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Multinodular Goiter

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61. DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors. Full Text available with Trip Pro

DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors. Nontoxic multinodular goiter (MNG) is frequently observed in the general population, but little is known about the underlying genetic susceptibility to this disease. Familial cases of MNG have been reported, and published reports describe 5 families that also contain at least 1 individual with a Sertoli-Leydig cell tumor of the ovary (SLCT). Germline mutations in DICER1, a gene that codes

2011 JAMA

62. Goitre causes, investigation and management

. References 1. Pinchera A, Aghini-lombardi F, Antonangeli l, Vitti P . multinodular goitre. Epidemiology and prevention. Ann ital chir 1996;67:317–25. 2. Knudsen n, laurberg P , Perrild h, Bülow i, ovesen l, Jørgensen t . Risk factors for goiter and thyroid nodules. thyroid 2002;12:879–88. 3. Vanderpas J. nutritional epidemiology and thyroid hormone metabolism. Ann Rev nutr 2006;26:293–322. 4. li m, Eastman cJ, Waite KV, et al. Are Australian children iodine deficient? Results of the Australian national (...) with goitre may be asymptomatic, or may present with compressive symptoms such as cough or dysphagia. Goitre may also present with symptoms due to associated hypothyroidism or hyperthyroidism. Thyroid stimulating hormone is the appropriate first test for all patients with goitre; if this hormone is low a radionuclide scan is helpful. Thyroid ultrasound has become an extension of physical examination and should be performed in all patients with goitre. Ultrasound can determine what nodules should

2012 Clinical Practice Guidelines Portal

63. Surgical Treatment of Retrosternal Goitre Full Text available with Trip Pro

). Multinodular goitre was found in 33 patients, diffuse goitre in 1 and ectopic thyroid in 1. The average vertical length of goitres in the collar incision group was 7.6 cm compared to 10.6 cm in the sternotomy group. The average weight of specimens was 156.3 g in patients with collar incisions and 307.5 g in the sternotomy group. Removal of retrosternal goitre is more commonly performed via a cervical collar incision with mandatory availability of sternotomy. Radiological measurement of craniocaudal length (...) Surgical Treatment of Retrosternal Goitre This study aims to evaluate surgical approaches to the management of retrosternal goitre. Between 2004 and 2014, 35 patients (eight males; mean age 67.4 ± 10.9 years) with retrosternal goitre (mainly right-sided in 9, left-sided in 14 and bilateral in 12) underwent surgery. A palpable neck mass was found in 11 (31.4%), stridor in 10 (28.6%) and thyrotoxicosis in 4 (11.4%) cases. 4 (11.4%) patients were asymptomatic. Tracheal compression was detected

2017 Indian Journal of Otolaryngology and Head & Neck Surgery

64. Less than total thyroidectomy for goiter: when and how? Full Text available with Trip Pro

Less than total thyroidectomy for goiter: when and how? Benign goiter is the most common endocrine disease that requires surgery, especially in endemic areas suffering from iodine-deficiency. Recent European and American guidelines recommended total thyroidectomy for the surgical treatment of multinodular goiter. Total thyroidectomy has now become the technique of choice and is widely considered the most reliable approach in preventing recurrence. Nevertheless, total thyroidectomy carries

2017 Gland surgery

65. Impact of pre-operative serum 25-hydroxyvitamin D on post-operative serum calcium in patients undergoing total thyroidectomy for benign goitre: retrospective study of 246 patients. (Abstract)

thyroidectomy for bilateral, benign, multinodular goitre. The correlation between pre-operative serum 25-hydroxyvitamin D and post-operative serum parathyroid hormone and serum calcium was studied to determine whether low pre-operative serum 25-hydroxyvitamin D was predictive of post-operative hypocalcaemia.Seventy-nine patients (32 per cent) had post-operative hypocalcaemia. Eighteen patients (7.32 per cent) experienced unintentional parathyroidectomy (1 parathyroid gland in 15 patients, 2 parathyroid (...) Impact of pre-operative serum 25-hydroxyvitamin D on post-operative serum calcium in patients undergoing total thyroidectomy for benign goitre: retrospective study of 246 patients. To determine whether pre-operative serum 25-hydroxyvitamin D has an impact on post-operative parathyroid hormone and serum calcium levels in patients undergoing total thyroidectomy for benign goitre.This single-centre, retrospective study comprised 246 unselected surgical patients who had undergone total

