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Multinodular Goiter

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41. Congenital thyroid hemiagenesis with multinodular goiter (Full text)

Congenital thyroid hemiagenesis with multinodular goiter Thyroid hemiagenesis is a rare form of thyroid dysgenesis characterized by an absence of half of the thyroid gland. Developmental hemi-thyroid anomalies can result from either an abnormal descent or an agenesis of one lobe of the thyroid gland. We report a case of a 40-year-old woman with history of a longstanding gradually progressive thyroid swelling without any complication. An ultrasonographic examination diagnosed the absence (...) of the left thyroid lobe and enlargement of the right lobe, which was confirmed on a computed tomography (CT) angiogram and a radionuclide scan of the neck. A cytological examination showed nodular goiter with cystic degeneration. Right subtotal thyroidectomy was performed and histopathological examination confirmed adenomatous goiter with degenerative changes. We report the rarity of the condition and emphasize the role of a comprehensive radiological, cytological, and radionuclide algorithm

2014 Acta Radiologica Short Reports PubMed abstract

42. The Underestimated Risk of Cancer in Patients with Multinodular Goiters After a Benign Fine Needle Aspiration. (Abstract)

The Underestimated Risk of Cancer in Patients with Multinodular Goiters After a Benign Fine Needle Aspiration. Ultrasound-guided fine needle aspiration (FNA) is an excellent tool for evaluating patients with solitary thyroid nodules, with a false-negative malignancy rate of <3%. The utility of FNA in patients with a cervical multinodular goiter (MNG) is unknown, because biopsy and surveillance of thyroids with numerous nodules may be impractical.To evaluate the incidence and risk factors

2014 World Journal of Surgery

43. Trigeminal Autonomic Headaches Caused by a Multinodular Goiter - A Case Report. (Abstract)

Trigeminal Autonomic Headaches Caused by a Multinodular Goiter - A Case Report. Though thyroid growths are considered to be a frequent cause of Horner's syndrome, concurrent headache attacks are not commonly seen.A 63-year-old woman presented with severe, daily occurring, unilateral headache attacks with ipsilateral Horner's syndrome. Magnetic resonance imaging arteriography showed a multinodular goiter displacing the left common carotid artery.This case exemplifies the combination of headache

2014 Headache

44. Multinodular Goiter in Children: an Important Pointer to a Germline DICER1 Mutation. (Full text)

Multinodular Goiter in Children: an Important Pointer to a Germline DICER1 Mutation. 24628552 2014 08 08 2014 06 04 1945-7197 99 6 2014 Jun The Journal of clinical endocrinology and metabolism J. Clin. Endocrinol. Metab. Multinodular Goiter in children: an important pointer to a germline DICER1 mutation. 1947-8 10.1210/jc.2013-3932 Rath Shoshana R SR Department of Endocrinology and Diabetes (S.R.R., T.J., C.S.Y.C.), Princess Margaret Hospital for Children; School of Pediatrics and Child Health (...) Goiter, Nodular complications diagnosis genetics Humans Kidney Neoplasms complications genetics Male Nephroma, Mesoblastic complications genetics Ribonuclease III genetics 2014 3 18 6 0 2014 3 19 6 0 2014 8 13 6 0 ppublish 24628552 10.1210/jc.2013-3932

2014 Journal of Clinical Endocrinology and Metabolism PubMed abstract

45. Adenomatous multinodular goiter causing airway obstruction in an infant. (Full text)

Adenomatous multinodular goiter causing airway obstruction in an infant. Nontoxic adenomatous multinodular goiter (AMNG) in infants is a rare condition. We discuss an extremely rare case of a nontoxic AMNG in a 3-month-old female presenting with airway obstruction. Surgical resection of the mass was performed to reduce the burden on the airway and for diagnosis. The literature is reviewed, and the clinical characteristics, pathology, and surgical treatment are discussed.© 2014 The American

2014 Laryngoscope PubMed abstract

46. Anaplastic Carcinoma and Toxic Multinodular Goiter: An Unusual Presentation (Full text)

Anaplastic Carcinoma and Toxic Multinodular Goiter: An Unusual Presentation A 70-year-old male was referred with hyperthyroidism and multinodular goiter (MNG). Thyroid ultrasonography showed 2 nodules, one in the isthmus and the other in the left lobe, 51 and 38 mm in diameter, respectively. Neck CT showed a large MNG, thyroid scintigraphy showed increased uptake in the nodule in the left lobe, and fine-needle aspiration biopsy showed a benign cytology of the nodule in the isthmus. The patient

