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Motion Sickness

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1. Motion sickness

Motion sickness Motion sickness - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Motion sickness Last reviewed: February 2019 Last updated: January 2018 Summary Common condition provoked by transportation or visual motion. Characterised by nausea/vomiting, possibly accompanied by other symptoms such as dizziness or headache. Controlled breathing is helpful during episodes. Drug therapy includes antimuscarinics (...) or antihistamines, both of which may have significant adverse effects (notably drowsiness) and impede habituation. Habituation (desensitisation) and cognitive behavioural therapy may be useful for people who must undergo repeated provocative motion (e.g., for their occupations). Definition Motion sickness is characterised by stomach discomfort, nausea, and vomiting, accompanied by autonomic features such as pallor and sweating. Vomiting often provides temporary or permanent relief of these symptoms. Once

2018 BMJ Best Practice

2. Motion Sifnos: A Study to Investigate the Efficacy of Tradipitant in Subjects Affected by Motion Sickness

Motion Sifnos: A Study to Investigate the Efficacy of Tradipitant in Subjects Affected by Motion Sickness Motion Sifnos: A Study to Investigate the Efficacy of Tradipitant in Subjects Affected by Motion Sickness - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Motion Sifnos: A Study to Investigate the Efficacy of Tradipitant in Subjects Affected by Motion Sickness The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03772340

2018 Clinical Trials

3. Orientation Preferences and Motion Sickness Induced in a Virtual Reality Environment. (PubMed)

Orientation Preferences and Motion Sickness Induced in a Virtual Reality Environment. Astronauts' orientation preferences tend to correlate with their susceptibility to space motion sickness (SMS). Orientation preferences appear universally, since variable sensory cue priorities are used between individuals. However, SMS susceptibility changes after proper training, while orientation preferences seem to be intrinsic proclivities. The present study was conducted to investigate whether (...) that visual information may be inefficient and unreliable for body orientation and stabilization in a rotating visual scene, while reprioritizing preferences for different sensory cues was dynamic and asymmetric between individuals. The present findings should facilitate customization of efficient and proper training for astronauts with different sensory prioritization preferences and dynamic characteristics.Chen W, Chao J-G, Zhang Y, Wang J-K, Chen X-W, Tan C. Orientation preferences and motion sickness

2017 Aerospace medicine and human performance

4. The influence of sleep deprivation and oscillating motion on sleepiness, motion sickness, and cognitive and motor performance. (PubMed)

The influence of sleep deprivation and oscillating motion on sleepiness, motion sickness, and cognitive and motor performance. Our goal was to determine how sleep deprivation, nauseogenic motion, and a combination of motion and sleep deprivation affect cognitive vigilance, visual-spatial perception, motor learning and retention, and balance. We exposed four groups of subjects to different combinations of normal 8h sleep or 4h sleep for two nights combined with testing under stationary (...) conditions or during 0.28Hz horizontal linear oscillation. On the two days following controlled sleep, all subjects underwent four test sessions per day that included evaluations of fatigue, motion sickness, vigilance, perceptual discrimination, perceptual learning, motor performance and learning, and balance. Sleep loss and exposure to linear oscillation had additive or multiplicative relationships to sleepiness, motion sickness severity, decreases in vigilance and in perceptual discrimination

2017 Autonomic neuroscience : basic & clinical

5. Storage of passive motion pattern in hippocampal CA1 region depends on CaMKII/CREB signaling pathway in a motion sickness rodent model (PubMed)

Storage of passive motion pattern in hippocampal CA1 region depends on CaMKII/CREB signaling pathway in a motion sickness rodent model Sensory mismatch between actual motion information and anticipated sensory patterns (internal model) is the etiology of motion sickness (MS). Some evidence supports that hippocampus might involve the neural storage of the "internal model". This study established an "internal model" acquisition-retention behavioral model using a repeated habituation rotation (...) behavioral responses on "internal model" retention day. Habituation training increased CaMKII and CREB activity but had no effect on CaMKIV and ERK1/2 activity in the CA1, while inhibition of CaMKII but not ERK1/2 impaired "internal model" retention. In het/het mice, CaMKII and CREB were not activated in the CA1 on the retention day. These results suggested that CaMKII/CREB pathway might potentially contribute to the storage of the "internal model" in the hippocampal CA1 after motion sickness induced

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2017 Scientific reports

6. Vection is the main contributor to motion sickness induced by visual yaw rotation: Implications for conflict and eye movement theories. (PubMed)