2017 Journal of Laryngology & Otology

66. Congenital hypothyroidism and thyroid dyshormonogenesis: a case report of siblings with a newly identified mutation in thyroperoxidase Full Text available with Trip Pro

Congenital hypothyroidism and thyroid dyshormonogenesis: a case report of siblings with a newly identified mutation in thyroperoxidase Thyroid dyshormonogenesis continues to be a significant cause of congenital hypothyroidism. Over time, forms of thyroid dyshormonogenesis can result in goiter, which can lead to difficult management decisions as the pathologic changes can both mimic or lead to thyroid cancer.Herein we describe the cases of two brothers diagnosed with congenital hypothyroidism (...) , with initial findings consistent with thyroid dyshormonogenesis. One brother eventually developed multinodular goiter with complex pathology on biopsy, resulting in thyroidectomy.Whole exome sequencing revealed the brothers carry a novel frameshift mutation in thyroperoxidase; the mutation, while not previously described, was likely both deleterious and pathogenic. Conlcusions: These cases highlight the complex pathology that can occur within thyroid dyshormonogenesis, with similar appearance to possible

2016 Journal of pediatric endocrinology & metabolism : JPEM

67. A Novel Mutation in Thyroid Peroxidase Gene Causing Congenital Goitrous Hypothyroidism in a German-Thai Patient Full Text available with Trip Pro

with levothyroxine replacement therapy. His goiter size had increased due to poor compliance to treatment. Ultrasonography of the thyroid gland showed a pattern suspicious for malignancy. The patient later underwent near-total thyroidectomy. Pathologic examination results were consistent with a multinodular goiter and no malignancy. Genetic analyses by direct sequencing of the entire exons and flanking regions of the TPO gene were performed in the index case and family members. The analyses revealed a compound (...) A Novel Mutation in Thyroid Peroxidase Gene Causing Congenital Goitrous Hypothyroidism in a German-Thai Patient Thyroid dyshormonogenesis is responsible for 10-15% of all cases of congenital hypothyroidism and is usually inherited. We report a 26-year-old German-Thai male with congenital hypothyroidism caused by a compound heterozygous mutation in the thyroid peroxidase (TPO) gene. He was diagnosed with congenital goitrous hypothyroidism at 4 months of age and had been treated

2016 Journal of clinical research in pediatric endocrinology

68. A rare presentation of a large goiter with papillary thyroid microcarcinoma as a chest wall mass: A case report Full Text available with Trip Pro

cystic with solid areas lesion over the chest. The patient underwent surgery and on histopathological examination, the predominant mass was characterized as a multinodular goiter with hemorrhage, necrosis and cystic change. A papillary thyroid microcarcinoma with a diameter of 0.2 cm was identified. The present study demonstrated a rare, to the best of our knowledge, presentation of a benign multinodular goiter in this way. (...) A rare presentation of a large goiter with papillary thyroid microcarcinoma as a chest wall mass: A case report Nodular goiter affects numerous individuals worldwide. As the thyroid enlarges, it normally extends into the mediastinum as a result of its anatomical location under the investing layer of the deep cervical fascia. The present study reports the rare case of a 76-year-old man who suffered from a goiter with papillary thyroid microcarcinoma, who presented as a subcutaneous partially

2016 Molecular and clinical oncology

69. Concomitant off-pump coronary artery bypass grafting and total thyroidectomy for a large retrosternal goitre: a case report and review of the literature Full Text available with Trip Pro