2014 European thyroid journal PubMed abstract

47. Clinicopathological Profile, Airway Management, and Outcome in Huge Multinodular Goiters: An Institutional Experience from an Endemic Goiter Region. (Abstract)

Clinicopathological Profile, Airway Management, and Outcome in Huge Multinodular Goiters: An Institutional Experience from an Endemic Goiter Region. Huge goiters are common in iodine-deficient endemic regions. They are of concern to the surgeons because of the anticipated risk of difficult dissection and increased chances of surgical complications. Similarly, they are of concern to the anesthesiologists because of anticipated intubation-related difficulties and post-thyroidectomy tracheomalacia (...) . In the present study we aimed to present our experience of managing goiters based on their gross weight, highlighting their clinicopathological profile, perioperative airway-related difficulties, and management of surgical morbidity.Retrospective analysis of patients who underwent total thyroidectomy in the primary setting at our institute from 1995 to 2009 was carried out based on the gross gland weight. The patients were thus grouped into group A: ≤200 g; group B: 201 to ≤400 g; group C: 401 to ≤600 g

2012 World Journal of Surgery

48. What is the best approach to goiter in euthyroid patients?

recommend ultrasound evaluation of nontoxic multinodular goiters (MNG) followed by fine-needle aspiration (FNA) of suspicious nodules (strength of recommendation [SOR]: C, consensus-based guidelines). Thyroid hormone suppression therapyreduces the size of MNG (SOR: A, systematic review of randomized controlled trials [RCTs]), but it risks inducing hyperthyroidism (SOR: C, expert opinion). Experts recommend thyroidectomy for compressive symptoms, progressive growth, or ultrasound or FNA results (...) What is the best approach to goiter in euthyroid patients? What is the best approach to goiter in euthyroid patients? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics What is the best approach to goiter in euthyroid patients? View/ Open Date 2014-01 Format Metadata Abstract In the absence of outcome studies, experts

2014 Clinical Inquiries

49. Combination Therapy of Temporary Tracheal Stenting and Radiofrequency Ablation for Multinodular Thyroid Goiter with Airway Compression (Full text)

Combination Therapy of Temporary Tracheal Stenting and Radiofrequency Ablation for Multinodular Thyroid Goiter with Airway Compression We report a case of multinodular thyroid goiter in an 80-year-old man who successfully underwent tracheal stent placement for respiratory distress caused by the thyroid goiter and following two radiofrequency (RF) ablation sessions performed for thyroid volume reduction. This sequential treatment allowed elective stent removals four weeks after the second RF (...) ablation session because the thyroid volume had been progressively reduced. Combination therapy of temporary airway stenting and RF ablation for the treatment of thyroid goiter has two advantages, i.e., immediate reliefs of dyspnea with airway stenting and reductions of the thyroid volume with RF ablation, and thus, allowing symptom reliefs even after the stent removals.

2013 Korean Journal of Radiology PubMed abstract

50. Efficacy and budget impact of the Focus harmonic scalpel compared to the ACS-14C device in total thyroidectomy due to multinodular goitre. A prospective randomised study. (Abstract)

Efficacy and budget impact of the Focus harmonic scalpel compared to the ACS-14C device in total thyroidectomy due to multinodular goitre. A prospective randomised study. To analyse the potential advantages and outcomes of the new Harmonic Focus™ (Focus) device compared to the Harmonic Scalpel™ ACS-14C in benign thyroid surgery.A controlled randomised study was conducted in which the Focus was compared to former ACS-14C device in patients undergoing total thyroidectomy for multinodular goitre

2013 Cirugía española Controlled trial quality: uncertain

51. Familial multinodular goiter syndrome with papillary thyroid carcinomas: mutational analysis of the associated genes in 5 cases from 1 Chinese family. (Full text)

Familial multinodular goiter syndrome with papillary thyroid carcinomas: mutational analysis of the associated genes in 5 cases from 1 Chinese family. Familial papillary thyroid cancer (fPTC) is recognized as a distinct entity only recently and no fPTC predisposing genes have been identified. Several potential regions and susceptibility loci for sporadic PTC have been reported. We aimed to evaluate the role of the reported susceptibility loci and potential risk genomic region in a Chinese (...) familial multinodular goiter (fMNG) with PTC family.We sequenced the related risk genomic regions and analyzed the known PTC susceptibility loci in the Chinese family members who consented to join the study. These loci included (1) the point mutations of the BRAF and RET; (2) the possible susceptibility loci to sporadic PTC; and (3) the suggested potential fMNG syndrome with PTC risk region.The members showed no mutations in the common susceptible BRAF and RET genomic region, although contained several

