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Multinodular Goiter

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181. Transient Hyperthyroidism Induced by Thyroid Ultrasound. (Abstract)

multinodular goiter who developed transient hyperthyroidism following an ultrasound of the thyroid gland. She was not treated with anti-thyroid medications.Two weeks later, her free T3 and free T4 were normal, and 11 weeks after the ultrasound, all thyroid tests, including her TSH, were within the reference range.We believe this is the first report of a euthyroid individual who developed hyperthyroidism caused by thyroid ultrasonography. We hypothesize that pressure from the ultrasound probe during

2018 Rhinology and Laryngology

182. Effect of IONM on Efficacy and Safety Using Sugammadex in Thyroid Surgery

: 18 Years to 75 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Clinical diagnosis of Multinodular goiter, Clinical diagnosis of thyroid cancer Clinical diagnosis of noduler goatr, Clinical diagnosis of basedow Graves disease, Exclusion Criteria: Patients with bleeding diathesis, Patients who have previously undergone laryngeal surgery (vocal polyps, nodules or laryngeal cancer), Contacts and Locations Go to Information from (...) Burat Government Hospital: multinoduler goitre thyroid cancer sugammadex sodium intraoperative nerve monitorization Additional relevant MeSH terms: Layout table for MeSH terms Paralysis Vocal Cord Paralysis Neurologic Manifestations Nervous System Diseases Signs and Symptoms Laryngeal Diseases Respiratory Tract Diseases Otorhinolaryngologic Diseases Vagus Nerve Diseases Cranial Nerve Diseases

2018 Clinical Trials

183. Diagnostic accuracy of a new fluoroenzyme immunoassay for the detection of TSH receptor autoantibodies in Graves’ disease Full Text available with Trip Pro

and Graves' orbitopathy, 52 with multinodular non-toxic goiter, 86 with Hashimoto's thyroiditis, 20 with toxic adenoma or toxic multinodular goiter, 55 with non-thyroid autoimmune diseases and 120 normal controls) were tested for TRAbs with the ELiA™ anti-TSH-R assay (ThermoFischer Scientific, Uppsala, Sweden), the TRAK™ RIA, Brahms (Thermo Scientific, Hennigsdorf, Germany) and the Immulite™ TSI assay (Siemens Healthcare, Llanberis, UK).Sensitivity and specificity of the ELiA™ anti-TSH-R assay, TRAK™ RIA

2018 Auto-Immunity Highlights

184. Harmonic Scalpel Thyroidectomy Versus Conventional Thyroidectomy

using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years to 70 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patients of both genders aging above 18 years presented with primary thyroid diseases requiring thyroidectomy including: Solitary thyroid nodule (STN) Multinodular goiter Controlled toxic goiter Inflammatory goiter (thyroiditis) Early-stage (...) Summary: This study was prospective randomized double-blinded clinical trial on patients with thyroid disease who underwent thyroidectomy in the general surgery department, Mansoura university hospitals during the period of February 2017 to February 2018.Two techniques for vascular sealing were compared: conventional tying and harmonic scalpel Condition or disease Intervention/treatment Phase Goiter Procedure: Conventional thyroidectomy Procedure: Harmonic scalpel thyroidectomy Not Applicable Study

2018 Clinical Trials

185. Transarterial Chemoembolization in Combination With Nivolumab Performed for Intermediate Stage Hepatocellular Carcinoma

) in patients with multinodular, intermediate stage hepatocellular carcinoma (HCC) as first line therapy. Condition or disease Intervention/treatment Phase Carcinoma, Hepatocellular Hepatic Carcinoma Hepatocellular Cancer Drug: Nivolumab Drug: TACE Phase 2 Detailed Description: Hepatocellular carcinoma (HCC) is one of the most lethal and prevalent cancers worldwide. The prognosis of patients with HCC is dismal and the mortality rates are almost the same as the incidence rates. The transarterial (...) Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion criteria: Written informed consent including participation in translational research and any locally-required authorization (EU Data Privacy Directive in the EU) obtained from the subject prior to performing any protocol-related procedures, including screening evaluations. Age ≥ 18 years at time of study entry Multinodular or large, solitary HCC, not eligible for resection or local ablation, Tumor burden below 50% of liver volume

