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Multinodular Goiter

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701. Mutational analysis of Peroxiredoxin IV: exclusion of a positional candidate for multinodular goitre Full Text available with Trip Pro

Mutational analysis of Peroxiredoxin IV: exclusion of a positional candidate for multinodular goitre Multinodular goitre (MNG) is a common disorder characterised by an enlargement of the thyroid, occurring as a compensatory response to hormonogenesis impairment. The incidence of MNG is dependent on sex (female:male ratio 5:1) and several reports have documented a genetic basis for the disease. Last year we mapped a MNG locus to chromosome Xp22 in a region containing the peroxiredoxin IV (Prx-IV

2002 BMC Medical Genetics

702. Submucosal haemorrhage--or ruptured nodule in a multinodular goitre? Ultrasound scan suggested recent haemorrhage in a left upper pole thyroid nodule. Full Text available with Trip Pro

Submucosal haemorrhage--or ruptured nodule in a multinodular goitre? Ultrasound scan suggested recent haemorrhage in a left upper pole thyroid nodule. 9158491 1997 06 09 2016 11 24 0959-8138 314 7090 1997 May 03 BMJ (Clinical research ed.) BMJ Submucosal haemorrhage--or ruptured nodule in a multinodular goitre? Ultrasound scan suggested recent haemorrhage in a left upper pole thyroid nodule. 1351 Issa B G BG Scanlon M F MF eng Case Reports Letter England BMJ 8900488 0959-8138 AIM IM Contusions (...) Diagnosis, Differential Female Goiter, Nodular diagnostic imaging Hemorrhage diagnostic imaging Humans Rupture, Spontaneous Ultrasonography 1997 5 3 1997 5 3 0 1 1997 5 3 0 0 ppublish 9158491 PMC2126571

1997 BMJ : British Medical Journal

703. The use of computed tomography in the evaluation of large multinodular goitres: Assessor's comment Full Text available with Trip Pro

The use of computed tomography in the evaluation of large multinodular goitres: Assessor's comment 19311321 2010 06 25 2010 06 25 0035-8843 73 1 1991 Jan Annals of the Royal College of Surgeons of England Ann R Coll Surg Engl The use of computed tomography in the evaluation of large multinodular goitres: Assessor's comment. 35 Reid D J DJ eng Journal Article England Ann R Coll Surg Engl 7506860 0035-8843 2009 3 25 9 0 1991 1 1 0 0 1991 1 1 0 1 ppublish 19311321 PMC2499349

1991 Annals of the Royal College of Surgeons of England

704. The gamma delta T cell repertoire in Graves' disease and multinodular goitre. Full Text available with Trip Pro

The gamma delta T cell repertoire in Graves' disease and multinodular goitre. gamma delta T cells are a subset of T cells with unknown function, and restriction of the gamma delta T cell receptor (TCR) repertoire has been described in rheumatoid arthritis and multiple sclerosis. Elevated numbers of gamma delta T cells have been reported in the peripheral blood and thyroids of patients with Graves' disease. We have carried out flow cytometric analysis on peripheral blood mononuclear cells (PBMC (...) ) and intrathyroidal lymphocytes (ITL) from 12 patients with Graves' disease and nine patients with multinodular goitre (MNG), a thyroid disease of unknown etiology. There was no significant difference between the proportion of gamma delta T cells in the PBMC of Graves' and MNG patients, nor between the PBMC and ITL populations in either patient group. We have also carried out polymerase chain reaction amplification on RNA prepared from matched PBMC, ITL and the activated (CD25+) subset of ITL using six TCR V

1993 Clinical and experimental immunology

705. Familial nontoxic multinodular thyroid goiter locus maps to chromosome 14q but does not account for familial nonmedullary thyroid cancer. Full Text available with Trip Pro

Familial nontoxic multinodular thyroid goiter locus maps to chromosome 14q but does not account for familial nonmedullary thyroid cancer. Thyroid goiter is a common condition that is often associated with iodine deficiency. Familial forms of goiter in areas not known to feature iodine deficiency are much less common. We have performed a genomic search on a single large Canadian family with 18 cases of nontoxic multinodular goiter in which 2 individuals also had papillary lesions highly (...) suggestive of papillary carcinoma. A locus on chromosome 14q (MNG1 [multinodular goiter 1]) has been identified, with a maximal two-point LOD score of 3.8 at D14S1030 and a multipoint LOD score of 4.88 at the same marker, defined by D14S1062 (upper boundary) and D14S267 (lower boundary). The gene encoding thyroid-stimulating hormone receptor (TSHR), which is located on chromosome 14q, is outside the linked region. To determine the role of this gene in familial nonmedullary thyroid cancer (NMTC), we

