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Monoclonal Gammopathy of Undetermined Significance

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1. Monoclonal gammopathy of undetermined significance

Monoclonal gammopathy of undetermined significance Monoclonal gammopathy of undetermined significance - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Monoclonal gammopathy of undetermined significance Last reviewed: February 2019 Last updated: January 2018 Summary Asymptomatic pre-malignant disorder associated with relatively low risk (on average 0.5%-1.0% per year) of progression to multiple myeloma or related (...) plasma cell proliferative malignancies. No aetiological risk factors have been defined. Male gender, older age, family history of monoclonal gammopathy of undetermined significance, black ancestry, and exposure to radiation or pesticide are associated with a higher prevalence. There is no indication for specific treatment. Clinical- and laboratory-based follow-up is recommended. Definition Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic disorder associated

2018 BMJ Best Practice

2. Long-Term Follow-up of Monoclonal Gammopathy of Undetermined Significance. Full Text available with Trip Pro

Long-Term Follow-up of Monoclonal Gammopathy of Undetermined Significance. Monoclonal gammopathy of undetermined significance (MGUS) occurs in approximately 3% of persons 50 years of age or older.We studied 1384 patients who were residing in southeastern Minnesota and in whom MGUS was diagnosed at the Mayo Clinic in the period from 1960 through 1994; the median follow-up was 34.1 years (range, 0.0 to 43.6). The primary end point was progression to multiple myeloma or another plasma-cell (...) (ratio of kappa to lambda free light chains) and a high serum monoclonal protein (M protein) level (≥1.5 g per deciliter) - was associated with a risk of progression at 20 years of 55%, as compared with 41% among patients who had one adverse risk factor and 19% among patients who had neither risk factor. Among patients with non-IgM MGUS, the risk of progression at 20 years was 30% among those who had the two risk factors, 20% among those who had one risk factor, and 7% among those who had neither

2018 NEJM

3. A risk-stratification model based on the initial concentration of the serum monoclonal protein and MYD88 mutation status identifies a subset of patients with IgM monoclonal gammopathy of undetermined significance at high risk of progression to Waldenström (Abstract)

A risk-stratification model based on the initial concentration of the serum monoclonal protein and MYD88 mutation status identifies a subset of patients with IgM monoclonal gammopathy of undetermined significance at high risk of progression to Waldenström IgM monoclonal gammopathies of undetermined significance (IgM MGUS) are associated with a risk of progression to Waldenström macroglobulinaemia (WM) or other lymphoproliferative disorders (LPD) of 1-2% per year. We analysed 176 consecutive (...) patients with IgM MGUS to evaluate risk factors for progression. With a median follow-up of 83 months (1214 person-years), 15 patients (8·5%) progressed to WM (n = 14) or marginal zone lymphoma (n = 1). The rate of progression was 1·32% per year (95% confidence interval [CI] 0·80-2·20). The serum monoclonal protein concentration and the MYD88 mutation were independent risk factors for progression (Hazard ratio [HR] 23·3, 95% CI 2·0-273·3, P = 0·012 and HR 24·4, 95% CI 2·2-275·3, P = 0·010, respectively

2019 British journal of haematology

4. Post-MGUS diagnosis serum monoclonal-protein velocity and the progression of monoclonal gammopathy of undetermined significance to multiple myeloma. (Abstract)

Post-MGUS diagnosis serum monoclonal-protein velocity and the progression of monoclonal gammopathy of undetermined significance to multiple myeloma. Multiple myeloma (MM) is a common hematologic malignancy consistently preceded by monoclonal gammopathy of undetermined significance (MGUS). Little is known about post-diagnosis clinical predictors of progression of MGUS to MM to guide MGUS management. This study aimed to investigate whether the rate of rise in serum monoclonal protein

2019 Cancer Epidemiology & Biomarkers and Prevention

5. Bone disease in monoclonal gammopathy of undetermined significance: results from a screened population-based study Full Text available with Trip Pro

Bone disease in monoclonal gammopathy of undetermined significance: results from a screened population-based study Previous studies have shown that individuals with monoclonal gammopathy of undetermined significance (MGUS) have an increased risk of fractures, although the underlying mechanisms remain unknown. Our aim was to analyze bone mineral density (BMD), bone volume, and risk of fractures among individuals with MGUS. We performed a screening using the Age, Gene/Environment Susceptibility (...) (AGES)-Reykjavik Study cohort, consisting of 5764 elderly individuals, identifying 300 individuals with MGUS, and 275 with light-chain MGUS. Quantitative computerized tomography was performed in the lumbar spine and hip to evaluate BMD and bone geometry. Analysis of variance and the Tukey honest significance test were used to compare the groups. Hospital records were used to record fractures, with a mean follow-up of 6.9 years. Cox proportional hazard was used to compare fracture risk. No difference

2017 Blood advances

6. MALDI-TOF analysis of blood serum proteome can predict the presence of monoclonal gammopathy of undetermined significance. Full Text available with Trip Pro