2018 Clinical Trials

186. Alterations in Quality of Life After Thyroidectomy for Benign Thyroid Disease

information: Groups and Cohorts Go to Group/Cohort Intervention/treatment Cases Patients who are going to undergo a thyroid surgery due to symptomatic non-toxic multinodular goiter, uncontrolled thyrotoxicosis or suspicious FNA Procedure: Thyroidectomy Thyroidectomy Controls Patients with benign thyroid disease, not undergoing thyroidectomy Outcome Measures Go to Primary Outcome Measures : Alterations in Quality of Life after thyroidectomy for benign thyroid disease [ Time Frame: 2 years ] To detect any (...) changes in Quality of Life in patients with benign thyroid diseases who undergo thyroidectomy compared to patients with benign thyroid diseases and conservative treatment. The Greek, cross-cultural validated, version of ThyPRO questionnaire will be used, as it comprises a reliable and validated instrument to measure thyroid-related quality of life. The 84 questions of ThyPRO are categorized in 13 scales that involve: goiter, hypothyroidism, hyperthyroidism and eyes symptoms, tiredness, cognitive

2018 Clinical Trials

187. Early Prediction of Hypocalcemia After Thyroidectomy Using Postoperative Second Hour Parathormone

decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 20 Years to 80 Years (Adult, Older Adult) Sexes Eligible for Study: All Sampling Method: Non-Probability Sample Study Population all patients with multinodular goiter, Graves, fine needle aspiartion (...) biopsy with Bethesda 3-4 undergoing total thyroidectomy Criteria Inclusion Criteria: patients with multinodular goiter, Graves, fine needle aspiartion biopsy with Bethesda 3-4 undergoing total thyroidectomy Exclusion Criteria: pregnant women patients with thyroid cancer or previous neck dissection Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided

2018 Clinical Trials

188. Lateral ectopic thyroid goiter with a normally located thyroid. (Abstract)

Lateral ectopic thyroid goiter with a normally located thyroid. Midline ectopic thyroid tissue is a common pathological entity. In contrast, laterally located ectopic thyroid tissue with a normally located thyroid gland is a very rare condition in head and neck surgery.We report the association of laterally located multinodular thyroid tissue and a normally located multinodular goiter. A woman was seen in the otolaryngology clinic with a right submandibular mass. Clinical examination (...) and investigations confirmed the presence of a multinodular goiter in an ectopic thyroid gland.Laterally located ectopic thyroid tissue is a very rare condition. Ectopic thyroid tissues can undergo the same pathological changes as a normally located thyroid gland. Ectopic thyroid goiter together with a normally located multinodular goiter is a rare entity, and this is the first to be reported in North America.

2010 Thyroid

189. Association of the Long QT Syndrome With Goiter and Deafness. (Abstract)

Association of the Long QT Syndrome With Goiter and Deafness. We report on the long QT syndrome occurring in conjunction with nontoxic multinodular goiter and sensorineural deafness in several siblings of a large family. Autosomal and X-linked recessive and dominant modes of inheritance are possible for the different phenotypes. The affected family members had various phenotype combinations, suggesting variable expressivity and incomplete penetrance.Copyright 2010. Published by Elsevier Inc.

2010 American Journal of Cardiology

190. Improving Voice Outcomes After Thyroid Surgery

, , , , , , Introduction Thyroidectomy (surgical removal of all or part of the thyroid gland) may be performed for clinical indications that include malignancy, benign nodules or cysts, suspicious findings on fine needle aspiration biopsy, dysphagia from cervical esophageal compression, or dyspnea from airway compression. Other indications for thyroidectomy include multinodular goiter, Hashimoto’s and other types of thyroiditis, and thyromegaly with significant cosmetic compromise. Additional surgery may involve neck (...) tumor invasion of, or compression injury to, the RLN (as seen with, eg, edema or large goiter), or from preexisting or non–thyroid-related causes. In addition, vocal fold edema or other tissue changes may be seen in endocrine abnormalities associated with thyroid problems. , One study demonstrated that individuals identified with presurgical RLN impairment due to tumor invasion exhibited improved voice function outcomes after a subsequent voice surgery compared to those who were not so identified