Vection is the main contributor to motion sickness induced by visual yaw rotation: Implications for conflict and eye movement theories. This study investigated the role of vection (i.e., a visually induced sense of self-motion), optokinetic nystagmus (OKN), and inadvertent head movements in visually induced motion sickness (VIMS), evoked by yaw rotation of the visual surround. These three elements have all been proposed as contributing factors in VIMS, as they can be linked to different motion (...) varies among participants (R2 = 0.48). Regression parameters for vection variability, head and eye movement parameters were not significant. These results may seem to be in line with the Sensory Conflict theory on motion sickness, but we argue that a more detailed definition of the exact nature of the conflict is required to fully appreciate the relationship between vection and VIMS.

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2017 PLoS ONE

7. The effects of the selective muscarinic M3 receptor antagonist darifenacin, and of hyoscine (scopolamine), on motion sickness, skin conductance & cognitive function. (PubMed)

The effects of the selective muscarinic M3 receptor antagonist darifenacin, and of hyoscine (scopolamine), on motion sickness, skin conductance & cognitive function. The aim of this study was to compare the effects of the selective M3 muscarinic acetylcholine receptor antagonist darifenacin, oral hyoscine hydrobromide and placebo on motion sickness induced by cross-coupled stimulation.The effects of darifenacin 10 mg or 20 mg, hyoscine hydrobromide 0.6 mg and placebo were assessed (...) in a randomized, double-blind, four-way cross over trial of 16 healthy subjects. Motion sickness, skin conductance (a measure of sweating) and psychomotor cognitive function tests were investigated.Hyoscine hydrobromide produced significantly increased tolerance to motion versus placebo (P < 0.05 to P < 0.01). The motion protection effect of darifenacin (10 or 20 mg) was approximately one third that of hyoscine hydrobromide but was not significant versus placebo. Darifenacin and hyoscine hydrobromide both

2018 British journal of clinical pharmacology

8. Effect of exposure to short-wavelength light on susceptibility to motion sickness. (PubMed)

Effect of exposure to short-wavelength light on susceptibility to motion sickness. This randomized cross-over study tested the hypothesis that exposure to short-wavelength light induces symptoms of motion sickness (MS). The study participants were 28 healthy adults (14 women; mean age±SD, 25.96±3.11 years). Two stimuli oscillating within a range of 0.4-0.6 Hz were used to induce MS: a blue wave stimulus with short-wavelength light (460 nm) and a green wave stimulus with middle-wavelength light (...) (555 nm). All participants were exposed to both stimuli throughout two separate periods. After a baseline period, participants were exposed to each stimulus three times for 4 min. The Simulator Sickness Questionnaire, a self-report checklist composed of three subscales (Oculomotor, Disorientation, and Nausea), heart rate variability, and electrogastrography were used to measure the degree of symptoms related to MS. A linear mixed-effects model was used for statistical analysis. The results showed

2018 Neuroreport

9. Effect of Prophylactic Medication on Associated Dizziness and Motion Sickness in Migraine. (PubMed)

Effect of Prophylactic Medication on Associated Dizziness and Motion Sickness in Migraine. To determine the efficacy of prophylactic medications for migraine in reducing associated dizziness and motion sickness.Multicenter prospective observational study.Nationwide 9 Dizziness Clinics in South Korea.One hundred thirty-eight patients who required a preventive medication for migraine accompanied by dizziness and motion sickness.At least one of the prophylactic medications was prescribed among (...) the beta-blockers, calcium channel blockers, tricyclic antidepressants, and antiepileptic drugs.For 3 months from the index visit, the patients had monthly assessments of the headache (frequency and duration), dizziness handicap inventory, University of California Los Angeles dizziness questionnaire, vertigo symptom scale, and motion sickness score.The prophylactic medications significantly improved the headache profiles, all three parameters of dizziness (dizziness handicap inventory, University

2018 Otology and Neurotology

10. Clinical Evaluation of the Use of Ginger Extract in the Management of Motion Sickness

Clinical Evaluation of the Use of Ginger Extract in the Management of Motion Sickness Clinical Evaluation of the Use of Ginger Extract in the Management of Motion Sickness - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Clinical Evaluation of the Use of Ginger Extract in the Management of Motion Sickness The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03755596 Recruitment Status : Not yet recruiting First Posted : November 28