Concomitant off-pump coronary artery bypass grafting and total thyroidectomy for a large retrosternal goitre: a case report and review of the literature A 76-year-old male presented with angina and a large retrosternal goitre causing marked dyspnoea. Coronary angiography revealed triple vessel disease and moderately impaired left ventricular function. CT imaging demonstrated a substantial multinodular goitre extending into the posterior mediastinum to the level of the carina, with associated (...) compression of the trachea and oesophagus. Preoperative thyroid function tests showed euthyroid state. The patient subsequently underwent off-pump coronary artery bypass grafting (OPCABG) ×2 with concomitant total thyroidectomy. A thyroid mass of dimensions 19 cm × 16 cm × 5.5 cm and weight 439 g was confirmed to be a multinodular goitre. Postoperative complications included bilateral recurrent laryngeal nerve damage, hypocalcaemia and ventilator-associated pneumonia. The patient was discharged 36 days

2016 Journal of thoracic disease

70. Phrenic Nerve Palsy as Initial Presentation of Large Retrosternal Goitre Full Text available with Trip Pro

Phrenic Nerve Palsy as Initial Presentation of Large Retrosternal Goitre Unilateral phrenic nerve palsy as initial presentation of the retrosternal goitre is extremely rare event. This is a case report of a 57-year-old woman with history of cough and breathlessness of 3 months duration, unaware of the thyroid mass. She had large cervico-mediastinal goiter and chest radiograph revealed raised left sided hemidiaphragm. Chest CT scan did not reveal any lung parenchymal or mediastinal pathology (...) . The patient underwent a total thyroidectomy through a cervical approach. The final pathology was in favor of multinodular goitre. Even after 1 year of follow up, phrenic nerve palsy did not improve indicating permanent damage. Phrenic nerve palsy as initial presentation of the retrosternal goitre is unusual event. This case is reported not only because of the rare nature of presentation, but also to make clinicians aware of the entity so that early intervention may prevent attendant morbidity.

2016 Indian journal of surgical oncology

71. Negative Fine-Needle Aspiration in Patients with Goiter: Should We Doubt It? (Abstract)

Negative Fine-Needle Aspiration in Patients with Goiter: Should We Doubt It? Epidemiologic studies demonstrated higher incidence of thyroid cancer in patients with multinodular goiters compared to the general population. The aim of this study was to evaluate the risk of finding significant thyroid cancer in patients undergoing thyroidectomy for presumed benign disease.The records of 273 patients operated for indications other than cancer or indeterminate cytology were reviewed and analyzed.202 (...) goiters is extremely low. A negative FNA excludes significant cancer with near certainty.

2015 World Journal of Surgery

72. Goitre multi-nodulaire révélant une tuberculose thyroïdienne Full Text available with Trip Pro

Goitre multi-nodulaire révélant une tuberculose thyroïdienne 26955411 2016 10 31 2016 12 30 1937-8688 22 2015 The Pan African medical journal Pan Afr Med J [Multinodular thyroid goiter revealing tuberculosis]. 220 10.11604/pamj.2015.22.220.8118 Lahiani Rim R Service ORL, Hôpital Charles Nicolle, Tunis, Tunisie. Mahfoudhi Madiha M Service de Médecine Interne A, Hôpital Charles Nicolle, Tunis, Tunisie. fre Case Reports Journal Article Goitre multi-nodulaire révélant une tuberculose (...) thyroïdienne. 2015 11 10 Uganda Pan Afr Med J 101517926 IM Female Goiter, Nodular diagnosis microbiology Humans Middle Aged Thyroid Diseases diagnosis microbiology Tuberculosis, Endocrine diagnosis microbiology granuloma multinodular goiter tuberculosis 2015 10 05 2015 10 16 2016 3 9 6 0 2015 1 1 0 0 2016 11 1 6 0 epublish 26955411 10.11604/pamj.2015.22.220.8118 PAMJ-22-220 PMC4760719

2015 The Pan African medical journal

73. Thiamazole pretreatment lowers the <sup>131</sup>I activity needed to cure hyperthyroidism in patients with nodular goiter. Full Text available with Trip Pro

