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1. Toxic multinodular goitre

Toxic multinodular goitre Toxic multinodular goitre - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Toxic multinodular goitre Last reviewed: February 2019 Last updated: December 2017 Summary Most common in older patients. Onset of symptoms is more insidious and symptoms less dramatic than for Graves' disease. Patients may have apathetic hyperthyroidism (minimal signs/symptoms) or sub-clinical hyperthyroidism (...) (isolated TSH suppression). Spontaneous remission is rare. Definitive treatment, most commonly radioactive iodine, is usually required. If untreated, complications may include sequelae of hyperthyroidism, such as cardiac dysfunction or bone loss, or tracheal compression by large goitres. Definition A toxic multinodular goitre (MNG; also known as Plummer's disease) contains multiple autonomously functioning nodules, resulting in hyperthyroidism. These nodules function independently of thyroid-stimulating

2017 BMJ Best Practice

2. Frailty is More Predictive than Age for Complications After Thyroidectomy for Multinodular Goiter

Frailty is More Predictive than Age for Complications After Thyroidectomy for Multinodular Goiter Frailty Is More Predictive Than Age for Complications After Thyroidectomy for Multinodular Goiter - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health U.S (...) Permalink Copy Page navigation World J Surg Actions . 2020 Feb 12. doi: 10.1007/s00268-020-05422-4. Online ahead of print. Frailty Is More Predictive Than Age for Complications After Thyroidectomy for Multinodular Goiter , , , , , Affiliations Expand Affiliations 1 Department of Surgery, New York Presbyterian Hospital, Weill Cornell Medicine, 525 E 68th Street, F-838, New York, NY, 10065, USA. bmf9002@med.cornell.edu. 2 Department of Surgery, New York Presbyterian Hospital, Weill Cornell Medicine, 525 E

2020 EvidenceUpdates

3. Long-term Effects of Radioiodine in Toxic Multinodular Goiter: Thyroid Volume, Function, and Autoimmunity. (Abstract)

Long-term Effects of Radioiodine in Toxic Multinodular Goiter: Thyroid Volume, Function, and Autoimmunity. Long-term studies evaluating the treatment of toxic multinodular goiter (TMNG) with fixed activities of radioiodine (RAI) are lacking.The objective of this work is to describe the effects of 15 mCi on thyroid volume, function, and autoimmunity in the long term.A population-based, retrospective analysis with up to 12 years of follow-up was conducted in Siena, Italy.Adult patients (n = 153 (...) ) with TMNG, naive to RAI, were included.Evaluation was performed of thyroid function, antithyroid antibodies, and ultrasound scans before and yearly after RAI.Evaluations included hyperthyroidism cure, hypothyroidism, volume reduction, nadir and regain, and antibody titer change.The study revealed mean volume reductions greater than or equal to 50% at 3 years after RAI; the greatest annual reduction was observed during the first year (30 ± 17.8%; P < .001). Most patients (60%) achieved their volume nadir

2020 Journal of Clinical Endocrinology and Metabolism

4. An association of myasthenia gravis with Hashimoto's thyroiditis in a patient with a multinodular goitre Full Text available with Trip Pro

An association of myasthenia gravis with Hashimoto's thyroiditis in a patient with a multinodular goitre The association of myasthenia gravis (MG) with other autoimmune diseases including autoimmune thyroid disease (ATD) is well recognised, although rare. The occurrence of both diseases can occur in two ways: either disease preceding the other, or concurrently. The presentation of MG in association with ATD can range from ocular to generalised disease.A 26-year-old Malay female with persistent (...) hyperthyroidism secondary to Hashimoto's thyroiditis in multinodular goitre was diagnosed with generalised MG after 2 years. She presented with right eye ptosis (ocular) and difficulty in swallowing and chewing (bulbar). The diagnosis of MG was confirmed by fatigability testing, electromyography and the presence of AChR antibodies. Her symptoms showed improvement with pyridostigmine (Mestinon) 60 mg 6-hourly. Her antithyroid drug was tapered down according to her thyroid function test. Throughout a year

2017 Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia

5. Treatment of toxic multinodular goiter: Comparison of radioiodine and long-term methimazole treatment. (Abstract)

Treatment of toxic multinodular goiter: Comparison of radioiodine and long-term methimazole treatment. To compare the effectiveness and safety of long-term methimazole (MMI) and radioiodine in treatment of toxic multinodular goiter (TMNG).In this randomized, parallel-group trial, 130 consecutive and untreated patients with TMNG, aged <60 years, were enrolled, and randomized to either long-term MMI or radioiodine (RAI) treatment. Both groups of patients were followed for 60-100 months (...) with median durations of 72 and 84 months in the MMI and RAI groups, respectively.Twelve and 11 patients in the MMI and RAI groups, respectively, were excluded because of side-effects, choosing other modes of treatment and not returning for follow-up; 53 and 54 patients in MMI and RAI groups completed the study for 60-100 months, respectively. In the MMI group, 2 patients (3.8%) experienced subclinical hypothyroidism and 51 (96.2%) remained euthyroid until the end of study. The dosage of MMI to maintain

