodular goiter, toxic adenoma). Diagnosis and determination of the cause rely on clinical evaluation, laboratory tests, and imaging studies. Hyperthyroidism is treated with antithyroid drugs, radioactive iodine ablation, or thyroidectomy. Other types of thyrotoxicosis

2020 Annals of Internal Medicine

128. Spot the Diagnosis! The case of the Pale Woman

paintings together, can you come up with a diagnosis? Susanna Lunden, Rubens (1625-28) What condition does this woman have? This woman has a features of hypothyroidism . In the first painting, she is slim but you cannot see her sternocleidomastoid muscles originate from the clavicles – which points to the findings of a goitre . 1 She is also very pale and appears to have gained significant weight from the first painting to the next, which albeit were the beauty standards of the time, are also clinical (...) manifestations of hypothyroidism. For the most part, thyroid disorders are insidious, slow-progressing conditions that can be managed in the outpatient setting. However, in rare circumstances, thyroid disorders may worsen and become medical emergencies. Goitre 1 What are the thyroid emergencies? The two main thyroid emergencies are myxedema coma and thyroid storm . Myxedema coma occurs when there is severe hypothyroidism, and is often precipitated by illness. Thyroid storm, on the other hand, manifests when

2017 CandiEM

129. CRACKCast E128 – Thyroid and Adrenal Disorders

hormone regulation, the hypothalamic-pituitary-thyroid axis [1] List 8 causes of thyrotoxicosis Thyrotoxicosis is a hypermetabolic condition that results from elevated levels of thyroid hormones—triiodothyronine (T3) and thyroxine (T4). This can occur from: Hormone overproduction (Graves’ disease, toxic multinodular goiter), Increased thyroid hormone release from an injured gland (thyroiditis, trauma), Exogenous thyroid hormone (thyrotoxicosis factitia). Most cases of thyrotoxicosis (>80%) are due (...) to autoimmune disease. For the purpose of this discussion, the terms hyperthyroidism and thyrotoxicosis are used interchangeably. Here’s the list of 8 causes: Graves’ disease: Most common cause! Autoimmune: autoantibodies bind to the TSH receptor and stimulate thyroid hormone production and release Toxic multinodular goiter: second most common cause Autonomously functioning nodules, usually in women older than 50 years Milder than Graves’ disease – but can present acutely in patients who are iodine

2017 CandiEM

130. Short term effects of levothyroxine treatment in thyroid multinodular disease. (Abstract)

Short term effects of levothyroxine treatment in thyroid multinodular disease. The levothyroxine suppressive efficacy in benign thyroid nodules treatment is well described in uninodular non-toxic goiter, whereas only few controlled trials enrolled patients with multinodular disease. The aim of the present study is to evaluate the short term effects of levothyroxine treatment in never treated, pre-menopausal women affected by thyroid multinodular disease. Seventy-one pre-menopausal women (...) with thyroid multinodular disease, still presenting normal TSH levels, from Latina area were randomly assigned to a levothyroxine treated or control group. Biochemical and ultrasonography evaluations of thyroid were monitored at the enrollment and after 6, 12 and 24 months of treatment. In the levothyroxine treated group, after 1 year of treatment, thyroid and dominant nodule volume and number of nodules >0.5 mL significantly decreased from a median of 12.0 to 9.8 mL (p <0.001), from 1.0 to 0.5 mL (p

2010 Endocrine journal Controlled trial quality: uncertain

131. Rare Undiagnosed Primary Amyloidosis Unmasked During Surgical Treatment of Primary Hyperparathyroidism: A Case Report Full Text available with Trip Pro

by the time of the diagnosis. However, if inadvertent diagnosis occurs before irreversible damage has taken place, as it did in the following case, some patients may benefit from the disease-arresting treatment. A 70-year-old female with a history of obstructive sleep apnea, hypertension, and arthritis presented with worsening dysphagia and biochemically confirmed primary hyperparathyroidism (PHPT). Further workup demonstrated multinodular goiter with compressive symptoms and substernal extension

2018 Journal of the Endocrine Society

132. Gynecologic and reproductive health in patients with pathogenic germline variants in DICER1. (Abstract)

these DICER1-carrier females, DICER1-related gynecological tumors occurred during childhood or adolescence in some after which women generally experienced healthy reproductive lives. Individual education and screening for these tumors is warranted. The high rate of DICER1-related multinodular goiter resulting in pre- and post-pregnancy thyroidectomy underscores the importance of thyroid monitoring during pregnancy to ensure maternal and fetal wellbeing.Published by Elsevier Inc.