2013 BMC Endocrine Disorders PubMed abstract

52. Long-term efficacy of modified-release recombinant human TSH (MRrhTSH) augmented radioiodine (131I) therapy for benign multinodular goiter. Results from a multicenter international, randomized, placebo-controlled dose-selection study. (Full text)

Long-term efficacy of modified-release recombinant human TSH (MRrhTSH) augmented radioiodine (131I) therapy for benign multinodular goiter. Results from a multicenter international, randomized, placebo-controlled dose-selection study. Enhanced reduction of multinodular goiter (MNG) can be achieved by stimulation with recombinant human thyrotropin (rhTSH) before radioiodine ((131)I) therapy. The objective was to compare the long-term efficacy and safety of two low doses of modified release rhTSH (...) among the groups, p=0.105. In the 0.03 mg MRrhTSH group, the subset of patients with basal (131)I uptake <20% had a 24% greater TV reduction at 36 months than the corresponding subset of patients in the placebo group (p=0.01). At 36 months, the largest relative increase in SCAT was observed in the 0.03 mg MRrhTSH group (13.4 ± 23.2%), but this was not statistically different from the increases observed in the placebo or the 0.01 mg MRrhTSH group (p=0.15). Goiter-related symptoms were reduced and QoL

2013 Thyroid Controlled trial quality: uncertain PubMed abstract

53. Prevalence of thyroid cancer in multinodular goiter versus single nodule: a systematic review and meta-analysis. (Abstract)

Prevalence of thyroid cancer in multinodular goiter versus single nodule: a systematic review and meta-analysis. Whether the prevalence of thyroid cancer is different in thyroid glands with a single nodule (SN) versus multinodular goiter (MNG) remains uncertain. Therefore, a meta-analysis was performed to evaluate the extant literature on the comparative prevalence of thyroid cancer in SN compared with MNG.We searched MEDLINE, EMBASE, Scopus, Cochrane Central, and reference list for selected

2013 Thyroid

54. Prevalence of Thyroid Cancer in Multinodular Goiter Versus Single Nodule: Iodine Intake and Cancer Phenotypes. (Abstract)

Prevalence of Thyroid Cancer in Multinodular Goiter Versus Single Nodule: Iodine Intake and Cancer Phenotypes. 23991912 2014 11 06 2018 12 02 1557-9077 24 3 2014 Mar Thyroid : official journal of the American Thyroid Association Thyroid Prevalence of thyroid cancer in multinodular goiter versus single nodule: iodine intake and cancer phenotypes. 604-5 10.1089/thy.2013.0326 Pasqualetti Giuseppe G 1 Geriatrics Unit, University of Pisa , Pisa, Italy . Caraccio Nadia N Basolo Fulvio F Miccoli Paolo (...) P Monzani Fabio F eng Letter Comment 2014 01 29 United States Thyroid 9104317 1050-7256 IM Thyroid. 2013 Apr;23(4):449-55 23067375 Goiter, Nodular epidemiology Humans Thyroid Neoplasms epidemiology 2013 9 3 6 0 2013 9 3 6 0 2014 11 7 6 0 ppublish 23991912 10.1089/thy.2013.0326

2013 Thyroid

55. Multinodular Goiter

) Ontology: Toxic multinodular goiter (C0154143) Concepts Disease or Syndrome ( T047 ) ICD9 242.2 ICD10 SnomedCT 190249001 , 154658002 , 26389007 English Thyrotox + tox multinod goiter , Thyrotox + tox multinod goitre , Thyrotoxic - multinodul goiter , Thyrotoxic - multinodul goitre , Toxic multinodular goiter NOS , Toxic multinodular goitre NOS , toxic multinodular goiter , toxic multinodular goiter (diagnosis) , parry disease , multinodular toxic goiter , Goitre;multinodular;toxic , multinodular toxic (...) goitre , Toxic multinodular goitre (disorder) , Toxic multinodular goiter NOS (disorder) , Toxic multinodular goiter , Secondary thyroid hyperplasia , Thyrotoxicosis due to multinodular goiter , Thyrotoxicosis due to multinodular goitre , Thyrotoxicosis with toxic multinodular goiter , Thyrotoxicosis with toxic multinodular goitre , Toxic multinodular goitre , Toxic multinodular goiter (disorder) , Parry , goiter; thyrotoxicosis, multinodular , multinodular; goiter, toxic or with hyperthyroidism

2015 FP Notebook

56. Displacement of the Recurrent Laryngeal Nerve in Patients with Recurrent Goiter Undergoing Redo Thyroid Surgery (Full text)