2019 Thyroid Controlled trial quality: uncertain

6. Ten-Year Follow-Up of a Randomized Clinical Trial of Total Thyroidectomy Versus Dunhill Operation Versus Bilateral Subtotal Thyroidectomy for Multinodular Non-toxic Goiter Full Text available with Trip Pro

Ten-Year Follow-Up of a Randomized Clinical Trial of Total Thyroidectomy Versus Dunhill Operation Versus Bilateral Subtotal Thyroidectomy for Multinodular Non-toxic Goiter The aim of this study was to validate in a 10-year follow-up the initial outcomes of various thyroid resection methods for multinodular non-toxic goiter (MNG) reported in World J Surg 2010;34:1203-13.Six hundred consenting patients with MNG were randomized to three groups of 200 patients each: total thyroidectomy (TT (...) ), Dunhill operation (DO), bilateral subtotal thyroidectomy (BST). Obligatory follow-up period of 60 months was extended up to 120 months for all the consenting patients. The primary outcome measure was the prevalence of recurrent goiter and need for revision thyroid surgery. The secondary outcome measure was the cumulative postoperative and post-revision morbidity rate.The primary outcomes were twice as inferior at 10 years when compared to 5-year results for DO and BST, but not for TT. Recurrent goiter

2017 EvidenceUpdates

7. Treatment of Goiter with Traditional Chinese Medicine Regimen Xing Qi Hua Ying Tang: A Clinical Study on 72 Patients with Multinodular and Diffuse Goiter. (Abstract)

Treatment of Goiter with Traditional Chinese Medicine Regimen Xing Qi Hua Ying Tang: A Clinical Study on 72 Patients with Multinodular and Diffuse Goiter. The present work aimed to further explore the therapeutic potential of Xing Qi Hua Ying Tang (XQHYT) by conducting a systemic clinical study in patients with goiter.Seventy-two patients with either multinodular or diffuse goiter were enrolled and randomly assigned into treatment group receiving XQHYT (n = 36) and control group receiving Hai (...) Zao Yu Hu Tang (n = 36).Traditional Chinese Medicine Hospital of Shanxi.Patients were diagnosed multinodular goiter or diffuse goiter resulting from Qi stagnation.All patients took the extract twice a day (100 mL each time) for two courses of treatment, of which a single course lasted for 3 months. Before the treatment was commenced and after the completion of the treatment, general body checks, thyroid function test, and goiter size examination were performed.Scoring of the clinical symptoms

2017 Journal of Alternative and Complementary Medicine Controlled trial quality: uncertain

8. Intra-capsular total thyroid enucleation versus total thyroidectomy in treatment of benign multinodular goiter. A prospective randomized controlled clinical trial. Full Text available with Trip Pro

Intra-capsular total thyroid enucleation versus total thyroidectomy in treatment of benign multinodular goiter. A prospective randomized controlled clinical trial. Due to high recurrence rate after subtotal thyroidectomy, most of centers have shifted to total thyroidectomy as a surgical treatment for benign multinodular goiter (BMNG), but serious complications, as laryngeal nerve affection & hypocalcaemia, are still present. This study aimed to evaluate treatment of BMNG using intra-capsular

2018 International journal of surgery (London, England) Controlled trial quality: uncertain

9. Thyroid hemiagenesis associated with multinodular goiter and Hashimoto’s thyroiditis Full Text available with Trip Pro

Thyroid hemiagenesis associated with multinodular goiter and Hashimoto’s thyroiditis Thyroid hemiagenesis is a rare congenital abnormality in which one of the thyroid lobes is not developed. It can be associated with various thyroid diseases, such as Grave's disease, nodular goiter and thyroid neoplasm, rarely with hyperparathyroidism. We report a case of a 50-year old woman with left thyroid lobe agenesis diagnosed by ultrasonography and scintigraphy. Right thyroidectomy was performed (...) and the histopathological examination showed diffuse hyperplasia, multinodular goiter and Hashimoto's thyroiditis. To our knowledge, this is the first description of multinodular goiter and Hashimoto's thyroiditis in a patient with thyroid hemiagenesis.

