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Mongolian Spot

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61. How to Spot Research Spin: The Case of the Not-So-Simple Abstract

How to Spot Research Spin: The Case of the Not-So-Simple Abstract How to Spot Research Spin: The Case of the Not-So-Simple Abstract | Absolutely Maybe PLOS Blogs Staff Blogs Blogs by Topic Biology & Life Sciences Earth & Environmental Sciences Multi-disciplinary Sciences Medicine & Health Research Analysis & Scientific Policy Diverse perspectives on science and medicine Staff Blogs Blogs by Topic Biology & Life Sciences Earth & Environmental Sciences Multi-disciplinary Sciences Medicine (...) papers in the top 1% in each year were excluded. That brought their sample down to 1%-ers concentrated in around 500 journals a year. (There was no data for papers that weren’t highly cited.) What fields of science these journals come from wasn’t analyzed. The authors argue that factoring out journals in some analyses means “any effect of differences between fields is also accounted for” . No analysis was provided to support that. Journals with policies with very short word limits for abstracts (like

2016 Absolutely Maybe

62. Rifts and Bright Spots in Evidence-Based Medicine

Rifts and Bright Spots in Evidence-Based Medicine Rifts and Bright Spots in Evidence-Based Medicine | Absolutely Maybe PLOS Blogs Staff Blogs Blogs by Topic Biology & Life Sciences Earth & Environmental Sciences Multi-disciplinary Sciences Medicine & Health Research Analysis & Scientific Policy Diverse perspectives on science and medicine Staff Blogs Blogs by Topic Biology & Life Sciences Earth & Environmental Sciences Multi-disciplinary Sciences Medicine & Health Research Analysis & Scientific (...) and somersaulted, smashing her to the ground. It left her with two broken arms, numbness in the fingers, neck injury – and a cracked bike helmet. Arms were set, rehab, then neck surgery, and more rehab ensued. How was this high-impact arm and neck injury in a 54-year-old ex-elite athlete summed up in the hospital record? “55 yr old female fell off bike”. Greenhalgh was then propelled down the highly irrelevant “preventing falls in the elderly” evidence guideline pathway. The twists and turns, of evidence

2015 Absolutely Maybe

63. Rifts and Bright Spots in Evidence-Based Medicine

Rifts and Bright Spots in Evidence-Based Medicine Rifts and Bright Spots in Evidence-Based Medicine | Absolutely Maybe PLOS Blogs Staff Blogs Blogs by Topic Biology & Life Sciences Earth & Environmental Sciences Multi-disciplinary Sciences Medicine & Health Research Analysis & Scientific Policy Diverse perspectives on science and medicine Staff Blogs Blogs by Topic Biology & Life Sciences Earth & Environmental Sciences Multi-disciplinary Sciences Medicine & Health Research Analysis & Scientific (...) and somersaulted, smashing her to the ground. It left her with two broken arms, numbness in the fingers, neck injury – and a cracked bike helmet. Arms were set, rehab, then neck surgery, and more rehab ensued. How was this high-impact arm and neck injury in a 54-year-old ex-elite athlete summed up in the hospital record? “55 yr old female fell off bike”. Greenhalgh was then propelled down the highly irrelevant “preventing falls in the elderly” evidence guideline pathway. The twists and turns, of evidence

2015 Absolutely Maybe

64. GM1 GANGLIOSIDOSIS ASSOCIATED WITH NEONATAL-ONSET OF DIFFUSE ECCHYMOSES AND MONGOLIAN SPOTS Full Text available with Trip Pro

GM1 GANGLIOSIDOSIS ASSOCIATED WITH NEONATAL-ONSET OF DIFFUSE ECCHYMOSES AND MONGOLIAN SPOTS A 7-month old girl with GM1 gangliosidosis type 1 manifested with diffuse ecchymosis and Mongolian spots. The cutaneous lesions were present at birth before the appearance of the other features of the disease. We postulate that dermal pigmentation may be recognized as an early sign of GM1 gangliosidosis.