1997 American Journal of Human Genetics

706. Pathogenesis of heterogeneity in human multinodular goiter. A study on growth and function of thyroid tissue transplanted onto nude mice. Full Text available with Trip Pro

Pathogenesis of heterogeneity in human multinodular goiter. A study on growth and function of thyroid tissue transplanted onto nude mice. Functional and morphologic heterogeneity of human multinodular goiters was investigated in 300 samples from "cold" and "hot" regions of 20 goiters transplanted onto nude mice. Transplants were labeled with [3H]thymidine and radioiodine, while the host's thyroid-stimulating hormone (TSH) secretion was either stimulated or suppressed. Proliferation and function (...) the individual growth pattern of the original tissue. Between 0.5% and 7% of all follicular cells replicated despite suppression of TSH. Up to 70% of these cells were clustered, forming scattered foci of autonomously growing tissue. Other cells only started replicating after long-term TSH stimulation. Thus, goiters contained subsets of cells with high and others with low growth response. Progenies of replicating cells remained clustered, sometimes budding outwards to form new follicles. Autonomy of growth

1985 Journal of Clinical Investigation

707. Total thyroidectomy. The preferred option for multinodular goiter. Full Text available with Trip Pro

Total thyroidectomy. The preferred option for multinodular goiter. Total thyroidectomy is an operation that has generally been reserved for the management of differentiated thyroid carcinoma. Over the last decade total thyroidectomy has become used increasingly and is now the preferred option in the authors' unit for the management of multinodular goiter affecting the entire gland. Over the period from 1975 to 1985, 853 thyroidectomies have been performed for multinodular goiter; of these, 115 (...) have been total thyroidectomies. During that time, the incidence of total thyroidectomy for multinodular goiter has increased in percentage terms from 9% in 1975 to 50% in 1985. There have been two cases of permanent hypoparathyroidism and one case of permanent recurrent laryngeal nerve injury, and these occurred in patients who had less than total thyroidectomy. Total thyroidectomy is an appropriate operation for the management of diffuse multinodular goiter where the entire gland is involved

1987 Annals of Surgery

708. Total thyroidectomy: the preferred option for multinodular goiter. Full Text available with Trip Pro

Total thyroidectomy: the preferred option for multinodular goiter. 3401066 1988 09 08 2018 11 13 0003-4932 208 2 1988 Aug Annals of surgery Ann. Surg. Total thyroidectomy: the preferred option for multinodular goiter. 244-5 Clark O H OH eng Letter United States Ann Surg 0372354 0003-4932 AIM IM Goiter, Nodular surgery Humans Recurrence Thyroidectomy methods 1988 8 1 1988 8 1 0 1 1988 8 1 0 0 ppublish 3401066 PMC1493613 Ann Surg. 1982 Sep;196(3):361-70 7114941

1988 Annals of Surgery

709. Reduction of size of thyroid with radioactive iodine in multinodular non-toxic goitre. Full Text available with Trip Pro

Reduction of size of thyroid with radioactive iodine in multinodular non-toxic goitre. 3179549 1988 12 05 2018 11 13 0959-8138 297 6649 1988 Sep 10 BMJ (Clinical research ed.) BMJ Reduction of size of thyroid with radioactive iodine in multinodular non-toxic goitre. 661-2 Hegedüs L L Department of Internal Medicine, Herlev Hospital, Denmark. Hansen B M BM Knudsen N N Hansen J M JM eng Journal Article England BMJ 8900488 0959-8138 0 Iodine Radioisotopes AIM IM Adult Aged Female Goiter, Nodular

1988 BMJ : British Medical Journal

710. Radioiodine treatment of multinodular non-toxic goitre. Full Text available with Trip Pro

risk 22%, 95% confidence interval 4.8% to 38.4%). Side effects were few: three cases of hyperthyroidism and two cases of radiation thyroiditis. Only one patient was dissatisfied with the result; she was referred for operation six months after treatment.A substantial reduction in thyroid volume accompanied by a low incidence of hypothyroidism and few side effects makes the use of radioactive iodine an attractive alternative to surgery in selected cases of non-toxic multinodular goitre. (...) Radioiodine treatment of multinodular non-toxic goitre. To investigate the long term effect of radioactive iodine on thyroid function and size in patients with non-toxic multinodular goitre.Consecutive patients with multinodular non-toxic goitre selected for radioactive iodine treatment and followed for a minimum of 12 months (median 48 months) after an intended dose of 3.7 MBq/g thyroid tissue corrected to a 100% uptake of iodine-131 in 24 hours.69 patients with a growing multinodular non