2018 Il Giornale di chirurgia

10. InDel in Phospholipase-C-B-1 is linked with euthyroid multinodular goitre. Full Text available with Trip Pro

InDel in Phospholipase-C-B-1 is linked with euthyroid multinodular goitre. Euthyroid multinodular goiter (MNG) is common, but little is known about the genetic variations conferring predisposition. Previously, a family with MNG of adolescent onset was reported in which some family members developed papillary thyroid carcinomas (PTC).Genome-wide linkage analysis and next-generation sequencing were conducted to identify genetic variants that may confer disease predisposition. A multipoint

2018 Thyroid

11. Nontoxic Multinodular Goitre and Incidental Thyroid Cancer: What Is the Best Surgical Strategy?—A Retrospective Study of 2032 Patients Full Text available with Trip Pro

Nontoxic Multinodular Goitre and Incidental Thyroid Cancer: What Is the Best Surgical Strategy?—A Retrospective Study of 2032 Patients A discussion with regard to the most optimal surgical procedure in nontoxic multinodular goitre (NTMNG). We assessed and compared three main types of operations in 2032 patients with NTMNG.This is a retrospective study of 2032 patients operated on in one center due to NTMNG. The observation period was 48 to 120 months (mean and SD: 87 ± 20).The early (...) , and DO are the following: URLNP: 9 (1.03%), 3 (0.64%), and 1 (0.14%), respectively (p = 0.086); BRLNP: 1 (0.11%), 1 (0.21%), and 0 (0.0%), respectively (p = 0.51); and OT: 11 (1.26%), 2 (0.43%), and 2 (0.28%), respectively (p = 0.052). Incidental thyroid cancer (ITC) was recognized after TT, STT, and DO in 18 (2.07%), 21 (4.52%), and 11 (1.56%), respectively (p = 0.039). Recurrent goitre (RG) was observed in 1 (0.11%) after TT, 3 (0.64%) after STT, and 2 (0.28%) after DO (p = 0.234).Performing less

2018 International journal of endocrinology

12. Diagnostic Accuracy of Preoperative Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Detecting Occult Papillary Thyroid Microcarcinomas in Benign Multinodular Goitres Full Text available with Trip Pro

Diagnostic Accuracy of Preoperative Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Detecting Occult Papillary Thyroid Microcarcinomas in Benign Multinodular Goitres To investigate the diagnostic accuracy of neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte (PLR) ratios in detecting occult papillary thyroid microcarcinomas in benign, multinodular goitres.397 total thyroidectomy patients were identified from the institutional thyroid surgery database between 2007 and 2016 (...) ranging between 45 and 50%.As surrogate indices of the systemic inflammatory response, NLR and PLR are inexpensive and universally available from routine blood tests. Although we found higher NLR values in cases of malignancy, NLR and PLR cannot effectively predict the presence of occult papillary microcarcinomas in otherwise benign, multinodular goitres.

2018 Journal of thyroid research

13. Quantification of thyroid cancer and multinodular goiter risk in the DICER1 syndrome: a family-based cohort study. Full Text available with Trip Pro

Quantification of thyroid cancer and multinodular goiter risk in the DICER1 syndrome: a family-based cohort study. The risk of thyroid cancer and multinodular goiter (MNG) in DICER1 syndrome, a rare tumor-predisposition disorder, is unknown.To quantify the risk of thyroid cancer and MNG in individuals with DICER1 syndrome.Family-based cohort study.National Institutes of Health (NIH) Clinical Center (CC).The National Cancer Institute DICER1 syndrome cohort included 145 individuals with a DICER1

2017 Journal of Clinical Endocrinology and Metabolism

14. Familial multinodular goiter and Sertoli-Leydig cell tumors associated with a large intragenic in-frame <i>DICER1</i> deletion. Full Text available with Trip Pro

Familial multinodular goiter and Sertoli-Leydig cell tumors associated with a large intragenic in-frame DICER1 deletion. Familial multinodular goiter (MNG), with or without ovarian Sertoli-Leydig cell tumor (SLCT), has been linked to DICER1 syndrome. We aimed to search for the presence of a germline DICER1 mutation in a large family with a remarkable history of MNG and SLCT, and to further explore the relevance of the identified mutation.Sanger sequencing, Fluidigm Access Array

2017 European Journal of Endocrinology

15. Non-traumatic rupture of the superior thyroid artery with concomitant parathyroid adenoma and multinodular goiter Full Text available with Trip Pro

Non-traumatic rupture of the superior thyroid artery with concomitant parathyroid adenoma and multinodular goiter Cervical hemorrhage due to non-traumatic, spontaneous rupture of the thyroid artery is rare, which usually results from arterial abnormalities or parathyroid or thyroid disorders. This report describes a 72-year-old woman who presented with a sore throat and slight neck swelling. Computed tomography (CT) revealed a large hematoma in the neck and mediastinum, due to extravasation (...) from the major branch of the left superior thyroid artery. A follow-up CT the next day demonstrated that the extravasation had resolved. Subsequent surgery revealed both parathyroid adenoma and multinodular goiter in the resected thyroid gland. A transient elevation of parathyroid hormone occurred immediately after the hemorrhage, suggesting that the hemorrhage may have been related to the parathyroid adenoma. However, ruptured thyroid arteries were not observed on histopathological examination