2011 Indian journal of dermatology

65. Evaluation of a Dried Blood Spot Assay to Measure Prenatal Screening Markers Pregnancy-Associated Plasma Protein A and Free β-Subunit of Human Chorionic Gonadotropin. Full Text available with Trip Pro

combined screening for trisomy 21.© 2013 American Association for Clinical Chemistry. (...) Evaluation of a Dried Blood Spot Assay to Measure Prenatal Screening Markers Pregnancy-Associated Plasma Protein A and Free β-Subunit of Human Chorionic Gonadotropin. First-trimester prenatal screening for aneuploidy by use of dried blood spots (DBSs) may offer practical benefits in settings where the instability of intact human chorionic gonadotropin (hCG) is problematic. We evaluated a DBS pregnancy-associated plasma protein A (PAPP-A) and free β-subunit of hCG (free hCGβ) dual assay

2013 Clinical Chemistry

66. Penaeus monodon Thioredoxin Restores the DNA Binding Activity of Oxidized White Spot Syndrome Virus IE1 Full Text available with Trip Pro

Penaeus monodon Thioredoxin Restores the DNA Binding Activity of Oxidized White Spot Syndrome Virus IE1 In this study we identified viral gene targets of the important redox regulator thioredoxin (Trx), and explored in depth how Trx interacts with the immediate early gene #1 (IE1) of the white spot syndrome virus (WSSV).In a pull-down assay, we found that recombinant Trx bound to IE1 under oxidizing conditions, and a coimmunoprecipitation assay showed that Trx bound to WSSV IE1 when (...) the transfected cells were subjected to oxidative stress. A pull-down assay with Trx mutants showed that no IE1 binding occurred when cysteine 62 was replaced by serine. Electrophoretic mobility shift assay (EMSA) showed that the DNA binding activity of WSSV IE1 was downregulated under oxidative conditions, and that Penaeus monodon Trx (PmTrx) restored the DNA binding activity of the inactivated, oxidized WSSV IE1. Another EMSA experiment showed that IE1's Cys-X-X-Cys motif and cysteine residue 55 were

2012 Antioxidants & redox signaling

67. Co-Interactive DNA-Binding between a Novel, Immunophilin-Like Shrimp Protein and VP15 Nucleocapsid Protein of White Spot Syndrome Virus Full Text available with Trip Pro

Co-Interactive DNA-Binding between a Novel, Immunophilin-Like Shrimp Protein and VP15 Nucleocapsid Protein of White Spot Syndrome Virus White spot syndrome virus (WSSV) is one of the most serious pathogens of penaeid shrimp. Although its genome has been completely characterized, the functions of most of its putative proteins are not yet known. It has been suggested that the major nucleocapsid protein VP15 is involved in packaging of the WSSV genome during virion formation. However, little (...) a putative FKBP-PPIase domain in the C-terminal region. Results from a GST pull-down assay and histological co-localization revealed that VP15 physically interacted with PmFKBP46 and that both proteins shared the same subcellular location in the nucleus. An electrophoretic mobility shift assay indicated that PmFKBP46 possessed DNA-binding activity and functionally co-interacted with VP15 in DNA binding. The overall results suggested that host PmFKBP46 might be involved in genome packaging by viral VP15

2011 PloS one

68. Hypertension in pregnancy: diagnosis and management

level 3 or severe pre-eclampsia with any of the following complications: eclampsia HELLP syndrome haemorrhage hyperkalaemia severe oliguria coagulation support intravenous antihypertensive treatment initial stabilisation of severe hypertension evidence of cardiac failure abnormal neurology Level 1 care Pre-eclampsia with hypertension Ongoing conservative antenatal management of severe preterm hypertension Step-down treatment after the birth 1.9 Antihypertensive treatment during the postnatal period (...) of birth 46 Antihypertensive treatment during the postnatal period, including during breastfeeding 48 Risk of recurrence of hypertensive disorders of pregnancy and long-term cardiovascular disease 49 Context 50 Hypertension in pregnancy: diagnosis and management (NG133) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 3 of 54Finding more information and resources 52 Update information 53 Hypertension in pregnancy