2013 American Academy of Otolaryngology - Head and Neck Surgery

191. SNMMI Procedure Standard for Therapy of Thyroid Disease with 131I (Sodium Iodide) 3.0

for the treatment of Graves disease and toxic nodular [uninod- ular or multinodular] disease (8)) and nontoxic nodular goiter ( 131 I therapy may be used successfully to diminish the size of nontoxic nodular goiters, especially when sur- geryiscontraindicatedorrefused(9,10)),anddifferentiated papillary and follicular thyroid cancer ( 131 I therapy is the principal treatment of residual thyroid tissue after thyroid- ectomy [thyroid remnant ablation], of residual or recurrent thyroid cancer, and of metastatic (...) /SPECIFICATIONS OF THE EXAMINATION See also the SNM Guideline for General Imaging. A. Therapy of Graves disease, toxic nodules, and nontoxic nodular goiter 1. Goals The goal of therapy for hyperthyroidism is to achieve a nonhyperthyroid status—either a euthy- roid state or iatrogenic hypothyroidism that has beencompletelycompensatedtotheeuthyroidstate with oral levothyroxine. The goal of therapy for a large nontoxic nodular goiter is the reduction of thyroid volume to relieve symptoms caused by compression

2012 Society of Nuclear Medicine and Molecular Imaging

192. Evaluating and managing patients with thyrotoxicosis

Evaluating and managing patients with thyrotoxicosis Thyroid 564 Reprinted from AustRAliAn F Amily PhysiciAn Vol. 41, no. 8, August 2012 Kirsten Campbell Matthew Doogue Evaluating and managing patients with thyrotoxicosis Background Thyrotoxicosis is common in the Australian community and is frequently encountered in general practice. Graves disease, toxic multinodular goitre, toxic adenoma and thyroiditis account for most presentations of thyrotoxicosis. Objective This article outlines (...) useful investigation in diagnosing the underlying cause. The selection of treatment differs according to the cause of thyrotoxicosis and the wishes of the individual patient. The preferred treatment for Graves disease is usually antithyroid drug therapy, almost always carbimazole. The primary treatment of a toxic multinodular goitre or toxic adenoma is usually radioactive iodine therapy. Specific therapy is usually not warranted in cases of thyroiditis, however, treatment directed at symptoms may

2012 Clinical Practice Guidelines Portal

193. Ultrasound in Anaesthesia and Intensive Care - A Guide to Training

and kidneys Thyroid Level 2 anatomy Additional knowledge of sectional anatomy Supraclavicular region Anterior and superior mediastinum Laryngeal cartilages and extrathoracic trachea Thyroid27 Pathology Level 1 pathology Pleural effusion Pleural thickening Pneumothorax Consolidated lung Atelectasis Level 2 pathology Interstitial thickening Pulmonary mass/abscess Paralysed diaphragm Mediastinal and pleural masses Multinodular goitre Competencies Level 1 competencies Performance of systematic examination (...) of diaphragmatic function Ultrasound guided pleural and lung biopsy Ultrasound guided percutaneous tracheostomy and cricthyroidotomy Identification of the cricoid cartilage and extrathoracic tracheal rings Knowledge of the appearance of normal thyroid versus goitre and Doppler assessment of vascularity Anatomy Level 1 anatomy Detailed knowledge of relevant sectional anatomy Right and left hemidiaphragm Chest wall layers Ribs and intercostal spaces Surface anatomy of pleural reflections Heart Liver, spleen

2012 Association of Anaesthetists of GB and Ireland

194. Alterations in Muscle's Functional Characteristics After Parathyroid Surgery for Primary Hyperparathyroidism.

follow up, 50 patients undergoing thyroid surgery due to nontoxic multinodular goiter or solitary nontoxic thyroid adenoma and 50 healthy control subjects, estimated up to 12 months to enroll. Duration of Treatment: During the operation Duration of Follow-up: Follow-up will be performed daily during hospitalization and at 3, 6 and 12 months after the procedure Endpoints: To evaluate the changes in functional characteristics of all the type of muscles which occur after parathyroidectomy for primary (...) to nontoxic multinodular goiter or solitary nontoxic thyroid adenoma. This group will be considered as control group. Group D healthy subjects. This group will be considered as control group. Outcome Measures Go to Primary Outcome Measures : Measuring stapedius reflex. [ Time Frame: It will be assessed before surgery and at 3, 6 and 12 months after parathyroidectomy ] Due to the fact that stapedius muscle is the smallest skeletal muscle in the human body, the investigators tend to measure stapedius reflex