2017 Acta Radiologica Open

16. Symptomatic Long Pauses and Bradycardia due to Massive Multinodular Goiter Full Text available with Trip Pro

Symptomatic Long Pauses and Bradycardia due to Massive Multinodular Goiter Sinus node dysfunction with symptomatic bradycardia or chronotropic incompetence is generally an indication for pacemaker implantation. However, in patients with symptomatic sinus bradycardia, the identification and treatment of underlying pathologies may avoid the need for permanent pacemaker implantation. We present a case of carotid sinus syndrome and severe obstructive sleep apnea due to a massive multinodular goiter

2017 Case reports in cardiology

17. Increased Chromosomal and Oxidative DNA Damage in Patients with Multinodular Goiter and Their Association with Cancer Full Text available with Trip Pro

Increased Chromosomal and Oxidative DNA Damage in Patients with Multinodular Goiter and Their Association with Cancer Thyroid nodules are a common clinical problem worldwide. Although thyroid cancer accounts for a small percentage of thyroid nodules, the majority are benign. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) levels are a marker of oxidative stress and play a key role in the initiation and development of a range of diseases and cancer types. This study evaluates cytokinesis-block micronucleus (...) cytome (CBMN-cyt) assay parameters and plasma 8-OHdG levels and their association with thyroid nodule size and thyroid hormones in patients with multinodular goiter. The study included 32 patients with multinodular goiter and 18 age- and sex-matched healthy controls. CBMN-cyt assay parameters in peripheral blood lymphocytes of patients with multinodular goiter and controls were evaluated, and plasma 8-OHdG levels were measured. The micronucleus (MN) frequency (chromosomal DNA damage), apoptotic

2017 International journal of endocrinology

18. A Case Report of Syndromic Multinodular Goitre in Adolescence: Exploring the Phenotype Overlap between Cowden and DICER1 Syndromes Full Text available with Trip Pro

A Case Report of Syndromic Multinodular Goitre in Adolescence: Exploring the Phenotype Overlap between Cowden and DICER1 Syndromes Hereditary tumour predisposition syndromes may increase the risk for development of thyroid nodules at a young age. We present the case of an adolescent female with Cowden syndrome who had some atypical phenotypic features which overlapped with the DICER1 syndrome.A 17-year-old female presented with a 3-month history of progressive right neck swelling. Fine needle

2017 European thyroid journal

19. Multinodular Goiter

) Ontology: Toxic multinodular goiter (C0154143) Concepts Disease or Syndrome ( T047 ) ICD9 242.2 ICD10 SnomedCT 190249001 , 154658002 , 26389007 English Thyrotox + tox multinod goiter , Thyrotox + tox multinod goitre , Thyrotoxic - multinodul goiter , Thyrotoxic - multinodul goitre , Toxic multinodular goiter NOS , Toxic multinodular goitre NOS , toxic multinodular goiter , toxic multinodular goiter (diagnosis) , parry disease , multinodular toxic goiter , Goitre;multinodular;toxic , multinodular toxic (...) goitre , Toxic multinodular goitre (disorder) , Toxic multinodular goiter NOS (disorder) , Toxic multinodular goiter , Secondary thyroid hyperplasia , Thyrotoxicosis due to multinodular goiter , Thyrotoxicosis due to multinodular goitre , Thyrotoxicosis with toxic multinodular goiter , Thyrotoxicosis with toxic multinodular goitre , Toxic multinodular goitre , Toxic multinodular goiter (disorder) , Parry , goiter; thyrotoxicosis, multinodular , multinodular; goiter, toxic or with hyperthyroidism

2018 FP Notebook

20. Patient outcomes following surgical management of multinodular goiter: Does multinodularity increase the risk of thyroid malignancy? Full Text available with Trip Pro

Patient outcomes following surgical management of multinodular goiter: Does multinodularity increase the risk of thyroid malignancy? the difference in the risk of thyroid malignancy for patients with multinodular goiter (MNG) and solitary nodular goiter (SNG) remains controversial. Although total thyroidectomy (TT) is the current preferred surgical option for MNG, permanent hypothyroidism in these patients may be a concern. Therefore, we discuss whether nontotal thyroidectomy is a reasonable (...) alternative surgical option.A retrospective cohort study was performed for 1598 consecutive patients who underwent thyroid surgery for nodular goiter between January 2007 and December 2012. Numerous clinical parameters were collected and analyzed.We reviewed 795 patients with MNG and 803 patients with SNG. The prevalence of malignancy on final pathology was significantly higher in the patients with MNG than in the patients with SNG (15.6% vs 10.1%, P = 0.001). However, a multivariate analysis revealed

2016 Medicine

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