1993 BMJ : British Medical Journal

711. Fine needle aspiration cytology in diffuse or multinodular goitre compared with solitary thyroid nodules. Full Text available with Trip Pro

Fine needle aspiration cytology in diffuse or multinodular goitre compared with solitary thyroid nodules. 8369686 1993 10 14 2018 11 13 0959-8138 307 6898 1993 Jul 24 BMJ (Clinical research ed.) BMJ Fine needle aspiration cytology in diffuse or multinodular goitre compared with solitary thyroid nodules. 240 Franklyn J A JA Thyroid Clinic, Birmingham General Hospital. Daykin J J Young J J Oates G D GD Sheppard M C MC eng Comparative Study Journal Article England BMJ 8900488 0959-8138 AIM IM (...) Biopsy, Needle Goiter, Nodular pathology Humans Sensitivity and Specificity Thyroid Gland pathology Thyroid Nodule pathology 1993 7 24 1993 7 24 0 1 1993 7 24 0 0 ppublish 8369686 PMC1678158 Clin Endocrinol (Oxf). 1977 Dec;7(6):481-93 598014 N Engl J Med. 1993 Feb 25;328(8):553-9 8426623 N Engl J Med. 1985 Aug 15;313(7):428-36 3894966

1993 BMJ : British Medical Journal

712. An autosomal dominant form of adolescent multinodular goiter. Full Text available with Trip Pro

An autosomal dominant form of adolescent multinodular goiter. Eighteen members of an extended pedigree have been found to have a form of euthyroid adolescent multinodular goiter. Histological examination showed multiple adenomata with areas of epithelial hyperplasia, hemorrhage, and calcification. In two subjects there were focal areas of epithelial hyperplasia reminiscent of low-grade papillary carcinoma, but capsular and vascular invasion was not found. The pattern of inheritance appeared

1986 American Journal of Human Genetics

713. Differences between endocrine surgeons and endocrinologists in the management of non-toxic multinodular goitre. (Abstract)

Differences between endocrine surgeons and endocrinologists in the management of non-toxic multinodular goitre. It is not known whether the management of multinodular goitre differs between endocrinologists and endocrine surgeons.A questionnaire containing a hypothetical case (a 42-year-old euthyroid woman with a 50-80-g multinodular goitre) and 11 variations on the case was sent to endocrinologists and endocrine surgeons in Australia.The response rate was 55 per cent, including 45 endocrine (...) per cent, surgery 10 per cent, radioiodine 3 per cent; surgeons: no treatment 67 per cent, thyroxine 2 per cent, surgery 31 per cent; P < 0.001) and for seven of the variations. In particular, for a patient with suppressed TSH, most endocrinologists (60 per cent) recommended radioiodine treatment, whereas there was no consensus among surgeons (surgery 40 per cent, no treatment 36 per cent, radioiodine 21 per cent). For a patient with a partly intrathoracic goitre, most surgeons (88 per cent

2003 British Journal of Surgery

714. Benign ectopic submandibular thyroid with a normotopic multinodular goitre. (Abstract)

Benign ectopic submandibular thyroid with a normotopic multinodular goitre. Ectopic submandibular thyroid tissue is a rare entity and poses difficult diagnostic and management problems. The first case of ectopic submandibular thyroid with a normotopic multinodular goitre is presented

2003 Journal of Laryngology & Otology

715. Birt-Hogg-Dube syndrome and multinodular goitre. (Abstract)

Birt-Hogg-Dube syndrome and multinodular goitre. A 50-year-old woman presented with multiple skin-coloured facial papules. There was a family history of similar lesions. Histology of one of these papules was consistent with fibrofolliculoma. Multiple fibrofolliculomas together with flexural acrochordons suggested the diagnosis of Birt-Hogg-Dubé syndrome. Investigations to exclude associated disease revealed changes consistent with multinodular goitre on thyroid ultrasound. The literature

2002 Australasian Journal of Dermatology

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