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

69. Genome-Wide Sequencing for Unexplained Developmental Disabilities or Multiple Congenital Anomalies

grouped together in the literature. In this report we refer to the group as having developmental disability. Congenital anomalies, also known as birth defects, can be structural or functional (e.g., metabolic) and can impair a person’s development. 4 Approximately 3% of babies in the developed world are born with some congenital anomaly. Down syndrome (trisomy 21) is considered the most prevalent, with an estimated 1 case in 691 births. 5 Congenital anomalies sometimes, but not always, can occur (...) Criteria 16 Literature Screening 18 Data Extraction 18 Evidence Synthesis 18 Critical Appraisal of Evidence 18 Results 20 Clinical Literature Search 20 Characteristics of Included Studies 21 Risk of Bias in the Included Studies 21 Diagnostic Yield 22 Clinical Utility 28 Ongoing Studies 30 Discussion 32 Conclusions 34 ECONOMIC EVIDENCE 35 Research Question 35 Methods 35 Economic Literature Search 35 Eligibility Criteria 35 Literature Screening 35 Data Extraction 36 Study Applicability and Limitations 36

2020 Health Quality Ontario

70. Toolkit to support the generation of robust estimates of hepatitis C prevalence

Toolkit to support the generation of robust estimates of hepatitis C prevalence TECHNICAL REPORT Technical protocol for hepatitis C prevalence surveys in the general population SPHERE-C Project www.ecdc.europa.euECDC TECHNICAL REPORT Technical protocol for hepatitis C prevalence surveys in the general population SPHERE-C Project ii This report was commissioned by the European Centre for Disease Prevention and Control (ECDC), coordinated by Erika Duffell and Andrew Amato-Gauci, and produced (...) : European Centre for Disease Prevention and Control. Technical protocol for hepatitis C prevalence surveys in the general population. Stockholm: ECDC; 2020. Stockholm, February 2020 ISBN 978-92-9498-423-4 doi: 10.2900/30190 Catalogue number TQ-03-19-928-EN-N © European Centre for Disease Prevention and Control, 2019 Cover picture: © Science Photo Reproduction is authorised, provided the source is acknowledged. For any use or reproduction of photos or other material that is not under the EU copyright

2020 European Centre for Disease Prevention and Control - Technical Guidance

71. COVID-19: infection prevention and control

Personal Protective Equipment (PPE) 18 5.4.1 Disposable apron/gown 18 COVID-19: Guidance for infection prevention and control in healthcare settings. Version 1.1, 27/03/20 Page 3 of 52 5.4.2 Disposable gloves 19 5.4.3 Eye protection/Face visor 19 5.5 Safe management of linen (laundry) 19 5.6 Staff uniforms/clothes 20 5.7 Management of blood and body fluid spills 21 5.8 Management of healthcare (including clinical) and non-clinical waste 21 6. Transmission based precautions (TBPs) for pandemic COVID-19 (...) Appendix 5: Best Practice - Management of blood and body fluid spillages 44 Appendix 6: Facial hair and FFP3 respirators 45 Appendix 7 Glossary 46 COVID-19: Guidance for infection prevention and control in healthcare settings. Version 1.1, 27/03/20 Page 5 of 52 References 52 Abbreviations ABHR Alcohol based hand rub AGP CDC DHSC Aerosol generating procedure Centers for Disease Control and Prevention Department of Health and Social Care FRSM FFP3 Fluid-resistant (Type IIR) surgical mask Filtering face