MALDI-TOF analysis of blood serum proteome can predict the presence of monoclonal gammopathy of undetermined significance. Monoclonal gammopathy of undetermined significance (MGUS) is a plasma cell dyscrasia that can progress to malignant multiple myeloma (MM). Specific molecular biomarkers to classify the MGUS status and discriminate the initial asymptomatic phase of MM have not been identified. We examined the serum peptidome profile of MGUS patients and healthy volunteers using MALDI-TOF

2018 PLoS ONE

7. Risk factors for monoclonal gammopathy of undetermined significance: a systematic review

Risk factors for monoclonal gammopathy of undetermined significance: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites

2019 PROSPERO

8. Identification of comorbidities in people with Monoclonal Gammopathy of Undetermined Significance (MGUS) or Smoldering Myeloma (SMM), their incidence, prevalence and associated risk factors: an original protocol for a systematic review

Identification of comorbidities in people with Monoclonal Gammopathy of Undetermined Significance (MGUS) or Smoldering Myeloma (SMM), their incidence, prevalence and associated risk factors: an original protocol for a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission

2019 PROSPERO

9. Obesity and risk of monoclonal gammopathy of undetermined significance and progression to multiple myeloma: a population-based study Full Text available with Trip Pro

Obesity and risk of monoclonal gammopathy of undetermined significance and progression to multiple myeloma: a population-based study All multiple myeloma (MM) cases are preceded by the premalignant state monoclonal gammopathy of undetermined significance (MGUS). Results from previous studies show a positive association between obesity and MM; however, the association between obesity and MGUS is controversial. The aims were to determine (1) if obesity is associated with an increased risk of MGUS

2017 Blood advances

10. Low knowledge and awareness of monoclonal gammopathy of undetermined significance (MGUS) among general practitioners. Full Text available with Trip Pro

Low knowledge and awareness of monoclonal gammopathy of undetermined significance (MGUS) among general practitioners. While multiple myeloma (MM) is a rare diagnosis within primary care, its precursor MGUS (monoclonal gammopathy of undetermined significance) is more common, particularly among older populations. Upon first detection, the majority of MGUS patients will be under the care of their General Practitioner (GP)/Family Doctor who is also often the first healthcare professional

2019 BMC Family Practice

11. Parental longevity and survival among patients with multiple myeloma and monoclonal gammopathy of undetermined significance: a population-based study. (Abstract)

Parental longevity and survival among patients with multiple myeloma and monoclonal gammopathy of undetermined significance: a population-based study. Parental longevity is associated with an increased life expectancy; results with regard to specific diseases are conflicting. There are limited data focusing on host characteristics and their effect on survival among multiple myeloma (MM) patients and individuals with monoclonal gammopathy of undetermined significance (MGUS). Therefore, our aim (...) ·87, 95% CI 0·78-0·96). Having one long lived parent significantly decreased the risk of death in both groups, but was not statistically significant when both parents exceeded 90 years of age. In conclusion, parental longevity decreases the risk of death for patients with MM and MGUS which may reflect the importance of the host's genetic and environmental factors in relation to survival.© 2019 British Society for Haematology and John Wiley & Sons Ltd.

2019 British journal of haematology

12. Monoclonal gammopathy of undetermined significance (MGUS). (Abstract)

Monoclonal gammopathy of undetermined significance (MGUS). Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant plasma cell dyscrasia that consistently precedes multiple myeloma (MM) with a 1% risk of progression per year. Recent advances have improved understanding of the complex genetic and immunologic factors that drive and permit progression from aberrant plasma cell clone to MGUS and overt MM. Additional evidence supports a bidirectional interaction of MGUS cells

2019 Blood

13. Paraproteinemic keratopathy associated with monoclonal gammopathy of undetermined significance (MGUS): clinical findings in twelve patients including recurrence after keratoplasty. (Abstract)

Paraproteinemic keratopathy associated with monoclonal gammopathy of undetermined significance (MGUS): clinical findings in twelve patients including recurrence after keratoplasty. To describe the ocular findings of 12 subjects with paraproteinemic keratopathy associated with monoclonal gammopathy of undetermined significance (MGUS).Ocular examination included corneal spectral domain optical coherence tomography. In three individuals with an initial diagnosis of a lattice or Thiel-Behnke

2019 Acta ophthalmologica

14. Dual anti-neutrophil cytoplasmic antibody and anti-glomerular basement membrane antibody-positive crescent glomerulonephritis in a patient with monoclonal gammopathy of undetermined significance: A case report. Full Text available with Trip Pro