2017 Clinical Trials

195. Identification of somatic and germ-line DICER1 mutations in pleuropulmonary blastoma, cystic nephroma and rhabdomyosarcoma tumors within a DICER1 syndrome pedigree. Full Text available with Trip Pro

from the proband was performed. The presence of somatic DICER1 mutation and further alterations in driver genes was investigated in genomic DNA obtained from available tumor samples.A nonsense germ-line mutation in DICER1 causing a truncated protein at the IIIb domain level was identified segregating within a family including two affected relatives who developed in one case cystic nephroma and pleuropulmonary blastoma, and rhabdomyosarcoma and multinodular goiter in the other. Additional in trans

2017 BMC Cancer

196. MANAGEMENT OF ENDOCRINE DISEASE: Subclinical Thyrotoxicosis: Prevalence, Causes and Choice of Therapy. Full Text available with Trip Pro

of subclinical thyrotoxicosis, and how treatment should be tailored to the specific cause. We advocate radioactive iodine treatment to be the first-line treatment in majority of patients suffering from subclinical thyrotoxicosis due to multinodular toxic goitre and solitary toxic adenoma, but we do generally not recommend it as the first-line treatment in patients suffering from subclinical Graves' hyperthyroidism. Such patients may benefit mostly from antithyroid drug therapy. Subclinical thyrotoxicosis

2017 European Journal of Endocrinology

197. Anaplastic thyroid carcinoma and foscarnet use in a multitarget treatment documented by 18F-FDG PET/CT: A case report. Full Text available with Trip Pro

Anaplastic thyroid carcinoma and foscarnet use in a multitarget treatment documented by 18F-FDG PET/CT: A case report. The case reported the rapid remission of disease recurrence achieved adding foscarnet, a DNA polymerase inhibitor that interacts with fibroblast growth factor 2, to low molecular weight heparin and sunitinib for the first time in a patient with an anaplastic thyroid cancer (ATC).A 65-year-old woman with a multinodular goiter referred for a rapid enlargement of a nodule

2017 Medicine

198. Postoperative Outcomes in Graves' Disease Patients: Results from the Nationwide Inpatient Sample Database. (Abstract)

its safety for this patient population.A retrospective cross-sectional analysis was performed using the Nationwide Inpatient Sample database from 2006 to 2011. Total thyroidectomy performed in patients with Graves' disease, benign multinodular goiter (MNG), and thyroid cancer was identified. Demographic factors, comorbidities, and postoperative complications were evaluated. Chi-square, one-way analysis of variance, and risk-adjusted multivariable logistic regression were performed.Of 215,068

2017 Thyroid

199. Temporal changes in thyroid nodule volume: lack of effect on paranodular thyroid tissue volume. (Abstract)

to as a "uni- or multinodular thyroid gland" and considered a distinct entity from "uni- or multinodular goiter." (...) Temporal changes in thyroid nodule volume: lack of effect on paranodular thyroid tissue volume. The term "nodular goiter" has long been used to refer to a nodular thyroid gland, based on the assumption that nodule growth may be associated with hyperplasia of the surrounding non-nodular tissue. The aim of this prospective, multicenter, observational study was to determine whether nodule growth is accompanied by growth in the non-nodular tissue.Eight Italian thyroid-disease referral centers

2017 Thyroid

200. Factors Associated With Discordance Between Preoperative Parathyroid 4-Dimensional Computed Tomographic Scans and Intraoperative Findings During Parathyroidectomy. Full Text available with Trip Pro

% [82 of 123] vs 24.3% [70 of 288], P < .001) and multinodular goiter or thyroid nodule (40.7% [50 of 123] vs 29.2% [84 of 288], P = .02). Missed parathyroid lesions were smaller (mean [SD], 0.86 [0.29] vs 1.24 [0.50] cm; P < .001) and were more likely to be in the inferior position (65.4% [87 of 133] vs 38.1% [177 of 465], P < .001). Parathyroid lesion size of 10 mm or less (odds ratio [OR], 4.37; 95% CI, 2.24-8.54), multigland disease (OR, 7.63; 95% CI, 3.49-16.69), multinodular goiter or thyroid

2017 JAMA surgery

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