2020 Public Health England

72. Considerations in adjusting public health and social measures in the context of COVID-19

approaches: (i) breaking chains of transmission by detecting, testing, isolating, and treating what measures are most appropriate depending on the most affected age group. https://www.who.int/emergencies/diseases/novel-coronavirus- 2019/technical-guidance/early-investigations Considerations in adjusting public health and social measures in the context of COVID-19: interim guidance -3- cases and quarantining contacts and (ii) monitoring hot spots of disease circulation through respiratory disease (...) Considerations in adjusting public health and social measures in the context of COVID-19 -1- Considerations in adjusting public health and social measures in the context of COVID-19 Interim guidance 16 April 2020 Background Across the globe, countries have implemented a number of control measures to comprehensively prepare for and respond to COVID-19. The overarching goal of the WHO global COVID-19 response strategy 1 is for all countries to control the pandemic by slowing down transmission

2020 WHO Coronavirus disease (COVID-19) Pandemic

73. Newborn screening for sickle cell disease

spots on filter paper can be used for SCD diagnostics. In the German expanded newborn screening programme performed in accordance with the G-BA’s paediatric guideline [23], in the 36 th to 72 nd hour of life, a blood sample is taken of the newborn from a vein or the heel, dripped onto filter paper cards and examined for various diseases. SCD is not among the diseases tested in the expanded newborn screening. According to a survey using routine data of children from the 2009 and 2010 birth cohorts (...) are cohort studies using a verification-of-only-positive testers (VOPT) design. Boemer 2006 [31] describes the results of a newborn screening programme in Belgium from June 2003 through February 2005. Samples were taken 5 days after birth in the form of blood spots on filter paper. The authors analysed the data of 27 010 newborns tested for HbS and HbC by means of ELISA (enzyme-linked immunosorbent assay). Extract of final report S18-01 Version 1.0 Newborn screening for sickle cell disease (SCD) 25 July

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

74. Nephrolithiasis

episodes. Definition Nephrolithiasis refers to the presence of crystalline stones (calculi) within the urinary system (kidneys and ureter). Such renal stones are composed of varying amounts of crystalloid and organic matrix. Ureteric stones almost always originate in the kidney but then pass down into the ureter. Stoller ML. Urinary stone disease. In: Tanagho EA, McAninch JW, eds. Smith's General Urology, 16th edition. New York, NY: McGraw-Hill: 2004: 256-291. History and exam acute, severe flank pain (...) , but with a warning and precaution regarding possible cardiovascular events. The manufacturer was required to conduct a large postmarketing safety clinical trial. The double-blind study (CARES) compared cardiovascular outcomes in patients with gout and major cardiovascular disease (n = 6198) who were randomised to febuxostat or to allopurinol. Treatment groups did not differ with respect to a primary composite outcome of cardiovascular events. However, cardiovascular death and all-cause mortality were

2019 BMJ Best Practice

75. Preparing Emerging Leaders for Alternative Futures in Health Systems Across Canada

to elicit feedback from two waves of key informants (as described in Box 1 and keeping in mind the equity considerations described in Box 2), the first of which included 26 innovative thinkers and the second of which included 19 health-system and other leaders. The drivers are: 1) changing population demographics, with aging and longer lifespans combined with increased prevalence of chronic diseases and highly diverse ethnocultural populations; 2) evolving perspectives within the health system (...) climate change, its effect on resource availability, and weather-related morbidity and mortality, o pollution and toxicity in the air and its impacts on health, o population mortality and work days lost to communicable disease as well as antibiotic resistance o access to sanitary tools to prevent exposure to waste and ensuring water and food quality, notably in Indigenous communities; • political forces such as: o ability and willingness of political bodies and organizations that have been given