Dual anti-neutrophil cytoplasmic antibody and anti-glomerular basement membrane antibody-positive crescent glomerulonephritis in a patient with monoclonal gammopathy of undetermined significance: A case report. Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and anti-glomerular basement membrane (GBM) antibody disease are both rare autoimmune diseases. Monoclonal gammopathy of undetermined significance (MGUS) is one of the most common causes of plasma cell dyscrasias (...) immunofixation electrophoresis found monoclonal immunoglobulin (MIg) G κ-light chain in the serum. Renal biopsy displayed crescentic formation in glomerule by microscopy and staining for liner IgG (+), sparse C3 (+-) and light chain (κ and λ) (+-) by immunofluorescence. The bone marrow examination indicated basically normal myelogram and sporadic plasma cells positive for CD38, CD138 staining, and κ light-chain restriction.Crescentic glomerulonephritis and MGUS.The patient was treated with plasmapheresis

2019 Medicine

15. Monoclonal gammopathy of undetermined significance: A primary care guide. Full Text available with Trip Pro

Monoclonal gammopathy of undetermined significance: A primary care guide. Monoclonal gammopathy of undetermined significance (MGUS) is commonly diagnosed in outpatients being worked up for an array of clinical concerns. It carries a risk of progression to myeloma and other lymphoproliferative disorders that, albeit low (1% per year), warrants regular follow-up. Patients with MGUS can be risk-stratified on the basis of the amount and type of their monoclonal protein as well as whether they have

2019 Cleveland Clinic Journal of Medicine

16. Malignant progression and survival of monoclonal gammopathy of undetermined significance: a systematic review and meta-analysis

Malignant progression and survival of monoclonal gammopathy of undetermined significance: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne

2018 PROSPERO

17. Prostate cancer leading to monoclonal gammopathy of undetermined significance: A case report Full Text available with Trip Pro

Prostate cancer leading to monoclonal gammopathy of undetermined significance: A case report Prostate cancer is one of the most common cancer types, affecting millions of individuals worldwide. The present study reported two cases of metastatic prostate cancer presenting with newly diagnosed monoclonal gammopathy of undetermined significance (MGUS). To the best of our knowledge, prostate cancer leading to MGUS has not been documented previously. MGUS is generally thought to be benign and has

2018 Molecular and clinical oncology

18. Sarcoidosis and Monoclonal Gammopathy of Undetermined Significance (MGUS): A True Association or Just a Coincidence? Full Text available with Trip Pro

Sarcoidosis and Monoclonal Gammopathy of Undetermined Significance (MGUS): A True Association or Just a Coincidence? Sarcoidosis is a systemic inflammatory disease characterized by the presence of noncaseating granulomas in different organs. Sarcoidosis associated with monoclonal gammopathy of undetermined significance (MGUS) is a rare finding with only 10 cases reported to date. We describe a 79-year-old male patient who presented with dry mouth for 4 months. Lip biopsy done prior to admission (...) monoclonal gammopathy with an M-spike of 1.47. Bone marrow biopsy was consistent with MGUS. The patient showed significant improvement with steroids and was discharged with close follow-up from nephrology and oncology. Salivary gland involvement in patients with sarcoidosis is a rare finding. Our case is a valuable addition to the small number of cases described in the literature supporting an association between plasma cell disorders and sarcoidosis. Larger prospective studies are needed to determine

2018 Case reports in hematology

19. Enrichment of B cell receptor signaling and epidermal growth factor receptor pathways in monoclonal gammopathy of undetermined significance: a genome-wide genetic interaction study Full Text available with Trip Pro

Enrichment of B cell receptor signaling and epidermal growth factor receptor pathways in monoclonal gammopathy of undetermined significance: a genome-wide genetic interaction study Recent identification of 10 germline variants predisposing to monoclonal gammopathy of undetermined significance (MGUS) explicates genetic dependency of this asymptomatic precursor condition with multiple myeloma (MM). Yet much of genetic burden as well as functional links remain unexplained. We propose a workflow

2018 Molecular Medicine

20. Risk of progression of monoclonal gammopathy of undetermined significance into lymphoplasmacytic malignancies: determining demographic differences in the USA Full Text available with Trip Pro

Risk of progression of monoclonal gammopathy of undetermined significance into lymphoplasmacytic malignancies: determining demographic differences in the USA 29269527 2019 03 06 2019 03 06 1592-8721 103 3 2018 03 Haematologica Haematologica Risk of progression of monoclonal gammopathy of undetermined significance into lymphoplasmacytic malignancies: determining demographic differences in the USA. e123-e125 10.3324/haematol.2017.179978 Go Ronald S RS Division of Hematology Mayo Clinic, Rochester (...) Care Delivery; Mayo Clinic, Rochester, MN, USA. Shah Nilay D ND Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery; Mayo Clinic, Rochester, MN, USA. eng Letter Research Support, Non-U.S. Gov't 2017 12 21 Italy Haematologica 0417435 0390-6078 IM Age Factors Cell Transformation, Neoplastic Demography Disease Progression Humans Monoclonal Gammopathy of Undetermined Significance pathology Neoplasms, Plasma Cell etiology Sex Factors United States 2017 12 23 6 0 2019 3 7 6 0

2018 Haematologica

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