, anatomical changes secondary to recurrent goiter mass and prior surgery, and results of IONM were studied. Frequent indications for redo surgery were multinodular goiter (MNG) in 19 (38.8%) and results of cytology in 14 (28.5%) patients. The mean time interval between primary and redo thyroid surgery was 23.4 years. We laterally approached 41 (67.2%) thyroid lobes between the sternocleidomastoid and sternohyoid muscles. 16 (26.2%) RLNs were found to be adherent to the lateral surface of the corresponding (...) Displacement of the Recurrent Laryngeal Nerve in Patients with Recurrent Goiter Undergoing Redo Thyroid Surgery Thyroid reoperations are surgically challenging because of scarring and disturbances in the anatomy of the recurrent laryngeal nerve (RLN). This study was conducted on 49 patients who underwent redo surgery. 61 RLNs were identified and completely exposed. Their functional integrity was evaluated using intraoperative nerve monitoring (IONM). Indications for secondary surgery

2018 Journal of thyroid research PubMed abstract

57. Prestimulation with recombinant human thyrotropin (rhTSH) improves the long-term outcome of radioiodine therapy for multinodular nontoxic goiter. (Full text)

Prestimulation with recombinant human thyrotropin (rhTSH) improves the long-term outcome of radioiodine therapy for multinodular nontoxic goiter. The objective of the study was to evaluate the long-term outcome of recombinant human TSH (rhTSH)-augmented radioiodine ((131)I) therapy for benign multinodular nontoxic goiter.Between 2002 and 2005, 86 patients with a multinodular nontoxic goiter were treated with (131)I in two randomized, double-blind, placebo-controlled trials. (131)I-therapy (...) , respectively (P < 0.0001)] increased to 16 and 52%, respectively, at final FU (P = 0.001).Enhanced goiter volume reduction with rhTSH-augmented (131)I therapy improves the long-term reduction in goiter-related symptoms and reduces the need for additional therapy compared with plain (131)I therapy. Overall patient satisfaction is benefited, despite a higher rate of permanent hypothyroidism.

2012 The Journal of clinical endocrinology and metabolism Controlled trial quality: predicted high PubMed abstract

58. A randomized trial of hemithyroidectomy versus Dunhill for the surgical management of asymmetrical multinodular goiter. (Abstract)

A randomized trial of hemithyroidectomy versus Dunhill for the surgical management of asymmetrical multinodular goiter. To assess the immediate and long-term clinical results of 2 different surgical procedures for the treatment of asymmetrical multinodular goiter (AMG).Half of the patients presenting with a single benign thyroid nodule have contralateral subclinical disease. There is a controversy whether these patients should be treated with hemithyroidectomy (HMT) or with a more extensive (...) < 0.001), and overall reoperation rate (9.2 vs 1.8%, P = 0.2) were more common in HMT, mostly because of undiagnosed cancer requiring completion thyroidectomy. Thirty percent of HMTs developed hypothyroidism and required long-term T4 supplementation.DUN appears superior to HMT for the treatment of AMG in terms of early reoperation for missed carcinomas and disease progression. Both procedures have a similarly uneventful postoperative course.

2012 Annals of surgery Controlled trial quality: uncertain

59. Massive multinodular goiter with stridor (Full text)

Massive multinodular goiter with stridor 22837944 2012 10 02 2018 11 13 2230-9500 16 4 2012 Jul Indian journal of endocrinology and metabolism Indian J Endocrinol Metab Massive multinodular goiter with stridor. 664-5 10.4103/2230-8210.98043 Kumar K V S Hari KV Department of Endocrinology, Command Hospital, Lucknow, Uttar Pradesh, India. Saini Mandeep M Kapoor Umesh U Banga Pawan P eng Journal Article India Indian J Endocrinol Metab 101555690 2230-9500 2012 7 28 6 0 2012 7 28 6 0 2012 7 28 6 1

2012 Indian journal of endocrinology and metabolism PubMed abstract

60. Galectin 3 Dosage in Diagnosis of Nodular and Multinodular Goiter

Galectin 3 Dosage in Diagnosis of Nodular and Multinodular Goiter Galectin 3 Dosage in Diagnosis of Nodular and Multinodular Goiter - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Galectin 3 Dosage (...) in Diagnosis of Nodular and Multinodular Goiter (Galectins) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01588288 Recruitment Status : Completed First Posted : April 30, 2012 Last Update Posted : October 10, 2016 Sponsor: University Hospital, Rouen Information provided by (Responsible Party): University

2012 Clinical Trials

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