Thiamazole pretreatment lowers the 131I activity needed to cure hyperthyroidism in patients with nodular goiter. Relatively low radioiodine uptake (RAIU) represents a common obstacle for radioiodine ((131)I) therapy in patients with multinodular goiter complicated by hyperthyroidism.To evaluate whether thiamazole (MTZ) pretreatment can increase (131)I therapeutic efficacy.Twenty-two patients with multinodular goiter, subclinical hyperthyroidism, and RAIU < 50% were randomized

2015 Journal of Clinical Endocrinology and Metabolism Controlled trial quality: uncertain

74. High levels of circulating chemokine (C-X-C motif) ligand 11 are associated with euthyroid or subclinically hypothyroid autoimmune thyroiditis and with chemokine (C-X-C motif) ligand 10. (Abstract)

multinodular goiter, all similar in gender distribution and age. CXCL11 was significantly higher in patients with AT (113±56 pg/mL) than in controls (67±16 pg/mL) or patients with multinodular goiter (75±18 pg/mL; P<0.0001). Among patients with AT, CXCL11 was significantly higher in those with a hypoechoic ultrasonographic pattern and hypothyroidism. In a multiple linear regression (MLR) model including age, thyroid volume, hypoechogenicity, hypervascularity, thyroid-stimulating hormone (TSH), and anti (...) High levels of circulating chemokine (C-X-C motif) ligand 11 are associated with euthyroid or subclinically hypothyroid autoimmune thyroiditis and with chemokine (C-X-C motif) ligand 10. No data are available for chemokine (C-X-C motif) ligand 11 (CXCL11), together with CXCL10, circulating levels in autoimmune thyroiditis (AT). We measured serum CXCL11 and CXCL10 in 158 patients with newly diagnosed AT (26% with subclinical hypothyroidism), 56 euthyroid controls, and 20 patients with nontoxic

2012 Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

75. Parapharyngeal ectopic thyroid mimicking deep lobe parotid tumour along with multinodular thyroid goitre—a very rare presentation Full Text available with Trip Pro

Parapharyngeal ectopic thyroid mimicking deep lobe parotid tumour along with multinodular thyroid goitre—a very rare presentation 22184631 2012 04 05 2018 11 13 0250-832X 41 1 2012 Jan Dento maxillo facial radiology Dentomaxillofac Radiol Parapharyngeal ectopic thyroid mimicking deep lobe parotid tumour along with multinodular thyroid goitre--a very rare presentation. 89-90 10.1259/dmfr/41618957 Sidana S S Millet B B Moss C C eng Case Reports Letter England Dentomaxillofac Radiol 7609576 0250 (...) -832X D Adenoma, Pleomorphic diagnosis Aged Choristoma complications diagnostic imaging Diagnosis, Differential Female Goiter, Nodular complications Humans Paraganglioma diagnosis Parotid Diseases complications diagnostic imaging Parotid Neoplasms diagnostic imaging Radiography Thyroid Gland diagnostic imaging 2011 12 21 6 0 2011 12 21 6 0 2012 4 6 6 0 ppublish 22184631 41/1/89 10.1259/dmfr/41618957 PMC3520279 Singapore Med J. 2008 May;49(5):e137-8 18465039 Head Neck. 1996 Jan-Feb;18(1):67-77

2012 Dentomaxillofacial Radiology

76. Serum thyrotrophin concentration: an unreliable test for detection of early hypothyroidism after thyroidectomy. Full Text available with Trip Pro

Serum thyrotrophin concentration: an unreliable test for detection of early hypothyroidism after thyroidectomy. Three groups of patients who had undergone subtotal thyroidectomy for Graves's disease, toxic multinodular goitre, or euthyroid multinodular goitre 12 to 15 years before and in whom a normal serum thyroxine (T-4) level was found were each divided into two subgroups on the basis of a normal or a raised serum thyrotrophin concentration. There was no difference in mean serum T-4 (...) concentration between patients with normal and those with raised serum thyrotrophin concentrations, and the values were similar to the mean T-4 values of the normal population. The mean serum triiodothyronine values of all groups were higher than normal, but the mean values of the groups with a normal and a raised serum thyrotrophin were similar. After thyroidectomy a mildly raised serum thyrotrophin does not in itself indicate the presence of hypothyroidism.