2018 Clinical Trials

11. Targeting TRPV1 to relieve motion sickness symptoms in mice by electroacupuncture and gene deletion (PubMed)

Targeting TRPV1 to relieve motion sickness symptoms in mice by electroacupuncture and gene deletion Motion sickness (MS) is an acute disorder that occurs in healthy individuals worldwide regardless of gender, age, or ethnicity. Our study used a mouse model to rule out the effects of any psychological factors related to MS and EA. Subjects were randomly separated into four groups, namely the control group (Con), motion sickness inducing group (MS), mentioning sickness inducing (...) with electroacupuncture treatment group (EA) and motion sickness inducing only in TRPV1 knockout mice group (TRPV1-/-). The consumption of kaolin, a non-nutrient substance, was measured as a behavior observed response of an emetic reflex in a murine model. This behavior is referred to as pica behavior. Our results showed that pica behavior was observed in the MS group. Moreover, kaolin consumption in the EA group decreased to the average baseline of the control group. A similar result was observed in TRPV1 null mice

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2018 Scientific reports

12. Evaluation of the effects of anti-motion sickness drugs on subjective sleepiness and cognitive performance of healthy males. (PubMed)

Evaluation of the effects of anti-motion sickness drugs on subjective sleepiness and cognitive performance of healthy males. This study aimed to investigate the clinical and cognitive side effects of baclofen (10 mg), meclizine (25 mg), dimenhydrinate (40 mg) plus cinnarizine (25 mg) and promethazine (25 mg) plus d-amphetamine (10 mg). The study had a double-blind, placebo controlled, repeated measures design and was conducted on healthy male volunteers. The psychomotor vigilance test

2018 Journal of psychopharmacology (Oxford, England)

13. More vection means more velocity storage activity: a factor in visually induced motion sickness? (PubMed)

More vection means more velocity storage activity: a factor in visually induced motion sickness? Full-field visual rotation around the vertical axis induces a sense of self-motion (vection), optokinetic nystagmus (OKN), and, eventually, also motion sickness (MS). If the lights are then suddenly switched off, optokinetic afternystagmus (OKAN) occurs. This is due to the discharge of the velocity storage mechanism (VSM), a central integrative network that has been suggested to be involved (...) in motion sickness. We previously showed that visually induced motion sickness (VIMS) following optokinetic stimulation is dependent on vection intensity. To shed light on this relationship, the current study investigated whether vection intensity is related to VSM activity, and thus, to the OKAN. In repetitive trials (eight per condition), 15 stationary participants were exposed to 120 s of visual yaw rotation (60°/s), followed by 90 s in darkness. The visual stimulus either induced strong vection (i.e

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2018 Experimental Brain Research

14. Responding to Other People’s Posture: Visually Induced Motion Sickness From Naturally Generated Optic Flow (PubMed)

Responding to Other People’s Posture: Visually Induced Motion Sickness From Naturally Generated Optic Flow Understanding the relationship between our actions and the perceptual information that is used to support them is becoming increasingly necessary as we utilize more digital and virtual technologies in our lives. Smart et al. (2014) found that altering the relationship between perception and action can have adverse effects, particularly if the perceptual information cannot be used (...) to guide behavior. They also found that motion characteristics varied between people who remained well and those that became motion sick. The purpose of this study was to determine the influence of naturally produced virtual motion on postural regulation and examine how people respond to different types of optical flow (produced by other people). Participants were either exposed to optic flow produced by the postural motion of a person who did not become motion sick, or a person who did exhibit motion

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2018 Frontiers in psychology

15. The Neurophysiology and Treatment of Motion Sickness. (PubMed)

The Neurophysiology and Treatment of Motion Sickness. Seasickness and travel sickness are classic types of motion illness. Modern simulation systems and virtual reality representations can also induce comparable symptoms. Such manifestations can be alleviated or prevented by various measures.This review is based on pertinent publications retrieved by a PubMed search, with special attention to clinical trials and review articles.Individuals vary in their susceptibility to autonomic symptoms (...) , ranging from fatigue to massive vomiting, induced by passive movement at relatively low frequencies (0.2 to 0.4 Hz) in situations without any visual reference to the horizontal plane. Younger persons and women are considered more susceptible, and twin studies have revealed a genetic component as well. The various types of motion sickness are adequately explained by the intersensory conflict model, incorporating the vestibular, visual, and proprioceptive systems and extended to include consideration