2019 McMaster Health Forum

76. Diagnosis and Management of Acute Pulmonary Embolism Full Text available with Trip Pro

of pulmonary embolism 14 Table 7 Original and simplified Pulmonary Embolism Severity Index 20 Table 8 Classification of pulmonary embolism severity and the risk of early (in-hospital or 30-day) death 21 Table 9 Treatment of right ventricular failure in acute high-risk pulmonary embolism 23 Table 10 Thrombolytic regimens, doses, and contra indications 25 Table 11 Categorization of risk factors for venous thromboembolism based on the risk of recurrence over the long-term 33 Table 12 Estimated radiation (...) natriuretic peptide BP Blood pressure BPA Balloon pulmonary angioplasty b.p.m Beats per minute CI Confidence interval CO Cardiac output CPET Cardiopulmonary exercise testing CPG Committee for Practice Guidelines CrCl Creatinine clearance CRNM Clinically relevant non-major (bleeding) CT Computed tomogram/tomographic/tomography CTED Chronic thromboembolic disease CTEPH Chronic thromboembolic pulmonary hypertension CTPA Computed tomography pulmonary angiography/angiogram CUS Compression ultrasonography

2019 European Society of Cardiology

77. Guidelines on Diabetes, Pre-Diabetes and Cardiovascular Diseases developed in collaboration with the EASD Full Text available with Trip Pro

for the management of patients with diabetes and acute or chronic coronary syndromes 33 Recommendations for coronary revascularization in patients with diabetes 35 Recommendations for the type of revascularization in patients with diabetes with stable coronary artery disease, suitable coronary anatomy for both procedures, and low predicted surgical mortality 36 Recommendations for the treatment of heart failure in patients with diabetes 39 Recommendations for the treatment of patients with type 2 diabetes (...) plasma glucose ABI Ankle–brachial index ABPM Ambulatory blood pressure monitoring ACCORD Action to Control Cardiovascular Risk in Diabetes ACE Acarbose Cardiovascular Evaluation ACEI Angiotensin-converting enzyme inhibitor ACS Acute coronary syndrome ADA American Diabetes Association ADVANCE Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation ADDITION Anglo-Danish-Dutch Study of Intensive Treatment In People with Screen Detected Diabetes in Primary Care ADOPT

2019 European Society of Cardiology

78. ISHLT Consensus Statement on Donor Organ Acceptability and Management in Pediatric Heart Transplantation Full Text available with Trip Pro

vascular disease or coexistent syndromes. Waitlisted patients at higher risk of mortality include those listed urgently and those on extracorporeal membrane oxygenation (ECMO) or ventilator support. x 1 Almond, CSD, Thiagarajan, RR, Piercey, GE et al. Waiting list mortality among children listed for heart transplantation in the United States. Circulation . 2009 ; 119 : 717–727 , x 8 Mah, D, Singh, TP, Thiagarajan, RR et al. Incidence and risk factors for mortality in infants awaiting heart (...) , FRCPC b , x Ryan R. Davies Affiliations Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Children's Medical Center, Dallas, Texas , MD c , x Oliver Miera Affiliations Department of Congenital Heart Disease/Pediatric Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany , MD d , x Gretchen Chapman Affiliations Carnegie Mellon University, Pittsburgh, Pennsylvania , PhD e , x Jennifer Conway Affiliations Department of Pediatrics, Division

2020 International Society for Heart and Lung Transplantation

79. Disseminated kaposi’s sarcoma and other lymphoproliferative disorders in the era of art

al: The role of immune suppression and HHV-8 in the increasing incidence of HIV associated multicentric Castleman’s disease. Ann Oncol, 20 Leidner RS, Aboulafia DM. Recrudescent Kaposi’s sarcoma after initiation of HAART: a manifestation of immune reconstitution syndrome. AIDS Patient Care STDS 2005; 19:635. Bower M, Nelson N, Young AM, et al. Immune reconstitution inflammatory syndrome associated with Kaposi’s sarcoma. J Clin Oncol 2005; 23: 522 Share: | | Sites We Follow Useful Links Questions (...) Recognize the differential of lymphoproliferative disorders that can be associated with AIDS and HHV8 A 42-year-old man with AIDS (diagnosed in 2012, CD4 124 cells/mm3, non-compliant with anti-retroviral therapy (ART)) presented with shortness of breath, productive cough and worsening bilateral lower extremity swelling and pain for 3 months. The patient began experiencing bilateral lower extremity swelling and an increasing number of dark purple spots on his lower extremities a year prior

2020 Clinical Correlations

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