1975 British medical journal

77. Malignancy rate in nondominant nodules in patients with multinodular goiter: Experience with 1,606 cases evaluated by ultrasound-guided fine needle aspiration cytology Full Text available with Trip Pro

Malignancy rate in nondominant nodules in patients with multinodular goiter: Experience with 1,606 cases evaluated by ultrasound-guided fine needle aspiration cytology Conventional medical sources recommend the use of fine needle aspiration cytology (FNAC) for single thyroid nodules and the dominant nodule in multinodular goiter (MNG). The purpose of the present study was to analyze the utility of FNAC for multiple thyroid nodules in patients with MNG and to determine the rate of malignancy

2011 CytoJournal

78. Modified-release recombinant human TSH (MRrhTSH) augments the effect of (131)I therapy in benign multinodular goiter: results from a multicenter international, randomized, placebo-controlled study. Full Text available with Trip Pro

Modified-release recombinant human TSH (MRrhTSH) augments the effect of (131)I therapy in benign multinodular goiter: results from a multicenter international, randomized, placebo-controlled study. Recombinant human TSH (rhTSH) can be used to enhance (131)I therapy for shrinkage of multinodular goiter (MG).The objective of the study was to compare the efficacy and safety of 0.01 and 0.03 mg modified-release (MR) rhTSH as an adjuvant to (131)I therapy, vs. (131)I alone, in a randomized, placebo (...) , with no significant difference among the groups. Goiter-related symptoms were effectively reduced and there were no major safety concerns.In this dose-selection study, 0.03 mg MRrhTSH was the most efficacious dose as an adjuvant to (131)I therapy of MG. It was well tolerated and significantly augmented the effect of (131)I therapy in the short term. Larger studies with long-term follow-up are warranted.

2011 The Journal of clinical endocrinology and metabolism Controlled trial quality: predicted high

79. A retrosternal retrotracheal multinodular goitre Full Text available with Trip Pro

A retrosternal retrotracheal multinodular goitre 22701027 2013 09 03 2018 11 13 1757-790X 2011 2011 Apr 15 BMJ case reports BMJ Case Rep A retrosternal retrotracheal multinodular goitre. 10.1136/bcr.01.2011.3758 bcr0120113758 Mistry Dipak D Department of ITU, Homerton University Hospital, London, UK. d.a.mistry@btinternet.com eng Case Reports Journal Article 2011 04 15 England BMJ Case Rep 101526291 1757-790X IM Female Goiter, Nodular diagnosis Goiter, Substernal diagnosis Humans Magnetic

2011 BMJ case reports

80. Approach to the patient with nontoxic multinodular goiter. Full Text available with Trip Pro

Approach to the patient with nontoxic multinodular goiter. Thyroid nodules are very common, and although the majority are benign, approximately 5% may harbor malignancy. The evaluation of the patient with solitary thyroid nodule is generally straightforward and will typically include measurement of serum TSH to assess thyroid function and fine-needle aspiration biopsy of the nodule, with or without ultrasound (US) guidance. The approach to the patient with nontoxic multinodular goiter (...) , patients with such nodules are generally advised to have surgery, unless autonomous function of these nodules can be confirmed by scintigraphy. Most of these patients, however, will ultimately prove to have benign follicular tumors. Many patients with benign but large goiters may experience clinical symptoms of pressure, such as dysphagia, choking sensation, or airway obstruction. Such patients will often require surgery for alleviation of symptoms. In the absence of malignancy, asymptomatic patients

2011 Journal of Clinical Endocrinology and Metabolism

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