2018 Deutsches Arzteblatt international

16. No Gain No Pain: Relations Between Vestibulo-Ocular Reflexes and Motion Sickness in Mice (PubMed)

No Gain No Pain: Relations Between Vestibulo-Ocular Reflexes and Motion Sickness in Mice Motion sickness occurs when the vestibular system is subjected to conflicting sensory information or overstimulation. Despite the lack of knowledge about the actual underlying mechanisms, several drugs, among which scopolamine, are known to prevent or alleviate the symptoms. Here, we aim at better understanding how motion sickness affects the vestibular system, as well as how scopolamine prevents motion (...) sickness at the behavioral and cellular levels. We induced motion sickness in adult mice and tested the vestibulo-ocular responses to specific stimulations of the semi-circular canals and of the otoliths, with or without scopolamine, as well as the effects of scopolamine and muscarine on central vestibular neurons recorded on brainstem slices. We found that both motion sickness and scopolamine decrease the efficacy of the vestibulo-ocular reflexes and propose that this decrease in efficacy might

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2018 Frontiers in neurology

17. Motion sickness in ancient China: Seasickness and cart-sickness. (PubMed)

Motion sickness in ancient China: Seasickness and cart-sickness. To find and analyze descriptions of motion sickness in Chinese historical sources.Databases and dictionaries were searched for various terms for seasickness and travel sickness, which were then entered into databases of full texts allowing selection of relevant passages from about the third to the 19th century ad.Already in 300 ad the Chinese differentiated cart-sickness, particularly experienced by persons from the arid north (...) of China, from a ship-illness experienced by persons from the south, where rivers were important for transportation and travel. In the Middle Ages, a third form of motion sickness was called litter-influence experienced by persons transported in a bed suspended between 2 long poles. The ancient Chinese recognized the particular susceptibility of children to motion sickness. Therapeutic recommendations include drinking the urine of young boys, swallowing white sand-syrup, collecting water drops from

2016 Neurology

18. Motion sickness increases functional connectivity between visual motion and nausea-associated brain regions (PubMed)

Motion sickness increases functional connectivity between visual motion and nausea-associated brain regions The brain networks supporting nausea not yet understood. We previously found that while visual stimulation activated primary (V1) and extrastriate visual cortices (MT+/V5, coding for visual motion), increasing nausea was associated with increasing sustained activation in several brain areas, with significant co-activation for anterior insula (aIns) and mid-cingulate (MCC) cortices. Here (...) , we hypothesized that motion sickness also alters functional connectivity between visual motion and previously identified nausea-processing brain regions. Subjects prone to motion sickness and controls completed a motion sickness provocation task during fMRI/ECG acquisition. We studied changes in connectivity between visual processing areas activated by the stimulus (MT+/V5, V1), right aIns and MCC when comparing rest (BASELINE) to peak nausea state (NAUSEA). Compared to BASELINE, NAUSEA reduced

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2016 Autonomic neuroscience : basic & clinical

19. Vestibular evoked myogenic potentials and motion sickness medications. (PubMed)

Vestibular evoked myogenic potentials and motion sickness medications. Seasickness is a widespread problem among naval crew, and has a major impact on their performance at sea. The three pharmacological agents most commonly employed in the treatment of seasickness are dimenhydrinate, cinnarizine, and scopolamine. At present, the effectiveness of anti-seasickness drugs is tested by a process of "trial and error", while sailing and exposed to sea conditions. A physiological test to evaluate (...) the action of a drug might save crew members long periods of suffering, as well as simplifying the procedure of selecting the appropriate treatment for each individual. The cervical vestibular evoked myogenic potentials (cVEMP) test has come to be recognized as a reliable procedure for the objective evaluation of saccular function. It was the hypothesis of the present study that cVEMP otolith responses may be affected by anti-motion sickness drugs, which might thus make cVEMP a useful clinical

2017 Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

20. Motion Sickness Medications and Vestibular Time Constant

Motion Sickness Medications and Vestibular Time Constant Motion Sickness Medications and Vestibular Time Constant - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Motion Sickness Medications and Vestibular (...) Force Information provided by (Responsible Party): Dror Tal, Medical Corps, Israel Defense Force Study Details Study Description Go to Brief Summary: Sea sickness represents a major limitation on the performance of ships' crew. One of the challenges faced by the physician in the motion sickness clinic when prescribing anti-sea sickness medication is to select the appropriate drug for the patient. Difficulties arise due to high variability in the response to different drugs. In the case of sea

2017 Clinical Trials

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