2020 Gynecologic Oncology

133. Predictors of euthyreosis in hyperthyroid patients treated with radioiodine <sup>131</sup>I<sup>-</sup>: a retrospective study. Full Text available with Trip Pro

predictors of euthyroidism after 12 months of follow-up. The predictors of normal thyroid function have also been analyzed separately for patients with GD (Graves' disease) and TMNG (toxic multinodular goiter).The analysis showed that age (OR 1,06; 95%CI 1.025-1.096, p = 0,001), thyroid gland volume (OR 1,04; 95%CI 1,02-1,06; p < 0.001) and iodine uptake level (OR 0,952; 95%CI 0,91-0,98; p = 0,004) were significant factors of achieving normal thyroid function after RAI therapy. According to multivariate

2020 BMC Endocrine Disorders

134. Measurement of anti-TSH receptor antibodies: what is the correct cut-off value? (Abstract)

, multinodular goitre, toxic adenoma, and thyroiditis. Furthermore, we included Graves' patients that were under treatment at the time of TRAb measurement.Whereas all patients with Graves' disease had positive TRAb, few patients with multinodular goitre, toxic adenoma, and thyroiditis scored positive for TRAb. ROC curve analysis revealed a cut-off value of 4.5 IU/l (compared to 3.3 IU/l established by the manufacturer). Newly diagnosed Graves' patients had higher TRAb concentrations compared to patients

2020 Netherlands Journal of Medicine

138. Unusual Cancers of Childhood Treatment (PDQ®): Health Professional Version

shown that it is possible to reduce the radiation dose to 55 Gy to 60 Gy for good responders.[ , ] Surgery. Surgery has a limited role in the management of nasopharyngeal carcinoma; the disease is usually considered unresectable because of extensive local spread. The combination of cisplatin-based chemotherapy and high doses of radiation therapy to the nasopharynx and neck are associated with a high probability of hearing loss, hypothyroidism and panhypopituitarism, trismus, xerostomia, dental

2018 PDQ - NCI's Comprehensive Cancer Database

139. AACE/ACE/AME Medical Guidelines for Clinical Practice for the Diagnosis and Management of Thyroid Nodules

goiters. • The recommendations should always be applied considering clinical setting, local medical exper- tise, available technical resources, and patient preferences [BEL 3, GRADE B]. 2. Clinical Evaluation and Diagnosis 2.1. History • We recommend that the following data be recorded: Age Personal or family history of thyroid disease or cancer Previous head or neck irradiation Rate of neck mass growth Anterior neck pain Dysphonia, dysphagia, or dyspnea Symptoms of hyper- or hypothyroidism Use (...) is not substantially different in patients with a solitary nodule versus patients with a multinodular goiter (MNG) [BEL 2, GRADE B]. 3. Thyroid Ultrasonography and Other Diagnostic Imaging Studies 3.1. When to Perform Thyroid Ultrasound • Ultrasound (US) evaluation is recommended for patients who are at risk for thyroid malignancy (see Table 3); have palpable thyroid nodules or goiter, or have neck lymphadenopathy sugges- tive of a malignant lesion [BEL 2, GRADE A]. • US evaluation is not recommended as a screen

2016 American Association of Clinical Endocrinologists

140. Consensus statement: using laryngeal electromyography for the diagnosis and treatment of vocal cord paralysis

of postoperative complications after total thy- roidectomy for multinodular goiters by surgeons with experience in endocrine surgery. Ann Surg 2004;240:18–25. 9. Steurer M, Passler C, Denk DM, Schneider B, Niederele B, Bigenzahn W. Advantages of recurrent laryngeal nerve identi?cation in thyroidectomy and parathyroidectomy and the importance of pre- operative and postoperative laryngoscopic examination in more than 1000 nerves at risk. Laryngoscope 2002;112:124–133. 10. Weddell G, Feinstein B, Pattle RE

2016 American Academy of Neurology

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